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公开(公告)号:US4603145A
公开(公告)日:1986-07-29
申请号:US492096
申请日:1983-05-06
IPC分类号: A61K31/165 , C07C233/12 , A61K31/22 , C07C103/78 , C07C103/84
CPC分类号: A61K31/165 , C07C233/12 , Y10S514/824
摘要: This disclosure describes novel diaryl-alkanamides. These compounds are useful as pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.
摘要翻译: 本公开描述了新的二芳基 - 烷酰胺。 这些化合物可用作通过抑制哺乳动物动脉壁中动脉粥样硬化病变的形成和发展来改善动脉粥样硬化的药物。
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公开(公告)号:US4536346A
公开(公告)日:1985-08-20
申请号:US492094
申请日:1983-05-06
IPC分类号: A61K31/165 , A61K31/19 , A61K31/195 , A61K31/215 , A61P9/10 , C07C33/24 , C07C51/347 , C07C51/36 , C07C57/30 , C07C57/38 , C07C57/58 , C07C57/60 , C07C57/72 , C07C57/76 , C07C59/64 , C07C59/88 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/11 , C07C233/12 , C07C233/15 , C07C233/53 , C07C235/38 , C07C253/00 , C07C255/58 , C07C255/60 , C07C301/00 , C07C303/40 , C07C311/46 , C07F9/38 , C07C121/78 , C07C101/44
CPC分类号: C07C255/00 , C07C233/11 , C07C33/24 , C07C51/347 , C07C51/36 , C07C57/30 , C07C57/38 , C07C57/58 , C07C57/60 , C07C57/72 , C07C57/76 , C07C59/64 , C07C59/88 , C07F9/3808
摘要: This disclosure describes novel substituted aralkanamidobenzoic acids and analogs thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.
摘要翻译: 本公开描述了新的取代的芳烷酰胺基苯甲酸及其类似物。 这些化合物是通过抑制哺乳动物动脉壁中动脉粥样硬化病变的形成和发展来改善动脉粥样硬化的有用的药剂。
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公开(公告)号:US4489094A
公开(公告)日:1984-12-18
申请号:US492095
申请日:1983-05-06
IPC分类号: C07C33/46 , C07C33/48 , C07C51/377 , C07C57/58 , C07C57/60 , C07C59/56 , A61K31/245 , A61K31/195 , C07C101/60 , C07C101/62
CPC分类号: C07C59/56 , C07C33/46 , C07C33/486 , C07C51/377 , C07C57/58 , C07C57/60 , Y10S514/824
摘要: This disclosure describes novel [Bis(phenyl or substituted phenyl)alkyl]amino benzoic acids, esters, and derivatives thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.
摘要翻译: 本公开描述了新的[双(苯基或取代的苯基)烷基]氨基苯甲酸,酯及其衍生物。 这些化合物是通过抑制哺乳动物动脉壁中动脉粥样硬化病变的形成和发展来改善动脉粥样硬化的有用的药剂。
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4.Hypolipidemic and antiatherosclerotic 4-(polyfluoroalkylamino) phenyl compounds 失效
标题翻译: 降血脂和抗动脉粥样硬化4-(多氟烷基氨基)苯基化合物公开(公告)号:US4310545A
公开(公告)日:1982-01-12
申请号:US93766
申请日:1979-11-13
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
IPC分类号: C07C17/093 , C07C45/45 , C07C323/25 , C07C327/22 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/30 , C07D213/65 , C07D213/80 , C07D233/54 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44 , C07C101/60 , A61K31/195 , A61K31/24 , C07C101/62
CPC分类号: C07D213/30 , C07C17/093 , C07C323/25 , C07C327/22 , C07C45/45 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/65 , C07D213/80 , C07D233/64 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44 , Y10S514/824
摘要: This disclosure describes novel 4-(polyfluoroalkylamino)phenyl compounds useful as hypolipidemic and antiatherosclerotic agents.
摘要翻译: 本公开描述了可用作降血脂和抗动脉粥样硬化剂的新型4-(多氟烷基氨基)苯基化合物。
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5.Hypolipidemic and antiatherosclerotic 4-[(cyclopropyl alkyl)amino]benzoic acids and derivatives 失效
标题翻译: 降血脂和抗动脉粥样硬化4 - [(环丙基烷基)氨基]苯甲酸及其衍生物公开(公告)号:US4230878A
公开(公告)日:1980-10-28
申请号:US884673
申请日:1978-03-08
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
IPC分类号: C07C17/093 , C07C45/45 , C07C323/25 , C07C327/22 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/30 , C07D213/65 , C07D213/80 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44 , C07C101/62 , C07C101/60
CPC分类号: C07D213/30 , C07C17/093 , C07C323/25 , C07C327/22 , C07C45/45 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/65 , C07D213/80 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44 , Y10S514/824
摘要: This disclosure describes 4-[(unsaturated or cyclopropylated alkyl)amino]benzoic acids and derivatives useful as hypolipidemic and antiatherosclerotic agents.
