公开(公告)号：US10137303B2

公开(公告)日：2018-11-27

申请号：US13473470

申请日：2012-05-16

申请人： Robert J Greenberg ,  David Daomin Zhou ,  Brian V Mech ,  Neil Hamilton Talbot ,  Rongqing Dai ,  Richard Agustin Castro ,  Kelly H. McClure

发明人： Robert J Greenberg ,  David Daomin Zhou ,  Brian V Mech ,  Neil Hamilton Talbot ,  Rongqing Dai ,  Richard Agustin Castro ,  Kelly H. McClure

IPC分类号： A61B5/04 ,  A61N1/00 ,  A61N1/36 ,  A61B5/00 ,  A61N1/05 ,  A61N1/375 ,  H05K1/11 ,  H05K1/18

摘要： The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to the at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. The output signals provide control for a motor prosthesis and the inputs signals provide sensory feedback for the motor prosthesis. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.

公开(公告)号：US20120296444A1

公开(公告)日：2012-11-22

申请号：US13473470

申请日：2012-05-16

申请人： Robert J. Greenberg ,  David Daomin Zhou ,  Brian V. Mech ,  Neil Hamilton Talbot ,  Rongqing Dai ,  Richard Agustin Castro ,  Kelly H. McClure

发明人： Robert J. Greenberg ,  David Daomin Zhou ,  Brian V. Mech ,  Neil Hamilton Talbot ,  Rongqing Dai ,  Richard Agustin Castro ,  Kelly H. McClure

IPC分类号： A61F2/72 ,  A61N1/04 ,  A61B5/0476

CPC分类号： A61N1/36082 ,  A61B5/04001 ,  A61B5/4064 ,  A61B5/6868 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/375 ,  H01L2224/05599 ,  H01L2224/45144 ,  H01L2224/48227 ,  H01L2224/48465 ,  H01L2224/85099 ,  H01L2224/85399 ,  H01L2924/3011 ,  H05K1/118 ,  H05K1/189 ,  H05K2201/0154 ,  H05K2201/10098 ,  H01L2924/00 ,  H01L2924/00014

摘要： The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to the at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. The output signals provide control for a motor prosthesis and the inputs signals provide sensory feedback for the motor prosthesis. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.

摘要翻译： 本发明包括具有至少一个封装的可植入装置，所述至少一个封装容纳电子装置，所述电子装置通过连接到所述至少一个封装件的至少一个线圈从外部系统发送和接收数据或信号，并且选择性地供电，并处理数据，包括 记录神经活动，并通过连接到至少一个包装的多个电极的至少一个阵列将电脉冲传递给神经组织。 该器件适用于电皮质（ECoG）和局部场电位（LFP）信号。 输出信号提供对电动机假体的控制，并且输入信号为电动机假体提供感觉反馈。 本发明或其组分旨在安装在头部，或在头颅或硬脑膜上，或脑中或脑中。

公开(公告)号：US20090118805A1

公开(公告)日：2009-05-07

申请号：US12168740

申请日：2008-07-07

申请人： Robert J. Greenberg ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  James Singleton Little ,  Kelly H. McClure ,  Brian V. Mech ,  Rongqing Dai ,  David Daomin Zhou ,  Gaillard R. Nolan

发明人： Robert J. Greenberg ,  Jordan Matthew Neysmith ,  Neil Hamilton Talbot ,  James Singleton Little ,  Kelly H. McClure ,  Brian V. Mech ,  Rongqing Dai ,  David Daomin Zhou ,  Gaillard R. Nolan

IPC分类号： A61F9/08 ,  A61N1/05

CPC分类号： A61N1/0543 ,  A61N1/36046 ,  H05K1/118

摘要： In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large.The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes.The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.

摘要翻译： 在视觉假体中，电极刺激视网膜组织以诱导植入假体的使用者对光的感知。 假体必须具有返回或常见的电极以与视网膜组织形成完整的电路。 为了避免用返回电极刺激组织，如果电极很大，则是有利的。 本发明涉及柔性电路电极阵列，其包括聚合物基底层，沉积在所述聚合物基底层上的金属迹线，包括适于刺激沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层的神经组织的电极和分离的回流电极 从所述刺激电极。 柔性电路电极阵列包括用于接收视觉数据的次级线圈; 电耦合到所述接收线圈的电子封装，以及电耦合到所述电子封装的多个刺激电极。

公开(公告)号：US08195302B2

公开(公告)日：2012-06-05

申请号：US11936497

申请日：2007-11-07

申请人： Kelly H. McClure ,  Arup Roy ,  Richard Agustin Castro ,  Sumit Yadav ,  Rongqing Dai ,  Robert J. Greenberg ,  Da-Yu Chang ,  Xiaofan Wu ,  Scott Loftin ,  Susan McCord

