-
公开(公告)号：US20100330190A1
公开(公告)日：2010-12-30
申请号：US12808741
申请日：2008-12-17
IPC分类号： A61K9/14 , A61K39/00 , C12N15/63 , C07K14/00 , C07H21/04 , C07K14/195 , C07K14/44 , C07K14/255 , C07K14/11 , C07K14/435 , A61K39/002 , A61K39/02 , A61K39/112 , A61K39/145
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/5258 , A61K2039/543 , A61K2039/55516 , C07K14/255 , C07K2319/02 , C07K2319/03 , C07K2319/40 , C12N7/00 , C12N2710/14043 , C12N2760/16123 , C12N2760/16134
摘要： Embodiments of the disclosure encompass compositions and methods for generating immune responses in an animal or human host. Embodiments of the compositions encompass proteins derived from the surface proteins of bacteria and protozoa, and in particular the flagellum component flagellin, and which have adjunctival properties when administered in conjunction with an immunogen. Embodiments of the compositions of the disclosure are modified to incorporate a heterologous transmembrane-cytoplasmic domain allowing the peptides to be incorporated into virus-like particles. Embodiments of the methods of generating an immunological response in an animal or human comprise exposing the immune system of an animal or human host to an immunogen and a virus-like particle comprising an adjuvant polypeptide including a host cell Toll-like receptor ligand polypeptide having a transmembrane-cytoplasmic tail polypeptide, and a heterologous signal peptide.
摘要翻译： 本公开的实施方案包括用于在动物或人类宿主中产生免疫应答的组合物和方法。 组合物的实施方案包括衍生自细菌和原生动物的表面蛋白质的蛋白质，特别是鞭毛成分鞭毛蛋白，并且当与免疫原联合施用时具有辅助性质。 本公开的组合物的实施方案被修饰为掺入异源跨膜 - 细胞质结构域，允许将肽掺入病毒样颗粒中。 在动物或人类中产生免疫应答的方法的实施方案包括将动物或人宿主的免疫系统暴露于免疫原和包含佐剂多肽的病毒样颗粒，所述佐剂多肽包括宿主细胞Toll样受体配体多肽，其具有 跨膜 - 细胞质尾肽多肽和异源信号肽。
-
公开(公告)号：US09683020B2
公开(公告)日：2017-06-20
申请号：US14236618
申请日：2012-07-31
申请人： Richard W. Compans , Baozhong Wang , Fu Shi Quan
发明人： Richard W. Compans , Baozhong Wang , Fu Shi Quan
IPC分类号： A61K39/12 , A61K39/145 , C07K14/005 , C07K14/195 , C12N7/00 , A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/543 , A61K2039/55516 , A61K2039/6068 , A61K2039/64 , C07K14/195 , C07K14/255 , C07K2319/02 , C07K2319/03 , C07K2319/42 , C07K2319/735 , C07K2319/75 , C12N7/00 , C12N2710/14043 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2799/026
摘要： This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a TLR5 agonist on the exterior without an antigen.
-
公开(公告)号：US20140255441A1
公开(公告)日：2014-09-11
申请号：US14236618
申请日：2012-07-31
IPC分类号： C07K14/37 , C07K14/005 , C07K14/195
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/145 , A61K2039/5258 , A61K2039/543 , A61K2039/55516 , A61K2039/6068 , A61K2039/64 , C07K14/195 , C07K14/255 , C07K2319/02 , C07K2319/03 , C07K2319/42 , C07K2319/735 , C07K2319/75 , C12N7/00 , C12N2710/14043 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2799/026
摘要： This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a TLR5 agonist on the exterior without an antigen.
