公开(公告)号：US5272803A

公开(公告)日：1993-12-28

申请号：US14342

申请日：1993-02-05

申请人： Richard Harrison ,  Lei Sun

发明人： Richard Harrison ,  Lei Sun

IPC分类号： H02K15/02 ,  H02K15/16 ,  H02K15/10

CPC分类号： H02K15/16 ,  Y10T29/49009 ,  Y10T29/49904 ,  Y10T29/53143

摘要： A press fit machine for assembling an electric motor which includes a hub having an upper bearing and a stator assembly having a lower bearing, includes an upper and lower press fit fixtures for holding the hub and stator respectively in a preloaded condition prior to motor assembly and for a predetermined period of time afterward. The machine press fits the two halves of the motor together while maintaining appropriate preloads on the upper and lower bearings to prevent excess looseness in the bearings or excessive stiffness. The preload ensures that the bearing will function correctly after assembly because it is maintained during a period of time that the glue joining the hub and stator assembly together sets.

摘要翻译： 一种用于组装电动机的压配机，其包括具有上轴承和具有下轴承的定子组件的轮毂，包括用于在电动机组装之前将轮毂和定子分别保持在预加载状态的上下压配夹具，以及 在预定的时间段之后。 机床将电机的两半安装在一起，同时在上下轴承上保持适当的预载荷，以防止轴承过多的松动或过大的刚度。 预紧力确保轴承在组装后能够正常工作，因为在将轮毂和定子组件接合在一起的胶水的一段时间内保持轴承。

公开(公告)号：US08024825B2

公开(公告)日：2011-09-27

申请号：US12321750

申请日：2009-01-26

申请人： Richard Harrison ,  William F Mann, III

发明人： Richard Harrison ,  William F Mann, III

IPC分类号： A47D7/00 ,  A47D13/06

CPC分类号： B62B3/02 ,  A61G5/0825 ,  A61G5/0841 ,  A61G5/0883 ,  A61G5/0891 ,  B62B2205/06 ,  B62B2205/20

摘要： The present invention relates to collapsible cribs. The cribs have one or more of the following characteristics: adjustable length and/or, width and/or height, lightweight, easily collapsed, very compact when collapsed and easily carried, stored and transported. Embodiments disclosed relate to pens, cribs, and play yards with and without wheels.

摘要翻译： 本发明涉及可折叠婴儿床。 婴儿床具有一个或多个以下特征：可变长度和/或宽度和/或高度，轻巧，容易折叠，当折叠并容易携带，储存和运输时非常紧凑。 所公开的实施例涉及具有和不具有轮子的笔，婴儿床和游戏场。

公开(公告)号：US5876126A

公开(公告)日：1999-03-02

申请号：US928184

申请日：1997-09-12

申请人： George Marshall ,  Richard Harrison

发明人： George Marshall ,  Richard Harrison

IPC分类号： F16C33/80 ,  G11B19/20 ,  H02K5/173

CPC分类号： G11B19/2009 ,  F16C33/80 ,  H02K5/173 ,  F16C2370/12

摘要： A motor incorporating a bearing guided labyrinth system of the present invention includes a shaft, a hub, a bearing assembly, and a bearing guided labyrinth. The bearing assembly includes an inner bearing ring and an outer bearing ring separated by a plurality of ball bearings. The inner bearing ring has an inner annular ring surface and the outer bearing ring has an outer annular ring surface. The bearing guided labyrinth has an inner prong and an outer prong. The inner prong is at least partially positionable between the inner ring surface and the shaft. The outer prong is at least partially positionable between the outer ring surface and the hub. The outer prong grips the bearing assembly and specifically the outer annular ring surface of the outer bearing ring.

摘要翻译： 包括本发明的轴承导向迷宫系统的电动机包括轴，轮毂，轴承组件和轴承引导的迷宫。 轴承组件包括由多个滚珠轴承分隔的内轴承环和外轴承圈。 内轴承环具有内环形表面，外轴承环具有外环形环表面。 轴承引导迷宫有一个内部分支和一个外部分支。 内销至少部分地位于内圈表面和轴之间。 外尖头至少部分地可定位在外环表面和轮毂之间。 外部插脚夹紧轴承组件，特别是外部轴承环的外部环形表面。

