公开(公告)号：US06881579B2

公开(公告)日：2005-04-19

申请号：US09919073

申请日：2001-07-30

申请人： Richard O. Hilson ,  Edward P. Donlon ,  Donald J. Schremp ,  Laurence R. Shea ,  Carol T. Schembri ,  Joseph P. Fredrick

发明人： Richard O. Hilson ,  Edward P. Donlon ,  Donald J. Schremp ,  Laurence R. Shea ,  Carol T. Schembri ,  Joseph P. Fredrick

IPC分类号： G01N35/00 ,  G01N35/04 ,  G01N35/02 ,  G01N33/50

CPC分类号： G01N35/04 ,  G01N35/00029 ,  G01N2035/00158 ,  G01N2035/0444 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/142222 ,  Y10T436/143333

摘要： Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An apparatus comprises an input element, a holding device for holding a plurality of support housings, one or more fluid dispensing stations, and an output element. Each of the support housings contains a support having attached thereto a plurality of biopolymer features. The holding device is movably mounted with respect to other components of the apparatus. The holding device is adapted to receive a support housing from the input element. The output element is adapted to receive a support housing from the holding device. The apparatus is adapted to index each support housing for a predetermined operation. In use, each of the support housings is moved to one or more processing stations by means of the movable holding device. The location and identity of each of the support housings is indexed. Fluid is applied to the surface of each of the supports at the processing stations to process the samples. Each of the support housings is moved away from the fluid dispensing stations, and fluid is physically removed from each of the supports within the support housings.

摘要翻译： 公开了用于在载体表面上包含在支撑壳体中的样品进行处理的装置和方法。 生物聚合物特征附着在支撑体的表面上。 一种装置包括输入元件，用于保持多个支撑壳体的保持装置，一个或多个流体分配站以及输出元件。 每个支撑壳体包含附着有多个生物聚合物特征的支撑体。 保持装置相对于装置的其它部件可移动地安装。 保持装置适于从输入元件接收支撑壳体。 输出元件适于从保持装置接纳支撑壳体。 该装置适于为每个支撑壳体索引预定的操作。 在使用中，通过可移动保持装置将每个支撑壳体移动到一个或多个处理站。 每个支撑壳体的位置和身份被索引。 将流体施加到处理站处的每个支撑件的表面以处理样品。 每个支撑壳体移动离开流体分配站，并且流体物理地从支撑壳体内的每个支撑件移除。

公开(公告)号：US20110077480A1

公开(公告)日：2011-03-31

申请号：US12731010

申请日：2010-03-24

申请人： Daniel Bloom ,  Nicholas A. Nelson ,  Morten J. Jensen ,  Laurence R. Shea ,  Edward Paul Donlon ,  Joseph Anthony Vivolo ,  Stuart Taylor

发明人： Daniel Bloom ,  Nicholas A. Nelson ,  Morten J. Jensen ,  Laurence R. Shea ,  Edward Paul Donlon ,  Joseph Anthony Vivolo ,  Stuart Taylor

IPC分类号： A61B6/00 ,  A61B5/15

CPC分类号： A61B5/150992 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150793 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150946 ,  A61B5/150961 ,  A61B5/1535 ,  A61B5/155 ,  A61B5/157 ,  A61B5/6866

摘要： Devices and methods for automatic monitoring of fluid of a patient are disclosed, comprising a patient line, a transfer disk which receives the fluid and controllably transfers the fluid to test substrates, and a sensor disk which houses the test substrates. The sterile transfer disk may be configured to maintain the sterility of the patient sampling assembly while transferring samples to non-sterile components, such as the sensor disk.

摘要翻译： 公开了一种用于患者流体自动监测的装置和方法，包括患者线，接收流体并可控制地将流体转移到测试基底的转移盘以及容纳测试基底的传感器盘。 无菌转移盘可以被配置为在将样品转移到非无菌组件（例如传感器盘）的同时保持患者采样组件的无菌性。

公开(公告)号：US06803019B1

公开(公告)日：2004-10-12

申请号：US09509337

申请日：2000-06-13

申请人： Torleif Ove Bjornson ,  Laurence R. Shea

发明人： Torleif Ove Bjornson ,  Laurence R. Shea

IPC分类号： G01N2700

CPC分类号： B01L3/50273 ,  B01L3/5025 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0487 ,  B81B2201/058 ,  B81C1/00119 ,  B81C2201/019 ,  G01N27/44791

摘要： A continuous form microstructure array device (20) is constructed as a flexible elongate film laminate containing microstructure arrays (26) arranged serially along the laminate. The laminate can be continuously drawn from a roll, passed through a processing and analysis device and rerolled or stacked for storage.

