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公开(公告)号：US20070197890A1
公开(公告)日：2007-08-23
申请号：US11675063
申请日：2007-02-14
申请人： Robert Boock , Monica Rixman , James Brauker , James Petisce , Peter Simpson , Mark Brister , Mark Tapsak , Victor Carr-Brendel
发明人： Robert Boock , Monica Rixman , James Brauker , James Petisce , Peter Simpson , Mark Brister , Mark Tapsak , Victor Carr-Brendel
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes.
摘要翻译： 本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。 更具体地说，本发明涉及新的有机硅 - 亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置。
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公开(公告)号：US20070213611A1
公开(公告)日：2007-09-13
申请号：US11692154
申请日：2007-03-27
申请人： Peter Simpson , James Brauker , Paul Goode , Apurv Kamath , James Petisce , Kum Woo , Melissa Nicholas , Robert Boock , Monica Rixman , John Burd , Rathbun Rhodes , Mark Tapsak
发明人： Peter Simpson , James Brauker , Paul Goode , Apurv Kamath , James Petisce , Kum Woo , Melissa Nicholas , Robert Boock , Monica Rixman , John Burd , Rathbun Rhodes , Mark Tapsak
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.
摘要翻译： 本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干涉域。
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3.发明申请ANALYTE SENSORS HAVING A SIGNAL-TO-NOISE RATIO SUBSTANTIALLY UNAFFECTED BY NON-CONSTANT NOISE 有权具有由不间断噪声主要影响的信号噪声分析的分析仪传感器公开(公告)号：US20070235331A1
公开(公告)日：2007-10-11
申请号：US11750907
申请日：2007-05-18
申请人： Peter Simpson , Robert Boock , James Petisce , Mark Brister , Monica Rixman , Kum Ming Woo , Lisa Nguyen , Seth Brunner , Arthur Chee , Melissa Nicholas , Matthew Wightlin , Jack Pryor , Dubravka Markovic
发明人： Peter Simpson , Robert Boock , James Petisce , Mark Brister , Monica Rixman , Kum Ming Woo , Lisa Nguyen , Seth Brunner , Arthur Chee , Melissa Nicholas , Matthew Wightlin , Jack Pryor , Dubravka Markovic
IPC分类号： G01N27/26
CPC分类号： A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14735 , A61B5/1486 , A61B5/14865 , A61B5/6848 , A61B5/7203
摘要： Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.
摘要翻译： 提供涉及具有基本上不受非恒定噪声影响的信噪比的传感器的系统和方法用于主机中的连续分析物测量。 在一些实施例中，连续分析物测量系统被配置为完全，经皮，血管内或体外植入。
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公开(公告)号：US20070027370A1
公开(公告)日：2007-02-01
申请号：US11503367
申请日：2006-08-10
申请人： James Brauker , Robert Boock , Monica Rixman , Peter Simpson , Mark Brister
发明人： James Brauker , Robert Boock , Monica Rixman , Peter Simpson , Mark Brister
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66 , Y02A50/55 , Y02A50/58
摘要： Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.
摘要翻译： 提供生物界面膜，其可以与可植入装置一起使用，例如用于检测生物样品中分析物浓度的装置。 更具体地，提供了使用包含这种膜的可植入分析物检测装置监测生物流体样品中的葡萄糖水平的方法。
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公开(公告)号：US20060270923A1
公开(公告)日：2006-11-30
申请号：US11439630
申请日：2006-05-23
申请人： James Brauker , Peter Simpson , Robert Boock , Monica Rixman , Mark Brister
发明人： James Brauker , Peter Simpson , Robert Boock , Monica Rixman , Mark Brister
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66 , Y02A50/55 , Y02A50/58
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.
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公开(公告)号：US20070045902A1
公开(公告)日：2007-03-01
申请号：US11439800
申请日：2006-05-23
申请人： James Brauker , Peter Simpson , Robert Boock , Monica Rixman , Mark Brister
发明人： James Brauker , Peter Simpson , Robert Boock , Monica Rixman , Mark Brister
IPC分类号： B29C35/08
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66 , Y02A50/55 , Y02A50/58
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.
摘要翻译： 本发明一般涉及与可植入装置一起使用的生物界面膜，例如用于检测生物样品中分析物浓度的装置。 更具体地，本发明涉及新颖的生物接触膜，包括这些膜的装置和可植入装置，在可植入装置上或周围形成生物接触膜的方法，以及使用可植入分析物检测来监测生物流体样品中的葡萄糖水平的方法 设备。
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公开(公告)号：US20060270922A1
公开(公告)日：2006-11-30
申请号：US11439559
申请日：2006-05-23
申请人： James Brauker , Peter Simpson , Robert Boock , Monica Rixman , Mark Brister
发明人： James Brauker , Peter Simpson , Robert Boock , Monica Rixman , Mark Brister
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/411 , A61B5/418 , A61B5/6848 , A61B2562/08 , C12Q1/006 , G01N33/54366 , G01N33/66 , Y02A50/55 , Y02A50/58
摘要： The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.
摘要翻译： 本发明一般涉及与可植入装置一起使用的生物界面膜，例如用于检测生物样品中分析物浓度的装置。 更具体地，本发明涉及新颖的生物接触膜，包括这些膜的装置和可植入装置，在可植入装置上或周围形成生物接触膜的方法，以及使用可植入分析物检测来监测生物流体样品中的葡萄糖水平的方法 设备。
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公开(公告)号：US20060200019A1
公开(公告)日：2006-09-07
申请号：US11410392
申请日：2006-04-25
IPC分类号： A61B5/05 , C12Q1/00 , G01N33/487
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译： 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。
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公开(公告)号：US20060189856A1
公开(公告)日：2006-08-24
申请号：US11410555
申请日：2006-04-25
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
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公开(公告)号：US20050245795A1
公开(公告)日：2005-11-03
申请号：US10838909
申请日：2004-05-03
申请人： Paul Goode , Arnold Holmquist , Mark Tapsak , Mark Shults , Victoria Carr-Brendel , James Brauker , Paul Neale , Jason McClure , Mark Brister , Peter Simpson , Rathbun Rhodes
发明人： Paul Goode , Arnold Holmquist , Mark Tapsak , Mark Shults , Victoria Carr-Brendel , James Brauker , Paul Neale , Jason McClure , Mark Brister , Peter Simpson , Rathbun Rhodes
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： Abstract of the DisclosureAn implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
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