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    Mixer with zero dead volume and method for mixing
    1.
    发明授权
    Mixer with zero dead volume and method for mixing 有权
    混合器具有零死体积和混合方法

    公开(公告)号：US09174182B2

    公开(公告)日：2015-11-03

    申请号：US13265569

    申请日：2010-04-16

    申请人： Reinhold Wimberger-Friedl ,  Ronald Cornelis De Gier ,  Peter Hermanus Bouma

    发明人： Reinhold Wimberger-Friedl ,  Ronald Cornelis De Gier ,  Peter Hermanus Bouma

    IPC分类号： G01N1/10 ,  G01N1/02 ,  G01N1/00 ,  B01F5/06 ,  B01F13/00 ,  B01F11/00

    CPC分类号： B01F13/0059 ,  B01F5/0683 ,  B01F5/0688 ,  B01F11/0071 ,  Y10T436/25 ,  Y10T436/2575

    摘要： A micro fluidics system includes a closed, expandable volume for mixing a fluid, and a flexible membrane for allowing mixing in the closed, expandable volume. The system further includes a surface having at least one channel for fluidically coupling a first side of the surface to the closed, expandable volume on a second side of the surface. The channel includes a first channel opening fluidically coupling the first side of the surface to the channel and a second channel opening fluidically coupling the channel to the closed, expandable volume. The expandable volume is defined by the flexible membrane closing the second channel opening when there is no fluid in the expandable volume.

    摘要翻译： 微流体系统包括用于混合流体的封闭的可膨胀体积和用于允许在封闭的可膨胀体积中混合的柔性膜。 该系统还包括具有至少一个通道的表面，用于将表面的第一侧流体耦合到表面的第二侧上的封闭的可膨胀体积。 通道包括将表面的第一侧与通道流体连接的第一通道开口以及将通道流体连接到封闭的可膨胀体积的第二通道开口。 当可膨胀体积中没有流体时，可膨胀体积由柔性膜封闭第二通道开口限定。

    MIXER WITH ZERO DEAD VOLUME AND METHOD FOR MIXING
    2.
    发明申请
    MIXER WITH ZERO DEAD VOLUME AND METHOD FOR MIXING 有权
    具有零死亡体积的混合器和用于混合的方法

    公开(公告)号：US20120100630A1

    公开(公告)日：2012-04-26

    申请号：US13265569

    申请日：2010-04-16

    申请人： Reinhold Wimberger-Friedl ,  Ronald Cornelis De Gier ,  Peter Hermanus Bouma

    发明人： Reinhold Wimberger-Friedl ,  Ronald Cornelis De Gier ,  Peter Hermanus Bouma

    IPC分类号： G01N1/10 ,  B01L3/00

    CPC分类号： B01F13/0059 ,  B01F5/0683 ,  B01F5/0688 ,  B01F11/0071 ,  Y10T436/25 ,  Y10T436/2575

    摘要： The invention relates to a micro fluidics system (1) comprising: a closed, expandable volume (35) for mixing a fluid; a flexible membrane (40) for allowing mixing in the closed, expandable volume (35), characterized in that the micro fluidics system (1) further comprises: a surface (5) comprising at least one channel (20, 20a, 20b, 20c, 20d) for fluidically coupling a first side (10) of the surface (5) to the closed, expandable volume (35) on a second side (15) of the surface (5), the channel (20, 20a, 20b, 20c, 20d) comprising a first channel opening (25) fluidically coupling the first side (10) of the surface (5) to the channel (20, 20a, 20b, 20c, 20d) and a second channel opening (30) fluidically coupling the channel (20, 20a, 20b, 20c, 20d) to the closed, expandable volume (35), the expandable volume (35) being defined by the flexible membrane (40) closing the second channel opening (30) when there is no fluid in the expandable volume (35). The invention further relates to a method for using such a microfluidics system (1).

    摘要翻译： 本发明涉及一种微流体系统（1），其包括：用于混合流体的封闭的可膨胀体积（35） 柔性膜（40），用于允许在封闭的可膨胀体积（35）中进行混合，其特征在于，微流体系统（1）还包括：表面（5），包括至少一个通道（20,20a，20b，20c ，20d），用于将所述表面（5）的第一侧（10）与所述表面（5）的第二侧（15）上的所述封闭的可膨胀体积（35）流体耦合，所述通道（20,20a，20b， 包括将表面（5）的第一侧（10）流体耦合到通道（20,20a，20b，20c，20d）的第一通道开口（25）和与流体连接的第二通道开口（30） 所述通道（20,20a，20b，20c，20d）到所述封闭的可膨胀容积（35），所述可膨胀容积（35）由所述柔性膜（40）限定，当不存在时，所述柔性膜（40）封闭所述第二通道开口 可膨胀体积（35）中的流体。 本发明还涉及一种使用这种微流体系统（1）的方法。

