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公开(公告)号：US08671569B1
公开(公告)日：2014-03-18
申请号：US12770054
申请日：2010-04-29
申请人： Robert T. White , James L. Arledge , Dennis C. Erickson , Dennis C. Erickson, Jr. , Russell K. Erickson
发明人： Robert T. White , James L. Arledge , Dennis C. Erickson , Dennis C. Erickson, Jr. , Russell K. Erickson
CPC分类号： B23P6/00
摘要： A cleaning and piston replacement kit for an accumulator of a vehicle transmission which includes a brush for cleaning, reconditioning and polishing worn accumulator bores and replacement pistons each of which includes a pair of sealing rings for supporting and spacing the replacement pistons from the accumulator bores to thereby prevent scrapping of the walls of the bores by movement of the pistons within the bores and a method of reconditioning the accumulator bore.
摘要翻译： 一种用于车辆变速器的蓄能器的清洁和活塞更换套件，其包括用于清洁，修复和抛光磨损的储存器孔的刷子和更换活塞，每个活塞包括一对密封环，用于将替换活塞从蓄能器孔支撑和间隔到 从而通过活塞在孔内的移动来防止孔的壁破坏，以及重新调节储存器孔的方法。
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公开(公告)号：US4933280A
公开(公告)日：1990-06-12
申请号：US857715
申请日：1986-04-30
IPC分类号： C12N15/09 , A61K38/00 , A61P11/00 , C07H21/04 , C07K1/22 , C07K14/00 , C07K14/705 , C07K14/785 , C12N1/20 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/12 , C12N15/85 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C12N15/85 , C07K14/785 , C12P21/02 , A61K38/00
摘要： The complete coding sequences and amino acid sequences for both canine and human 32K alveolar surfactant proteins (ASP) are disclosed; clones for the 10K protein have also been obtained. Methods and vectors for obtaining these proteins in recombinant form are described. The availability of large amounts of these proteins through recombinant techniques permits the use of ASP in suitable pharmaceutical compositions in the treatment of respiratory deficiency syndromes.
摘要翻译： 公开了犬和人类32K肺泡表面活性蛋白（ASP）的完整编码序列和氨基酸序列; 也获得了10K蛋白的克隆。 描述了用于获得重组形式的这些蛋白质的方法和载体。 大量这些蛋白质通过重组技术的可用性允许在合适的药物组合物中使用ASP来治疗呼吸缺陷综合征。
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3.发明授权
公开(公告)号：US5169761A
公开(公告)日：1992-12-08
申请号：US699960
申请日：1991-05-14
申请人： Bradley J. Benson , Robert T. White , James W. Schilling, Jr. , Douglas I. Buckley , Robert M. Scarborough
发明人： Bradley J. Benson , Robert T. White , James W. Schilling, Jr. , Douglas I. Buckley , Robert M. Scarborough
IPC分类号： A61K38/00 , C07K14/785 , C12N1/21 , C12N5/18 , C12N15/12 , C12N15/70 , C12N15/85 , C12P21/04
CPC分类号： C12N15/70 , C07K14/785 , C12N15/85 , A61K38/00 , C12N2830/002 , C12N2830/30 , C12N2830/55 , C12N2830/60
摘要： Various specific human SP-18 and human SP-5 derived peptides have alveolar surfactant protein (ASP) activity. These peptides are prepared using synthetic methods or by recombinant techniques.
摘要翻译： 各种特异性人SP-18和人SP-5衍生肽具有肺泡表面活性蛋白（ASP）活性。 使用合成方法或通过重组技术制备这些肽。
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公开(公告)号：US5104853A
公开(公告)日：1992-04-14
申请号：US524360
申请日：1990-05-17
申请人： Bradley J. Benson , Robert T. White , James W. Schilling, Jr. , Douglas I. Buckley , Robert M. Scarborough
发明人： Bradley J. Benson , Robert T. White , James W. Schilling, Jr. , Douglas I. Buckley , Robert M. Scarborough
IPC分类号： A61K38/00 , A61P11/00 , C07K14/00 , C07K14/785 , C07K19/00 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/70 , C12N15/85 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C12N15/70 , C07K14/785 , C12N15/85 , A61K38/00
摘要： Various specific human SP-18 and human SP-5 derived peptides have alveolar surfactant protein (ASP) activity. These peptides are prepared using synthetic methods or by recombinant techniques. The peptides of the invention include surfactant proteins having serine replacements for the cysteines.
