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1.发明申请公开(公告)号：US20080262312A1
公开(公告)日：2008-10-23
申请号：US11749959
申请日：2007-05-17
IPC分类号： A61B1/04
CPC分类号： A61B1/07 , A61B1/00009 , A61B1/00096 , A61B1/00172 , A61B1/041 , A61B5/0062
摘要： In connection with imaging an inner surface of a body lumen, a mosaiced image is created from discrete images or a video produced with a small camera, as the camera is moved through the lumen. In one embodiment, a tethered capsule with a scanning optical fiber provides the images, although other types of endoscopic cameras can instead be used. A surface model of the lumen and camera pose estimates for each image or frame are required for this task. Camera pose parameters, which define camera alignment, are determined for six degrees-of-freedom. The size of each frame projected as a strip on the surface model depends on the longitudinal movement of the camera. The projected frames are concatenated, and the cylinder is unrolled to produce the mosaic image. Further processing, such as applying surface domain blending, improves the quality of the mosaic image.
摘要翻译： 结合对体腔的内表面进行成像，当照相机移动通过管腔时，从离散图像或用小型照相机产生的视频创建马赛克图像。 在一个实施例中，具有扫描光纤的系留胶囊提供图像，但是可以替代地使用其他类型的内窥镜照相机。 该任务需要每个图像或帧的流明和相机姿态估计的表面模型。 确定摄像机对准的摄像机姿态参数被确定为六自由度。 在表面模型上作为条带投影的每个框架的尺寸取决于相机的纵向移动。 投影帧连接，滚筒展开以产生马赛克图像。 进一步的处理，如应用表面域混合，提高了马赛克图像的质量。
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2.发明授权公开(公告)号：US07813538B2
公开(公告)日：2010-10-12
申请号：US11749959
申请日：2007-05-17
CPC分类号： A61B1/07 , A61B1/00009 , A61B1/00096 , A61B1/00172 , A61B1/041 , A61B5/0062
摘要： In connection with imaging an inner surface of a body lumen, a mosaiced image is created from discrete images or a video produced with a small camera, as the camera is moved through the lumen. In one embodiment, a tethered capsule with a scanning optical fiber provides the images, although other types of endoscopic cameras can instead be used. A surface model of the lumen and camera pose estimates for each image or frame are required for this task. Camera pose parameters, which define camera alignment, are determined for six degrees-of-freedom. The size of each frame projected as a strip on the surface model depends on the longitudinal movement of the camera. The projected frames are concatenated, and the cylinder is unrolled to produce the mosaic image. Further processing, such as applying surface domain blending, improves the quality of the mosaic image.
摘要翻译： 结合对体腔的内表面进行成像，当照相机移动通过管腔时，从离散图像或用小型照相机产生的视频创建马赛克图像。 在一个实施例中，具有扫描光纤的系留胶囊提供图像，但是可以替代地使用其他类型的内窥镜照相机。 该任务需要每个图像或帧的流明和相机姿态估计的表面模型。 确定摄像机对准的摄像机姿态参数被确定为六自由度。 在表面模型上作为条带投影的每个框架的尺寸取决于相机的纵向移动。 投影帧连接，滚筒展开以产生马赛克图像。 进一步的处理，如应用表面域混合，提高了马赛克图像的质量。
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公开(公告)号：US09161684B2
公开(公告)日：2015-10-20
申请号：US11852227
申请日：2007-09-07
CPC分类号： A61B1/2733 , A61B1/00009 , A61B1/00055 , A61B1/0008 , A61B1/00087 , A61B1/00147 , A61B1/00172 , A61B1/015 , A61B1/041 , A61B1/043 , A61B1/0638 , A61B1/0661 , A61B1/07 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/1455 , A61B5/14556 , A61B5/4233 , A61N5/0603 , A61N5/062 , A61N2005/0609
摘要： A scanning flexible endoscope includes a tether attached to a capsule. The tether controls a disposition of the capsule within a body lumen such as the esophagus. A scanning device in the capsule optically scans the adjacent tissue on the inside surface of the body lumen as the capsule is moved axially through the body lumen. A non-contact sensor responds to indicia on the tether to measure a relative position of the tether and the capsule in the body lumen. The indicia can be analog or digital in form and the sensor can be either magnetic, or optical. A wiper is optionally provided to remove bodily fluids from the tether when pulled from the body lumen past the sensor. A pulse of fluid can be delivered to the distal end of the tether to cause the body lumen to distend, facilitating free movement of the capsule in the lumen.