发明人： Kelly H. McClure ,  Arup Roy ,  Richard Agustin Castro ,  Sumit Yadav ,  Rongqing Dai ,  Robert J. Greenberg ,  Da-Yu Chang ,  Xiaofan Wu ,  Scott Loftin ,  Susan McCord

IPC分类号： A61N1/36

CPC分类号： A61N1/36046 ,  A61N1/37252 ,  G06K9/605

摘要： A video processing unit configured to convert a video image to stimulation patterns for stimulating neural tissue in a subject's eye, the video processing unit comprising a video processor for converting a video image to a digital video stream; a memory for storing the digital video stream; and a video preprocessor data interface for forming stimulation patterns based on the stored digital video stream.

摘要翻译： 视频处理单元，被配置为将视频图像转换为用于刺激受试者眼睛中的神经组织的刺激模式，所述视频处理单元包括用于将视频图像转换为数字视频流的视频处理器; 用于存储数字视频流的存储器; 以及用于基于所存储的数字视频流形成刺激模式的视频预处理器数据接口。

公开(公告)号：US20080154336A1

公开(公告)日：2008-06-26

申请号：US11893260

申请日：2007-08-15

申请人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

发明人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

IPC分类号： A61N1/00

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： A visor for retinal stimulation of visually impaired subjects is shown. The visor comprises a frame, an external coil, a camera and a mounting system. A connector allows the external coil to be positioned along a first direction. A sliding device allows the external coil to be positioned along a second direction. Positioning of the visor on a subject's nose allows the external coil to be positioned along a third direction. Positioning of the external coil along the first, second or third direction is useful to maximize coupling RF coupling between the external coil and an internal coil implanted on a subject wearing the visor.

摘要翻译： 显示视网膜刺激视力障碍受试者的遮阳板。 遮阳板包括框架，外部线圈，照相机和安装系统。 连接器允许外部线圈沿第一方向定位。 滑动装置允许外部线圈沿第二方向定位。 遮阳板在被检者的鼻子上的定位允许外部线圈沿第三方向定位。 外部线圈沿着第一，第二或第三方向的定位对于使外部线圈和植入戴着遮阳板的物体上的内部线圈之间的耦合RF耦合最大化是有用的。

公开(公告)号：US08498713B2

公开(公告)日：2013-07-30

申请号：US11926039

申请日：2007-10-28

申请人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

发明人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

IPC分类号： A61N1/00

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： The present invention is a visor for retinal stimulation of visually impaired subjects. The visor comprises a frame, an external coil, a camera and a mounting system. A connector allows the external coil to be positioned along a first direction. A sliding device allows the external coil to be positioned along a second direction. Positioning of the visor on a subject's nose allows the external coil to be positioned along a third direction. Positioning of the external coil along the first, second or third direction is useful to maximize coupling RF coupling between the external coil and an internal coil implanted on a subject wearing the visor.

摘要翻译： 本发明是视觉障碍受试者的视网膜刺激的面罩。 遮阳板包括框架，外部线圈，照相机和安装系统。 连接器允许外部线圈沿第一方向定位。 滑动装置允许外部线圈沿第二方向定位。 遮阳板在被检者的鼻子上的定位允许外部线圈沿第三方向定位。 外部线圈沿着第一，第二或第三方向的定位对于使外部线圈和植入戴着遮阳板的物体上的内部线圈之间的耦合RF耦合最大化是有用的。

公开(公告)号：US20090118792A1

公开(公告)日：2009-05-07

申请号：US11936478

申请日：2007-11-07

申请人： Kelly H. McClure ,  Arup Roy ,  Richard Agustin Castro ,  Sumit Yadav ,  Rongqing Dai ,  Robert J. Greenberg ,  Da-Yu Chang ,  Xiaofan Wu ,  Scott Loftin ,  Susan McCord

发明人： Kelly H. McClure ,  Arup Roy ,  Richard Agustin Castro ,  Sumit Yadav ,  Rongqing Dai ,  Robert J. Greenberg ,  Da-Yu Chang ,  Xiaofan Wu ,  Scott Loftin ,  Susan McCord

IPC分类号： A61N1/00

CPC分类号： A61N1/36046 ,  A61F9/08 ,  A61N1/37229 ,  A61N1/37252

摘要： A video processing unit configured to convert a video image to stimulation patterns for stimulating neural tissue in a subject's eye and comprising a power button, wherein the video processing unit is configured to be powered on after a first time interval upon activation of a power button, wherein the video processing unit is configured to be powered off after a second time interval upon activation of a power button.

