公开(公告)号：US20070071798A1

公开(公告)日：2007-03-29

申请号：US11525390

申请日：2006-09-22

申请人： Steve Herweck ,  Thomas Swanick ,  Joseph Ferraro ,  Paul Martakos ,  Lisa Rogers ,  Theodore Karwoski ,  Keith Faucher ,  Philip McNamara ,  Roger Labrecque ,  Suzanne Conroy ,  Trevor Carlton

发明人： Steve Herweck ,  Thomas Swanick ,  Joseph Ferraro ,  Paul Martakos ,  Lisa Rogers ,  Theodore Karwoski ,  Keith Faucher ,  Philip McNamara ,  Roger Labrecque ,  Suzanne Conroy ,  Trevor Carlton

IPC分类号： A61K9/70

CPC分类号： B65B55/18 ,  A61B2017/00004 ,  A61B2017/320044 ,  A61B2090/0816 ,  A61F2/0059 ,  A61F2/0095 ,  A61L2/07 ,  A61L2/081 ,  A61L2/087 ,  A61L2/14 ,  A61L2/186 ,  A61L2/206 ,  A61L2/208 ,  A61L31/00 ,  A61L31/145 ,  A61L31/148 ,  A61L2202/24 ,  B26F1/18 ,  B29C39/02 ,  B65B31/04 ,  Y10T83/0481

摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.

摘要翻译： 生物可吸收的独立膜至少部分地由脂肪酸衍生。 生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。 独立膜具有形成在其中的一个或多个穿孔或凹陷。 使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。 所得到的独立膜是生物可吸收的。

公开(公告)号：US20070084144A1

公开(公告)日：2007-04-19

申请号：US11525328

申请日：2006-09-22

申请人： Roger Labrecque ,  Suzanne Conroy ,  Keith Faucher ,  Thomas Swanick ,  Paul Martakos ,  Theodore Karwoski ,  Steve Herweck ,  Trevor Carlton

发明人： Roger Labrecque ,  Suzanne Conroy ,  Keith Faucher ,  Thomas Swanick ,  Paul Martakos ,  Theodore Karwoski ,  Steve Herweck ,  Trevor Carlton

IPC分类号： A61L2/20 ,  A61L2/07 ,  A61L2/08 ,  A61L2/14 ,  B65B55/02

CPC分类号： A61L2/08 ,  A61B50/30 ,  A61B2050/314 ,  A61F2/0095 ,  A61F2/82 ,  A61L2/07 ,  A61L2/087 ,  A61L2/14 ,  A61L2/186 ,  A61L2/20 ,  A61L2/206 ,  A61L2/208 ,  A61L2/26 ,  A61L2202/181 ,  A61L2202/24 ,  B65B55/16 ,  B65B55/18

摘要： A method for the sterilization and packaging of a chemically sensitive medical device is provided. The chemically sensitive medical device has a coating derived from fish oil, a vitamin E compound or a combination thereof. The packaging pouch for the chemically sensitive medical device comprises a non-permeable chamber and a gas-permeable header. The sterilizing agent is administered to the packaged chemically sensitive medical device at a temperature of between about 20° C. and 40° C.

摘要翻译： 提供了一种杀菌和包装化学敏感性医疗装置的方法。 化学敏感性医疗装置具有衍生自鱼油，维生素E化合物或其组合的涂层。 用于化学敏感的医疗装置的包装袋包括不可渗透室和透气性头部。 灭菌剂在约20℃至40℃的温度下施用于包装的化学敏感性医疗装置。

公开(公告)号：US20050113687A1

公开(公告)日：2005-05-26

申请号：US10943075

申请日：2004-09-15

申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

IPC分类号： A61B5/05 ,  A61F2/82 ,  A61M20060101

CPC分类号： A61M25/10 ,  A61F2/82 ,  A61F2/958 ,  A61F2250/0067 ,  A61M25/1027 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1088

摘要： A non-polymeric or biological coating applied to porous radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

