Containers for supports comprising biopolymers

    公开(公告)号:US07008788B2

    公开(公告)日:2006-03-07

    申请号:US09919062

    申请日:2001-07-30

    Abstract: Devices and methods are disclosed for containing and processing samples on the surface of supports. Biopolymer features are attached to the surfaces of the supports. A device in accordance with the invention comprises a housing and a support confined by the housing. The housing comprises a well having walls and at least one wall extending from the edge of the well. The height of the walls of the well is at least great enough, and the design of the at least one wall is such, that liquid contained in the well is not drawn out of the well to any substantial degree by surface tension or small movements or small mechanical vibrations. In one embodiment, the at least one wall is designed such that corners thereof are curved or are distant from the edge of the well to substantially eliminate wicking of liquid from the well. Also disclosed are methods for mixing materials on the surface of a support. A sample is incubated with the surface of the support of the aforementioned device. The sample is removed from the surface, a residual amount of the sample remaining on the surface. The surface is contacted with a wash solution. A stream of gas is directed at the surface of the support. The pressure of the stream and the angle of the stream create a vortex on the surface sufficient to mix the sample and the wash solution. The wash solution is then removed from the surface. Also disclosed are methods for conducting binding reactions using the devices of the invention.

    Methods and apparatuses for bonding in athermal optical fiber packages

    公开(公告)号:US06859584B2

    公开(公告)日:2005-02-22

    申请号:US10335629

    申请日:2002-12-31

    CPC classification number: G02B6/0218

    Abstract: An athermal package for fiber photonic devices includes a ferrule to attach the optical fiber to the package. The ferrule has an opening to receive the optical fiber. The ferule is collapsed to attach the optical fiber to the athermal package. Alternatively, the athermal package uses adhesive bonds disposed in pockets of the package. The pockets have a narrow end and a wide end, with the narrow ends facing each other. The adhesive bonds are disposed in the pockets in contact the narrow ends of the pockets but not with the wide ends. The narrow ends physically confine the adhesive bonds so that if the bonds expand or contract due to environmental conditions (or the curing process), the adhesive either expands or contracts near the wide ends of the pockets. This allows the strain on the optical fiber segment between the bonds to remain substantially constant.

    Method and apparatus for osteoporosis screening
    3.
    发明授权
    Method and apparatus for osteoporosis screening 有权
    用于骨质疏松筛查的方法和装置

    公开(公告)号:US06490339B2

    公开(公告)日:2002-12-03

    申请号:US10007815

    申请日:2001-11-09

    Abstract: A method and apparatus for forming and reading a radiation image of an object is provided. The method is performed by placing an object of which a radiation image is to be taken adjacent a platform that is positioned between a storage layer radiation screen and an electromagnetic wave radiation source such that radiation from the electromagnetic wave radiation source which traverses the object is absorbed by the storage layer radiation screen; forming a latent radiation image of the object on the storage layer radiation screen by causing the electromagnetic wave radiation source to emit radiation, a portion of the emitted radiation traversing the object and being absorbed by the storage layer radiation screen; and reading the latent radiation image of the object from the storage layer radiation screen.

    Abstract translation: 提供了一种用于形成和读取物体的辐射图像的方法和装置。 该方法通过将放射线图像的对象放置在与位于存储层辐射屏和电磁波辐射源之间的平台附近来实现,使得来自穿过物体的电磁波辐射源的辐射被吸收 通过存储层辐射屏; 通过使电磁波辐射源发射辐射,发射的辐射的一部分穿过物体并被存储层辐射屏幕吸收,在存储层辐射屏上形成物体的潜在辐射图像; 以及从存储层辐射屏幕读取物体的潜在辐射图像。

    Scanning system with flexible drive assembly
    5.
    发明授权
    Scanning system with flexible drive assembly 失效
    具有灵活驱动装置的扫描系统

    公开(公告)号:US06492654B1

    公开(公告)日:2002-12-10

    申请号:US09782923

    申请日:2001-02-13

    CPC classification number: G01N23/046 A61B6/14 G01N2223/419

    Abstract: A system is provided for scanning an object, the system comprising: a drive shaft having a proximal portion and a longitudinal axis; a motor including a motor shaft having a rotational axis, the motor serving to rotate the motor shaft about the rotational axis; a flexible joint coupling the drive shaft to the motor shaft by the proximal portion of the drive shaft, the flexible joint having a range of motion which allows the longitudinal axis of the drive shaft to move relative to the rotational axis of the motor shaft; and an object attached to the drive shaft which is movable along the longitudinal axis of the drive shaft in response to the drive shaft being rotated by the motor. This system may be used in a drum scanner system and may be used to read storage layer radiation screens.

