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    Application of a therapeutic substance to a tissue location using a porous medical device
    5.
    发明申请
    Application of a therapeutic substance to a tissue location using a porous medical device 审中-公开
    使用多孔医疗装置将治疗物质施用于组织位置

    公开(公告)号：US20050113687A1

    公开(公告)日：2005-05-26

    申请号：US10943075

    申请日：2004-09-15

    申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61B5/05 ,  A61F2/82 ,  A61M20060101

    CPC分类号： A61M25/10 ,  A61F2/82 ,  A61F2/958 ,  A61F2250/0067 ,  A61M25/1027 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1088

    摘要： A non-polymeric or biological coating applied to porous radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

    摘要翻译： 应用于多孔径向可扩张介入医疗装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

    Application of a therapeutic substance to a tissue location using an expandable medical device
    9.
    发明申请
    Application of a therapeutic substance to a tissue location using an expandable medical device 有权
    使用可扩张医疗装置将治疗物质施用于组织位置

    公开(公告)号：US20050106206A1

    公开(公告)日：2005-05-19

    申请号：US10942764

    申请日：2004-09-15

    申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

    IPC分类号： A61K9/22 ,  A61K31/225 ,  A61L29/16 ,  A61L31/16 ,  A61M20060101 ,  A61M25/16

    CPC分类号： A61L29/16 ,  A61L31/16 ,  A61L2300/606

    摘要： A non-polymeric or biological coating applied to radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

    摘要翻译： 施加到可径向扩张的介入医疗装置的非聚合或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。