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    Sample processing apparatus and methods
    1.
    发明授权
    Sample processing apparatus and methods 失效
    样品处理设备和方法

    公开(公告)号：US06881579B2

    公开(公告)日：2005-04-19

    申请号：US09919073

    申请日：2001-07-30

    申请人： Richard O. Hilson ,  Edward P. Donlon ,  Donald J. Schremp ,  Laurence R. Shea ,  Carol T. Schembri ,  Joseph P. Fredrick

    发明人： Richard O. Hilson ,  Edward P. Donlon ,  Donald J. Schremp ,  Laurence R. Shea ,  Carol T. Schembri ,  Joseph P. Fredrick

    IPC分类号： G01N35/00 ,  G01N35/04 ,  G01N35/02 ,  G01N33/50

    CPC分类号： G01N35/04 ,  G01N35/00029 ,  G01N2035/00158 ,  G01N2035/0444 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/142222 ,  Y10T436/143333

    摘要： Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An apparatus comprises an input element, a holding device for holding a plurality of support housings, one or more fluid dispensing stations, and an output element. Each of the support housings contains a support having attached thereto a plurality of biopolymer features. The holding device is movably mounted with respect to other components of the apparatus. The holding device is adapted to receive a support housing from the input element. The output element is adapted to receive a support housing from the holding device. The apparatus is adapted to index each support housing for a predetermined operation. In use, each of the support housings is moved to one or more processing stations by means of the movable holding device. The location and identity of each of the support housings is indexed. Fluid is applied to the surface of each of the supports at the processing stations to process the samples. Each of the support housings is moved away from the fluid dispensing stations, and fluid is physically removed from each of the supports within the support housings.

    摘要翻译： 公开了用于在载体表面上包含在支撑壳体中的样品进行处理的装置和方法。 生物聚合物特征附着在支撑体的表面上。 一种装置包括输入元件，用于保持多个支撑壳体的保持装置，一个或多个流体分配站以及输出元件。 每个支撑壳体包含附着有多个生物聚合物特征的支撑体。 保持装置相对于装置的其它部件可移动地安装。 保持装置适于从输入元件接收支撑壳体。 输出元件适于从保持装置接纳支撑壳体。 该装置适于为每个支撑壳体索引预定的操作。 在使用中，通过可移动保持装置将每个支撑壳体移动到一个或多个处理站。 每个支撑壳体的位置和身份被索引。 将流体施加到处理站处的每个支撑件的表面以处理样品。 每个支撑壳体移动离开流体分配站，并且流体物理地从支撑壳体内的每个支撑件移除。

    Methods to detect cross-contamination between samples contacted with a multi-array substrate
    2.
    发明授权
    Methods to detect cross-contamination between samples contacted with a multi-array substrate 失效
    检测与多阵列基板接触的样品之间的交叉污染的方法

    公开(公告)号：US07108979B2

    公开(公告)日：2006-09-19

    申请号：US10655430

    申请日：2003-09-03

    申请人： Joseph P. Fredrick ,  Jacqueline M. Tso

    发明人： Joseph P. Fredrick ,  Jacqueline M. Tso

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/6876 ,  C12Q1/6837 ,  C12Q2600/166 ,  C12Q2537/143

    摘要： Methods and compositions for detecting cross-contamination between samples contacted with different arrays of a multi-array substrate are provided. The methods involve contacting sample to arrays of a multi-array substrate that contains cross-contamination probes in each of its arrays, and evaluating the resultant sample contacted arrays for cross-contamination between the samples. In many embodiments, the arrays of the multi-array substrate contain a set of cross-contamination probes for a corresponding set of cross-contamination targets in the sample(s). Kits and systems are provided for performing the invention. The subject methods may be used in a variety of different applications, such as gene expression analysis, DNA sequencing, mutation detection, as well as other genomics and proteomics applications.

    摘要翻译： 提供了用于检测与多阵列基板的不同阵列接触的样品之间的交叉污染的方法和组合物。 该方法包括将样品接触到阵列中的多阵列基底，该阵列在其阵列中包含交叉污染探针，并评估所得样品接触的阵列以用于样品之间的交叉污染。 在许多实施例中，多阵列基板的阵列包含用于样品中相应的一组交叉污染目标的一组交叉污染探针。 提供了用于执行本发明的套件和系统。 主题方法可用于各种不同的应用，如基因表达分析，DNA测序，突变检测以及其他基因组学和蛋白质组学应用。