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公开(公告)号：US5371284A
公开(公告)日：1994-12-06
申请号：US98767
申请日：1993-07-23
IPC分类号： C07C57/42 , C07C323/52 , C07C321/00
CPC分类号： C07C323/52 , C07C57/42
摘要： Phenyl acetylenic acetals and thioacetals and their use in the treatment of allergy, asthma, inflammation, arthritis, hyperproliferative skin disease, psoriasis or contact dermatitis are disclosed. Also disclosed are intermediates useful for producing said phenyl acetylenic acetals and thioacetals.
摘要翻译： 公开了苯基炔属缩醛和硫缩醛及其在治疗过敏，哮喘，炎症，关节炎，过度增生性皮肤病，牛皮癣或接触性皮炎中的用途。 还公开了可用于制备所述苯基炔属缩醛和硫缩醛的中间体。
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公开(公告)号：US4810708A
公开(公告)日：1989-03-07
申请号：US17027
申请日：1987-02-17
申请人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
发明人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
IPC分类号： C07D221/16 , C07D471/04 , C07D471/14 , C07D491/113 , C07D491/14 , C07D491/147 , C07D491/20 , C07D495/14 , C07D498/14 , C07D498/22 , A61K31/435 , C07D491/044 , C07D491/056
CPC分类号： C07D471/04 , C07D221/16 , C07D471/14 , C07D491/14 , C07D495/14
摘要： Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
摘要翻译： 公开了可用于治疗过敏反应，炎症，消化性溃疡，高血压和过度增生性皮肤病以及抑制哺乳动物免疫应答的新型多环喹啉，萘啶和吡嗪并吡啶衍生物。 还公开了制备所述化合物的方法。
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公开(公告)号：US5126352A
公开(公告)日：1992-06-30
申请号：US576318
申请日：1990-08-31
申请人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
发明人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
IPC分类号： C07D221/16 , C07D471/04 , C07D471/14 , C07D491/14 , C07D491/147 , C07D491/20 , C07D495/14 , C07D498/14 , C07D498/22
CPC分类号： C07D471/04 , C07D221/16 , C07D471/14 , C07D491/14 , C07D495/14
摘要： Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treatment allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
摘要翻译： 公开了可用于治疗过敏反应，炎症，消化性溃疡，高血压和过度增生性皮肤病以及抑制哺乳动物免疫应答的新型多环喹啉，萘啶和吡嗪并吡啶衍生物。 还公开了制备所述化合物的方法。
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公开(公告)号：US4988705A
公开(公告)日：1991-01-29
申请号：US307646
申请日：1989-02-07
申请人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
发明人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
IPC分类号： C07D221/16 , C07D471/04 , C07D471/14 , C07D491/14 , C07D491/147 , C07D491/20 , C07D495/14 , C07D498/14 , C07D498/22
CPC分类号： C07D471/04 , C07D221/16 , C07D471/14 , C07D491/14 , C07D495/14
摘要： Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
摘要翻译： 公开了可用于治疗过敏反应，炎症，消化性溃疡，高血压和过度增生性皮肤病以及抑制哺乳动物免疫应答的新型多环喹啉，萘啶和吡嗪并吡啶衍生物。 还公开了制备所述化合物的方法。
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公开(公告)号：US5767120A
公开(公告)日：1998-06-16
申请号：US479418
申请日：1995-06-06
申请人： Pauline C. Ting , Daniel M. Solomon , Richard J. Friary , John J. Piwinski , Joe F. Lee , Vera A. Seidl , James P. Jakway
发明人： Pauline C. Ting , Daniel M. Solomon , Richard J. Friary , John J. Piwinski , Joe F. Lee , Vera A. Seidl , James P. Jakway
IPC分类号： C07D295/02 , A61K31/125 , A61K31/135 , A61K31/18 , A61K31/195 , A61K31/335 , A61K31/40 , A61K31/4025 , A61K31/403 , A61K31/4035 , A61K31/404 , A61K31/44 , A61K31/443 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/08 , A61P43/00 , C07C33/38 , C07C45/44 , C07C47/235 , C07C47/453 , C07C69/608 , C07C69/618 , C07C211/26 , C07C211/32 , C07C215/42 , C07C217/52 , C07C229/14 , C07C233/05 , C07C233/18 , C07C233/73 , C07C251/40 , C07C271/10 , C07C271/12 , C07C271/16 , C07C311/03 , C07C311/04 , C07C311/17 , C07D207/16 , C07D209/08 , C07D209/44 , C07D209/48 , C07D213/89 , C07D221/16 , C07D261/02 , C07D295/03 , C07D295/084 , C07D313/12 , C07D405/06 , C07D401/00 , A61K31/495 , C07D221/00
CPC分类号： C07D295/03 , A61K31/00 , A61K31/135 , C07C211/32 , C07C217/52 , C07C229/14 , C07C233/18 , C07C233/73 , C07C251/40 , C07C271/12 , C07C271/16 , C07C311/04 , C07C311/17 , C07D221/16 , C07D295/092 , C07D313/12 , C07C2101/02 , C07C2103/32
摘要： Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl;R.sup.4 is H, alkyl, alkenyl, alkoxy, or --OH. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha. and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.