公开(公告)号：US20060111389A1

公开(公告)日：2006-05-25

申请号：US11157977

申请日：2005-06-22

申请人： Stephen Neidle ,  Richard Harrison ,  Lloyd Kelland ,  Sharon Gowan ,  Martin Read ,  Anthony Reszka

发明人： Stephen Neidle ,  Richard Harrison ,  Lloyd Kelland ,  Sharon Gowan ,  Martin Read ,  Anthony Reszka

IPC分类号： C07D219/04 ,  A61K31/473

CPC分类号： C07D219/08 ,  C07D219/06 ,  C07D219/10

摘要： The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones): or, (b) K is a 9-substituent. L is absent, alpha is a double bond, beta is a single bond, gamma is a double bond and wherein: J1 is a 2- or 3-substituent; J2 is a 6- or 7-substituent; J1 and J2 are each independently a group of the formula —NHCO(CH2)nNR1R2, wherein: n is an integer from 1 to 5; and, R1 and R2 are independently hydrogen, C1-7alkyl, C3-20heterocyclyl, or C5-20aryl, or R1 and R2, taken together with the nitrogen atom to which they are attached, form a heterocyclic ring having from 3 to 8 ring atoms; and wherein, when K is a 9-substituent, K is a group of the formula —N(RN)Q, wherein: RN is an amino substituent and is hydrogen. C1-7alkyl, C3-20heterocyclyl, or C5-20aryl; and, Q is C1-7alkyl, C3-20heterocyclyl, or C5-20aryl, and is optionally substituted; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo to inhibit telomerase, to regulate cell proliferation, and in the treatment of proliferative conditions, such as cancer.

摘要翻译： 本发明涉及式（I）的吖啶酮和吖啶化合物，其中：（a）K是-O，L是-H，α是单键，β是双键，γ是单键（吖啶酮 ）：或（b）K为9-取代基。 L不存在，α是双键，β是单键，γ是双键，并且其中：J 1是2-或3-取代基; J 2是6-或7-取代基; J 1和J 2各自各自独立地是式-NHCO（CH 2 CH 2）n NR n的基团， 其中：n为1至5的整数;其中n为1至5的整数; 且R 1和R 2独立地为氢，C 1-7烷基，C 3-20杂环基 或C 5-20-20芳基或R 1和R 2与它们所连接的氮原子一起形成一个 具有3至8个环原子的杂环; 并且其中当K是9-取代基时，K是式-N（R“N”）Q的基团，其中：R N是氨基取代基，并且是 氢。 C 1-7烷基，C 3-20杂环基或C 5-20-20芳基; 且Q为C 1-7烷基，C 3-20杂环基或C 5-20芳基，且为任选取代的; 和其药学上可接受的盐，酯，酰胺，溶剂合物，水合物及其保护形式。 本发明还涉及包含这种化合物的药物组合物，以及这些化合物和组合物在体外和体内都用于抑制端粒酶调节细胞增殖以及治疗增殖性疾病如癌症的用途。

公开(公告)号：US20050070568A1

公开(公告)日：2005-03-31

申请号：US10501474

申请日：2003-01-14

申请人： Stephen Neidle ,  Richard Harrison ,  Lloyd Kelland ,  Sharon Gowan ,  Martin Read ,  Anthony Reszka

发明人： Stephen Neidle ,  Richard Harrison ,  Lloyd Kelland ,  Sharon Gowan ,  Martin Read ,  Anthony Reszka

IPC分类号： A61K31/473 ,  A61P35/00 ,  A61P43/00 ,  C07D219/04 ,  C07D219/08 ,  C07D219/10 ,  C07D219/12

CPC分类号： C07D219/08 ,  C07D219/10

摘要： This invention pertains to certain acridine and acridine compounds of the formula (1) which inhibit telomerase, regulate cell proliteration, etc., and/or treat cancer proliferative conditions, etc.: wherein either: (a) K is ═O, L is —H, alpha single bond beta is a double bond, gamma is a single bond (acridines); or, (b) K is a 9-substituent, L is absent, alpha is a double bond, beta is a single bond, gamma is a double bond (acridines); and wherein: J1 is a 2- or 3-substituent; J2 is a 6- or 7-substituent; J1 and J2 are each a group of the formula —N(RN)—W, wherein: RN is a nitrogen substituent and is hydrogen, C1-7alkyl, C3-20 heterocyclyl, or C5-20aryl, and is optionally substituted; and, W is C1-7alkyl, C3-20heterocyclyl, or C5-20aryl, and is optionally substitute; and wherein when K is a 9-substituent, K is a group of the formula —N(RN)-Q, wherein: RN is an amino substituent and is hydrogen, C1-7alkyl, C3-20heterocyclyl, or C5-20aryl; and, Q is C1-7alkyl, C3-20heterocyclyl, or C5-20aryl, and is optionally substituted; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit telomerase, to regulate cell proliferation, etc., and/or in the treatment of cancer, proliferative conditions, etc.

