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公开(公告)号：US08133992B2
公开(公告)日：2012-03-13
申请号：US12362269
申请日：2009-01-29
申请人： Richard Martin , Tie-Lin Wang , Brenton T. Flatt , Xiao-Hui Gu , Ronald Griffith
发明人： Richard Martin , Tie-Lin Wang , Brenton T. Flatt , Xiao-Hui Gu , Ronald Griffith
IPC分类号： C07D223/14 , C07D487/00
CPC分类号： C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US20090326218A1
公开(公告)日：2009-12-31
申请号：US12362269
申请日：2009-01-29
申请人： Richard Martin , Tie-Lin Wang , Brenton T. Flatt , Xiao-Hui Gu , Ronald Griffith
发明人： Richard Martin , Tie-Lin Wang , Brenton T. Flatt , Xiao-Hui Gu , Ronald Griffith
IPC分类号： C07D487/04 , C07D487/20
CPC分类号： C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US07485634B2
公开(公告)日：2009-02-03
申请号：US10447302
申请日：2003-05-27
申请人： Richard Martin , Tie-Lin Wang , Brenton T Flatt , Xiao-Hui Gu , Ronald Griffith
发明人： Richard Martin , Tie-Lin Wang , Brenton T Flatt , Xiao-Hui Gu , Ronald Griffith
IPC分类号： A61P3/00 , A61K31/55 , C07D487/04
CPC分类号： C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US08367667B2
公开(公告)日：2013-02-05
申请号：US13214665
申请日：2011-08-22
申请人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
发明人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
IPC分类号： A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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5.发明申请公开(公告)号：US20110144128A1
公开(公告)日：2011-06-16
申请号：US11813482
申请日：2006-01-06
申请人： Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Brett Murphy , Michael C. Nyman , William C. Stevens, JR. , Tie-Lin Wang
发明人： Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Brett Murphy , Michael C. Nyman , William C. Stevens, JR. , Tie-Lin Wang
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/4172 , C07D413/14
CPC分类号： C07D231/14 , C07D233/90 , C07D307/68 , C07D333/38
摘要： Heterocyclic carboxamide compounds are described herein as being useful in modulating the activity of steroid nuclear receptors. Pharmaceutical compositions containing the compounds, methods of using the compounds and processes for making the compounds are also described.
摘要翻译： 本文描述的杂环羧酰胺化合物可用于调节类固醇核受体的活性。 还描述了含有化合物的药物组合物，使用该化合物的方法和制备该化合物的方法。
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6.发明申请TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY 有权用作TGR5治疗糖尿病和肥胖的激素的三唑和咪唑衍生物公开(公告)号：US20120040985A1
公开(公告)日：2012-02-16
申请号：US13148811
申请日：2010-02-12
申请人： Venkataiah Bollu , Brant Clayton Boren , Jackaline Dalgard Julien , Brenton T. Flatt , Nadia Haq , Sarah Hudson , Raju Mohan , Michael Morrissey , Benjamin Pratt , Tie-Lin Wang , Richard Martin , Xiao-Hui Gu
发明人： Venkataiah Bollu , Brant Clayton Boren , Jackaline Dalgard Julien , Brenton T. Flatt , Nadia Haq , Sarah Hudson , Raju Mohan , Michael Morrissey , Benjamin Pratt , Tie-Lin Wang , Richard Martin , Xiao-Hui Gu
IPC分类号： A61K31/5377 , A61K31/498 , A61K31/473 , A61K31/423 , A61K31/4196 , C07D233/84 , C07D413/06 , C07D403/06 , C07D403/12 , C07D249/12 , A61K31/4164 , C07D405/14 , A61P3/00 , A61P3/04 , A61P9/10 , A61P3/10 , A61P3/06 , C12N5/02
CPC分类号： C07D233/84 , C07D233/64 , C07D233/90 , C07D249/12 , C07D401/04 , C07D401/12 , C07D403/06 , C07D403/14
摘要： The present invention comprises TGR5 agonists of structural formula I, wherein X, R1, R2, and R5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprises composition comprising the compounds, N-oxides, and/or pharmaceutically acceptable salts thereof. The invention also comprises use of the compounds and compositions for treating diseases in which TGR5 is a mediator or is implicated. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases in which TGR5 is a mediator or is implicated.