    Abstract translation: 提供一种用于扫描物体的系统,该系统包括:具有近端部分和纵向轴线的驱动轴; 包括具有旋转轴线的马达轴的马达,所述马达用于使所述马达轴绕所述旋转轴线旋转; 柔性接头通过驱动轴的近侧部分将驱动轴连接到电动机轴,柔性接头具有允许驱动轴的纵向轴线相对于电动机轴的旋转轴线移动的运动范围; 以及附接到所述驱动轴的物体,所述物体响应于所述驱动轴由所述马达旋转而沿着所述驱动轴的纵向轴线移动。 该系统可以用于鼓式扫描器系统中,并且可以用于读取存储层辐射屏幕。

    Athermal package for fiber Bragg gratings with two or more bonding regions
    7.
    发明授权
    Athermal package for fiber Bragg gratings with two or more bonding regions 有权
    具有两个或多个接合区域的光纤布拉格光栅的热包装

    公开(公告)号:US06856730B2

    公开(公告)日:2005-02-15

    申请号:US10201463

    申请日:2002-07-22

    CPC classification number: G02B6/022

    Abstract: An athermal package for fiber photonic devices includes at least two bonding regions at each end of the optical fiber containing the photonic device. At each end of the optical fiber, the bonding region nearest the photonic device (i.e., the inner bonding region) has a width that is less than that of the other bonding region (i.e., the outer bonding region). The smaller widths of the inner bonding regions allow for relatively precise control of the positions on the optical fiber that the inner bonding regions are attached. The larger widths of the outer bonding regions help provide reliable attachments.

    Abstract translation: 用于光纤光子器件的无热封装包括在包含光子器件的光纤的每个端部处的至少两个结合区域。 在光纤的两端,最靠近光子器件的接合区域(即内部接合区域)的宽度小于另一个接合区域(即,外部接合区域)的宽度。 内部接合区域的较小宽度允许相对精确地控制内部粘结区域附着在光纤上的位置。 外部结合区域的较大宽度有助于提供可靠的附件。

    Device for time lag focusing time-of-flight mass spectrometry
    9.
    发明授权
    Device for time lag focusing time-of-flight mass spectrometry 失效
    时差聚焦飞行时间质谱仪的设备

    公开(公告)号:US5777325A

    公开(公告)日:1998-07-07

    申请号:US643708

    申请日:1996-05-06

    CPC classification number: H01J49/40 H01J49/025

    Abstract: A laser desorption ionization instrument for and method of measuring the molecular weight of large organic molecules includes a time of flight mass spectrometer (TOF MS). The TOF MS instrument provides optimized optic design for both DC and TLF modes. The invention further provides dynamic resolution enhancement for a given ejection pulse, along with optimized ion ejection pulses relative to the ion optic elements. The invention also provides means for compensating for difference in total kinetic energy among ions of different mass; high resolution detection means for improved sensitivity for large molecular weight species. The invention further provides x-y-z stage for sample presentation of both standard MALDI and gel or membrane based samples.

    Abstract translation: 用于测量大型有机分子分子量的激光解吸电离仪及其测定方法包括飞行时间质谱仪(TOF MS)。 TOF MS仪器为DC和TLF模式提供优化的光学设计。 本发明还提供了对于给定的喷射脉冲的动态分辨率增强以及相对于离子光学元件的优化的离子喷射脉冲。 本发明还提供了补偿不同质量离子之间总动能差异的方法; 高分辨率检测手段,用于提高大分子量物种的灵敏度。 本发明还提供用于标准MALDI和基于凝胶或膜的样品的样品呈现的x-y-z级。

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