公开(公告)号：US06881579B2

公开(公告)日：2005-04-19

申请号：US09919073

申请日：2001-07-30

申请人： Richard O. Hilson ,  Edward P. Donlon ,  Donald J. Schremp ,  Laurence R. Shea ,  Carol T. Schembri ,  Joseph P. Fredrick

发明人： Richard O. Hilson ,  Edward P. Donlon ,  Donald J. Schremp ,  Laurence R. Shea ,  Carol T. Schembri ,  Joseph P. Fredrick

IPC分类号： G01N35/00 ,  G01N35/04 ,  G01N35/02 ,  G01N33/50

CPC分类号： G01N35/04 ,  G01N35/00029 ,  G01N2035/00158 ,  G01N2035/0444 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/142222 ,  Y10T436/143333

摘要： Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An apparatus comprises an input element, a holding device for holding a plurality of support housings, one or more fluid dispensing stations, and an output element. Each of the support housings contains a support having attached thereto a plurality of biopolymer features. The holding device is movably mounted with respect to other components of the apparatus. The holding device is adapted to receive a support housing from the input element. The output element is adapted to receive a support housing from the holding device. The apparatus is adapted to index each support housing for a predetermined operation. In use, each of the support housings is moved to one or more processing stations by means of the movable holding device. The location and identity of each of the support housings is indexed. Fluid is applied to the surface of each of the supports at the processing stations to process the samples. Each of the support housings is moved away from the fluid dispensing stations, and fluid is physically removed from each of the supports within the support housings.

摘要翻译： 公开了用于在载体表面上包含在支撑壳体中的样品进行处理的装置和方法。 生物聚合物特征附着在支撑体的表面上。 一种装置包括输入元件，用于保持多个支撑壳体的保持装置，一个或多个流体分配站以及输出元件。 每个支撑壳体包含附着有多个生物聚合物特征的支撑体。 保持装置相对于装置的其它部件可移动地安装。 保持装置适于从输入元件接收支撑壳体。 输出元件适于从保持装置接纳支撑壳体。 该装置适于为每个支撑壳体索引预定的操作。 在使用中，通过可移动保持装置将每个支撑壳体移动到一个或多个处理站。 每个支撑壳体的位置和身份被索引。 将流体施加到处理站处的每个支撑件的表面以处理样品。 每个支撑壳体移动离开流体分配站，并且流体物理地从支撑壳体内的每个支撑件移除。

公开(公告)号：US07008788B2

公开(公告)日：2006-03-07

申请号：US09919062

申请日：2001-07-30

申请人： Donald J. Schremp ,  Richard O. Hilson ,  Edward P. Donlon

发明人： Donald J. Schremp ,  Richard O. Hilson ,  Edward P. Donlon

IPC分类号： C12M3/00

CPC分类号： B01L9/52 ,  B01F11/0014 ,  B01F11/0022 ,  B01F13/0059 ,  B01F13/02 ,  B01F13/0272 ,  B01F2005/0017 ,  B01F2215/0454 ,  B01F2215/0468 ,  B01L3/502 ,  B01L3/508 ,  B01L2300/0636 ,  B01L2300/0822 ,  B01L2300/0851 ,  C12M23/04 ,  C12Q1/6834 ,  Y10S436/809 ,  Y10S436/823

摘要： Devices and methods are disclosed for containing and processing samples on the surface of supports. Biopolymer features are attached to the surfaces of the supports. A device in accordance with the invention comprises a housing and a support confined by the housing. The housing comprises a well having walls and at least one wall extending from the edge of the well. The height of the walls of the well is at least great enough, and the design of the at least one wall is such, that liquid contained in the well is not drawn out of the well to any substantial degree by surface tension or small movements or small mechanical vibrations. In one embodiment, the at least one wall is designed such that corners thereof are curved or are distant from the edge of the well to substantially eliminate wicking of liquid from the well. Also disclosed are methods for mixing materials on the surface of a support. A sample is incubated with the surface of the support of the aforementioned device. The sample is removed from the surface, a residual amount of the sample remaining on the surface. The surface is contacted with a wash solution. A stream of gas is directed at the surface of the support. The pressure of the stream and the angle of the stream create a vortex on the surface sufficient to mix the sample and the wash solution. The wash solution is then removed from the surface. Also disclosed are methods for conducting binding reactions using the devices of the invention.