摘要翻译： 应用于多孔径向可扩张介入医疗装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

公开(公告)号：US08367099B2

公开(公告)日：2013-02-05

申请号：US11525390

申请日：2006-09-22

申请人： Steve A. Herweck ,  Thomas M. Swanick ,  Joseph Ferraro ,  Paul Martakos ,  Lisa Rogers ,  Theodore Karwoski ,  Keith M. Faucher ,  Philip McNamara ,  Roger Labrecque ,  Suzanne Conroy ,  Trevor Carlton

发明人： Steve A. Herweck ,  Thomas M. Swanick ,  Joseph Ferraro ,  Paul Martakos ,  Lisa Rogers ,  Theodore Karwoski ,  Keith M. Faucher ,  Philip McNamara ,  Roger Labrecque ,  Suzanne Conroy ,  Trevor Carlton

IPC分类号： A61L15/16

CPC分类号： B65B55/18 ,  A61B2017/00004 ,  A61B2017/320044 ,  A61B2090/0816 ,  A61F2/0059 ,  A61F2/0095 ,  A61L2/07 ,  A61L2/081 ,  A61L2/087 ,  A61L2/14 ,  A61L2/186 ,  A61L2/206 ,  A61L2/208 ,  A61L31/00 ,  A61L31/145 ,  A61L31/148 ,  A61L2202/24 ,  B26F1/18 ,  B29C39/02 ,  B65B31/04 ,  Y10T83/0481

摘要： A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable.

摘要翻译： 生物可吸收的独立膜至少部分地由脂肪酸衍生。 生物吸收性独立膜可以具有抗粘连性，抗炎性，非炎性和伤口愈合性，并且还可以包括一种或多种掺入其中的治疗剂。 独立膜具有形成在其中的一个或多个穿孔或凹陷。 使具有一个或多个穿孔或凹陷的生物吸收性独立薄膜的相应方法包括成型，切割，雕刻，穿刺或以其它方式适当地在生物吸收性独立薄膜中产生穿孔或凹陷的方法。 所得到的独立膜是生物可吸收的。

公开(公告)号：US20050106206A1

公开(公告)日：2005-05-19

申请号：US10942764

申请日：2004-09-15

申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

IPC分类号： A61K9/22 ,  A61K31/225 ,  A61L29/16 ,  A61L31/16 ,  A61M20060101 ,  A61M25/16

CPC分类号： A61L29/16 ,  A61L31/16 ,  A61L2300/606

摘要： A non-polymeric or biological coating applied to radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

摘要翻译： 施加到可径向扩张的介入医疗装置的非聚合或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

公开(公告)号：US20080015500A1

公开(公告)日：2008-01-17

申请号：US11804478

申请日：2007-05-18

申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

IPC分类号： A61M29/02

CPC分类号： A61M25/1027 ,  A61L29/085 ,  A61L29/146 ,  A61L29/16 ,  A61L2300/22 ,  A61L2300/606 ,  A61M2025/1075 ,  A61M2025/1088 ,  C08L27/18

摘要： A non-polymeric or biological coating applied to radially expandable medical delivery device provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The delivery device is expanded using the pressure of an inflation fluid. After expanding the delivery device to a pre-determined size and shape, the inflation fluid weeps through the porous surface of the delivery device. The coating releases the delivery device and floats on the inflation fluid until bonding to the tissue due to its affinity for the tissue. Once the coating bonds or affixes to the tissue, through an absorption mechanism by the tissue cells of the coating material, the coating and any therapeutics contained therein are delivered to the tissue. The fluid can contain a therapeutic agent, or can be otherwise biocompatible and/or inert.

摘要翻译： 应用于可径向扩张的医疗输送装置的非聚合物或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 输送装置使用充气流体的压力膨胀。 在将输送装置膨胀至预定尺寸和形状之后，充气流体通过输送装置的多孔表面而流失。 涂层释放输送装置并漂浮在充气流体上，直到由于其对组织的亲和力而结合到组织。 一旦涂层通过涂层材料的组织细胞通过吸收机制结合或固定到组织，涂层和其中包含的任何治疗剂被递送到组织。 流体可以含有治疗剂，或者可以以其他方式生物相容和/或惰性。

公开(公告)号：US20060112536A1

公开(公告)日：2006-06-01

申请号：US11250768

申请日：2005-10-14

申请人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

发明人： Steve Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

IPC分类号： B23P17/04

CPC分类号： B05D1/00 ,  A61F2/82 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/08 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/1027 ,  A61M25/1038 ,  A61M2025/1031 ,  B05D2259/00 ,  Y10T29/49

摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.