摘要翻译： 扫描柔性内窥镜包括附接到胶囊的系绳。 系绳控制胶囊在诸如食道的体腔内的布置。 当胶囊沿轴向移动通过体腔时，胶囊中的扫描装置对体腔的内表面上的相邻组织进行光学扫描。 非接触式传感器响应系绳上的标记以测量系链和胶囊在体腔中的相对位置。 标记可以是模拟或数字形式，传感器可以是磁性的或光学的。 可选地提供擦拭器以当从身体腔腔被拉出传感器时从体系中除去体液。 流体脉冲可以被输送到系绳的远端，以使体腔扩张，促进胶囊在内腔中的自由运动。
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4.发明授权公开(公告)号：US08867803B2
公开(公告)日：2014-10-21
申请号：US13091088
申请日：2011-04-20
申请人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall
发明人： Eric J. Seibel , Qin Miao , Ryan Lee Coe , Per G. Reinhall
IPC分类号： G06K9/00
CPC分类号： G01N1/30
摘要： Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.
摘要翻译： 声称是使用光学投影断层显微镜和计算机生成三维图像的样本的焦点扫描的成像和诊断系统和方法。 一个实施例包括光源和具有可调节焦点位置的成像系统，其获取放置在以螺旋图案转动和旋转经过光学透镜的样本管内的生物组织的多个数字2D投影图像。 计算机捕获图像并生成3D合成图像。 还要求的是用于制备用于光学显微镜的样品的系统和方法。 一个实施方案包括在放置在样品管中之前固定，染色和/或光学清除微流体样品室内的生物组织。
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5.发明授权Scanning laser projection display devices and methods for projecting one or more images onto a surface with a light-scanning optical fiber 有权扫描激光投影显示装置和用光扫描光纤将一个或多个图像投影到表面上的方法公开(公告)号：US08757812B2
公开(公告)日：2014-06-24
申请号：US12468832
申请日：2009-05-19
申请人： Charles D. Melville , Richard S. Johnston , Cameron M. Lee , Eric J. Seibel , Brian T. Schowengerdt
发明人： Charles D. Melville , Richard S. Johnston , Cameron M. Lee , Eric J. Seibel , Brian T. Schowengerdt
CPC分类号： H04N9/3135 , A61B1/0008 , A61B1/00165 , A61B1/00172 , A61B1/0638 , A61B1/07 , A61B5/0062 , G02B6/262 , G02B26/103 , G03B21/00 , G03B21/20 , H04N9/3129 , H04N9/3173
摘要： Image projection devices, high-speed fiber scanned displays and related methods for projecting an image onto a surface and interfacing with the projected image are provided. A method for projecting one or more images and obtaining feedback with an optical input-output assembly is provided. The input-output assembly comprising a light-scanning optical fiber and a sensor. The method includes generating a sequence of light in response to one or more image representations and a scan pattern of the optical fiber, articulating the optical fiber in the scan pattern, projecting the sequence of light from the articulated optical fiber, and generating a feedback signal with the sensor in response to reflections of the sequence of light.
