Systems and methods for identifying a portion of a molecule
    4.
    发明申请
    Systems and methods for identifying a portion of a molecule 审中-公开
    用于鉴定分子的一部分的系统和方法

    公开(公告)号:US20110287414A1

    公开(公告)日:2011-11-24

    申请号:US12658603

    申请日:2010-02-08

    摘要: Techniques for identifying a portion of a molecule are described herein. In one example, multiple electrical measurements associated with a molecule are acquired, wherein each of the multiple electrical measurements corresponds to a discrete position of the molecule within a nanopore. The multiple electrical measurements are correlated with one or more sequences of electrical measurements corresponding to a possible structure of the molecule. The portion of molecule is determined to include the possible structure of the molecule based on the correlation.

    摘要翻译: 本文描述了用于鉴定分子的一部分的技术。 在一个示例中,获得与分子相关联的多个电测量,其中多个电测量中的每一个对应于分子在纳米孔内的离散位置。 多个电测量与对应于分子的可能结构的一个或多个电测量序列相关联。 基于相关性确定分子的部分包括分子的可能结构。

    Systems and methods for forming a nanopore in a lipid bilayer
    5.
    发明申请
    Systems and methods for forming a nanopore in a lipid bilayer 有权
    在脂质双层中形成纳米孔的系统和方法

    公开(公告)号:US20110193249A1

    公开(公告)日:2011-08-11

    申请号:US12658591

    申请日:2010-02-08

    IPC分类号: B29C67/24

    摘要: Techniques for forming a nanopore in a lipid bilayer are described herein. In one example, an agitation stimulus level such as an electrical agitation stimulus is applied to a lipid bilayer wherein the agitation stimulus level tends to facilitate the formation of nanopores in the lipid bilayer. In some embodiments, a change in an electrical property of the lipid bilayer resulting from the formation of the nanopore in the lipid bilayer is detected, and a nanopore has formed in the lipid bilayer is determined based on the detected change in the lipid bilayer electrical property.

    摘要翻译: 本文描述了在脂质双层中形成纳米孔的技术。 在一个实例中,将搅动刺激水平(例如电刺激刺激)施加到脂质双层,其中搅动刺激水平倾向于促进脂质双层中的纳米孔的形成。 在一些实施方案中,检测由在脂质双层中形成纳米孔而导致的脂质双层的电性质的变化,并且基于检测到的脂质双层电性能的变化来确定在脂质双层中形成的纳米孔 。

    Systems and methods for assembling a lipid bilayer on a substantially planar solid surface
    7.
    发明申请
    Systems and methods for assembling a lipid bilayer on a substantially planar solid surface 审中-公开
    用于在基本平坦的固体表面上组装脂质双层的系统和方法

    公开(公告)号:US20120052188A1

    公开(公告)日:2012-03-01

    申请号:US12658602

    申请日:2010-02-08

    摘要: Techniques for assembling a lipid bilayer on a substantially planar solid surface are described herein. In one example, a lipid material such as a lipid suspension is deposited on a substantially planar solid surface, a bubble filled with fast diffusing gas molecules is formed on the solid surface, and the gas molecules are allowed to diffuse out of the bubble to form a lipid bilayer on the solid surface.

    摘要翻译: 本文描述了在基本上平面的固体表面上组装脂质双层的技术。 在一个实例中,脂质材料如脂质悬浮液沉积在基本上平面的固体表面上,在固体表面上形成填充有快速扩散气体分子的气泡,并使气体分子扩散出气泡形成 固体表面上的脂质双层。

    Systems and methods for manipulating a molecule in a nanopore
    9.
    发明申请
    Systems and methods for manipulating a molecule in a nanopore 审中-公开
    用于操纵纳米孔分子的系统和方法

    公开(公告)号:US20110192723A1

    公开(公告)日:2011-08-11

    申请号:US12658601

    申请日:2010-02-08

    IPC分类号: G01N27/447 G01N33/50 B82Y5/00

    摘要: Techniques for manipulating a molecule in a nanopore embedded in a lipid bilayer are described. In one example, an acquiring electrical stimulus level is applied across a lipid bilayer wherein a region of the lipid bilayer containing the nanopore is characterized by a resistance and wherein the acquiring electrical stimulus level tends to draw the molecule from a surrounding fluid into the nanopore, a change in the resistance of the lipid bilayer resulting from the acquisition of at least a portion of a molecule into the nanopore is detected, the acquiring electrical stimulus level is changed to a holding electrical stimulus level wherein the portion of the molecule remains in the nanopore upon the changing of the acquiring electrical stimulus level to the holding electrical stimulus level.

    摘要翻译: 描述了在嵌入脂质双层中的纳米孔中操纵分子的技术。 在一个实例中,获得电刺激水平跨越脂质双层施加,其中含有纳米孔的脂质双层的区域的特征在于电阻,并且其中获取电刺激水平倾向于将分子从周围流体吸入纳米孔, 检测到从分子的至少一部分获取到纳米孔中产生的脂质双层的电阻的变化,将获得的电刺激水平改变为保持电刺激水平,其中分子的部分保留在纳米孔中 将获取的电刺激水平改变为保持电刺激水平。

    OPTOELECTRONIC DEVICE AND METHOD OF MANUFACTURE
    10.
    发明申请
    OPTOELECTRONIC DEVICE AND METHOD OF MANUFACTURE 有权
    光电器件及其制造方法

    公开(公告)号:US20130341537A1

    公开(公告)日:2013-12-26

    申请号:US13529843

    申请日:2012-06-21

    IPC分类号: G02B27/00 H01R43/00

    CPC分类号: H04B10/802 Y10T29/49117

    摘要: An optoelectronic device is disclosed. The optoelectronic device may be employed as a single or multi-channel opto-coupler that electrically isolates one circuit from another circuit. The opto-coupler may include one or more folded leads that establish an enhanced isolation gap. The enhanced isolation gap increases the creepage distance of the opto-coupler and increases operational voltages that can be accommodated by the opto-coupler.

    摘要翻译: 公开了一种光电子器件。 光电子器件可以用作将一个电路与另一个电路电隔离的单通道或多通道光耦合器。 光耦合器可以包括建立增强隔离间隙的一个或多个折叠引线。 增强的隔离间隙增加了光耦合器的爬电距离,并增加了光耦合器可以适应的工作电压。