    Micro fluidic device
    5.
    发明授权
    Micro fluidic device 有权
    微流体装置

    公开(公告)号：US08425863B2

    公开(公告)日：2013-04-23

    申请号：US12519373

    申请日：2007-12-12

    申请人： Chris Van Haag ,  Ronald Cornelis De Gier ,  Adrianus Wilhelmus Dionisius Maria Van Den Brijgaart ,  Gheorghe Sorin Stan

    发明人： Chris Van Haag ,  Ronald Cornelis De Gier ,  Adrianus Wilhelmus Dionisius Maria Van Den Brijgaart ,  Gheorghe Sorin Stan

    IPC分类号： G01N33/00

    CPC分类号： F15C5/00 ,  Y10T137/0971 ,  Y10T137/3584 ,  Y10T137/3631 ,  Y10T137/6416

    摘要： A micro fluidic device includes a valve/pump-unit with reduced dead volume having a substrate. The lower surface of the substrate includes two micro channels spaced apart by a valve area of the substrate that separates the two micro channels. A flexible membrane is arranged on the lower surface of the substrate facing an actuating element located in a through going cut-out of a cover element. Movement of the actuating element towards and away from the valve area of the substrate causes a pump and/or valve action of the flexible membrane area, respectively, to cause or stop a directed fluid flow between the two micro channels through a channel formed between the valve area of the substrate and the flexible membrane.

    摘要翻译： 微流体装置包括具有降低的死体积的阀/泵单元，其具有基底。 衬底的下表面包括两个微通道，其通过分离两个微通道的衬底的阀区域间隔开。 柔性膜布置在基板的下表面上，面向位于盖元件的通过切口中的致动元件。 致动元件朝向和远离基板的阀区域的移动分别导致柔性膜区域的泵和/或阀动作，以通过形成在两个微通道之间的通道来引起或停止在两个微通道之间的定向流体流动 基板和柔性膜的阀面积。

    Device for mixing a liquid medium
    6.
    发明授权
    Device for mixing a liquid medium 失效
    用于混合液体介质的装置

    公开(公告)号：US08262281B2

    公开(公告)日：2012-09-11

    申请号：US11917953

    申请日：2006-06-19

    申请人： Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart ,  Ronald Cornelis De Gier ,  Sergei Shulepov ,  Chris Van Haag

    发明人： Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart ,  Ronald Cornelis De Gier ,  Sergei Shulepov ,  Chris Van Haag

    IPC分类号： B01F11/00

    CPC分类号： B01F13/0059 ,  B01F11/0045 ,  B01L3/508

    摘要： The invention provides a device for mixing a liquid medium, an apparatus for mixing a liquid medium, a system comprising a device and an apparatus and a method for mixing a liquid medium. The device comprises a flexible membrane (12) and a structural part (16), which device further comprises an actuation part (14) located on a first side of the membrane, which device further comprises a mixing chamber (20) located on a second side of the membrane, wherein at least a partial inclination of the membrane results from an inclination of the actuation part relative to the structural part.

    摘要翻译： 本发明提供了一种用于混合液体介质的装置，用于混合液体介质的装置，包括装置的系统和装置以及用于混合液体介质的方法。 该装置包括柔性膜（12）和结构部分（16），该装置还包括位于膜的第一侧上的致动部分（14），该装置还包括位于第二侧面上的混合室（20） 其中膜的至少部分倾斜度来自致动部分相对于结构部件的倾斜。

    NEEDLE INTERFACE FOR FLUID CONNECTIONS
    8.
    发明申请
    NEEDLE INTERFACE FOR FLUID CONNECTIONS 审中-公开
    用于流体连接的针式接口

    公开(公告)号：US20100083776A1

    公开(公告)日：2010-04-08

    申请号：US12516372

    申请日：2007-11-23

    申请人： Arnold Aalders ,  Adrianus WilheImus Dionisius Maria Van Den Bijgaart ,  Jozef Christiaan Mathieu Versleegers ,  Ronald Cornelis De Gier ,  Petrus Henricus Maria Timmermans

    发明人： Arnold Aalders ,  Adrianus WilheImus Dionisius Maria Van Den Bijgaart ,  Jozef Christiaan Mathieu Versleegers ,  Ronald Cornelis De Gier ,  Petrus Henricus Maria Timmermans

    IPC分类号： G01N30/18

    CPC分类号： G01N30/18 ,  G01N2030/185

    摘要： The invention relates to a coupling system that can particularly be applied for interfacing a consumable component with a sample chamber to a laboratory instrument for processing a sample fluid. The coupling system comprises a female interface module (10) integrated into the consumable component that has an elastic 5 sealing component (12) with a preformed channel (12a). Moreover, it comprises a male interface module (20) integrated into the instrument and comprising a hollow needle (23) fixed in a first section (22a) of a bush (22), wherein the flexible free end of said needle (23) is partially surrounded by a second section (22b) of the bush that limits the lateral movement of the needle. The diameter of the channel in the sealing 10 component (12) is preferably smaller than the diameter (d) of the needle (23), thus providing an airtight connection and a self-cleaning effect.

