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公开(公告)号：US4587053A
公开(公告)日：1986-05-06
申请号：US604282
申请日：1984-04-26
IPC分类号： C07D507/00 , C07D498/04 , C07D505/00
CPC分类号： C07D505/00 , Y02P20/55
摘要： Oxazolino-azetidinones are prepared by reaction of a phosphorus compound with a 3-exomethylenecepham sulfoxide.
摘要翻译： 恶唑啉 - 氮杂环丁酮通过磷化合物与3-异丙基亚甲基头孢烯亚砜的反应来制备。
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公开(公告)号：US5658907A
公开(公告)日：1997-08-19
申请号：US455347
申请日：1995-05-31
IPC分类号： A61K31/17 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/444 , A61K31/47 , A61K31/49 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/535 , A61K45/06 , C07C335/16 , C07C335/22 , C07D213/75 , C07D213/85 , C07D215/38 , C07D231/40 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D239/42 , C07D241/20 , C07D249/14 , C07D257/06 , C07D263/48 , C07D275/02 , C07D275/03 , C07D277/18 , C07D277/48 , C07D277/56 , C07D277/82 , C07D285/12 , C07D285/135 , C07D307/52 , C07D401/12 , C07D403/12 , C07D417/04 , C07D417/12
CPC分类号： C07D213/75 , A61K31/17 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/444 , A61K31/47 , A61K31/49 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/535 , A61K45/06 , C07C335/16 , C07C335/22 , C07D213/85 , C07D215/38 , C07D231/40 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D239/42 , C07D241/20 , C07D249/14 , C07D257/06 , C07D263/48 , C07D275/03 , C07D277/18 , C07D277/48 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/52 , C07D401/12 , C07D403/12 , C07D417/04 , C07D417/12
摘要： Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.
摘要翻译： 公开了治疗AIDS，抑制HIV复制及其相关病毒，以及使用硫脲衍生物化合物或其盐的制剂。 还公开了新的硫脲衍生物化合物。
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3.发明授权Photochemical conversion of cephalosporins, 1-carba(1-dethia)cephalosporins and 1-oxa(1-dethia)cephalosporins 失效头孢菌素，1-咔唑（1-脱氢）头孢菌素和1-氧杂（1-脱硫）头孢菌素的光化学转化
公开(公告)号：US4888100A
公开(公告)日：1989-12-19
申请号：US324169
申请日：1989-03-15
IPC分类号： B01J19/12 , C07B61/00 , C07D463/00 , C07D501/04 , C07D501/22 , C07D501/24 , C07D501/36 , C07D505/00
CPC分类号： B01J19/123 , C07D463/06 , C07D463/08 , C07D505/00
摘要： A process for photochemically converting 3-exomethylene cephams (or 1-carba(1-dethia)cephams or and 1-oxa(1-dethia)cephams) from the corresponding 3-alkyl-3-cephem (or 1-carba(1-dethia)cephem or 1-oxa(1-dethia)cephem) is provided. Further provided are 3-cephams useful as intermediates to 3-cephem compounds.
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公开(公告)号：US5618843A
公开(公告)日：1997-04-08
申请号：US255821
申请日：1994-07-08
申请人： Matthew J. Fisher , Anne M. Happ , Joseph A. Jakubowski , Michael D. Kinnick , Allen D. Kline , John M. Morin, Jr. , Daniel J. Sall , Marshall A. Skelton , Robert T. Vasileff
发明人： Matthew J. Fisher , Anne M. Happ , Joseph A. Jakubowski , Michael D. Kinnick , Allen D. Kline , John M. Morin, Jr. , Daniel J. Sall , Marshall A. Skelton , Robert T. Vasileff
IPC分类号： C07D487/04 , A61K31/015 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/335 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/44 , A61K31/47 , A61K31/472 , A61K31/4725 , A61K31/495 , A61P7/02 , A61P9/10 , C07C257/18 , C07C271/64 , C07D211/22 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D221/00 , C07D311/22 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12 , C07D491/052 , C07D497/04 , G03F7/20 , C07C251/02
CPC分类号： C07C271/64 , C07C257/18 , C07D211/22 , C07D211/34 , C07D213/82 , C07D217/04 , C07D217/06 , C07D217/24 , C07D311/22 , C07D311/58 , C07D333/38 , C07D401/12 , C07D405/06 , C07D405/12 , C07C2102/10
摘要： This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
摘要翻译： 本发明涉及具有由两个稠合的六元环形成的核的某些双环化合物，例如异喹啉，异喹啉酮，四氢萘，二氢萘或四氢萘酮，其被碱性和酸性官能团所取代，其可用于抑制血小板聚集。
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公开(公告)号：US4665066A
公开(公告)日：1987-05-12
申请号：US685676
申请日：1984-12-24
申请人： John M. Morin, Jr.