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公开(公告)号：US5574173A
公开(公告)日：1996-11-12
申请号：US162686
申请日：1993-12-06
申请人： Pauline C. Ting , Richard J. Friary , Wing C. Tom , Joe F. Lee , Vera A. Seidl
发明人： Pauline C. Ting , Richard J. Friary , Wing C. Tom , Joe F. Lee , Vera A. Seidl
IPC分类号： C07D211/14 , A61K31/135 , A61K31/165 , A61K31/335 , A61K31/445 , A61K31/451 , A61P29/00 , A61P37/08 , C07C211/31 , C07C211/32 , C07C215/20 , C07C215/38 , C07C217/16 , C07C217/48 , C07C233/05 , C07C233/13 , C07C235/34 , C07D211/70 , C07D313/12 , C07D313/10
CPC分类号： C07C211/32 , C07C215/38 , C07C217/48 , C07C233/13 , C07D313/12
摘要： Disclosed are compounds of Formula I: ##STR1## or a pharmaceutically acceptable salt or solvate thereof, wherein: R.sup.4 is alkenyl, alkoxy, or --OH.Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor-.alpha., and methods for treating septic shock, inflammation, or allergic disease.
摘要翻译： 公开了式I的化合物：其中：R4是烯基，烷氧基或-OH。 还公开了含有式I化合物，抑制肿瘤坏死因子-α的方法，以及治疗败血性休克，炎症或过敏性疾病的方法的药物组合物。
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公开(公告)号：US5116840A
公开(公告)日：1992-05-26
申请号：US576640
申请日：1990-08-31
申请人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
发明人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Vera A. Seidl , Edmund J. Sybertz
IPC分类号： C07D221/16 , C07D471/04 , C07D471/14 , C07D491/14 , C07D491/147 , C07D491/20 , C07D495/14 , C07D498/14 , C07D498/22
CPC分类号： C07D471/04 , C07D221/16 , C07D471/14 , C07D491/14 , C07D495/14
摘要： Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
摘要翻译： 公开了可用于治疗过敏反应，炎症，消化性溃疡，高血压和过度增生性皮肤病以及抑制哺乳动物免疫应答的新型多环喹啉，萘啶和吡嗪并吡啶衍生物。 还公开了制备所述化合物的方法。
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公开(公告)号：US07071213B2
公开(公告)日：2006-07-04
申请号：US10292778
申请日：2002-11-12
申请人： Richard J. Friary , Joseph A. Kozlowski , Bandarpalle B. Shankar , Michael K. C. Wong , Guowei Zhou , Brian J. Lavey , Neng-Yang Shih , Ling Tong , Lei Chen , Youheng Shu
发明人： Richard J. Friary , Joseph A. Kozlowski , Bandarpalle B. Shankar , Michael K. C. Wong , Guowei Zhou , Brian J. Lavey , Neng-Yang Shih , Ling Tong , Lei Chen , Youheng Shu
IPC分类号： A61K31/445 , C07D401/12
CPC分类号： C07D401/12 , C07D211/26 , C07D211/96 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： There are disclosed compounds of the formula I: or a pharmaceutically acceptable salt of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds.
摘要翻译： 公开了具有抗炎和免疫调节活性的式I化合物或化合物的药学上可接受的盐。 还公开了含有所述化合物的药物组合物。
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公开(公告)号：US5439916A
公开(公告)日：1995-08-08
申请号：US576319
申请日：1990-08-31
申请人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Edmund J. Sybertz
发明人： Ashit K. Ganguly , Richard J. Friary , John H. Schwerdt , Marvin I. Siegel , Sidney R. Smith , Edmund J. Sybertz
IPC分类号： C07D221/16 , C07D471/04 , C07D471/14 , C07D491/14 , C07D491/147 , C07D491/20 , C07D495/14 , C07D498/14 , C07D498/22 , A61K31/38 , A61K31/395 , C07D239/04
CPC分类号： C07D471/04 , C07D221/16 , C07D471/14 , C07D491/14 , C07D495/14
摘要： Novel polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives are disclosed which are useful for treating allergic reactions, inflammation, peptic ulcers, hypertension, and hyperproliferative skin diseases and for suppressing the immune response in mammals. Methods for preparing said compounds are also disclosed.
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公开(公告)号：US6051575A
公开(公告)日：2000-04-18
申请号：US313150
申请日：1999-05-17
申请人： David J. Blythin , Xiao Chen , Richard J. Friary , Kevin D. McCormick , John J. Piwinski , Neng-Yang Shih , Ho-Jane Shue
发明人： David J. Blythin , Xiao Chen , Richard J. Friary , Kevin D. McCormick , John J. Piwinski , Neng-Yang Shih , Ho-Jane Shue
IPC分类号： C07D241/04 , C07D401/12 , C07D403/12 , C07D453/06 , C07D487/08 , A61K31/496 , C07D409/14 , C07D417/14
CPC分类号： C07D401/12 , C07D241/04 , C07D403/12 , C07D453/06 , C07D487/08
摘要： The invention relates to compounds of the formula ##STR1## wherein Z, R.sub.c, y, m, u, Ar.sub.2, n, X, R.sub.c', I and Ar.sub.2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.
摘要翻译： 本发明涉及下式化合物其中Z，Rc，y，m，u，Ar2，n，X，Rc'，I和Ar2如本文所述。 这些化合物是神经激肽拮抗剂。 这些化合物可用于治疗慢性气道疾病如哮喘。
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