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    Sample processing apparatus and methods
    1.
    发明授权
    Sample processing apparatus and methods 失效
    样品处理设备和方法

    公开(公告)号：US06881579B2

    公开(公告)日：2005-04-19

    申请号：US09919073

    申请日：2001-07-30

    申请人： Richard O. Hilson ,  Edward P. Donlon ,  Donald J. Schremp ,  Laurence R. Shea ,  Carol T. Schembri ,  Joseph P. Fredrick

    发明人： Richard O. Hilson ,  Edward P. Donlon ,  Donald J. Schremp ,  Laurence R. Shea ,  Carol T. Schembri ,  Joseph P. Fredrick

    IPC分类号： G01N35/00 ,  G01N35/04 ,  G01N35/02 ,  G01N33/50

    CPC分类号： G01N35/04 ,  G01N35/00029 ,  G01N2035/00158 ,  G01N2035/0444 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/142222 ,  Y10T436/143333

    摘要： Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An apparatus comprises an input element, a holding device for holding a plurality of support housings, one or more fluid dispensing stations, and an output element. Each of the support housings contains a support having attached thereto a plurality of biopolymer features. The holding device is movably mounted with respect to other components of the apparatus. The holding device is adapted to receive a support housing from the input element. The output element is adapted to receive a support housing from the holding device. The apparatus is adapted to index each support housing for a predetermined operation. In use, each of the support housings is moved to one or more processing stations by means of the movable holding device. The location and identity of each of the support housings is indexed. Fluid is applied to the surface of each of the supports at the processing stations to process the samples. Each of the support housings is moved away from the fluid dispensing stations, and fluid is physically removed from each of the supports within the support housings.

    摘要翻译： 公开了用于在载体表面上包含在支撑壳体中的样品进行处理的装置和方法。 生物聚合物特征附着在支撑体的表面上。 一种装置包括输入元件，用于保持多个支撑壳体的保持装置，一个或多个流体分配站以及输出元件。 每个支撑壳体包含附着有多个生物聚合物特征的支撑体。 保持装置相对于装置的其它部件可移动地安装。 保持装置适于从输入元件接收支撑壳体。 输出元件适于从保持装置接纳支撑壳体。 该装置适于为每个支撑壳体索引预定的操作。 在使用中，通过可移动保持装置将每个支撑壳体移动到一个或多个处理站。 每个支撑壳体的位置和身份被索引。 将流体施加到处理站处的每个支撑件的表面以处理样品。 每个支撑壳体移动离开流体分配站，并且流体物理地从支撑壳体内的每个支撑件移除。

    Multiple analyte detection systems and methods of detecting multiple analytes
    2.
    发明申请
    Multiple analyte detection systems and methods of detecting multiple analytes 有权
    多种分析物检测系统和检测多种分析物的方法

    公开(公告)号：US20080171397A1

    公开(公告)日：2008-07-17

    申请号：US11653568

    申请日：2007-01-16

    申请人： Ian Hardcastle ,  Carol T. Schembri ,  John Francis Petrilla ,  Rene B. Helbing ,  Daniel B. Roitman

    发明人： Ian Hardcastle ,  Carol T. Schembri ,  John Francis Petrilla ,  Rene B. Helbing ,  Daniel B. Roitman

    IPC分类号： G01N21/76

    CPC分类号： G01N21/78 ,  G01N21/253 ,  G01N21/8483

    摘要： A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.

    摘要翻译： 多分析物检测系统包括具有在其上设置的试剂的载体，其中每种试剂能够响应于暴露于相应分析物而光学变化。 该系统还包括光电检测器，其被定位成共同检测与每个试剂相互作用的光;处理器，用于响应于总体检测的光来确定每个分析物的存在或不存在;以及指示器， 存在或不存在每种分析物。 检测多种分析物的方法包括将暴露于相应分析物的样品响应于能够进行光学变化的试剂露出。 该方法还包括共同检测与每种试剂相互作用的光，响应于共同检测的光，确定每种分析物的存在或不存在，并指示所确定的每种分析物的存在或不存在。