发明人： John M. Morin, Jr.
IPC分类号： C07D501/18 , A61K31/435 , A61K31/535 , A61K31/545 , A61K31/546 , A61P31/04 , C07D463/00 , C07D501/46 , C07D501/57 , C07D505/00
CPC分类号： C07D505/00 , C07D463/22
摘要： 7.beta.-[2-(2-Aminothiazol(oxazol)-4-yl)-2-oximinoacetamido]-3-(thiazolium or substituted thiazolium-3-yl)methyl-3-cephem-4-carboxylates and the correspondingly substituted 1-oxadethia and 1-carbadethia 3-cephem compounds are potent antibacterials useful in a therapeutic method for treating bacterial diseases. Also provided are pharmaceutical formulations of these thiazolium-substituted compounds and intermediates useful in the preparation thereof.
摘要翻译： 7β-[2-（2-氨基噻唑（恶唑）-4-基）-2-肟基乙酰胺基] -3-（噻唑鎓或取代的噻唑鎓-3-基）甲基-3-头孢烯-4-羧酸酯和相应的取代的1 - 恶二唑和1-碳氮烯3-头孢烯化合物是用于治疗细菌性疾病的治疗方法中的有效抗菌剂。 还提供了这些噻唑鎓取代的化合物的药物制剂和可用于其制备的中间体。
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公开(公告)号：US5593993A
公开(公告)日：1997-01-14
申请号：US395702
申请日：1995-02-28
IPC分类号： A61K31/17 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/444 , A61K31/47 , A61K31/49 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/535 , A61K45/06 , C07C335/16 , C07C335/22 , C07D213/75 , C07D213/85 , C07D215/38 , C07D231/40 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D239/42 , C07D241/20 , C07D249/14 , C07D257/06 , C07D263/48 , C07D275/02 , C07D275/03 , C07D277/18 , C07D277/48 , C07D277/56 , C07D277/82 , C07D285/12 , C07D285/135 , C07D307/52 , C07D401/12 , C07D403/12 , C07D417/04 , C07D417/12
CPC分类号： C07D213/75 , A61K31/17 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/444 , A61K31/47 , A61K31/49 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/535 , A61K45/06 , C07C335/16 , C07C335/22 , C07D213/85 , C07D215/38 , C07D231/40 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D239/42 , C07D241/20 , C07D249/14 , C07D257/06 , C07D263/48 , C07D275/03 , C07D277/18 , C07D277/48 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/52 , C07D401/12 , C07D403/12 , C07D417/04 , C07D417/12
摘要： Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.
摘要翻译： 公开了治疗AIDS，抑制HIV复制及其相关病毒，以及使用硫脲衍生物化合物或其盐的制剂。 还公开了新的硫脲衍生物化合物。
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公开(公告)号：US4992545A
公开(公告)日：1991-02-12
申请号：US410173
申请日：1989-09-20
IPC分类号： C01B6/10 , C07D205/08 , C07D205/085 , C07D205/095 , C07F7/10 , C25B3/04
CPC分类号： C07D205/085 , C07D205/08 , C07D205/095 , C07F7/10
摘要： A process for preparing 3-4-cis-.beta.,.beta.-(4)-substituted and 3-4-trans,.beta.,.alpha.- (4)-substituted azetidinones is provided. Also provided are novel 4,4-disubstituted azetidinones.