摘要翻译： 本发明包括结构式I的TGR5激动剂，其中X，R 1，R 2和R 5在本文中定义，以及它们的N-氧化物及其药学上可接受的盐。 本发明还包括包含化合物，N-氧化物和/或其药学上可接受的盐的组合物。 本发明还包括使用化合物和组合物来治疗其中TGR5是介质或涉及的疾病。 本发明还包括在药物中和用于制备药物中的用途，特别是用于治疗其中TGR5是介质或涉及的疾病。
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公开(公告)号：US20100331295A1
公开(公告)日：2010-12-30
申请号：US11993806
申请日：2006-06-26
申请人： Brett B Busch , Brenton T. Flatt , Xiao Hui Gu , Shao Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, JR. , Tie Lin Wang , Yinong Xie
发明人： Brett B Busch , Brenton T. Flatt , Xiao Hui Gu , Shao Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, JR. , Tie Lin Wang , Yinong Xie
IPC分类号： A61K31/4155 , C07D409/04 , C07D231/12 , C07D401/04 , C07D413/10 , C07D409/14 , C07D403/10 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/496 , A61P3/06 , A61P3/10 , A61P9/10 , A61P17/10 , A61P25/16 , A61P25/28 , A61P35/00 , A61P29/00 , A61P37/00 , A61P3/04
CPC分类号： C07D233/64 , C07D231/12 , C07D231/22 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/08
摘要： Compounds of the invention, such as compounds of Formulae Ia, Ib, Ic, or Id and pharmaceutically acceptable salts, isomers, and prodrugs thereof, which are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3, and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明的化合物，例如式Ia，Ib，Ic或Id的化合物及其药学上可接受的盐，异构体和前药，其可用作肝脏X受体活性的调节剂，其中R1，R2，R21，R3 ，和G在本文中定义。 还公开了含有该化合物的药物组合物和使用该化合物的方法。
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公开(公告)号：US20090203577A1
公开(公告)日：2009-08-13
申请号：US12096961
申请日：2006-12-12
申请人： Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang
发明人： Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang
IPC分类号： A61K31/55 , C07D487/04 , A61P3/00 , A61K38/22 , A61K38/28
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.
摘要翻译： 本发明涉及对法呢酯X受体表现出亲和性的式I化合物。
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公开(公告)号：US20080234270A1
公开(公告)日：2008-09-25
申请号：US11572962
申请日：2005-07-30
申请人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
发明人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
IPC分类号： A61K31/40 , C07D207/34 , C07D403/02 , C07D413/02 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US08569352B2
公开(公告)日：2013-10-29
申请号：US11993529
申请日：2006-06-26
申请人： Brett B. Busch , Brenton T. Flatt , Xiao-Hui Gu , Shao-Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie-Lin Wang , Yinong Xie
发明人： Brett B. Busch , Brenton T. Flatt , Xiao-Hui Gu , Shao-Po Lu , Richard Martin , Raju Mohan , Michael Charles Nyman , Edwin Schweiger , William C. Stevens, Jr. , Tie-Lin Wang , Yinong Xie
IPC分类号： A61K31/4174 , C07D233/64
CPC分类号： C07D233/64 , C07D231/12 , C07D231/22 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14 , C07D487/08
摘要： Compounds of the invention, such as compounds of Formulae IIa, IIb, IIc or IId, and pharmaceutically acceptable salts, isomers, and prodrugs thereof, are useful as modulators of the activity of liver X receptors, where R1, R2, R21, R3 and G are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.
摘要翻译： 本发明的化合物，例如式IIa，IIb，IIc或IId的化合物及其药学上可接受的盐，异构体和前药可用作肝脏X受体活性的调节剂，其中R1，R2，R21，R3和 G在本文中定义。 还公开了含有化合物的药物组合物和使用该化合物的方法。
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