摘要翻译： 视频处理单元，被配置为将视频图像转换成用于刺激被检者眼睛中的神经组织的刺激图案，并且包括电源按钮，其中所述视频处理单元被配置为在激活电源按钮之后在第一时间间隔之后通电， 其中，所述视频处理单元被配置为在激活电源按钮之后的第二时间间隔之后关闭所述视频处理单元。

公开(公告)号：US20090118794A1

公开(公告)日：2009-05-07

申请号：US11936534

申请日：2007-11-07

申请人： Kelly H. McClure ,  Arup Roy ,  Richard Agustin Castro ,  Sumit Yadav ,  Rongqing Dai ,  Robert J. Greenberg ,  Da-Yu Chang ,  Xiaofan Wu ,  Scott Loftin ,  Susan McCord

发明人： Kelly H. McClure ,  Arup Roy ,  Richard Agustin Castro ,  Sumit Yadav ,  Rongqing Dai ,  Robert J. Greenberg ,  Da-Yu Chang ,  Xiaofan Wu ,  Scott Loftin ,  Susan McCord

IPC分类号： A61N1/04

CPC分类号： A61N1/36046 ,  A61N1/37252

摘要： A visual prosthesis apparatus comprising: a video capture device for capturing a video image; a video processing unit associated with the video capture device, the video processing unit configured to convert the video image to stimulation patterns; and a retinal stimulation system configured to stimulate neural tissue in a subject's eye based on the stimulation patterns, wherein the video processing unit is configured to be powered on after a first time interval upon activation of a power button, wherein the video processing unit is configured to be powered off after a second time interval upon activation of a power button.

摘要翻译： 一种视觉假体装置，包括：用于捕获视频图像的视频捕获装置; 视频处理单元，被配置为将视频图像转换为刺激图案;视频处理单元， 以及视网膜刺激系统，被配置为基于所述刺激图案来刺激受试者眼睛中的神经组织，其中所述视频处理单元被配置为在激活电源按钮之后在第一时间间隔之后通电，其中所述视频处理单元被配置 在激活电源按钮之后，在第二时间间隔之后关闭电源。

公开(公告)号：US20080154337A1

公开(公告)日：2008-06-26

申请号：US11926039

申请日：2007-10-28

申请人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

发明人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

IPC分类号： A61N1/00 ,  A61F9/00

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： A visor for retinal stimulation of visually impaired subjects is shown. The visor comprises a frame, an external coil, a camera and a mounting system. A connector allows the external coil to be positioned along a first direction. A sliding device allows the external coil to be positioned along a second direction. Positioning of the visor on a subject's nose allows the external coil to be positioned along a third direction. Positioning of the external coil along the first, second or third direction is useful to maximize coupling RF coupling between the external coil and an internal coil implanted on a subject wearing the visor.

摘要翻译： 显示视网膜刺激视力障碍受试者的遮阳板。 遮阳板包括框架，外部线圈，照相机和安装系统。 连接器允许外部线圈沿第一方向定位。 滑动装置允许外部线圈沿第二方向定位。 遮阳板在被检者的鼻子上的定位允许外部线圈沿第三方向定位。 外部线圈沿着第一，第二或第三方向的定位对于使外部线圈和植入戴着遮阳板的物体上的内部线圈之间的耦合RF耦合最大化是有用的。

公开(公告)号：US09095709B2

公开(公告)日：2015-08-04

申请号：US11893260

申请日：2007-08-15

申请人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

发明人： Kelly H. McClure ,  Richard Agustin Castro ,  Sanjay Gaikwad ,  Da-Yu Chang ,  Scott M. Loftin ,  Rongqing Dai ,  Robert J. Greenberg

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/05

CPC分类号： A61N1/36046 ,  A61N1/0543

摘要： A visor for retinal stimulation of visually impaired. The visor comprises a frame, an external coil, a camera and a mounting system. A connector allows the external coil to be positioned along a first direction. A sliding device allows the external coil to be positioned along a second direction. Positioning of the visor on a subject's nose allows the external coil to be positioned along a third direction. Positioning of the external coil along the first, second or third direction is useful to maximize coupling RF coupling between the external coil and an internal coil implanted on a subject wearing the visor.

摘要翻译： 视网膜刺激视力障碍的遮阳板。 遮阳板包括框架，外部线圈，照相机和安装系统。 连接器允许外部线圈沿第一方向定位。 滑动装置允许外部线圈沿第二方向定位。 遮阳板在被检者的鼻子上的定位允许外部线圈沿第三方向定位。 外部线圈沿着第一，第二或第三方向的定位对于使外部线圈和植入戴着遮阳板的物体上的内部线圈之间的耦合RF耦合最大化是有用的。