摘要翻译： 本发明涉及抑制端粒酶，调节细胞增殖等的某些式（1）的吖啶和吖啶化合物，和/或治疗癌症增殖病症等。其中：（a）K为= O，L为 -H，α单键β是双键，γ是单键（吖啶）; 或（b）K是9取代基，L不存在，α是双键，β是单键，γ是双键（吖啶）; 并且其中：J 1是2-或3-取代基; J 2是6-或7-取代基; J 1和J 2各自为式-N（R N）-W的基团，其中：R N为氮取代基且为氢，C 1-7烷基，C 3-20杂环基， 或C 5-20芳基，并且任选被取代; 并且W是C 1-7烷基，C 3-20杂环基或C 5-20芳基，并且任选被取代; 并且其中当K是9-取代基时，K是式-N（R N）-Q的基团，其中：R N是氨基取代基并且是氢，C 1-7烷基，C 3-20杂环基， 或C5-20芳基; 且Q为C 1-7烷基，C 3-20杂环基或C 5-20芳基，并且任选被取代; 和其药学上可接受的盐，酯，酰胺，溶剂合物，水合物及其保护形式。 本发明还涉及包含这种化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制端粒酶，调节细胞增殖等，和/或治疗癌症，增殖性 条件等

公开(公告)号：US08398336B2

公开(公告)日：2013-03-19

申请号：US11993973

申请日：2006-06-15

申请人： Vincent George McCarthy ,  Richard Harrison ,  Dmytro Nalywajko

发明人： Vincent George McCarthy ,  Richard Harrison ,  Dmytro Nalywajko

IPC分类号： F16L9/18

CPC分类号： F16L1/123 ,  F16L1/16 ,  F16L9/18 ,  F16L53/70

摘要： A pipe structure suitable for being laid in the sea comprises an inner pipe (2) for conveying fluid to be transported along the pipe structure and an outer pipe (3) around the inner pipe and supporting the inner pipe with space between the inner and outer pipes, the outer pipe having openings to allow water first to flow into the space between the inner pipe and the outer pipe and then to flow out of the space.

摘要翻译： 适于放置在海中的管道结构包括：内管（2），用于输送沿着管结构输送的流体;以及外管（3），内管围绕内管支撑内管，内管与内外 管道，外管具有开口，以允许水首先流入内管和外管之间的空间，然后流出空间。

公开(公告)号：US20090134603A1

公开(公告)日：2009-05-28

申请号：US12321750

申请日：2009-01-26

申请人： Richard Harrison ,  William F. Mann, III

发明人： Richard Harrison ,  William F. Mann, III

IPC分类号： B62B7/06

CPC分类号： B62B3/02 ,  A61G5/0825 ,  A61G5/0841 ,  A61G5/0883 ,  A61G5/0891 ,  B62B2205/06 ,  B62B2205/20

摘要： The present invention relates to collapsible cribs. The cribs have one or more of the following characteristics: adjustable length and/or, width and/or height, lightweight, easily collapsed, very compact when collapsed and easily carried, stored and transported. Embodiments disclosed relate to pens, cribs, and play yards with and without wheels.

公开(公告)号：US3956945A

公开(公告)日：1976-05-18

申请号：US447002

申请日：1974-02-28

申请人： Geoffrey Donald Eggleton ,  Richard Harrison

发明人： Geoffrey Donald Eggleton ,  Richard Harrison

IPC分类号： B60K17/344 ,  F16H48/30 ,  F16H1/44

CPC分类号： F16H48/30 ,  B60K17/344 ,  F16H48/08 ,  F16H48/24 ,  F16H2048/082 ,  F16H2048/305 ,  F16H2048/426

摘要： A driving transmission has two half shafts connected to a pair of land wheels driven by a differential gear mechanism connected to the half shafts, and a differential lock coaxial with one of the half shafts and drivingly connectable with the differential carrier. The differential lock is separated from the differential carrier by a hollow shaft encircling said one half shaft, and the hollow shaft is adapted to be driven by the differential carrier and drivingly connectable with the differential lock. Drive means are also provided in driving relation between the hollow shaft and a second pair of land wheels.