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公开(公告)号：US5714503A
公开(公告)日：1998-02-03
申请号：US455217
申请日：1995-05-31
IPC分类号： A61K31/17 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/444 , A61K31/47 , A61K31/49 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/535 , A61K45/06 , C07C335/16 , C07C335/22 , C07D213/75 , C07D213/85 , C07D215/38 , C07D231/40 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D239/42 , C07D241/20 , C07D249/14 , C07D257/06 , C07D263/48 , C07D275/02 , C07D275/03 , C07D277/18 , C07D277/48 , C07D277/56 , C07D277/82 , C07D285/12 , C07D285/135 , C07D307/52 , C07D401/12 , C07D403/12 , C07D417/04 , C07D417/12
CPC分类号： C07D213/75 , A61K31/17 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/444 , A61K31/47 , A61K31/49 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/535 , A61K45/06 , C07C335/16 , C07C335/22 , C07D213/85 , C07D215/38 , C07D231/40 , C07D233/88 , C07D235/30 , C07D237/20 , C07D237/22 , C07D239/42 , C07D241/20 , C07D249/14 , C07D257/06 , C07D263/48 , C07D275/03 , C07D277/18 , C07D277/48 , C07D277/56 , C07D277/82 , C07D285/135 , C07D307/52 , C07D401/12 , C07D403/12 , C07D417/04 , C07D417/12
摘要： Treatment of AIDS, inhibition of the replication of HIV and related viruses thereof, and formulations using thiourea derivative compounds or salts thereof is disclosed. Also disclosed are novel thiourea derivative compounds.
摘要翻译： 公开了治疗AIDS，抑制HIV复制及其相关病毒，以及使用硫脲衍生物化合物或其盐的制剂。 还公开了新的硫脲衍生物化合物。
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公开(公告)号：US5106475A
公开(公告)日：1992-04-21
申请号：US598527
申请日：1990-10-16
IPC分类号： C07D205/08 , C07D205/085 , C07D205/095 , C07F7/10
CPC分类号： C07F7/10 , C07D205/08 , C07D205/085 , C07D205/095
摘要： A process for preparing 3-4-cis-.beta.,.beta.-(4)-substituted and 3-4-trans,.beta.,.alpha.-(4)-substituted azetidinones is provided. Also provided are novel 4,4-disubstituted azetidinones.
摘要翻译： 提供了制备3-4-cis-β，β - （4） - 取代和3-4 - 反式，β，α - （4）取代的氮杂环丁酮的方法。 还提供了新的4,4-二取代的氮杂环丁酮。
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10.发明授权Azetidinone intermediates for 1-carba(dethia)caphalosporins 失效氮杂环丁酮中间体，用于1-carba（dethia）caphalosporins
公开(公告)号：US4885362A
公开(公告)日：1989-12-05
申请号：US202287
申请日：1988-06-06
IPC分类号： C07D205/085 , C07F7/10
CPC分类号： C07D205/085 , C07F7/10
摘要： Azetidinone-2 intermediates represented by the formula ##STR1## wherein R is phenyl, phenoxy or thienyl, R.sub.1 is --CH.dbd.CH--COOR.sub.1 ' wherein R.sub.1 ' is an ester, e.g., benzyl; --CH.sub.2 CH.sub.2 COR.sub.2 wherein R.sub.2 is OH or imidazol-1-yl; --CH.sub.2 CH.sub.2 C(O)CH.sub.2 COOR.sub.1 ' where R.sub.1 ' is an ester, e.g., p-nitrobenzyl; and R', R" and R'" are C.sub.1 -C.sub.4 alkyl, aryl or aralkyl; are converted to 1-carba(dethia)cephalosporin antibiotics. Preferably, R is phenoxy and the 1-silyl group is dimethyl-t-butylsilyl. Also provided is 3.beta.-phenoxyacetylamino-4.beta.-(2-carboxyethyl)azetidinone, likewise useful in the preparation of 1-carbacephalosporin antibiotics.
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