    Chemical arrays
    3.
    发明授权
    Chemical arrays 失效
    化学阵列

    公开(公告)号：US07300798B2

    公开(公告)日：2007-11-27

    申请号：US10167662

    申请日：2001-10-18

    申请人： Michel G. M. Perbost ,  Steven M. Lefkowitz ,  Roy H. Kanemoto ,  Carol T. Schembri

    发明人： Michel G. M. Perbost ,  Steven M. Lefkowitz ,  Roy H. Kanemoto ,  Carol T. Schembri

    IPC分类号： G01N30/00

    CPC分类号： B01J19/0046 ,  Y10T436/110833 ,  Y10T436/143333 ,  Y10T436/25

    摘要： A method and apparatus for using arrays of polymers each having a pattern of features over a corresponding array region on a surface of a flexible elongated web. In this method each array region may be exposed to a corresponding continuous volume of a sample fluid. A method and apparatus are also provided for reading arrays disposed along a surface of a flexible elongated web. In one such method the web with the arrays thereon may be transported in a lengthwise direction past a reading location at which a characteristic of the features is read, while restraining the web on both surfaces on either side of the reading location to assist in maintaining the reading location flat.

    摘要翻译： 一种使用聚合物阵列的方法和装置，每个聚合物阵列具有在柔性细长网的表面上的相应阵列区域上的特征图案。 在该方法中，每个阵列区域可以暴露于相应的连续体积的样品流体。 还提供了一种用于读取沿着柔性细长网的表面设置的阵列的方法和装置。 在一种这样的方法中，其上具有阵列的幅材可以沿长度方向传送通过读取特征的特征的读取位置，同时在读取位置的任一侧的两个表面上限制纸幅以帮助维持 阅读位置平坦。

    Devices for performing array hybridization assays and methods of using the same
    5.
    发明授权
    Devices for performing array hybridization assays and methods of using the same 失效
    用于进行阵列杂交测定的装置及其使用方法

    公开(公告)号：US06773676B2

    公开(公告)日：2004-08-10

    申请号：US09884792

    申请日：2001-06-19

    申请人： Carol T. Schembri

    发明人： Carol T. Schembri

    IPC分类号： B01L300

    CPC分类号： G02B21/34 ,  B01L3/508 ,  B01L2200/0689 ,  B01L2300/041 ,  B01L2300/0809 ,  G01N21/0332 ,  Y10T436/2575

    摘要： Array hybridization devices and methods for their use are provided. The subject devices are characterized by having a substantially planar bottom surface, a cover, at least one fluid port and at least one adjustable spacing element for adjusting the spacing between an array and the bottom surface. In using the subject devices, an array is placed on the at least one adjustable spacing element in the chamber and the space between the array and the bottom surface is adjusted by moving the at least one adjustable spacing element. The adjusted array is contacted with at least one biological sample introduced into the chamber. The subject inventions find use in a variety of array-based applications, including nucleic acid array hybridizations.

    摘要翻译： 提供阵列杂交装置及其使用方法。 主题装置的特征在于具有基本上平坦的底表面，盖，至少一个流体端口和用于调节阵列和底表面之间的间隔的至少一个可调间隔元件。 在使用主体装置时，将阵列放置在腔室中的至少一个可调间隔元件上，并且通过移动至少一个可调间隔元件来调节阵列与底表面之间的空间。 经调节的阵列与引入腔室的至少一个生物样品接触。 本发明可用于各种基于阵列的应用，包括核酸阵列杂交。

    Method and multiple reservoir apparatus for fabrication of biomolecular arrays
    8.
    发明授权
    Method and multiple reservoir apparatus for fabrication of biomolecular arrays 失效
    用于制造生物分子阵列的方法和多储层装置

    公开(公告)号：US06461812B2

    公开(公告)日：2002-10-08

    申请号：US09150507

    申请日：1998-09-09

    申请人： Phillip W. Barth ,  Michael P. Caren ,  William H. McAllister ,  Carol T. Schembri ,  Arthur Schleifer

    发明人： Phillip W. Barth ,  Michael P. Caren ,  William H. McAllister ,  Carol T. Schembri ,  Arthur Schleifer

    IPC分类号： C12Q168

    CPC分类号： B01L3/0268 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00722 ,  B41J2/14145 ,  B41J2002/14387 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14

    摘要： Apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological material, includes a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.

