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41 条记录 (耗时 0.03 秒)

    Modified polytetrafluoroethylene resins and blends thereof
    3.
    发明授权
    Modified polytetrafluoroethylene resins and blends thereof 失效
    改性聚四氟乙烯树脂及其共混物

    公开(公告)号：US4952630A

    公开(公告)日：1990-08-28

    申请号：US431948

    申请日：1989-11-06

    申请人： Richard A. Morgan ,  Charles W. Stewart

    发明人： Richard A. Morgan ,  Charles W. Stewart

    IPC分类号： C08F214/26 ,  C08F259/08 ,  C08L27/18 ,  C08L51/06

    CPC分类号： C08L27/18 ,  C08F214/26 ,  C08F259/08 ,  C08L51/06

    摘要： Dispersion-process-produced, non-melt-processible, particulate, core-shell, tetrafluoroethylene copolymer comprising recurring units of tetrafluoroethylene and modifying recurring units of at least one ethylenically unsaturated comonomer that is copolymerizable with the tetrafluoroethylene, the number of recurring units of comonomer in the shell being sufficient to enable the copolymer to compound uniformly with an elastomer or plastic without forming visible agglomerates, and blends thereof with elastomeric and plastic resins.

    摘要翻译： 分散工艺制造的不可熔融加工的颗粒，核 - 壳，四氟乙烯共聚物，其包含四氟乙烯的重复单元并修饰可与四氟乙烯共聚的至少一种烯键式不饱和共聚单体的重复单元，共聚单体的重复单元数 在壳中足以使共聚物能够与弹性体或塑料均匀地复合而不形成可见的附聚物，以及其与弹性体和塑料树脂的共混物。

    MODIFIED T CELL RECEPTORS AND RELATED MATERIALS AND METHODS
    9.
    发明申请
    MODIFIED T CELL RECEPTORS AND RELATED MATERIALS AND METHODS 有权
    改良的T细胞受体及相关材料与方法

    公开(公告)号：US20100034834A1

    公开(公告)日：2010-02-11

    申请号：US12443111

    申请日：2007-09-26

    申请人： Paul F. Robbins ,  Richard A. Morgan ,  Steven A. Rosenberg ,  Alan David Bennett

    发明人： Paul F. Robbins ,  Richard A. Morgan ,  Steven A. Rosenberg ,  Alan David Bennett

    IPC分类号： A61K39/395 ,  C07K16/30 ,  C12N15/11 ,  C12N15/00 ,  C12N5/10 ,  G01N33/53 ,  G01N33/574 ,  C12Q1/68

    CPC分类号： G01N33/505 ,  A61K38/00 ,  C07K14/7051 ,  G01N33/5091

    摘要： The invention is directed to a modified T cell receptor (TCR) comprising an amino acid sequence of a wild-type (WT) TCR with no more than three amino acid substitutions, wherein the modified TCR, as compared to the WT TCR, (i) has an enhanced ability to recognize target cells when expressed by CD4+ T cells and (ii) does not exhibit a decrease in antigen specificity when expressed by CD8+ T cells. Polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions related to the modified TCR also are part of the invention. Further, the invention is directed to methods of detecting a diseased cell in a host, methods of treating or preventing a disease in a host, and methods of identifying a candidate adoptive immunotherapy TCR.

    摘要翻译： 本发明涉及包含不超过三个氨基酸取代的野生型（WT）TCR的氨基酸序列的修饰的T细胞受体（TCR），其中与WT TCR相比，修饰的TCR（i ）当由CD4 + T细胞表达时具有增强的识别靶细胞的能力，和（ii）当由CD8 + T细胞表达时不显示抗原特异性的降低。 多肽，蛋白质，核酸，重组表达载体，宿主细胞，细胞群，抗体和与修饰的TCR相关的药物组合物也是本发明的一部分。 此外，本发明涉及检测宿主中的病变细胞的方法，治疗或预防宿主疾病的方法，以及鉴定候选的过继性免疫治疗TCR的方法。

    Electronically commutated motor driven apparatus including an impeller in a housing driven by a stator on the housing
    10.
    发明授权
    Electronically commutated motor driven apparatus including an impeller in a housing driven by a stator on the housing 失效
    电动换向马达驱动装置，其包括在由外壳上的定子驱动的壳体中的叶轮

    公开(公告)号：US4876492A

    公开(公告)日：1989-10-24

    申请号：US160526

    申请日：1988-02-26

    申请人： Gene D. Lester ,  Richard A. Morgan ,  Harold B. Harms ,  John P. Barrett ,  Tsung K. Chang ,  Donald S. Cushing ,  Richard F. Broo ,  William M. Hood

    发明人： Gene D. Lester ,  Richard A. Morgan ,  Harold B. Harms ,  John P. Barrett ,  Tsung K. Chang ,  Donald S. Cushing ,  Richard F. Broo ,  William M. Hood

    IPC分类号： F01P7/16 ,  F04D3/02 ,  F04D13/06 ,  H02K5/12 ,  H02K5/128 ,  H02K7/14 ,  H02K29/00

    CPC分类号： F04D13/06 ,  F01P7/164 ,  F04D3/02 ,  H02K5/12 ,  H02K7/14 ,  H02K5/128

    摘要： An apparatus for pumping fluid such as an integral pump/motor is provided. A housing having an inlet and an outlet has a rotatable assembly including an impeller located within and adapted to rotate within the housing to move fluid through the housing from the inlet to the outlet. Secured to the exterior of the housing is a stationary assembly for applying an electromagnetic field through the housing to and around the impeller to rotate the impeller and thereby to cause it to move fluid through the housing.The apparatus is for use in a cooling system, such as a cooling system of an automobile engine, to pump fluid through the cooling system. A temperature sensor is provided for sensing the temperature of the fluid within the cooling system. An electronic control, responsive to the temperature sensor, supplies electrical power to stationary assembly.Also, a method of circulating fluid within a system, such as a cooling system of an automobile engine, is disclosed. An electromagnetic field is applied through a housing to and around a rotatable assembly including an impeller located in the housing thereby to axially rotate the impeller and cause it to move fluid through the housing.

    摘要翻译： 提供了一种用于泵送流体的装置，例如一体式泵/马达。 具有入口和出口的壳体具有可旋转组件，其包括位于壳体内并适于在壳体内旋转的叶轮以将流体从入口移动到出口。 安装在壳体外部的是固定的组件，用于将电磁场通过壳体施加到叶轮周围并绕叶轮旋转叶轮，从而使其将流体移动通过壳体。 该装置用于诸如汽车发动机的冷却系统的冷却系统中以将流体泵送通过冷却系统。 提供温度传感器用于感测冷却系统内的流体的温度。 响应于温度传感器的电子控制器向固定组件提供电力。 另外，公开了一种在诸如汽车发动机的冷却系统的系统内循环流体的方法。 电磁场通过壳体施加到包括位于壳体中的叶轮的可旋转组件上并围绕其旋转，从而轴向地旋转叶轮并使其将流体移动通过壳体。