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公开(公告)号：US20070213611A1
公开(公告)日：2007-09-13
申请号：US11692154
申请日：2007-03-27
申请人： Peter Simpson , James Brauker , Paul Goode , Apurv Kamath , James Petisce , Kum Woo , Melissa Nicholas , Robert Boock , Monica Rixman , John Burd , Rathbun Rhodes , Mark Tapsak
发明人： Peter Simpson , James Brauker , Paul Goode , Apurv Kamath , James Petisce , Kum Woo , Melissa Nicholas , Robert Boock , Monica Rixman , John Burd , Rathbun Rhodes , Mark Tapsak
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/14865 , B33Y70/00
摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.
摘要翻译： 本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干涉域。
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公开(公告)号：US20070197890A1
公开(公告)日：2007-08-23
申请号：US11675063
申请日：2007-02-14
申请人： Robert Boock , Monica Rixman , James Brauker , James Petisce , Peter Simpson , Mark Brister , Mark Tapsak , Victor Carr-Brendel
发明人： Robert Boock , Monica Rixman , James Brauker , James Petisce , Peter Simpson , Mark Brister , Mark Tapsak , Victor Carr-Brendel
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , A61B5/418 , B33Y70/00
摘要： The present invention relates generally to membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel silicone-hydrophilic polymer blend membranes, and to devices and implantable devices including these membranes.
摘要翻译： 本发明一般涉及与可植入装置一起使用的膜，例如用于检测生物样品中分析物浓度的装置。 更具体地说，本发明涉及新的有机硅 - 亲水性聚合物共混膜，以及包括这些膜的装置和可植入装置。
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公开(公告)号：US20050245795A1
公开(公告)日：2005-11-03
申请号：US10838909
申请日：2004-05-03
申请人： Paul Goode , Arnold Holmquist , Mark Tapsak , Mark Shults , Victoria Carr-Brendel , James Brauker , Paul Neale , Jason McClure , Mark Brister , Peter Simpson , Rathbun Rhodes
发明人： Paul Goode , Arnold Holmquist , Mark Tapsak , Mark Shults , Victoria Carr-Brendel , James Brauker , Paul Neale , Jason McClure , Mark Brister , Peter Simpson , Rathbun Rhodes
CPC分类号： A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14865 , A61B2560/04 , A61B2560/0462 , H04B1/03 , Y10T29/49117
摘要： Abstract of the DisclosureAn implantable analyte sensor including a sensing region for measuring the analyte and a non-sensing region for immobilizing the sensor body in the host. The sensor is implanted in a precisely dimensioned pocket to stabilize the analyte sensor in vivo and enable measurement of the concentration of the analyte in the host before and after formation of a foreign body capsule around the sensor. The sensor further provides a transmitter for RF transmission through the sensor body, electronic circuitry, and a power source optimized for long-term use in the miniaturized sensor body.