    摘要翻译： 用于将多个不同生物材料输送到接收表面上的离散位置上的装置，例如制造不同生物材料的阵列，包括孔口构件中的多个孔，至少六个输送腔，其各自与 所述孔中的至少一个，多个储存器，每个储存器各自与至少一个输送室流体连通，与每个孔相关联的装置，用于将流体从与所述孔流体导通关系的输送室相推进， 以及用于通常排放至少两个储存器的通风口。 在一些实施例中，腔室和储存器通过将所选择的流体通过孔抽入室中来装载含有选定的生物分子的流体; 在其它实施例中，将流体引入储存器。 此外，用于将生物材料沉积到表面上的方法，例如制备生物分子阵列，采用该装置。

    Method for controlling reactions
    9.
    发明授权
    Method for controlling reactions 失效
    控制反应的方法

    公开(公告)号：US06395553B1

    公开(公告)日：2002-05-28

    申请号：US09695008

    申请日：2000-10-23

    申请人： Carol T. Schembri

    发明人： Carol T. Schembri

    IPC分类号： G01N110

    CPC分类号： G01N35/1097 ,  B01L3/502 ,  B01L2300/0636 ,  B01L2300/0877 ,  B01L2400/0409 ,  B01L2400/0633 ,  G01N33/491 ,  Y10T137/108 ,  Y10T436/111666 ,  Y10T436/2575

    摘要： The invention relates to a method and an apparatus for performing an assay on chemical, biochemical, or biological fluids. The apparatus includes an assay chamber for fluid reactions and a centrifugal force activated-valve for controlling fluid movement through the assay chamber. An active surface can be positioned in the assay chamber to react with fluids passed through the assay chamber. The active surface may contain biomolecular probes. The biomolecular probes can be DNA, DNA fragments, RNA, RNA fragments, reagents, protein, protein fragments, lipids, and lipid fragments. The apparatus is particularly useful when multiple reactions, dilutions, or washing steps are required to determine a final answer. The centrifugal force activated-valve provides positive control over fluid in the assay chamber and allows for repeated use of the same chamber for multiple reaction steps. The apparatus can be disposed of after an assay to eliminate potential contamination from reuse of the same apparatus. Fluids passed through the assay chamber may be recovered for subsequent analysis, processing, or reactions.

    摘要翻译： 本发明涉及用于对化学，生物化学或生物流体进行测定的方法和装置。 该装置包括用于流体反应的测定室和用于控制通过测定室的流体运动的离心力活化阀。 可以将活性表面置于测定室中以与通过测定室的流体反应。 活性表面可以含有生物分子探针。 生物分子探针可以是DNA，DNA片段，RNA，RNA片段，试剂，蛋白质，蛋白质片段，脂质和脂质片段。 当需要多次反应，稀释或洗涤步骤来确定最终答案时，该装置特别有用。 离心力活化阀对分析室中的流体提供积极控制，并允许反复使用相同的室进行多个反应步骤。 该装置可以在分析之后进行处置，以消除重复使用相同装置的潜在污染。 通过测定室的流体可以被回收用于随后的分析，处理或反应。

    Modified siphons for improved metering precision
    10.
    发明授权
    Modified siphons for improved metering precision 失效
    改进的虹吸管，以提高计量精度

    公开(公告)号：US06235531B1

    公开(公告)日：2001-05-22

    申请号：US08562327

    申请日：1995-11-22

    申请人： Anne R. Kopf-Sill ,  Carol T. Schembri

    发明人： Anne R. Kopf-Sill ,  Carol T. Schembri

    IPC分类号： G01N3500

    CPC分类号： B01L3/502738 ,  B01L2300/0806 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0409 ,  G01N21/07 ,  Y10T436/111666 ,  Y10T436/25375 ,  Y10T436/2575

    摘要： The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors include siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.

    摘要翻译： 本发明提供了用于将预先测量的体积的液体输送到转子中的室的离心转子。 特别地，转子包括用于在转子中的第一和第二室之间输送预先测量的液体体积的虹吸管。 本发明的虹吸设计成使得第一室上的虹吸入口在第二室上的虹吸出口的径向外侧。 第一个室被排空到与虹吸出口的径向位置相当的水平。