摘要翻译： 各种特异性人SP-18和人SP-5衍生肽具有肺泡表面活性蛋白（ASP）活性。 使用合成方法或通过重组技术制备这些肽。 本发明的肽包括具有丝氨酸替代半胱氨酸的表面活性蛋白。
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公开(公告)号：US4912038A
公开(公告)日：1990-03-27
申请号：US808843
申请日：1985-12-13
IPC分类号： A61K38/00 , C07K14/785 , C12N15/12 , C12N15/85 , C12P21/02
CPC分类号： C07K14/785 , C12N15/85 , C12P21/02 , A61K38/00
摘要： The complete coding sequences and amino acid sequences for both canine and human 32K alveolar surfactant proteins (ASP) are disclosed; clones for the 10K protein have also been obtained. Methods and vectors for obtaining these proteins in recombinant form are described. The availability of large amounts of these proteins through recombinant techniques permits the use of ASP in suitable pharmaceutical compositions in the treatment of respiratory deficiency syndromes.
摘要翻译： 公开了犬和人类32K肺泡表面活性蛋白（ASP）的完整编码序列和氨基酸序列; 也获得了10K蛋白的克隆。 描述了用于获得重组形式的这些蛋白质的方法和载体。 大量这些蛋白质通过重组技术的可用性允许在合适的药物组合物中使用ASP来治疗呼吸缺陷综合征。
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公开(公告)号：US4659805A
公开(公告)日：1987-04-21
申请号：US680358
申请日：1984-12-11
IPC分类号： A61K38/00 , A61K9/10 , A61K9/127 , A61K35/12 , A61K35/42 , A61K35/74 , A61P11/00 , C07H21/04 , C07K14/00 , C07K14/785 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12P21/02 , C12R1/91 , C07K13/00 , A61K37/02
CPC分类号： C07K14/785 , A61K38/00 , Y10S930/30
摘要： The complete coding sequences and amino acid sequences for both canine and human alveolar surfactant protein (ASP) are disclosed. Methods and vectors for obtaining these proteins in recombinant form are described. The availability of large amounts of these proteins through recombinant techniques permits the use of ASP in suitable pharmaceutical compositions in the treatment of respiratory deficiency syndromes.
摘要翻译： 公开了犬和人肺泡表面活性蛋白（ASP）的完整编码序列和氨基酸序列。 描述了用于获得重组形式的这些蛋白质的方法和载体。 大量这些蛋白质通过重组技术的可用性允许在合适的药物组合物中使用ASP来治疗呼吸缺陷综合征。
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公开(公告)号：US5840527A
公开(公告)日：1998-11-24
申请号：US483939
申请日：1995-06-07
IPC分类号： A61K38/00 , C07K14/785 , C12N15/70 , C12N15/85 , C12N1/00 , C12N5/10 , C12N15/12 , C12N15/63
CPC分类号： C07K14/785 , C12N15/70 , C12N15/85 , A61K38/00 , C12N2800/108 , C12N2830/002 , C12N2830/15 , C12N2830/60 , C12N2830/85
摘要： Recombinant materials for the production of low molecular weight hydrophobic lung surfactant proteins are disclosed and claimed. The monomeric forms of the proteins from human and canine sources have apparent molecular weights of about 5 kd and form dimers under some conditions. The availability of these recombinant materials permits production of large amounts of these proteins through recombinant techniques and permits the use of these proteins in pharmaceutical compositions in the treatment of respiratory deficiency syndromes.