公开(公告)号：US08213069B2

公开(公告)日：2012-07-03

申请号：US12494041

申请日：2009-06-29

申请人： Lawrence J. DaQuino ,  Edwin de Groot ,  Donald J. Schremp

发明人： Lawrence J. DaQuino ,  Edwin de Groot ,  Donald J. Schremp

IPC分类号： G02B26/08

CPC分类号： G02B7/028 ,  G01N2021/6482 ,  G02B21/26

摘要： A lens stage for use in a scanning system is provided. In certain embodiments, the lens stage comprises: a) a support comprising a first rail and a second rail, in which the first rail and the second rail are mounted to the support in parallel; and b) a linearly moveable lens assembly comprising: i) a voice coil comprising a moving coil that moves in a direction parallel to the rails; ii) a lens; iii) a bracket that is attached to: a) the moving coil and b) the lens, and moveably engaged with the rails via a set of bearing cars; and iv) means to reduce force exerted on the set of bearing cars due to thermal expansion of the moving coil.

摘要翻译： 提供了用于扫描系统的透镜台。 在某些实施例中，透镜台包括：a）包括第一轨道和第二轨道的支撑件，其中第一轨道和第二轨道平行地安装到支撑件; 以及b）线性可移动透镜组件，包括：i）包括沿平行于所述轨道的方向移动的移动线圈的音圈; ii）镜头; iii）支架，其附接到：a）移动线圈和b）透镜，并且通过一组轴承座可移动地与轨道接合; 以及iv）由于运动线圈的热膨胀而减小施加在轴承座组上的力的装置。

公开(公告)号：US20100328746A1

公开(公告)日：2010-12-30

申请号：US12494041

申请日：2009-06-29

申请人： Lawrence J. DaQuino ,  Edwin de Groot ,  Donald J. Schremp

发明人： Lawrence J. DaQuino ,  Edwin de Groot ,  Donald J. Schremp

IPC分类号： G02B26/10 ,  G02B7/02

CPC分类号： G02B7/028 ,  G01N2021/6482 ,  G02B21/26

摘要： A lens stage for use in a scanning system is provided. In certain embodiments, the lens stage comprises: a) a support comprising a first rail and a second rail, in which the first rail and the second rail are mounted to the support in parallel; and b) a linearly moveable lens assembly comprising: i) a voice coil comprising a moving coil that moves in a direction parallel to the rails; ii) a lens; iii) a bracket that is attached to: a) the moving coil and b) the lens, and moveably engaged with the rails via a set of bearing cars; and iv) means to reduce force exerted on the set of bearing cars due to thermal expansion of the moving coil.

摘要翻译： 提供了用于扫描系统的透镜台。 在某些实施例中，透镜台包括：a）包括第一轨道和第二轨道的支撑件，其中第一轨道和第二轨道平行地安装到支撑件; 以及b）线性可移动透镜组件，包括：i）包括沿平行于所述轨道的方向移动的移动线圈的音圈; ii）镜头; iii）支架，其附接到：a）移动线圈和b）透镜，并且通过一组轴承座可移动地与轨道接合; 以及iv）由于运动线圈的热膨胀而减小施加在轴承座组上的力的装置。

公开(公告)号：US07159959B2

公开(公告)日：2007-01-09

申请号：US10839577

申请日：2004-05-05

申请人： Donald J. Schremp

发明人： Donald J. Schremp

IPC分类号： B41J29/38

CPC分类号： B41J29/393

摘要： Methods, systems and computer readable media for identifying print errors caused by erroneous print pattern data received at the printhead of a printer. Methods, systems and computer readable media are also provided for preventing printing according to erroneous printing pattern data received at the printhead. Methods, systems and computer readable media are provided for enhancing the printing speed of a system adapted to identify or prevent printing errors. Further, methods and systems for providing delayed clocking are used for accurate clocking of a printing signal that is sent back from the printhead to the printhead controller for purposes of comparison with a locally stored set of printhead pattern data.

摘要翻译： 方法，系统和计算机可读介质，用于识别由在打印机的打印头处接收到的错误打印图案数据引起的打印错误。 还提供了方法，系统和计算机可读介质，用于根据在打印头处接收到的错误打印图案数据来防止打印。 提供了方法，系统和计算机可读介质，用于增强适于识别或防止打印错误的系统的打印速度。 此外，用于提供延迟时钟的方法和系统用于从打印头向打印头控制器发送的打印信号的准确时钟，以便与本地存储的打印头图案数据集进行比较。