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公开(公告)号：US4251310A
公开(公告)日：1981-02-17
申请号：US854762
申请日：1977-11-25
CPC分类号： B29C65/44 , A61M25/0014 , B21G1/08 , B29C65/04 , B29C65/5057 , B29C66/5344 , B29C66/81263 , B29C66/8322 , B29C66/742 , B29K2705/00 , B29L2031/7544
摘要： There is disclosed herein an improved needle assembly or fistula set which includes a hollow metal needle, a larger plastic fluid-carrying conduit, and plastic spacers between the needle and the conduit. The conduit and spacers are heat sealed to each other so as to provide a fluid-tight junction with the needle.A method for heat sealing the fistula set is also disclosed. In that method, the needle is used as one electrode and the other electrode includes jaw-like members which engage and surround the conduit at the junction where the heat seal is to be formed. During the heat sealing operation, the conduit and needle are maintained in substantial coaxial alignment so as to assure coaxial alignment thereafter.A fixture or tooling apparatus is also disclosed for effecting heat sealing and assuring substantial coaxial alignment.
摘要翻译： 本文公开了一种改进的针组件或瘘组，其包括中空金属针，较大的塑料流体输送导管和针与导管之间的塑料间隔物。 导管和间隔件彼此热密封，以便提供与针的流体密封连接。 还公开了一种用于热封瘘组的方法。 在该方法中，针被用作一个电极，而另一个电极包括在形成热封的接合部处接合和围绕导管的颚状构件。 在热封操作期间，导管和针保持基本上同轴对准，以便此后保证同轴对齐。 还公开了用于实现热密封并确保基本上同轴对准的固定装置或模具装置。
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公开(公告)号：US4208193A
公开(公告)日：1980-06-17
申请号：US959113
申请日：1978-11-09
申请人： John M. Munsch , Ludwig Wolf, Jr.
发明人： John M. Munsch , Ludwig Wolf, Jr.
CPC分类号： A61M1/3627 , A61M1/325
摘要： A blood reservoir comprises a rigid casing and a perforated tubular member positioned within the casing and extending between the edges thereof. An inlet aperture is at a position at the upper end of the reservoir in communication with the bore of the tubular member while an outlet aperture is positioned adjacent the bottom of the casing exterior to the tubular member. The bore of the tubular member contains first blood-defoaming means, and the tubular member carries a blood filter. In accordance with this invention, second blood defoaming means are positioned about the exterior of the tubular member to dissipate the fine bubbles without interference from the larger bubbles, which have been previously removed by passage through the first blood defoaming means.
摘要翻译： 血液贮存器包括刚性壳体和定位在壳体内并在其边缘之间延伸的多孔管状构件。 入口孔位于储存器的上端处与管状构件的孔连通的位置，同时出口孔邻近管状构件外部的壳体的底部定位。 管状构件的孔包含第一血液消泡装置，并且管状构件携带血液过滤器。 根据本发明，第二血液消泡装置围绕管状构件的外部定位，以消散细小气泡，而不受来自通过第一血液消泡装置的先前去除的较大气泡的干扰。
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公开(公告)号：US4340052A
公开(公告)日：1982-07-20
申请号：US194733
申请日：1980-10-07
CPC分类号： A61M39/1011 , A61M39/165 , A61M2039/1033 , A61M2039/1066 , Y10S604/905
摘要： A contamination protector for a medical device, principally for use in surrounding and protecting a connection between a plastic dialysis solution container (10) and tubing (22) carried by a patient practicing continuous ambulatory peritoneal dialysis. The protector is generally cylindrical in shape, and opens and closes much like a "clamshell." The inner wall surface (34) of the protector is adapted to carry a material (36) which holds a sterilizing agent in contact with a medical connection when the protector is in the closed position.
摘要翻译： 一种用于医疗装置的污染保护器，主要用于围绕和保护塑料透析溶液容器（10）和由执行连续不卧床腹膜透析的患者携带的管（22）之间的连接。 保护器通常为圆柱形，并且打开和关闭非常像“蛤壳”。 当保护器处于关闭位置时，保护器的内壁表面（34）适于承载保持灭菌剂与医疗连接接触的材料（36）。
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公开(公告)号：US06319662B1
公开(公告)日：2001-11-20
申请号：US08168438
申请日：1993-12-17
申请人： Jack Foley , John Chapman , Ludwig Wolf, Jr.
发明人： Jack Foley , John Chapman , Ludwig Wolf, Jr.