摘要翻译： 提供了图像投影设备，高速光纤扫描显示器和用于将图像投影到表面上并与投影图像接口的相关方法。 提供了一种用于投影一个或多个图像并且利用光学输入 - 输出组件获得反馈的方法。 输入 - 输出组件包括光扫描光纤和传感器。 该方法包括响应于光纤的一个或多个图像表示和扫描图案产生光序列，将扫描图案中的光纤铰接，从铰接的光纤投射光序列，并产生反馈信号 传感器响应于光序列的反射。
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公开(公告)号：US20080221388A1
公开(公告)日：2008-09-11
申请号：US11684417
申请日：2007-03-09
IPC分类号： A61B1/07
CPC分类号： A61B1/07 , A61B1/0008 , A61B1/00096 , A61B1/00167 , A61B1/00172 , A61B1/00177 , G02B23/243 , G02B26/103
摘要： An optical fiber conveys light from a source at a proximal end, to a distal end, where a piezoelectric material tube applies a force that causes the distal end of the optical fiber to scan in a desired pattern. Light from the distal end of the optical fiber passes through a lens system and is at least partially reflected by a reflective surface toward a side of the scope, to illuminate tissue within a patient's body. Light received from the internal tissue is reflected back either to collection optical fibers, which convey the light to proximally disposed optical detectors, or directly toward distal optical detectors. The optical detectors produce electrical signals indicative of an intensity of the light that can be used for producing an image of the internal tissue. The light received from the tissue can be either scattered, polarized, fluorescent, or filtered, depending on the illumination light.
摘要翻译： 光纤将光从近端传送到远端，其中压电材料管施加使光纤的远端以期望的图案扫描的力。 来自光纤的远端的光通过透镜系统，并且至少部分地被反射表面朝向镜的一侧反射，以照射患者体内的组织。 从内部组织接收的光被反射回收集光纤，其将光传送到近端设置的光学检测器，或者直接朝向远端光学检测器传送。 光学检测器产生指示可用于产生内部组织的图像的光强度的电信号。 根据照明光，从组织接收的光可以是散射的，极化的，荧光的或过滤的。
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公开(公告)号：US20080147000A1
公开(公告)日：2008-06-19
申请号：US11610084
申请日：2006-12-13
申请人： Eric J. Seibel , Per G. Reinhall
发明人： Eric J. Seibel , Per G. Reinhall
IPC分类号： A61M25/01
CPC分类号： A61M25/0158 , A61M25/0141 , A61M25/0155 , A61M2025/0058
摘要： A distal end of a flexible catheter can be selectively deflected in a desired direction by actuating one or more actuators that extend outwardly of an exterior surface of the catheter. Each actuator can be a balloon disposed within a non-extendible balloon or sheath. Inflation of one (or both) of the balloon and the non-extendible balloon with a pressurized fluid can deflect the distal tip of the catheter. Another actuator embodiment comprises a strip of a bimorph material that bends outwardly when actuated, e.g., by heat, applying a force against adjacent tissue to deflect the distal tip. Yet another embodiment includes a strip of material that shortens when heated and can be coupled to a balloon that is inflated outwardly to increase a radial moment arm of the force applied thereby, relative to a neutral axis of the catheter, to more readily deflect the distal tip.
摘要翻译： 柔性导管的远端可以通过致动一个或多个从导管的外表面向外延伸的致动器而在期望的方向上选择性地偏转。 每个致动器可以是设置在不可扩展的气球或护套内的球囊。 一个（或两个）球囊和不可延伸球囊与加压流体的充气可偏转导管的远端。 另一致动器实施例包括双压电晶片材料的条带，当致动例如通过加热时向外弯曲，向相邻组织施加力以偏转远侧末端。 另一个实施例包括材料条，其在加热时缩短并且可以联接到向外膨胀的球囊，以相对于导管的中性轴线增加由其施加的力的径向力矩臂，以更容易地偏转远端 小费。
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公开(公告)号：US06563105B2
公开(公告)日：2003-05-13
申请号：US09938467
申请日：2001-08-23
IPC分类号： H01L2700
CPC分类号： G02B26/10 , A61B1/0008 , A61B1/00165 , A61B1/00172 , A61B1/00193 , A61B1/0051 , A61B1/043 , A61B1/05 , A61B1/0638 , A61B1/07 , A61B3/12 , A61B5/0062 , A61B5/0064 , A61B5/0068 , A61B5/0071 , A61B5/0086 , A61B5/7239 , A61B2562/028 , G01S7/481 , G01S7/4814 , G01S7/4817 , G01S7/4818 , G01S17/88 , G01S17/89 , G02B26/103 , G06T7/586 , G06T2207/10068 , G06T2207/30004 , H04N5/2254 , H04N5/2256 , H04N5/349 , H04N13/239 , H04N13/254 , H04N2005/2255
摘要： A minimally invasive, medical, image acquisition system outputs a light beam or pulse which illuminates a precise spot size. A plurality of photon detector detect returning photons from the object, including the spot. Pixel resolution is determined by the area of the illumination spot (and thus the lens configuration), rather than an area sensed by the detector. Depth enhancement is determined by correlating images detected by the respective detectors, or alternatively by a range finding method based on phase difference, time of flight, frequency or interferometry.
