Tribological Applications of Polyelectrolyte Multilayers
    1.
    发明申请
    Tribological Applications of Polyelectrolyte Multilayers 失效
    聚电解质多层膜的摩擦学应用

    公开(公告)号:US20080228280A1

    公开(公告)日:2008-09-18

    申请号:US11834256

    申请日:2007-08-06

    IPC分类号: A61F2/30

    摘要: One aspect of the present invention relates to an implantable medical device comprising a surface coated with a polyelectrolyte multilayer, wherein said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of preparing a PEM-coated implantable medical device, comprising the step of applying a film to a surface of an implantable medical device, wherein said film comprises a polyelectrolyte multilayer and said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of reducing the wear between two contacting materials, comprising the step of moving a first material in contact with a second material in an environment, wherein a first surface of said first material is in contact with a second surface of said second material, wherein said first surface, said second surface, or both is coated with a polyelectrolyte multilayer, thereby decreasing the wear of said first material, said second material, or both compared to the wear in the absence of said polyelectrolyte multilayer.

    摘要翻译: 本发明的一个方面涉及可植入医疗装置,其包括涂覆有聚电解质多层的表面,其中所述表面是玻璃,金属,塑料,聚合物或玻璃纤维。 本发明的另一方面涉及一种制备PEM涂覆的可植入医疗装置的方法,包括将膜施加到可植入医疗装置的表面的步骤,其中所述膜包括聚电解质多层,所述表面是玻璃,金属, 塑料,聚合物或玻璃纤维。 本发明的另一方面涉及一种减少两种接触材料之间的磨损的方法,包括在环境中移动与第二材料接触的第一材料的步骤,其中所述第一材料的第一表面与第二材料接触 所述第二材料的表面,其中所述第一表面,所述第二表面或两者均涂覆有聚电解质多层,从而与不存在所述聚电解质多层体的磨损相比,降低所述第一材料,所述第二材料或两者的磨损 。

    Tribological applications of polyelectrolyte multilayers
    2.
    发明授权
    Tribological applications of polyelectrolyte multilayers 失效
    聚电解质多层膜的摩擦学应用

    公开(公告)号:US08241698B2

    公开(公告)日:2012-08-14

    申请号:US11834256

    申请日:2007-08-06

    IPC分类号: A61L27/00 A61F2/28

    摘要: One aspect of the present invention relates to an implantable medical device comprising a surface coated with a polyelectrolyte multilayer, wherein said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of preparing a PEM-coated implantable medical device, comprising the step of applying a film to a surface of an implantable medical device, wherein said film comprises a polyelectrolyte multilayer and said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of reducing the wear between two contacting materials, comprising the step of moving a first material in contact with a second material in an environment, wherein a first surface of said first material is in contact with a second surface of said second material, wherein said first surface, said second surface, or both is coated with a polyelectrolyte multilayer, thereby decreasing the wear of said first material, said second material, or both compared to the wear in the absence of said polyelectrolyte multilayer.

    摘要翻译: 本发明的一个方面涉及可植入医疗装置,其包括涂覆有聚电解质多层的表面,其中所述表面是玻璃,金属,塑料,聚合物或玻璃纤维。 本发明的另一方面涉及一种制备PEM涂覆的可植入医疗装置的方法,包括将膜施加到可植入医疗装置的表面的步骤,其中所述膜包括聚电解质多层,所述表面是玻璃,金属, 塑料,聚合物或玻璃纤维。 本发明的另一方面涉及减少两种接触材料之间的磨损的方法,包括在环境中移动与第二材料接触的第一材料的步骤,其中所述第一材料的第一表面与第二材料接触 所述第二材料的表面,其中所述第一表面,所述第二表面或两者均涂覆有聚电解质多层,从而与不存在所述聚电解质多层体的磨损相比,降低所述第一材料,所述第二材料或两者的磨损 。

    Tribological applications of polyelectrolyte multilayers
    3.
    发明授权
    Tribological applications of polyelectrolyte multilayers 失效
    聚电解质多层膜的摩擦学应用

    公开(公告)号:US07251893B2

    公开(公告)日:2007-08-07

    申请号:US10453453

    申请日:2003-06-03

    IPC分类号: B21D53/10 B23P19/04 A61F2/30

    摘要: One aspect of the present invention relates to an implantable medical device comprising a surface coated with a polyelectrolyte multilayer, wherein said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of preparing a PEM-coated implantable medical device, comprising the step of applying a film to a surface of an implantable medical device, wherein said film comprises a polyelectrolyte multilayer and said surface is glass, metal, plastic, polymer, or fiberglass. Another aspect of the present invention involves a method of reducing the wear between two contacting materials, comprising the step of moving a first material in contact with a second material in an environment, wherein a first surface of said first material is in contact with a second surface of said second material, wherein said first surface, said second surface, or both is coated with a polyelectrolyte multilayer, thereby decreasing the wear of said first material, said second material, or both compared to the wear in the absence of said polyelectrolyte multilayer.

    摘要翻译: 本发明的一个方面涉及可植入医疗装置,其包括涂覆有聚电解质多层的表面,其中所述表面是玻璃,金属,塑料,聚合物或玻璃纤维。 本发明的另一方面涉及一种制备PEM涂覆的可植入医疗装置的方法,包括将膜施加到可植入医疗装置的表面的步骤,其中所述膜包括聚电解质多层,所述表面是玻璃,金属, 塑料,聚合物或玻璃纤维。 本发明的另一方面涉及一种减少两种接触材料之间的磨损的方法,包括在环境中移动与第二材料接触的第一材料的步骤,其中所述第一材料的第一表面与第二材料接触 所述第二材料的表面,其中所述第一表面,所述第二表面或两者均涂覆有聚电解质多层,从而与不存在所述聚电解质多层体的磨损相比,降低所述第一材料,所述第二材料或两者的磨损 。

    Synthetically functionalized living cells
    7.
    发明授权
    Synthetically functionalized living cells 有权
    合成功能化活细胞

    公开(公告)号:US08323637B2

    公开(公告)日:2012-12-04

    申请号:US12421162

    申请日:2009-04-09

    IPC分类号: A01N63/00 C12N11/00 C12Q1/00

    摘要: Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs).

    摘要翻译: 均匀的功能性聚合物贴剂可以附着在活细胞表面积的一部分。 这些表面修饰的细胞在附着功能性贴片后保持活性。 贴片不会完全遮挡周围环境中的细胞表面。 由贴片携带的功能性有效载荷可以包括例如药物或其它小分子,肽,蛋白质,热响应聚合物和纳米颗粒,或可并入亚细胞尺寸的聚合物贴片中的任何其它材料。 贴剂可以包括一种或多种聚电解质多层(PEM)。

    Synthetically Functionalized Living Cells
    10.
    发明申请
    Synthetically Functionalized Living Cells 有权
    合成功能化的活细胞

    公开(公告)号:US20090258057A1

    公开(公告)日:2009-10-15

    申请号:US12421162

    申请日:2009-04-09

    IPC分类号: A61K9/70 A61K35/12 A61K47/48

    摘要: Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs).

    摘要翻译: 均匀的功能性聚合物贴剂可以附着在活细胞表面积的一部分。 这些表面修饰的细胞在附着功能性贴片后保持活性。 贴片不会完全遮挡周围环境中的细胞表面。 由贴片携带的功能性有效载荷可以包括例如药物或其它小分子,肽,蛋白质,热响应聚合物和纳米颗粒,或可并入亚细胞尺寸的聚合物贴片中的任何其它材料。 贴剂可以包括一种或多种聚电解质多层(PEM)。