摘要翻译: 本公开描述了用作降血脂和抗动脉粥样硬化剂的4 - [(不饱和或环丙基烷基)氨基]苯甲酸和衍生物。
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6.Certain pyridyl esters of 4-(monoalkylamino) benzoic hydroxyalkanoic acids 失效
标题翻译: 某些4-(单烷基氨基)苯甲酸羟基链烷酸酯的吡啶基酯公开(公告)号:US4196208A
公开(公告)日:1980-04-01
申请号:US861736
申请日:1977-12-19
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
IPC分类号: C07C45/45 , C07C275/54 , C07D257/04 , C07D295/192 , C07D213/69 , A61K31/44 , C07D213/66 , C07D213/84
CPC分类号: C07D257/04 , C07C275/54 , C07C45/45 , C07D295/192
摘要: This disclosure describes esters of 4-(monoalkylamino)benzoic acids with hydroxyalkanoic acids and derivatives, phenols, or 3-pyridinols useful as hypolipidemic agents.
摘要翻译: 本公开内容描述了4-(一烷基氨基)苯甲酸与羟基链烷酸的酯,以及可用作降血脂药的衍生物,酚或3-吡啶醇。
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公开(公告)号:US4489090A
公开(公告)日:1984-12-18
申请号:US492097
申请日:1983-05-06
IPC分类号: C07D335/14 , A61K31/22 , A61K31/38 , C07C103/733 , C07D335/12
CPC分类号: C07D335/14 , Y10S514/824
摘要: This disclosure describes novel dibenzocycloalkanamido-benzoic acids and esters. Also described are dibenzothioxanthenyl-benzoic acids and esters. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial walls of mammals.
摘要翻译: 本公开描述了新的二苯并环烷酰氨基 - 苯甲酸和酯。 还描述了二苯并噻二苯并苯甲酸和酯。 这些化合物是通过抑制哺乳动物动脉壁中动脉粥样硬化病变的形成和发展来改善动脉粥样硬化的有用的药剂。
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公开(公告)号:US4439606A
公开(公告)日:1984-03-27
申请号:US375507
申请日:1982-05-06
申请人: Mila T. Du , Robert G. Shepherd
发明人: Mila T. Du , Robert G. Shepherd
IPC分类号: C07D295/18 , A61K31/495 , A61P9/10 , C07D213/38 , C07D215/38 , C07D241/20 , C07D241/44 , C07D277/20 , C07D277/42 , C07D295/185 , C07D401/06 , C07D401/12 , C07D403/04 , C07D401/04
CPC分类号: C07D215/38 , C07D213/38 , C07D241/20 , C07D241/44 , C07D277/42 , C07D295/185 , C07D401/06 , Y10S514/824
摘要: This disclosure describes 4-aryl, -heteroaryl and -heteroarylmethyl-1-piperazinecarbonyl compounds which are capable of ameliorating atherosclerosis in mammals.
摘要翻译: 本公开描述了能够改善哺乳动物动脉粥样硬化的4-芳基 - 杂芳基和 - 杂芳基甲基-1-哌嗪羰基化合物。
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9.Hypolipidemic and antiatherosclerotic 4-(polyfluoro-alkylamino)phenyl compounds 失效
标题翻译: 降血脂和抗动脉粥样硬化4-(多氟 - 烷基氨基)苯基化合物公开(公告)号:US4305959A
公开(公告)日:1981-12-15
申请号:US93767
申请日:1979-11-13
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
IPC分类号: C07C17/093 , C07C45/45 , C07C323/25 , C07C327/22 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/30 , C07D213/65 , C07D213/80 , C07D233/54 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44 , A01N33/02 , C07C87/60
CPC分类号: C07D213/30 , C07C17/093 , C07C323/25 , C07C327/22 , C07C45/45 , C07D207/34 , C07D207/42 , C07D211/46 , C07D213/65 , C07D213/80 , C07D233/64 , C07D239/42 , C07D263/10 , C07D265/06 , C07D277/06 , C07D303/16 , C07D307/54 , C07D307/66 , C07D307/68 , C07D307/71 , C07D309/12 , C07D317/28 , C07D333/16 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/36 , C07D333/38 , C07D333/44 , Y10S514/824
摘要: This disclosure describes novel 4-(polyfluoroalkylamino)phenyl compounds useful as hypolipidemic and antiatherosclerotic agents.
摘要翻译: 本公开描述了可用作降血脂和抗动脉粥样硬化剂的新型4-(多氟烷基氨基)苯基化合物。
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10.Benzaldehydes, alkanophenones, and benzophenones and derivatives thereof containing a 4-monoalkylamino group 失效
标题翻译: 苯甲醛,烷基苯醌和二苯甲酮及其衍生物含有4-单烷基氨基公开(公告)号:US4273785A
公开(公告)日:1981-06-16
申请号:US836947
申请日:1977-09-27
申请人: Robert G. Shepherd
发明人: Robert G. Shepherd
IPC分类号: C07C45/45 , C07C275/54 , C07D257/04 , C07D295/192 , A61K31/135 , A61K31/205 , C07C95/08
CPC分类号: C07D257/04 , C07C275/54 , C07C45/45 , C07D295/192 , Y10S514/824
摘要: Novel 4-monoalkylamino-benzaldehydes, 4-mono-alkylamino-alkanophenones, and 4-monoalkylamino-benzophenones, and derivatives and salts thereof, are disclosed which are useful as anti-atherosclerotic agents.
摘要翻译: 公开了新的4-单烷基氨基 - 苯甲醛,4-单烷基氨基 - 亚烷基苯甲酸和4-单烷基氨基 - 二苯甲酮及其衍生物和盐,其可用作抗动脉粥样硬化剂。
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