摘要翻译： 本公开涉及增强对抗原的免疫应答的免疫原性组合物和方法。 在某些实施方案中，本公开涉及在外部没有抗原的包含TLR5激动剂的病毒样载体。
-
公开(公告)号：US20100196419A1
公开(公告)日：2010-08-05
申请号：US12598271
申请日：2008-05-02
申请人： Richard W. Compans , Baozhong Wang , Beatrice Hahn , Weimin Liu , Gale Smith , Peter Pushko
发明人： Richard W. Compans , Baozhong Wang , Beatrice Hahn , Weimin Liu , Gale Smith , Peter Pushko
CPC分类号： C07K14/43572 , A61K39/12 , A61K39/21 , A61K2039/5258 , C07K14/005 , C07K2319/02 , C07K2319/03 , C12N9/2442 , C12N2710/14022 , C12N2740/12022 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2760/10022 , C12N2760/16122 , C12Y302/01014
摘要： Embodiments of the present disclosure encompasses virus-like particles, methods of making virus-like particles, including expression vectors, wherein the virus-like particles may comprise enhanced levels of capsid-bound a chimeric HN-Env polypeptide compared to VLPs derived from unmodified HIV-env polypeptides. Embodiments of the virus-like particle may have Env-specific epitopes exposed on the outer surface thereof. In one embodiment, the Env-specific epitopes exposed on the outer surface of the virus-like particle may specifically bind with an anti-HIV-Env specific antibody. Embodiments of the disclosure further includes methods of generating an antibody specific to an epitope of an HIV-Env polypeptide, comprising delivering to an animal or a human an effective amount of a suspension of virus-like particles comprising a chimeric HIV-Eny polypeptide, thereby inducing the formation of an antibody specific to an epitope of an HIV-1 eny polypeptide.
摘要翻译： 本公开的实施方案包括病毒样颗粒，制备病毒样颗粒的方法，包括表达载体，其中与源自未修饰的HIV的VLPs相比，病毒样颗粒可以包含增强的衣壳结合嵌合HN-Env多肽的水平 -env多肽。 病毒样颗粒的实施方案可能具有暴露在其外表面上的Env特异性表位。 在一个实施方案中，暴露在病毒样颗粒的外表面上的Env特异性表位可以与抗HIV-Env特异性抗体特异性结合。 本公开的实施方案还包括产生对HIV-Env多肽的表位特异性的抗体的方法，包括向动物或人类递送有效量的包含嵌合HIV-Eny多肽的病毒样颗粒的悬浮液，由此 诱导对HIV-1烯多肽的表位特异的抗体的形成。
-
5.发明授权Virus-like particles comprising chimeric human immunodeficiency virus (HIV)/mouse mammary tumor virus (MMTV) envelopes 有权包含嵌合人类免疫缺陷病毒（HIV）/小鼠乳腺肿瘤病毒（MMTV）包膜的病毒样颗粒公开(公告)号：US08795682B2
公开(公告)日：2014-08-05
申请号：US12598271
申请日：2008-05-02
申请人： Richard W. Compans , Baozhong Wang , Beatrice Hahn , Weimin Liu , Gale Smith , Peter Pushko
发明人： Richard W. Compans , Baozhong Wang , Beatrice Hahn , Weimin Liu , Gale Smith , Peter Pushko
CPC分类号： C07K14/43572 , A61K39/12 , A61K39/21 , A61K2039/5258 , C07K14/005 , C07K2319/02 , C07K2319/03 , C12N9/2442 , C12N2710/14022 , C12N2740/12022 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2760/10022 , C12N2760/16122 , C12Y302/01014
摘要： Embodiments of the present disclosure encompasses virus-like particles, methods of making virus-like particles, including expression vectors, wherein the virus-like particles may comprise enhanced levels of capsid-bound a chimeric HN-Env polypeptide compared to VLPs derived from unmodified HIV-env polypeptides. Embodiments of the virus-like particle may have Env-specific epitopes exposed on the outer surface thereof. In one embodiment, the Env-specific epitopes exposed on the outer surface of the virus-like particle may specifically bind with an anti-HIV-Env specific antibody. Embodiments of the disclosure further includes methods of generating an antibody specific to an epitope of an HIV-Env polypeptide, comprising delivering to an animal or a human an effective amount of a suspension of virus-like particles comprising a chimeric HIV-Eny polypeptide, thereby inducing the formation of an antibody specific to an epitope of an HIV-1 eny polypeptide.
摘要翻译： 本公开的实施方案包括病毒样颗粒，制备病毒样颗粒的方法，包括表达载体，其中与源自未修饰的HIV的VLPs相比，病毒样颗粒可以包含增强的衣壳结合嵌合HN-Env多肽的水平 -env多肽。 病毒样颗粒的实施方案可能具有暴露在其外表面上的Env特异性表位。 在一个实施方案中，暴露在病毒样颗粒的外表面上的Env特异性表位可以与抗HIV-Env特异性抗体特异性结合。 本公开的实施方案还包括产生对HIV-Env多肽的表位特异性的抗体的方法，包括向动物或人类递送有效量的包含嵌合HIV-Eny多肽的病毒样颗粒的悬浮液，由此 诱导对HIV-1烯多肽的表位特异的抗体的形成。
-
-
-
-
搜索结果
5 条记录 (耗时 0.028 秒)
