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    Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
    5.
    发明授权
    Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy 有权
    用于靶向下调血管发生和抗癌治疗的多核苷酸构建体，药物组合物和方法

    公开(公告)号：US07585666B2

    公开(公告)日：2009-09-08

    申请号：US10490746

    申请日：2002-05-01

    申请人： Dror Harats ,  Shoshana Greenberger ,  Eyal Breitbart

    发明人： Dror Harats ,  Shoshana Greenberger ,  Eyal Breitbart

    IPC分类号： C12N15/00 ,  C12N5/00 ,  C12N5/02

    CPC分类号： A61K38/191 ,  A61K31/711 ,  A61K38/177 ,  A61K38/1793 ,  A61K48/00 ,  A61K48/0008 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2800/108 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/85 ,  C12N2840/20

    摘要： A novel nucleic acid construct for down-regulating angiogenesis in a tissue of a subject is provided. The nucleic acid construct includes: (a) a first polynucleotide region encoding a chimeric polypeptide including a ligand binding domain fused to an effector domain of an apoptosis signaling molecule; and (b) a second polynucleotide region encoding a cis acting regulatory element being for directing expression of the chimeric polypeptide in a specific tissue or cell; wherein the ligand binding domain is selected such that it is capable of binding a ligand present in the specific tissue or cell, whereas binding of the ligand to the ligand binding domain activates the effector domain of the apoptosis signaling molecule. Also provided are methods of utilizing this nucleic acid construct for treating diseases characterized by excessive or aberrant neo-vascularization or cell growth.

    摘要翻译： 提供了用于在受试者的组织中下调血管生成的新型核酸构建体。 核酸构建体包括：（a）编码嵌合多肽的第一多核苷酸区域，其包含与凋亡信号分子的效应结构域融合的配体结合结构域; 和（b）编码顺式作用调节元件的第二多核苷酸区域，用于引导嵌合多肽在特定组织或细胞中的表达; 其中选择配体结合结构域使得其能够结合存在于特定组织或细胞中的配体，而配体与配体结合结构域的结合激活凋亡信号分子的效应结构域。 还提供了利用该核酸构建体治疗以过度或异常新血管形成或细胞生长为特征的疾病的方法。

    Methods of treating ophthalmic disorders
    8.
    发明授权
    Methods of treating ophthalmic disorders 有权
    眼科疾病治疗方法

    公开(公告)号：US08529907B2

    公开(公告)日：2013-09-10

    申请号：US12989817

    申请日：2009-04-27

    申请人： Michael Belkin ,  Aviv Shaish ,  Dror Harats ,  Ygal Rotenstreich

    发明人： Michael Belkin ,  Aviv Shaish ,  Dror Harats ,  Ygal Rotenstreich

    IPC分类号： A61K36/05 ,  A61P27/02

    CPC分类号： A61K36/05

    摘要： Provided is a method for improving day photopic vision and/or cone-derived visual field and visual function in a subject suffering from a retinal disease or trauma including administering to the subject a pharmaceutically effective amount of crude Dunaliella powder. Also provided is a method for improving night vision and/or rod derived visual field in a subject suffering from a retinal disease including administering to the subject a pharmaceutically effective amount of crude Dunaliella powder. A pharmaceutical composition for improving day vision and/or visual field in a subject suffering from a retinal disease including crude Dunaliella powder is also provided.

    摘要翻译： 提供了一种在患有视网膜疾病或创伤的受试者中改善日视觉和/或锥形视野和视觉功能的方法，包括向受试者施用药学有效量的粗制杜氏盐藻粉。 还提供了一种在患有视网膜疾病的受试者中改善夜视和/或杆状视野的方法，包括向受试者施用药学有效量的粗制杜氏盐藻粉。 还提供了用于改善患有视网膜疾病，包括粗制杜氏盐藻粉末的受试者的日视力和/或视野的药物组合物。