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    HYDROGEL TISSUE ADHESIVE HAVING INCREASED DEGRADATION TIME
    4.
    发明申请
    HYDROGEL TISSUE ADHESIVE HAVING INCREASED DEGRADATION TIME 审中-公开
    HYDROGEL TISSUE粘合剂具有降低的降解时间

    公开(公告)号：US20100160960A1

    公开(公告)日：2010-06-24

    申请号：US12614659

    申请日：2009-11-09

    申请人： Mark E. Wagman ,  Kai Qi ,  Keith Kunitsky ,  Hing Wan Yim

    发明人： Mark E. Wagman ,  Kai Qi ,  Keith Kunitsky ,  Hing Wan Yim

    IPC分类号： A61B17/03 ,  C08K5/05 ,  C08L5/00

    CPC分类号： A61L24/0031 ,  A61B17/00491 ,  A61L24/08 ,  C08B37/0021 ,  C08G2650/50 ,  C08J3/075 ,  C08L71/02 ,  C08L2205/05 ,  C08L5/00

    摘要： A hydrogel tissue adhesive having increased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm amine in the presence of a polyol additive, which retards the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, including but not limited to, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; as a plug to seal a fistula or the punctum; adhesion prevention to prevent undesired tissue to tissue adhesions resulting from trauma or surgery; and as a hemostat sealant.

    摘要翻译： 描述了具有增加的降解时间的水凝胶组织粘合剂。 通过在多元醇添加剂的存在下使氧化多糖与水分散性多臂胺反应形成水凝胶组织粘合剂，其延缓了水凝胶的降解。 水凝胶可用作用于医疗应用的组织粘合剂或密封剂，包括但不限于眼科应用，例如由诸如角膜撕裂等创伤引起的伤口，或外科手术如玻璃体切除术，白内障手术，LASIK手术， 青光眼手术和角膜移植; 神经外科应用如密封硬脑膜; 作为密封瘘管或泪点的塞子; 防止粘附以防止由创伤或手术导致的不想要的组织到组织粘连; 并作为止血剂密封胶。

    METHOD FOR PREPARING GLYCIDYLOXYSTYRENE MONOMERS AND POLYMERS THEREOF
    7.
    发明申请
    METHOD FOR PREPARING GLYCIDYLOXYSTYRENE MONOMERS AND POLYMERS THEREOF 失效
    制备甘氨酰基苯乙烯单体及其聚合物的方法

    公开(公告)号：US20080167433A1

    公开(公告)日：2008-07-10

    申请号：US11961093

    申请日：2007-12-20

    申请人： KEITH KUNITSKY ,  Mukesh C. Shah ,  Steven W. Shuey ,  Mark E. Wagman

    发明人： KEITH KUNITSKY ,  Mukesh C. Shah ,  Steven W. Shuey ,  Mark E. Wagman

    IPC分类号： C08F2/00 ,  C07D301/02 ,  C07D407/02

    CPC分类号： C08F12/22 ,  C07D303/23

    摘要： It was found that glycidyloxystyrenes, including glycidyloxystyrene and substituted glycidyloxystyrene, can be synthesized from hydroxycinnamic acid or substituted hydroxycinnamic acids in a one-pot, two-step process. The substrate can be thermally decarboxylated and then without purification, reacted in the presence of a halomethyl-oxirane and a base. The resulting product can be polymerized or coppolymerized to a fully substituted product.

    摘要翻译： 发现缩水甘油氧基苯乙烯，包括缩水甘油氧基苯乙烯和取代的缩水甘油氧基苯乙烯，可以一锅二步法从羟基肉桂酸或取代的羟基肉桂酸合成。 底物可以热脱羧，然后不经纯化，在卤代甲基 - 环氧乙烷和碱的存在下反应。 所得产物可以被聚合或共聚合成完全取代的产物。

    METHOD OF DISSOLVING AN OXIDIZED POLYSACCHARIDE IN AN AQUEOUS SOLUTION
    9.
    发明申请
    METHOD OF DISSOLVING AN OXIDIZED POLYSACCHARIDE IN AN AQUEOUS SOLUTION 审中-公开
    在水溶液中溶解氧化多糖的方法

    公开(公告)号：US20120094955A1

    公开(公告)日：2012-04-19

    申请号：US13263379

    申请日：2010-04-09

    申请人： Mark E. Wagman

    发明人： Mark E. Wagman

    IPC分类号： A61K31/721 ,  A61K47/26 ,  A61P43/00 ,  C09J105/02

    CPC分类号： A61K31/721 ,  C08B37/0021 ,  C08J3/05 ,  C08J2301/04 ,  C08J2301/28 ,  C08J2303/02 ,  C08J2303/10 ,  C08J2305/00 ,  C08J2305/02 ,  C08J2305/08 ,  C08J2305/12 ,  C08L3/02 ,  C08L5/00 ,  C08L5/02 ,  C09D105/02 ,  C08L71/02

    摘要： A method of dissolving an oxidized polysaccharide in an aqueous solution using an oligomer additive is described. The resulting aqueous solution of the oxidized polysaccharide may be used in combination with an aqueous solution comprising an amine-containing component to prepare hydrogel tissue adhesives and sealants for medical and veterinary applications, such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions.

    摘要翻译： 描述了使用低聚物添加剂将氧化多糖溶解在水溶液中的方法。 所得到的氧化多糖水溶液可与包含含胺组分的水溶液组合使用以制备用于医疗和兽医应用的水凝胶组织粘合剂和密封剂，例如伤口闭合，补充或更换内部手术中的缝线或缝钉 手术如肠吻合和血管吻合术，组织修复，眼科手术，药物递送，并防止手术后粘连。