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公开(公告)号：US20060258761A1
公开(公告)日：2006-11-16
申请号：US11404418
申请日：2006-04-14
申请人： Robert Boock , Monica Rixman , Mark Tapsak , Mark Shults , Rathbun Rhodes
发明人： Robert Boock , Monica Rixman , Mark Tapsak , Mark Shults , Rathbun Rhodes
IPC分类号： C08J9/00
CPC分类号： C08L83/04 , A61B5/14532 , A61B5/14865 , A61B5/6848 , B01D69/141 , B01D71/54 , B01D71/80 , C08G77/12 , C08G77/20 , C08G77/46 , C12Q1/002 , C08L2666/14
摘要： Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
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公开(公告)号：US20050192557A1
公开(公告)日：2005-09-01
申请号：US10789359
申请日：2004-02-26
申请人： James Brauker , Mark Tapsak , Sean Saint , Apurv Kamath , Paul Neale , Peter Simpson , Michael Mensinger , Dubravka Markovic
发明人： James Brauker , Mark Tapsak , Sean Saint , Apurv Kamath , Paul Neale , Peter Simpson , Michael Mensinger , Dubravka Markovic
CPC分类号： A61M5/31525 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/4839 , A61B2560/0443 , A61M5/1723 , A61M11/00 , A61M15/0001 , A61M2005/1726 , A61M2205/18 , A61M2205/3303 , A61M2205/502 , A61M2205/52 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H20/17 , G16H40/63
摘要： Abstract of the DisclosureSystems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
摘要翻译： 公开的摘要提供了一种用于集成包括接收器，药物输送装置和任选的单点葡萄糖监测器的连续葡萄糖传感器的系统和方法。 手动集成提供了用户（例如，患者或医生）手动选择数量，类型和/或递送时间的设备之间的物理关联。 设备的半自动化集成包括集成，其中集成组件之间的可操作连接有助于用户（例如患者或医生）在选择，输入，计算或验证葡萄糖值的药物递送量，类型或时间 例如，通过将数据发送到另一个组件，从而减少所需的用户输入量。 设备之间的自动集成包括集成，其中集成组件之间的可操作连接提供对系统的完全控制，而不需要用户交互。
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公开(公告)号：US20060200019A1
公开(公告)日：2006-09-07
申请号：US11410392
申请日：2006-04-25
IPC分类号： A61B5/05 , C12Q1/00 , G01N33/487
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
摘要翻译： 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。
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公开(公告)号：US20060189856A1
公开(公告)日：2006-08-24
申请号：US11410555
申请日：2006-04-25
CPC分类号： A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
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公开(公告)号：US07081195B2
公开(公告)日：2006-07-25
申请号：US11007635
申请日：2004-12-07
申请人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
发明人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
IPC分类号： G01N27/327
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/14865 , C12Q1/006 , G01N27/3274
摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
摘要翻译： 提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本上无干扰的分析物浓度测量。 当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适合于计算基本无干扰的分析物浓度测定。
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公开(公告)号：US20050161346A1
公开(公告)日：2005-07-28
申请号：US11007635
申请日：2004-12-07
申请人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
发明人： Peter Simpson , James Brauker , Victoria Carr-Brendel , Paul Goode , Mark Tapsak
IPC分类号： A61B5/00 , G01N20060101 , G01N27/26
CPC分类号： A61B5/14532 , A61B5/1486 , A61B5/14865 , C12Q1/006 , G01N27/3274
摘要： An analyte-measuring device, particularly an electrochemical sensor, is provided for measuring current values at multiple bias potential settings to assess the quality of the analyte measurement, identify interference in the signal, and calculate substantially interference-free analyte concentration measurements. The device and method are suitable for calculating substantially interference-free analyte concentration measurements when glucose is the analyte and acetaminophen is an interfering species.
摘要翻译： 提供分析物测量装置，特别是电化学传感器，用于在多个偏置电位设置下测量电流值，以评估分析物测量的质量，识别信号中的干扰，并计算基本上无干扰的分析物浓度测量。 当葡萄糖是分析物和对乙酰氨基酚是干扰物质时，该装置和方法适合于计算基本无干扰的分析物浓度测定。
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公开(公告)号：US20050033132A1
公开(公告)日：2005-02-10
申请号：US10846150
申请日：2004-05-14
申请人： Mark Shults , James Brauker , Victoria Carr-Brendel , Mark Tapsak , Dubravka Markovic , Stuart Updike , Rathbun Rhodes
发明人： Mark Shults , James Brauker , Victoria Carr-Brendel , Mark Tapsak , Dubravka Markovic , Stuart Updike , Rathbun Rhodes
CPC分类号： A61L31/10 , A61B5/14532 , A61B5/14865 , A61B5/1495 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/00 , B33Y80/00 , C12Q1/006
摘要： An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
摘要翻译： 一种可植入分析物测量装置，其包括适于促进血管形成和/或干扰屏障细胞层形成的膜。 膜包括材料，结构和生物活性剂的任何组合，其促进分析物传输以提供可植入分析物测量装置的长期体内性能。
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