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1.发明授权Virus-like particles comprising chimeric human immunodeficiency virus (HIV)/mouse mammary tumor virus (MMTV) envelopes 有权包含嵌合人类免疫缺陷病毒（HIV）/小鼠乳腺肿瘤病毒（MMTV）包膜的病毒样颗粒公开(公告)号：US08795682B2
公开(公告)日：2014-08-05
申请号：US12598271
申请日：2008-05-02
申请人： Richard W. Compans , Baozhong Wang , Beatrice Hahn , Weimin Liu , Gale Smith , Peter Pushko
发明人： Richard W. Compans , Baozhong Wang , Beatrice Hahn , Weimin Liu , Gale Smith , Peter Pushko
CPC分类号： C07K14/43572 , A61K39/12 , A61K39/21 , A61K2039/5258 , C07K14/005 , C07K2319/02 , C07K2319/03 , C12N9/2442 , C12N2710/14022 , C12N2740/12022 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2760/10022 , C12N2760/16122 , C12Y302/01014
摘要： Embodiments of the present disclosure encompasses virus-like particles, methods of making virus-like particles, including expression vectors, wherein the virus-like particles may comprise enhanced levels of capsid-bound a chimeric HN-Env polypeptide compared to VLPs derived from unmodified HIV-env polypeptides. Embodiments of the virus-like particle may have Env-specific epitopes exposed on the outer surface thereof. In one embodiment, the Env-specific epitopes exposed on the outer surface of the virus-like particle may specifically bind with an anti-HIV-Env specific antibody. Embodiments of the disclosure further includes methods of generating an antibody specific to an epitope of an HIV-Env polypeptide, comprising delivering to an animal or a human an effective amount of a suspension of virus-like particles comprising a chimeric HIV-Eny polypeptide, thereby inducing the formation of an antibody specific to an epitope of an HIV-1 eny polypeptide.
摘要翻译： 本公开的实施方案包括病毒样颗粒，制备病毒样颗粒的方法，包括表达载体，其中与源自未修饰的HIV的VLPs相比，病毒样颗粒可以包含增强的衣壳结合嵌合HN-Env多肽的水平 -env多肽。 病毒样颗粒的实施方案可能具有暴露在其外表面上的Env特异性表位。 在一个实施方案中，暴露在病毒样颗粒的外表面上的Env特异性表位可以与抗HIV-Env特异性抗体特异性结合。 本公开的实施方案还包括产生对HIV-Env多肽的表位特异性的抗体的方法，包括向动物或人类递送有效量的包含嵌合HIV-Eny多肽的病毒样颗粒的悬浮液，由此 诱导对HIV-1烯多肽的表位特异的抗体的形成。
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公开(公告)号：US20100196419A1
公开(公告)日：2010-08-05
申请号：US12598271
申请日：2008-05-02
申请人： Richard W. Compans , Baozhong Wang , Beatrice Hahn , Weimin Liu , Gale Smith , Peter Pushko
发明人： Richard W. Compans , Baozhong Wang , Beatrice Hahn , Weimin Liu , Gale Smith , Peter Pushko
CPC分类号： C07K14/43572 , A61K39/12 , A61K39/21 , A61K2039/5258 , C07K14/005 , C07K2319/02 , C07K2319/03 , C12N9/2442 , C12N2710/14022 , C12N2740/12022 , C12N2740/16023 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2760/10022 , C12N2760/16122 , C12Y302/01014
摘要： Embodiments of the present disclosure encompasses virus-like particles, methods of making virus-like particles, including expression vectors, wherein the virus-like particles may comprise enhanced levels of capsid-bound a chimeric HN-Env polypeptide compared to VLPs derived from unmodified HIV-env polypeptides. Embodiments of the virus-like particle may have Env-specific epitopes exposed on the outer surface thereof. In one embodiment, the Env-specific epitopes exposed on the outer surface of the virus-like particle may specifically bind with an anti-HIV-Env specific antibody. Embodiments of the disclosure further includes methods of generating an antibody specific to an epitope of an HIV-Env polypeptide, comprising delivering to an animal or a human an effective amount of a suspension of virus-like particles comprising a chimeric HIV-Eny polypeptide, thereby inducing the formation of an antibody specific to an epitope of an HIV-1 eny polypeptide.