摘要翻译： 驱动变速器具有连接到由与半轴连接的差速齿轮机构驱动的一对车轮的两个半轴，以及与半轴中的一个轴同轴并且与差速器载体可驱动连接的差速器锁。 差速锁通过围绕所述一个半轴的中空轴与差速器载体分离，并且中空轴适于由差速器载体驱动并且可与差速锁驱动连接。 驱动装置也设置在空心轴与第二对车轮之间的驱动关系中。

公开(公告)号：US20070254957A1

公开(公告)日：2007-11-01

申请号：US11737475

申请日：2007-04-19

申请人： Francis WILSON ,  Alison Reid ,  Valerie Reader ,  Richard Harrison ,  Mihiro Sunose ,  Remedios Hernandez-Perni ,  Jeremy Major ,  Cyrille Boussard ,  Kathryn Smelt ,  Jess Taylor ,  Adeline LeFormal ,  Andrew Cansfield ,  Svenja Burckhardt ,  Yan Zhang ,  Chih Ho

发明人： Francis WILSON ,  Alison Reid ,  Valerie Reader ,  Richard Harrison ,  Mihiro Sunose ,  Remedios Hernandez-Perni ,  Jeremy Major ,  Cyrille Boussard ,  Kathryn Smelt ,  Jess Taylor ,  Adeline LeFormal ,  Andrew Cansfield ,  Svenja Burckhardt ,  Yan Zhang ,  Chih Ho

IPC分类号： A61K31/192 ,  C07C59/40 ,  C07C62/30

CPC分类号： C07D257/04 ,  C07C51/09 ,  C07C57/38 ,  C07C57/58 ,  C07C59/56 ,  C07C59/64 ,  C07C63/331 ,  C07C69/65

摘要： The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.

摘要翻译： 本发明涉及具有通式（I）的化合物，其具有X，Y，R 1，R 2，R 3，R 3， R 4，R 9，R 10，及其溶剂合物，水合物，酯和药学上可接受的盐。 此外，本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。

公开(公告)号：US20070037938A1

公开(公告)日：2007-02-15

申请号：US10549856

申请日：2004-03-24

申请人： Richard Harrison ,  Bruce Gilbert ,  Andrew Parsons ,  Derek Irvine

发明人： Richard Harrison ,  Bruce Gilbert ,  Andrew Parsons ,  Derek Irvine

IPC分类号： C08F2/00 ,  B01J31/00

CPC分类号： C08F4/50

摘要： Ethylenically unsaturated, particularly acrylic, monomers are polymerised using a catalyst system including a manganese carbonyl initiator, an organic halogen reactive substrate and an allylic halide chain termination agent. Desirably the manganese carbonyl initiator is a dimanganese compound, particularly dimanganese decacarbonyl (Mn2(CO)10). The catalysis mechanism appears to involve initiator homolysis, abstraction of halogen from the reactive substrate forming an organic free radical which acts as a chain initiator for polymerisation and eventual reaction of the propagating chain radical with the chain terminating agent. The speed or extent of reaction may be modified by the inclusion of Lewis acids in the reaction mixture. The resulting polymers are telechelic and may have different end groups. The polymers can be reacted further to functionalise them and/or to form block copolymers.

摘要翻译： 使用包括羰基羰基引发剂，有机卤素反应性底物和烯丙基卤化物链终止剂的催化剂体系来聚合乙烯基不饱和的，特别是丙烯酸的单体。 期望地，羰基羰基引发剂是二甘氨酸化合物，特别是二甘氨酸的十羧基（Mn 2 N（CO）10））。 催化机理似乎涉及引发剂均聚，从反应性底物中提取卤素，形成有机自由基，其起到用于聚合的链引发剂和增链链基团与链终止剂的最终反应。 可以通过在反应混合物中加入路易斯酸来改变反应的速度或程度。 所得聚合物是遥爪的并且可以具有不同的端基。 聚合物可进一步反应以使其功能化和/或形成嵌段共聚物。