摘要翻译： 以折叠的，包裹的或折叠的构造施加到可径向展开的介入医疗装置的非聚合或生物涂层。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。

公开(公告)号：US08021331B2

公开(公告)日：2011-09-20

申请号：US11250768

申请日：2005-10-14

申请人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

发明人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

IPC分类号： A61M37/00 ,  A61M31/00

CPC分类号： B05D1/00 ,  A61F2/82 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/08 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/1027 ,  A61M25/1038 ,  A61M2025/1031 ,  B05D2259/00 ,  Y10T29/49

摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.

摘要翻译： 以折叠的，包裹的或折叠的构造施加到可径向展开的介入医疗装置的非聚合或生物涂层。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。

公开(公告)号：US07572245B2

公开(公告)日：2009-08-11

申请号：US10942764

申请日：2004-09-15

申请人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

发明人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton

IPC分类号： A61M31/00

CPC分类号： A61L29/16 ,  A61L31/16 ,  A61L2300/606

摘要： A non-polymeric or biological coating applied to radially expandable interventional medical devices provides uniform drug distribution and permeation of the coating and any therapeutic agents mixed therewith into a targeted treatment area within the body. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device. Thus, atraumatic local tissue transference delivery is achieved for uniform therapeutic agent distribution and controlled bio-absorption into the tissue after placement within a patient's body with a non-inflammatory coating.

摘要翻译： 施加到可径向扩张的介入医疗装置的非聚合或生物涂层提供了涂层和与其混合的任何治疗剂的均匀的药物分布和渗透到体内的目标治疗区域。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。 因此，在用非炎性涂层放置在患者体内之后，实现了不均匀的局部组织转移递送，用于均匀的治疗剂分布和对组织的受控生物吸收。

公开(公告)号：US08308684B2

公开(公告)日：2012-11-13

申请号：US13102876

申请日：2011-05-06

申请人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

发明人： Steve A. Herweck ,  Paul Martakos ,  Geoffrey Moodie ,  Roger Labrecque ,  Theodore Karwoski ,  Trevor Carlton ,  Lisa Rogers ,  Joseph Ferraro

IPC分类号： A61M37/00 ,  A61M31/00

CPC分类号： B05D1/00 ,  A61F2/82 ,  A61F2/958 ,  A61F2250/0067 ,  A61L29/08 ,  A61L29/16 ,  A61L2300/606 ,  A61M25/1027 ,  A61M25/1038 ,  A61M2025/1031 ,  B05D2259/00 ,  Y10T29/49

摘要： A non-polymeric or biological coating applied to a radially expandable interventional medical device in a collapsed, wrapped, or folded configuration, the coating applied within at least one fold. Properties of the coating material applied to the medical device are adjusted or varied to result in a desired combination of coverage of the surface of the medical device, drug loading, and coating thickness. The coating is sterile, and is capable of being carried by a sterile medical device to a targeted tissue location within the body following radial expansion. The therapeutic coating transfers off the medical device due in part to a biological attraction with the tissue and in part to a physical transference from the medical device to the targeted tissue location in contact with the medical device.

摘要翻译： 以折叠的，包裹的或折叠的形式施加到可径向展开的介入医疗装置的非聚合物或生物涂层，所述涂层施用在至少一个折叠内。 调整或改变施加到医疗装置上的涂层材料的性质，以产生医疗装置的表面，药物负载和涂层厚度的覆盖范围的期望组合。 涂层是无菌的，并且能够在径向膨胀后由无菌医疗装置携带到身体内的目标组织位置。 治疗涂层部分地由于与组织的生物吸引而部分地转移离开医疗装置，并且部分地从医疗装置到与医疗装置接触的目标组织位置的物理转移。