公开(公告)号：US20140300891A1

公开(公告)日：2014-10-09

申请号：US14309598

申请日：2014-06-19

Applicant: ROBERT R. ALFANO ,  Yang Pu ,  Wubao Wang

Inventor： ROBERT R. ALFANO ,  Yang Pu ,  Wubao Wang

IPC: G01N33/02 ,  G01N21/27 ,  G01N21/33

CPC classification number: G01N21/27 ,  G01N21/6486 ,  G01N33/12

Abstract: A method detects the degree of spoilage of food by exposing a food sample to an excitation wave having a first wavelength of about 340 nm or about 380 nm, wherein the excitation wave has a bandwidth of 40 nm or less. The excitation wave is permitted to interact with the food sample and return emission spectra. A detector detects the emission spectra. A predetermined threshold value is established which defines when a food sample is or is not spoiled. The emission spectra is analyzed at a second wavelength of about 400 nm, about 450 nm or about 530 nm to provide a test or measured value of the emission spectra indicative of the degree of spoilage of the food sample. Whether or not a food sample is spoiled beyond the predetermined threshold is determined by comparing the measured value to the predetermined threshold value.

Abstract translation: 一种方法通过将食物样品暴露于第一波长为约340nm或约380nm的激发波来检测食物的变质程度，其中激发波具有40nm或更小的带宽。 激发波被允许与食物样品相互作用并返回发射光谱。 检测器检测发射光谱。 建立了一个预定的阈值，其定义何时食物样本是否被损坏。 在约400nm，约450nm或约530nm的第二波长处分析发射光谱，以提供指示食物样品的变质程度的发射光谱的测试值或测量值。 通过将测量值与预定阈值进行比较来确定食物样品是否损坏超过预定阈值。

公开(公告)号：US20220166177A1

公开(公告)日：2022-05-26

申请号：US17532834

申请日：2021-11-22

Applicant: Robert R. Alfano

Inventor： ROBERT R. ALFANO ,  Shah Faisal B. Mazhar ,  Mikhail Sharonov ,  Lingyan Shi

IPC: H01S3/00 ,  G21K7/00 ,  A61B6/00 ,  G02F1/35 ,  H01S3/11

Abstract: In this patent, we teach methods to generate coherent X-ray and UUV rays beams for X ray and UUV microscopes using intense femtosecond pulses resulting the Ultra-Supercontinuum (USC) and Higher Harmonic Generation (HHG) from χ3 and χ5 media produce from electronic and molecular Kerr effect. The response of n2 (χ3) and n4 (χ5) at the optical frequency from instantaneously response of carrier phase of envelope results in odd HHG and spectral broadening about each harmonic on the anti-Stokes side of the pump pulse at wo typically in the visible, NIR, and MIR. From the slower molecular Kerr response on femtosecond to picosecond from orientation and molecular motion on n2 and n4 which follow the envelope of optical field of the laser gives rise to extreme broadening without HHG. The resulting spectra extend on the Stokes side towards the IR, RF to DC covering most of the electromagnetic spectrum. These HHG and Super broadening covering UUV to X rays and possibly to gamma ray regime for microscopes.

公开(公告)号：US20170082640A1

公开(公告)日：2017-03-23

申请号：US15272086

申请日：2016-09-21

Applicant: Robert R. Alfano

Inventor： ROBERT R. ALFANO ,  Lingyan Shi

IPC: G01N33/68 ,  G01N21/64 ,  A61B10/00 ,  A61B5/00 ,  A61B10/02

CPC classification number: A61B5/0071 ,  A61B5/4076 ,  A61B10/0045 ,  A61B10/02 ,  A61B2010/0077 ,  G01N21/645 ,  G01N21/6486 ,  G01N33/483 ,  G01N33/6896 ,  G01N2021/6484 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/2835

Abstract: A label free single or multi-photon optical spectroscopy for measuring the differences between the levels of fluorophores from tryptophan, collagen, reduced nicotinamide adenine dinucleotide (NADH). and flavins exist in brain samples from a of Alzheimer's disease (AD) and in normal (N) brain samples with label-free fluorescence spectroscopy. Relative quantities of these molecules are shown by the spectral profiles of the AD and N brain samples at excitation wavelengths 266 nm, 300 nm, and 400 nm. The emission spectral profile levels of tryptophan and flavin were much higher in AD samples, while collagen emission levels were slightly lower and NADH levels were much lower in AD samples. These results yield a new optical method for detection of biochemical differences in animals and humans for Alzheimer's disease.

公开(公告)号：US20150320319A1

公开(公告)日：2015-11-12

申请号：US14710222

申请日：2015-05-12

Applicant: ROBERT R. ALFANO ,  Wubao Wang ,  Yang Pu ,  Yury Budansky ,  Laura Sordillo ,  Guichen Tang ,  James Eastham

Inventor： ROBERT R. ALFANO ,  Wubao Wang ,  Yang Pu ,  Yury Budansky ,  Laura Sordillo ,  Guichen Tang ,  James Eastham

IPC: A61B5/00 ,  A61B1/00 ,  A61B1/31

CPC classification number: A61B5/4381 ,  A61B1/00142 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/31 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0086

Abstract: A rectal near infrared (NIR) scanning polarization imaging system uses NIR Photonic Prostatoscopy Analyzer (NIRPPA) for prostate cancer detection using light. The NIRPPA consists of a portable rectal NIR scanning polarization imaging unit and an optical fiber-based rectal probe capable of recording sets of 2D images of a prostate through rectum at different wavelengths and depths and obtaining a three dimensional (3D) image of the prostate and 3D locations of abnormal tissue inside the prostate. Diode lasers/light emission diodes (LEDs) with selected emitting wavelengths are used in the NIR spectral range from 650 nm to 2,400 nm corresponding to the four tissue optical windows (#I, 650 nm-950 nm; #II, 1,100 nm-1,350 nm; #III, 1,600 nm-1,870 nm; and #IV, 2,100 nm-2,300 nm). The fingerprint absorptions of water (H2O), Oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb) in the prostate are used as native biomarkers for prostate cancer detection.

Abstract translation: 直肠近红外（NIR）扫描偏振成像系统使用NIR光子预分析仪（NIRPPA）进行前列腺癌检测。 NIRPPA包括便携式直肠近红外扫描偏振成像单元和基于光纤的直肠探针，其能够通过不同波长和深度的直肠记录前列腺的2D图像，并获得前列腺的三维（3D）图像， 前列腺内异常组织的3D位置。 具有选定发射波长的二极管激光器/发光二极管（LED）用于对应于四个组织光学窗口（＃I，650nm-950nm;＃II,1,100nm-1,350）的650nm至2,400nm的NIR光谱范围 nm;＃III，1,600nm-1,870nm;和#IV，2100nm-2,300nm）。 前列腺中水（H2O），氧血红蛋白（HbO2）和脱氧血红蛋白（Hb）的指纹吸收被用作前列腺癌检测的天然生物标志物。