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公开(公告)号：US06294775B1
公开(公告)日：2001-09-25
申请号：US09425528
申请日：1999-10-22
IPC分类号： H01L2700
CPC分类号： A61B1/07 , A61B1/0008 , A61B1/00172 , A61B1/00193 , A61B1/05 , A61B3/12 , G02B26/103
摘要： A minimally invasive, medical, image acquisition having a flexible optical fiber serving as an illuminating wave guide. In one resonance mode, the distal end of the fiber is a stationary node. The fiber includes a lens at the distal tip which collimates emitted light. A scan lens is positioned off the end of the fiber. The relative magnifications of the lenses and the relative positions determines the pixel resolution. In particular, the illumination fiber outputs a light beam or pulse which illuminates a precise spot size. A photon detector detects reflected photons from the object, including the spot. Pixel resolution is determined by the area of the illumination spot (and thus the lens configuration), rather than an area sensed by the detector.
摘要翻译： 具有用作照明波导的柔性光纤的微创医疗图像采集。 在一种谐振模式中，光纤的远端是固定节点。 纤维包括在远侧末端的准直发射光的透镜。 扫描镜头位于光纤末端。 透镜的相对放大率和相对位置决定像素分辨率。 特别地，照明光纤输出照射精确光斑尺寸的光束或脉冲。 光子检测器检测来自物体的反射光子，包括光斑。 像素分辨率由照明光斑的面积决定（因此由透镜配置决定），而不是由检测器感测的区域。
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公开(公告)号：US08840566B2
公开(公告)日：2014-09-23
申请号：US11695287
申请日：2007-04-02
CPC分类号： A61B10/02 , A61B1/0008 , A61B1/00172 , A61B10/0266 , A61B10/0283 , A61B10/04 , A61B10/06 , A61B2017/320004 , A61B2017/320008
摘要： A catheter having an imaging device on its distal end serves as a guidewire for cannula tools, enabling the tools to be advanced to a desired site in a patient's body. One exemplary embodiment of such a catheter is a scanning fiber endoscope. The images facilitate navigation through linked body lumens and also enable an operator to view a site where a biopsy sample is to be taken with a cannula tool. Exemplary cannula tools include bristles or sharp points that scrub cells from adjacent tissue, a biopsy needle that can be thrust into tissue, a loop that cuts away tissue, a cutting edge that slices tissue from a site, and forceps. The sample can be carried by a bodily or introduced fluid to a proximal end of the catheter through an annular gap between the catheter and the cannula tool, or the cannula tool can retain the sample.
摘要翻译： 在其远端具有成像装置的导管用作插管工具的导丝，使得工具能够前进到患者身体中的期望位置。 这种导管的一个示例性实施例是扫描光纤内窥镜。 图像便于通过连接的体腔导航，并且还使得操作者能够观察使用套管工具将活检样本取出的位置。 示例性的套管工具包括从相邻组织洗刷细胞的刷毛或尖锐点，可以推入组织的活检针，切除组织的切口，切割来自部位的组织的切割边缘以及镊子。 样品可以通过身体或引入的流体通过导管和套管工具之间的环形间隙携带到导管的近端，或者套管工具可以保持样品。
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