摘要翻译： 公开和要求保护用于生产低分子量疏水性肺表面活性蛋白质的重组材料。 来自人和犬源的蛋白质的单体形式具有约5kd的表观分子量，并且在某些条件下形成二聚体。 这些重组材料的可用性允许通过重组技术生产大量的这些蛋白质，并允许在药物组合物中使用这些蛋白质来治疗呼吸缺陷综合征。
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公开(公告)号：US5430020A
公开(公告)日：1995-07-04
申请号：US74290
申请日：1993-06-09
IPC分类号： A61K38/00 , C07K14/785 , C12N15/70 , C12N15/85 , C07K7/00
CPC分类号： C07K14/785 , C12N15/70 , C12N15/85 , A61K38/00 , C12N2800/108 , C12N2830/002 , C12N2830/15 , C12N2830/55 , C12N2830/85
摘要： The complete coding sequences and amino acid sequences for both canine and human 32K alveolar surfactant proteins (ASP) are disclosed; clones encoding variants of the SP-18 and SP-5 forms of human protein are disclosed. Methods and vectors for obtaining these proteins in recombinant form are also described. An improved method for purification of the 32K protein takes advantage of its carbohydrate affinity. Pharmaceutical compositions in the treatment of respiratory deficiency syndrome use the 10K proteins with or without the 32K form. Synthetic peptides based on the human SP-5 protein are provided as well, which peptides show significant ASP activity.
摘要翻译： 公开了犬和人类32K肺泡表面活性蛋白（ASP）的完整编码序列和氨基酸序列; 公开了编码SP-18和SP-5形式的人类蛋白质的变体的克隆。 还描述了用于获得重组形式的这些蛋白质的方法和载体。 改进的32K蛋白质的纯化方法利用其碳水化合物亲合力。 治疗呼吸缺陷综合症的药物组合物使用具有或不具有32K形式的10K蛋白质。 还提供了基于人SP-5蛋白的合成肽，该肽显示出显着的ASP活性。
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公开(公告)号：US5385840A
公开(公告)日：1995-01-31
申请号：US965745
申请日：1992-10-23
申请人： Bradley J. Benson , Robert T. White , James W. Schilling, Jr. , Douglas I. Buckley , Robert M. Scarborough
发明人： Bradley J. Benson , Robert T. White , James W. Schilling, Jr. , Douglas I. Buckley , Robert M. Scarborough
IPC分类号： A61K38/00 , C07K14/785 , C12N1/21 , C12N5/18 , C12N15/12 , C12N15/70 , C12N15/85 , C12P21/04 , C12N5/10 , C12N15/63
CPC分类号： C12N15/70 , C07K14/785 , C12N15/85 , A61K38/00 , C12N2830/002 , C12N2830/30 , C12N2830/55 , C12N2830/60
摘要： Various specific human SP-18 and human SP-5 derived peptides have alveolar surfactant protein (ASP) activity. These peptides are prepared using synthetic methods or by recombinant techniques.
摘要翻译： 各种特异性人SP-18和人SP-5衍生肽具有肺泡表面活性蛋白（ASP）活性。 使用合成方法或通过重组技术制备这些肽。
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公开(公告)号：US5035133A
公开(公告)日：1991-07-30
申请号：US477452
申请日：1990-02-09
IPC分类号： B21D25/02
CPC分类号： B21D25/02
摘要： A method and apparatus for draw forming a metal sheet over a male form to produce a three-dimensional shape. A sheet of metal is clamped between upper and lower draw plates positioned above the male form. The upper plate has an edge conforming to the male form shape. The plates and sheet are moved downwardly over the form with the edge of the upper plate firmly pressing the sheet against the form. The clamping pressure between the draw plates allows suitable slippage as drawing proceeds to produce a drawn shape of intended thickness. The drawn shape has a configuration conforming to the outer surface of the male form and has an outer surface of improved uniformity and appearance due to the wiping action of the upper plate edge.
摘要翻译： 用于在阳模形成金属片以产生三维形状的方法和装置。 一块金属被夹在位于阳形式上方的上和下拉板之间。 上板具有符合阳模形状的边缘。 板和片材向下移动到形式上，其中上板的边缘牢固地将纸张压靠在纸上。 当绘图继续进行以产生预期厚度的拉伸形状时，拉伸板之间的夹紧压力允许适当的滑动。 拉伸形状具有符合阳型外表面的构造，并且具有由于上板边缘的擦拭作用而具有改善的均匀性和外观的外表面。
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