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21 条记录 (耗时 0.032 秒)

    CL-1577 Antibiotic compounds and their production
    2.
    发明授权
    CL-1577 Antibiotic compounds and their production 失效
    CL-1577抗生素化合物及其生产

    公开(公告)号：US4530835A

    公开(公告)日：1985-07-23

    申请号：US512088

    申请日：1983-07-08

    申请人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Tim A. Smitka ,  Josefino B. Tunac

    发明人： Richard H. Bunge ,  James C. French ,  Timothy R. Hurley ,  Tim A. Smitka ,  Josefino B. Tunac

    IPC分类号： A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C07G11/00 ,  C12N1/20 ,  C12P1/06 ,  C12R1/465

    CPC分类号： C12P1/06

    摘要： A purified isolate of an actinomycete identified as ATCC 39363 is capable of producing a complex of sulfur-containing antibiotic compounds having activity against transplanted tumors.Antibiotic compounds CL-1577A and CL-1577B and their closely related congeners are produced by cultivating isolate ATCC 39363 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1577 complex is produced, and subsequently isolating the complex or one or more of the compounds.The antibiotic compounds CL-1577A, CL-1577B, their congeners, and pharmaceutical compositions comprising these substances together with a suitable carrier are also disclosed.

    摘要翻译： 确定为ATCC 39363的放线菌的纯化分离物能够产生具有针对移植肿瘤的活性的含硫抗生素化合物的复合物。 抗生素化合物CL-1577A和CL-1577B及其密切相关的同系物通过在需氧条件下培养分离物ATCC 39363，在含有可同化碳源和氮的来源的培养基中培养，直到产生大量的CL-1577复合物，随后 分离复合物或一种或多种化合物。 还公开了抗生素化合物CL-1577A，CL-1577B，它们的同系物和包含这些物质的药物组合物和合适的载体。

    CL-1957B antibiotic compound and its production
    3.
    发明授权
    CL-1957B antibiotic compound and its production 失效
    CL-1957B抗生素复方及其生产

    公开(公告)号：US4918100A

    公开(公告)日：1990-04-17

    申请号：US763577

    申请日：1985-08-08

    申请人： Gerard C. Hokanson ,  John P. Schaumberg ,  James C. French ,  Josefino B. Tunac

    发明人： Gerard C. Hokanson ,  John P. Schaumberg ,  James C. French ,  Josefino B. Tunac

    IPC分类号： C07D309/22 ,  C07D309/32 ,  C12P17/06

    CPC分类号： C12R1/01 ,  C07D309/22 ,  C07D309/32 ,  C12P17/06

    摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957B which also exhibits antitumor properties.The antimicrobial compound CL-1957B is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957B compound is produced, and subsequently isolating the compound.The antibiotic compound CL-1957B, its pharmaceutically acceptable salts, the pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

    摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够生产也具有抗肿瘤性质的抗微生物化合物CL-1957B。 抗微生物化合物CL-1957B是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957B化合物，然后分离该化合物。 还公开了抗生素化合物CL-1957B及其药学上可接受的盐，包含该物质的药物组合物和药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。

    CL-1957A antibiotic compound
    5.
    发明授权
    CL-1957A antibiotic compound 失效
    CL-1957A抗生素化合物

    公开(公告)号：US4771070A

    公开(公告)日：1988-09-13

    申请号：US912684

    申请日：1986-09-26

    申请人： Gerard C. Hokanson ,  John P. Schaumberg ,  James C. French ,  Josefino B. Tunac

    发明人： Gerard C. Hokanson ,  John P. Schaumberg ,  James C. French ,  Josefino B. Tunac

    IPC分类号： C07D309/22 ,  C12P17/06 ,  A61K31/365 ,  C07D309/38

    CPC分类号： C07D309/22 ,  C12P17/06

    摘要： A purified isolate of an actinomycete identified as ATCC 39366 is capable of producing the anti-microbial compound CL-1957A which also exhibits antitumor properties.The antimicrobial compound CL-1957A is produced by cultivating isolate ATCC 39366 under aerobic conditions in a culture medium containing assimilable sources of carbon and nitrogen until a substantial quantity of the CL-1957A compound is produced, and subsequently isolating the CL-1957A compound.The antibiotic compound CL-1957A and pharmaceutical compositions comprising this substance together with a pharmaceutically acceptable carrier is also disclosed, as are methods of treating microbial infections and tumors in mammals, employing these pharmaceutical compositions.

    摘要翻译： 确定为ATCC 39366的放线菌的纯化分离物能够产生也具有抗肿瘤性质的抗微生物化合物CL-1957A。 抗微生物化合物CL-1957A是通过在需氧条件下培养含有可同化碳源和氮源的培养基中分离的ATCC 39366产生的，直到产生大量的CL-1957A化合物，然后分离出CL-1957A化合物。 还公开了抗生素化合物CL-1957A和包含该物质的药物组合物与药学上可接受的载体，以及使用这些药物组合物治疗哺乳动物的微生物感染和肿瘤的方法。

    PHENAZINE COMPOUNDS AND USE THEREOF IN AUTOIMMUNE AND INFLAMMATORY DISEASES
    10.
    发明申请
    PHENAZINE COMPOUNDS AND USE THEREOF IN AUTOIMMUNE AND INFLAMMATORY DISEASES 失效
    PHENAZINE化合物及其在自身免疫和炎症疾病中的应用

    公开(公告)号：US20100190799A1

    公开(公告)日：2010-07-29

    申请号：US12523304

    申请日：2008-01-16

    申请人： Josefino B. Tunac

    发明人： Josefino B. Tunac

    IPC分类号： A61K31/498 ,  C07D241/46 ,  A61P29/00 ,  A61P19/02 ,  A61P37/00

    CPC分类号： C07D241/52

    摘要： The invention discloses compounds, compositions and methods useful for preventing and/or treating autoimmune diseases and inflammatory diseases. The methods and compositions utilize water-soluble phenazine compounds, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent autoimmune diseases and inflammatory diseases such as those caused by arthritis and rheumatoid arthritis.

    摘要翻译： 本发明公开了可用于预防和/或治疗自身免疫性疾病和炎性疾病的化合物，组合物和方法。 该方法和组合物使用水溶性吩嗪化合物或其盐或溶剂合物。 这些分子可以单独递送或与治疗或预防自身免疫性疾病和炎症性疾病如由关节炎和类风湿性关节炎引起的疾病的药物组合递送。