IPC分类号： A01N102
CPC分类号： A61M1/0209 , A61L2/0088 , A61M1/0218 , A61M1/3686 , A61M1/3687
摘要： A method for treating a body fluid to at least substantially inactivate viral contaminants that may be present therein is provided. The method includes the steps of: providing a body fluid; adding to the body fluid a viral inactivating agent to create a resultant product; and passing the resultant product through a column including material having an affinity for the viral inactivating agent.
摘要翻译： 提供了一种用于治疗体液至少基本上灭活可能存在于其中的病毒污染物的方法。 该方法包括以下步骤：提供体液; 向体液中加入病毒灭活剂以产生所得产物; 并使所得产物通过包含对病毒灭活剂具有亲和力的材料的柱。
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5.发明授权
公开(公告)号：US5527704A
公开(公告)日：1996-06-18
申请号：US434700
申请日：1995-05-04
申请人： Ludwig Wolf, Jr. , William Bratten , John Foley
发明人： Ludwig Wolf, Jr. , William Bratten , John Foley
CPC分类号： C12M37/00 , A61L2/0011
摘要： A method and apparatus for inactivating viruses in a body fluid. A mixture including a therapeutically effective amount of methylene blue and an amount of a body fluid is formed in a container under sterile conditions and then the container is irradiated with a light field of a suitable intensity and wavelength for activating the methylene blue for a time sufficient to inactivate viruses in the mixture. The mixture is maintained in a substantially static state within the container.
摘要翻译： 用于灭活体液中的病毒的方法和装置。 在无菌条件下在容器中形成包含治疗有效量的亚甲基蓝和体液的混合物，然后用适当强度和波长的光场照射容器以足够的时间活化亚甲基蓝 灭活混合物中的病毒。 混合物在容器内维持在基本上静止的状态。
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公开(公告)号：US4151088A
公开(公告)日：1979-04-24
申请号：US871269
申请日：1978-01-23
CPC分类号： A61M1/1698 , A61M1/1629 , B01D63/087 , A61M1/3627 , B01D2313/38 , B01D2313/50
摘要： A diffusion system for blood including a membrane diffusion device comprising a plurality of blood flow paths positioned in interleaving diffusion exchange relation, with second fluid flow paths positioned on opposite sides of semi-permeable membrane means. The first and second flow paths each communicate with an inlet and an outlet. Heat exchange means having an inlet and an outlet is connected at the inlet thereof to the outlet of the first flow paths. A rigid reservoir, also having an inlet and an outlet is connected at its inlet to the outlet of the heat exchange means. A blood flow circuit is defined through the membrane diffusion device, heat exchange means, and reservoir. The flow circuit defines an essentially constant width, perpendicular to the directions of blood flow, from its beginning to end, to provide a system having good flow distribution in combination with a low pressure drop.
摘要翻译： 一种用于血液的扩散系统，包括膜扩散装置，该膜扩散装置包括以交错扩散交换关系定位的多个血流路径，第二流体流动路径位于半透膜装置的相对侧上。 第一和第二流动路径各自与入口和出口连通。 具有入口和出口的热交换装置在其入口处连接到第一流动路径的出口。 还具有入口和出口的刚性贮存器在其入口处连接到热交换装置的出口。 通过膜扩散装置，热交换装置和储存器限定血流回路。 流动回路限定了垂直于血液流动方向的基本上恒定的宽度，从其开始到结束，以提供与低压降相结合的具有良好流动分布的系统。
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公开(公告)号：US06635324B1
公开(公告)日：2003-10-21
申请号：US09009969
申请日：1998-01-21
IPC分类号： A61M2500
CPC分类号： A61M39/146 , A61M39/08 , B29C65/2046 , B29C65/2061 , B29C65/2076 , B29C65/7802 , B29C65/7841 , B29C66/1142 , B29C66/5221 , B29C66/71 , B29C66/723 , B29C66/73143 , B29C66/857 , B29C66/91421 , B29C66/919 , B29K2023/0608 , B29K2023/083 , B29K2027/06 , B29K2031/04 , B29K2077/00 , B29L2009/00 , B29L2023/007 , B32B1/08 , Y10T428/1338 , Y10T428/139 , Y10T428/31746 , Y10T428/31909 , Y10T428/31913 , Y10T428/3192 , Y10T428/31924 , Y10T428/31928 , Y10T428/31935 , B29K2023/0616 , B29K2023/06
摘要： A medical grade tubing that includes a layer of ultra low density polyethylene that has been let down, or drawn down, in diameter approximately 10% to about 50% in an extrusion process and an inner layer of an RF responsive material, the tubing allowing for the selective connection of the tubing to another tubing using a sterile welding device.