摘要翻译： 连续形式的微结构阵列器件（20）被构造为包含沿着层压体串联设置的微结构阵列（26）的柔性细长膜层压体。 层压板可以从卷筒中连续拉出，通过处理和分析装置，并重新卷起或堆叠进行存放。

公开(公告)号：US20090247902A1

公开(公告)日：2009-10-01

申请号：US12057245

申请日：2008-03-27

申请人： Julie A. Reichert ,  Wayne Siebrecht ,  Nicholas A. Nelson ,  Laurence R. Shea

发明人： Julie A. Reichert ,  Wayne Siebrecht ,  Nicholas A. Nelson ,  Laurence R. Shea

IPC分类号： A61B5/00 ,  C12M1/34

CPC分类号： G01N35/025 ,  B01L3/0262 ,  B01L3/5025 ,  B01L2200/0642 ,  B01L2300/0803 ,  B01L2300/0829 ,  G01N35/00029 ,  G01N35/04 ,  G01N2035/0465

摘要： Devices and methods for performing automated fluid sampling of a patient are disclosed, comprising a patient sampling assembly, test substrates, and a sample transfer assembly to transfer fluid samples from the sampling assembly to the test substrates. The sample transfer assembly may be configured to maintain the sterility of the patient sampling assembly while transferring samples to non-sterile components, test substrates.

摘要翻译： 公开了用于执行患者的自动化流体取样的装置和方法，包括患者采样组件，测试基板和样品转移组件以将流体样品从采样组件传送到测试基板。 样品转移组件可以被配置为在将样品转移到非无菌组分，测试底物的同时保持患者采样组件的无菌性。

公开(公告)号：US07223592B2

公开(公告)日：2007-05-29

申请号：US10177192

申请日：2002-06-21

申请人： Laurence R. Shea ,  Douglas G. Summers

发明人： Laurence R. Shea ,  Douglas G. Summers

IPC分类号： C12M1/34

CPC分类号： B01L9/52 ,  B01J19/0046 ,  B01J2219/00549 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/508 ,  B01L2300/041 ,  B01L2300/0636 ,  B01L2300/0822 ,  C40B40/06 ,  C40B40/10 ,  C40B70/00 ,  G01N33/54366

摘要： Devices and methods for assaying a sample for the presence of at least one analyte are provided. The subject compression devices include a base and a cover configured to apply a compression force to a structure comprising a first substrate separated from a second substrate by a separator when present in the device. The subject methods include contacting a sample with a first surface of a first substrate to produce a substrate supported sample, placing the substrate supported sample in contact with a second substrate to form a structure that includes the first and second substrates spaced-apart from each other by a separator, wherein one of the substrates is an array substrate having at least one array, applying a compression force to compress the structure together using a compression device and reading the at least one array to obtain a result.

公开(公告)号：US08753290B2

公开(公告)日：2014-06-17

申请号：US12731010

申请日：2010-03-24

申请人： Daniel Bloom ,  Nicholas A. Nelson ,  Morten J. Jensen ,  Laurence R. Shea ,  Ed Donlon ,  Joe Vivolo ,  Stuart Taylor

发明人： Daniel Bloom ,  Nicholas A. Nelson ,  Morten J. Jensen ,  Laurence R. Shea ,  Ed Donlon ,  Joe Vivolo ,  Stuart Taylor

IPC分类号： A61B5/00

CPC分类号： A61B5/150992 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150793 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/150946 ,  A61B5/150961 ,  A61B5/1535 ,  A61B5/155 ,  A61B5/157 ,  A61B5/6866

摘要： Devices and methods for automatic monitoring of fluid of a patient are disclosed, comprising a patient line, a transfer disk which receives the fluid and controllably transfers the fluid to test substrates, and a sensor disk which houses the test substrates. The sterile transfer disk may be configured to maintain the sterility of the patient sampling assembly while transferring samples to non-sterile components, such as the sensor disk.

摘要翻译： 公开了一种用于患者流体自动监测的装置和方法，包括患者线，接收流体并可控制地将流体转移到测试基底的转移盘以及容纳测试基底的传感器盘。 无菌转移盘可以被配置为在将样品转移到非无菌组件（例如传感器盘）的同时保持患者取样组件的无菌性。

公开(公告)号：US06827906B1

公开(公告)日：2004-12-07

申请号：US09568456

申请日：2000-05-09

申请人： Torleif Ove Björnson ,  Laurence R. Shea

发明人： Torleif Ove Björnson ,  Laurence R. Shea

IPC分类号： G01N3120

CPC分类号： B01L3/50273 ,  B01L3/5025 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0487 ,  B81B2201/058 ,  B81C1/00119 ,  B81C2201/019 ,  G01N27/44791

摘要： A continuous form microstructure array device is constructed as a flexible elongate film laminate containing a plurality of microstructures or arrays of microstructures arranged serially lengthwise along the laminate. The laminate can be continuously drawn from a supply roll or stack, advanced within an analytic device and, when analysis is complete, taken up in a storage roll or stack. The device provides for high throughput microfluidic processing.

摘要翻译： 连续形式的微结构阵列器件被构造为柔性细长膜层压体，其包含多个沿着层压体串联地纵向排列的微结构或微阵列阵列。 层压板可以从供应辊或堆叠中连续拉出，在分析装置内进行，并且当分析完成时，将其吸收在储存辊或堆中。 该设备提供高通量微流控处理。