    摘要翻译： 本发明涉及一种耦合系统，其特别可应用于将消耗部件与样品室连接到用于处理样品流体的实验室仪器。 联接系统包括集成到消耗部件中的阴接口模块（10），其具有带有预制通道（12a）的弹性5密封部件（12）。 此外，它包括集成在仪器中并包括固定在衬套（22）的第一部分（22a）中的中空针（23）的阳接口模块（20），其中所述针（23）的柔性自由端是 部分地被衬套的第二部分（22b）包围，这限制了针的横向移动。 密封10部件（12）中的通道的直径优选小于针（23）的直径（d），从而提供气密连接和自清洁效果。

    MICRO FLUIDIC DEVICE
    9.
    发明申请
    MICRO FLUIDIC DEVICE 有权

    公开(公告)号：US20100104474A1

    公开(公告)日：2010-04-29

    申请号：US12519373

    申请日：2007-12-12

    申请人： Chris Van Haag ,  Ronald Cornelis De Gier ,  Adrianus Wilhelmus Dionisius Maria Van Den Brijgaart ,  Gheorghe Sorin Stan

    发明人： Chris Van Haag ,  Ronald Cornelis De Gier ,  Adrianus Wilhelmus Dionisius Maria Van Den Brijgaart ,  Gheorghe Sorin Stan

    IPC分类号： G01N33/00

    CPC分类号： F15C5/00 ,  Y10T137/0971 ,  Y10T137/3584 ,  Y10T137/3631 ,  Y10T137/6416

    摘要： The present invention is directed to a micro fluidic device (1) comprising at least one valve/pump-unit (2) with reduced dead volume, wherein the micro fluid device comprises: —a substrate (3), wherein on the lower surface of said substrate (3) at least two micro channels (4) are arranged to direct a fluid sample (5) flow on the substrate (3), whereby said two micro channels (4) are not end-to-end connected and spaced apart by a valve area (6) of said substrate (3); —at least one flexible membrane (7), wherein the flexible membrane (7) is arranged on the lower surface of said substrate (3); —an actuating element (8) with an upper surface (9) adjacent arranged to the flexible membrane (7); —at least one cover element (10) arranged on the lower surface of the flexible membrane (7), wherein the cover element (10) comprises at least one through going cut-out (11) for receiving an actuating element (8), so that movement of said actuating element (8) causes a pump and/or valve action of the adjacent arranged flexible membrane area to cause or stop a directed fluid flow on said substrate (3); so that a fluid flow between said two not end-to-end connected micro channels is directed among the valve area (6) of the lower surface of the substrate (3) and the upper surface of the flexible membrane (7) through a temporally formable channel (12) formed by the flexible membrane (7) covering the valve area (6), whereby a movement of the actuating element (8) towards to the lower surface of the substrate causes a valve action and a movement opposite to the lower surface of the substrate releases a space in a chamber (13) into which the flexible membrane (7) can engage to form the temporally channel (12) and the upper surface (9) of the actuating element (8) covers at least partly the membrane surface (7) at the valve area (6).

    VALVE DEVICE
    10.
    发明申请
    VALVE DEVICE 有权
    阀门设备

    公开(公告)号：US20100078584A1

    公开(公告)日：2010-04-01

    申请号：US11993503

    申请日：2006-06-26

    申请人： Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart ,  Ronald Cornelis De Gier

    发明人： Adrianus Wilhelmus Dionisius Maria Van Den Bijgaart ,  Ronald Cornelis De Gier

    IPC分类号： F16K1/00

    CPC分类号： F16K7/16 ,  F15C3/04 ,  F15C5/00 ,  F16K7/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0084 ,  Y10T137/7895

    摘要： The present invention relates to a valve device (10) comprising a substrate (12) and an elastic membrane (13), the membrane being joined at least around a valve area to the substrate. The substrate comprises a first channel (16) and a second channel (17), both ending in the valve area, the first channel having in the valve area a first channel end surface (19) and the second channel having in the valve area a second channel end surface (21), wherein the area of the first channel end surface is substantially larger than the area of the second channel end surface.

    摘要翻译： 本发明涉及一种阀装置（10），其包括基板（12）和弹性膜（13），所述膜至少围绕阀区域连接到所述基板。 衬底包括第一通道（16）和第二通道（17），两者都终止在阀区域中，第一通道在阀区域中具有第一通道端面（19），并且第二通道在阀区域 第二通道端面（21），其中第一通道端面的面积基本上大于第二通道端面的面积。