摘要翻译： 本公开的实施方案包括病毒样颗粒，制备病毒样颗粒的方法，包括表达载体，其中与源自未修饰的HIV的VLPs相比，病毒样颗粒可以包含增强的衣壳结合嵌合HN-Env多肽的水平 -env多肽。 病毒样颗粒的实施方案可能具有暴露在其外表面上的Env特异性表位。 在一个实施方案中，暴露在病毒样颗粒的外表面上的Env特异性表位可以与抗HIV-Env特异性抗体特异性结合。 本公开的实施方案还包括产生对HIV-Env多肽的表位特异性的抗体的方法，包括向动物或人类递送有效量的包含嵌合HIV-Eny多肽的病毒样颗粒的悬浮液，由此 诱导对HIV-1烯多肽的表位特异的抗体的形成。
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公开(公告)号：US08951537B2
公开(公告)日：2015-02-10
申请号：US13297125
申请日：2011-11-15
申请人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
发明人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
IPC分类号： A61K39/145 , C12N7/00 , C12N7/04 , C07K14/005 , C12N15/86 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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4.发明申请VARICELLA ZOSTER VIRUS VIRUS-LIKE PARTICLES (VLPs) AND ANTIGENS 审中-公开VARICELLA ZOSTER病毒样病毒颗粒（VLPs）和抗原公开(公告)号：US20100330122A1
公开(公告)日：2010-12-30
申请号：US12669700
申请日：2008-07-21
申请人： Gale Smith , Peter Pushko
发明人： Gale Smith , Peter Pushko
CPC分类号： C12N7/00 , A61K2039/5258 , C12N2710/16723 , Y02A50/386 , Y02A50/388
摘要： The present invention discloses novel Varicella Zoster Virus (VZV) virus-like particles (VLPs) comprising glycoprotein E of VZV. The invention also discloses vaccine formulations of the VZV-VLPs and methods of inducing an immune response in subjects.
摘要翻译： 本发明公开了包含VZV糖蛋白E的新型水痘带状疱疹病毒（VZV）病毒样颗粒（VLP）。 本发明还公开了VZV-VLP的疫苗制剂和在受试者中诱导免疫应答的方法。
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公开(公告)号：US08992939B2
公开(公告)日：2015-03-31
申请号：US13280043
申请日：2011-10-24
申请人： Gale Smith , Yingyun Wu , Michael Massare , Peter Pushko , Margret Nathan , Thomas Kort , Robin Robinson
发明人： Gale Smith , Yingyun Wu , Michael Massare , Peter Pushko , Margret Nathan , Thomas Kort , Robin Robinson
CPC分类号： C12N7/00 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , A61K2039/55555 , C07K14/005 , C07K2319/01 , C07K2319/03 , C12N9/2402 , C12N2710/14143 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12N2760/16222 , C12N2760/16223 , C12N2760/16251 , C12N2770/20022 , C12N2770/20023 , C12N2770/20051 , C12N2800/22 , C12Y302/01018
摘要： This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs.
摘要翻译： 本发明公开了一种增加包含表达禽流感基因蛋白质的病毒样颗粒的生产的方法。 本发明还包括制备和使用所述VLP的方法。
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公开(公告)号：US20120207786A1
公开(公告)日：2012-08-16
申请号：US13297125
申请日：2011-11-15
申请人： Gale SMITH , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
发明人： Gale SMITH , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
IPC分类号： A61K39/145 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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公开(公告)号：US20070184526A1
公开(公告)日：2007-08-09
申请号：US11582540
申请日：2006-10-18
申请人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
发明人： Gale Smith , Rick Bright , Peter Pushko , Jinyou Zhang , Kutub Mahmood
CPC分类号： A61K39/145 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55555 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/14143 , C12N2760/16023 , C12N2760/16034 , C12N2760/16071 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134
摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.
摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLPs）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。
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公开(公告)号：US20110245186A1
公开(公告)日：2011-10-06
申请号：US13071398
申请日：2011-03-24
申请人： Gale Smith , Peter Pushko , Vittoria Cioce
发明人： Gale Smith , Peter Pushko , Vittoria Cioce
IPC分类号： A61K38/16 , C07K14/435 , C12N15/12 , C12N7/00 , C12N15/63 , C12N5/07 , C12N1/21 , C12P21/00 , A61K31/7052 , A61P29/00
CPC分类号： C07K14/70564 , A61K38/00
摘要： The inventive features include recombinant mammalian E-selectin peptides, nucleic acids encoding said peptides, vectors and cells having these nucleic acids, and methods of making the peptides. Further inventive features include methods of treating diseases and conditions associated with inflammation using recombinant mammalian E-selectin peptides to induce mucosal tolerance to E-selectin.
摘要翻译： 本发明的特征包括重组哺乳动物E-选择蛋白肽，编码所述肽的核酸，具有这些核酸的载体和细胞，以及制备肽的方法。 其它发明特征包括使用重组哺乳动物E-选择蛋白肽治疗与炎症相关的疾病和病症以诱导对E-选择素的粘膜耐受的方法。
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公开(公告)号：US20100247574A1
公开(公告)日：2010-09-30
申请号：US12527844
申请日：2008-02-21
申请人： Kutub Mahmood , Gale Smith , Peter Pushko
发明人： Kutub Mahmood , Gale Smith , Peter Pushko
CPC分类号： C12N7/00 , A61K2039/5258 , C07K14/005 , C12N2710/14143 , C12N2760/18122 , C12N2760/18123 , Y02A50/386
摘要： The present invention discloses and claims chimeric virus like particles (VLPs) that express and/or contains Newcastle disease matrix protein. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising chimeric VLPs of the inventions. The invention also includes methods of making and administrating chimeric VLPs to vertebrates, including methods of inducing immunity to infections.
摘要翻译： 本发明公开并要求表达和/或含有新城疫基质蛋白的嵌合病毒样颗粒（VLP）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，包含本发明的嵌合VLP的制剂和疫苗。 本发明还包括制备和给予脊椎动物嵌合VLP的方法，包括诱导感染免疫的方法。
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10.发明申请NOVEL VLPS DERIVED FROM CELLS THAT DO NOT EXPRESS A VIRAL MATRIX OR CORE PROTEIN 有权从不能表达病毒基质或核心蛋白质的细胞衍生的新型VLPS公开(公告)号：US20090017066A1
公开(公告)日：2009-01-15
申请号：US12127625
申请日：2008-05-27
申请人： Gale Smith , Peter Pushko , Kutub Mahmood , Bin Zhao
发明人： Gale Smith , Peter Pushko , Kutub Mahmood , Bin Zhao
IPC分类号： A61K39/145 , C07K14/11 , A61P31/16 , C12P21/02
CPC分类号： A61K39/145 , A61K2039/5258 , C07K2319/00 , C12N7/00 , C12N2710/16723 , C12N2760/16123
摘要： The present invention discloses novel influenza virus-like particles (VLPs) that contain chimeric proteins or influenza membrane proteins. The chimeric proteins are derived from fragments of influenza membrane proteins fused to heterologous proteins. The invention includes antigenic formulations and vaccines comprising VLPs of the invention as well as methods of making and administering VLPs to vertebrates, including methods of inducing immunity to infections, such as influenza.
摘要翻译： 本发明公开了含有嵌合蛋白或流感病毒膜蛋白的新型流感病毒样颗粒（VLPs）。 嵌合蛋白质衍生自与异源蛋白质融合的流感病毒膜蛋白片段。 本发明包括抗原制剂和包含本发明的VLP的疫苗以及向脊椎动物制备和施用VLP的方法，包括诱导感染免疫的方法，例如流感。
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