摘要翻译： 一种医用级管，其包括一层超低密度聚乙烯，其在挤出过程中直径约10％至约50％，并且RF反应材料的内层已经被放下或拉下，该管允许 使用无菌焊接装置将管道选择性地连接到另一管道。
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公开(公告)号：US06213334B1
公开(公告)日：2001-04-10
申请号：US08711765
申请日：1996-09-05
IPC分类号： A61B1900
CPC分类号： A61J1/10 , A61J1/12 , B29C35/041 , B29C65/04 , B29C66/0242 , B29C66/1122 , B29C66/3452 , B29C66/53262 , B29C66/71 , B29C66/8242 , B29C66/8322 , B29L2031/7148 , B29K2023/06 , B29K2023/083 , B29K2023/086 , B29K2023/12 , B29K2027/06
摘要： A flexible, three-dimensional container is made by a prescribed vacuum-molding and heat sealing process. The container possesses a precise, defined geometry before and during use. The container is formed from first and second walls. The first wall has a planar area and a vacuum-molded cavity area drawn out of the plane of the planar area into a predefined three-dimensional geometry. A second wall overlies the first wall to close the cavity area and thereby forms an interior compartment. A thermal seal joins the two walls together. The seal is formed by heating the second wall and the first wall in the planar area, while assuring that the cavity area of the first wall is not subject to heating and possible deformation of its precise vacuum-molded geometry.
摘要翻译： 通过规定的真空成型和热封工艺制成柔软的三维容器。 容器在使用之前和使用期间具有精确的定义的几何形状。 容器由第一和第二壁形成。 第一壁具有平面区域和从平面区域的平面引出到预定义的三维几何形状的真空模制空腔区域。 第二壁覆盖第一壁以封闭空腔区域，从而形成内部隔室。 热封将两个墙壁连在一起。 密封件通过加热平面区域中的第二壁和第一壁而形成，同时确保第一壁的空腔区域不受其加热和其精确的真空模制几何形状的可能的变形。
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公开(公告)号：US6059968A
公开(公告)日：2000-05-09
申请号：US009479
申请日：1998-01-20
申请人： Ludwig Wolf, Jr.
发明人： Ludwig Wolf, Jr.
CPC分类号： A61M1/0209 , A61M2202/0462
摘要： Assemblies and methods process cord blood in a sterile fashion to avoid exposure to bacterial contamination. A transfer tube couples a cord blood processing container to an other container, which, in use, holds a cryopreservative solution. The transfer tube has an interior diameter that is restricted substantially along its entire length, to meter the introduction of cryopreservation solution into cord blood at a desired rate, thereby avoiding damage or trauma to the cord blood cells.
摘要翻译： 装配和方法以无菌方式处理脐带血，以避免暴露于细菌污染。 输送管将脐带血处理容器连接到另一个容器中，其在使用中保持冷冻保存溶液。 转移管具有基本上沿着其整个长度受到限制的内径，以便以所需的速率将冷冻保存溶液引入脐带血中，从而避免对脐带血细胞的损伤或创伤。
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10.发明授权Systems and methods for eradicating contaminants using photoactive materials in fluids like blood 失效在血液中使用光敏材料消除污染物的系统和方法
公开(公告)号：US5300019A
公开(公告)日：1994-04-05
申请号：US991758
申请日：1992-12-17
CPC分类号： A61L2/0011 , A61M1/3681 , A61M1/3683 , B01J19/122
摘要： A system and method for treating a fluid carrying a biological contaminant to which a photoactive material has been bound include a treatment device that defines a flow passage with a gap. The system and method operate to establish a flow of fluid from the inlet end of the gap to the outlet end of the gap. The system and method expose the fluid, as it transits the gap, to a source of radiation that activates the photoactive material bound to the contaminant. The system and method also mix the fluid as it flows within the gap.
摘要翻译： 用于处理携带光活性材料已经结合的生物污染物的流体的系统和方法包括限定具有间隙的流动通道的处理装置。 系统和方法操作以建立从间隙的入口端到间隙的出口端的流体流。 该系统和方法使流体在其间隙中暴露于激发与污染物结合的光活性材料的辐射源。 当流体在间隙内流动时，系统和方法也混合流体。
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