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1.发明申请PREPARATION AND USE OF BIPHENYL-4-YL-CARBONYLAMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 审中-公开联苯胺-4-甲酰氨基酸衍生物用于治疗肥胖症的制备和使用公开(公告)号：US20110118302A1
公开(公告)日：2011-05-19
申请号：US12836035
申请日：2010-07-14
申请人： Roger Smith , Stephen J. O'Connor , Philip Coish , Derek Lowe , Roger B. Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
发明人： Roger Smith , Stephen J. O'Connor , Philip Coish , Derek Lowe , Roger B. Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
IPC分类号： A61K31/437 , A61K31/428 , A61P3/04 , A61P3/10 , A61P3/00 , A61P3/08 , A61P9/10 , A61P9/00 , A61P9/12
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D513/04
摘要： This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些联苯-4-基羰基氨基酸化合物，组合物和治疗或预防肥胖症及相关疾病的方法。
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2.发明授权Preparation and use of biphenyl-4-yl-carbonylamino acid derivatives for the treatment of obesity 失效联苯-4-基 - 羰基氨基酸衍生物的制备和用途，用于治疗肥胖症公开(公告)号：US07759376B2
公开(公告)日：2010-07-20
申请号：US11665317
申请日：2005-10-14
申请人： Roger Smith , Stephen J. O'Connor , Philip Coish , Derek Lowe , Roger B. Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
发明人： Roger Smith , Stephen J. O'Connor , Philip Coish , Derek Lowe , Roger B. Clark , Jeffrey Stebbins , Ann-Marie Campbell , Christiana Akuche , Tatiana Shelekhin
IPC分类号： A61K31/425 , C07D277/82
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D513/04
摘要： This invention relates to certain biphenyl-4-yl carbonylamino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些联苯-4-基羰基氨基酸化合物，组合物和治疗或预防肥胖症及相关疾病的方法。
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3.发明申请PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 审中-公开联苯胺酸衍生物用于治疗肥胖症的制备和使用公开(公告)号：US20100234307A1
公开(公告)日：2010-09-16
申请号：US12775249
申请日：2010-05-06
申请人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
发明人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
IPC分类号： A61K38/06 , C07D211/34 , A61K38/05 , A61P3/04 , C07C229/14 , C07D207/48 , A61K31/401 , C07C311/46 , A61K31/198 , C07D209/42
CPC分类号： C07D211/60 , C07C237/36 , C07C237/42 , C07C275/42 , C07C311/46 , C07C311/47 , C07D207/16 , C07D207/48 , C07D209/08 , C07D209/42 , C07D213/75 , C07D307/84 , C07D413/12
摘要： This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些联苯氨基酸化合物，组合物和用于治疗或预防肥胖症和相关疾病的方法。
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4.发明申请Preparation and Use of Biphenyl Amino Acid Derivatives for the Treatment of Obesity 审中-公开联苯氨基酸衍生物治疗肥胖症的制备与应用公开(公告)号：US20100016295A1
公开(公告)日：2010-01-21
申请号：US11989506
申请日：2006-07-31
申请人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
发明人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
IPC分类号： A61K31/198 , C07D211/60 , A61P3/04 , A61K31/44 , C07C229/02 , C07D207/00 , A61K31/40 , C07D261/18 , A61K31/42 , C07D307/00 , A61K31/34 , C07D209/42 , C07D279/12 , A61K31/54 , C07D265/30 , A61K31/5375 , C07D241/04 , A61K31/4965
CPC分类号： C07D211/60 , C07C237/36 , C07C237/42 , C07C275/42 , C07C311/46 , C07C311/47 , C07D207/16 , C07D207/48 , C07D209/08 , C07D209/42 , C07D213/75 , C07D307/84 , C07D413/12
摘要： This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些联苯氨基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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公开(公告)号：US08013166B2
公开(公告)日：2011-09-06
申请号：US12231878
申请日：2008-09-05
申请人： Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： C07D277/42 , C07D277/62 , C07D263/34 , C07D263/58
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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6.发明授权Preparation and use of aryl alkyl acid derivatives for the treatment of obesity 失效芳基烷基酸衍生物的制备和用途用于治疗肥胖症公开(公告)号：US07968576B2
公开(公告)日：2011-06-28
申请号：US12206721
申请日：2008-09-08
申请人： Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/4168 , A61K31/421 , A61K31/426 , C07D277/42 , C07D277/82 , C07D263/48 , C07D263/58 , C07D233/88 , C07D235/30
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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7.发明授权2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US06660752B2
公开(公告)日：2003-12-09
申请号：US10131448
申请日：2002-04-22
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K3144
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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8.发明授权Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists 失效二取代氨基甲基 - 苯并二氢吡喃衍生物β-3肾上腺素受体激动剂公开(公告)号：US06699860B2
公开(公告)日：2004-03-02
申请号：US10008928
申请日：2001-12-07
申请人： Gaetan H. Ladouceur , William H. Bullock , Steven R. Magnuson , Stephen J. O'Connor , Roger A. Smith , Quanrong Shen , Qingjie Liu , Ning Su , Emil J. Velthuisen , Ann-Marie Campbell , Paul P. Ehrlich
发明人： Gaetan H. Ladouceur , William H. Bullock , Steven R. Magnuson , Stephen J. O'Connor , Roger A. Smith , Quanrong Shen , Qingjie Liu , Ning Su , Emil J. Velthuisen , Ann-Marie Campbell , Paul P. Ehrlich
IPC分类号： C07D40112
CPC分类号： C07D405/12 , C07D311/58 , C07D407/04 , C07D409/04 , C07D417/04
摘要： This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3受体介导的病症的新型二取代氨基甲基苯并二氢吡喃衍生物。
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9.发明授权2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US06919371B2
公开(公告)日：2005-07-19
申请号：US10666903
申请日：2003-09-17
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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公开(公告)号：US20090247502A1
公开(公告)日：2009-10-01
申请号：US12409626
申请日：2009-03-24
IPC分类号： A61K31/5383 , C07D498/04
CPC分类号： C07D498/04
摘要： The invention provides compounds having the structure of formula I, and prodrugs, stereoisomers, racemates, salts, hydrates, solvates, acid salt hydrates and isomorphic crystalline forms thereof, wherein A, Y and the groups R1, R2, R3 and R4 are defined in the specification. These compounds can be administered in pharmaceutical formulations to modulate cannabinoid receptor activity for the prevention and treatment of a variety of diseases and conditions, including pain, inflammation and pruritis.
摘要翻译： 本发明提供了具有式I结构的化合物及其前体药物，立体异构体，外消旋物，盐，水合物，溶剂合物，酸盐水合物和同构晶体形式，其中A，Y和基团R 1，R 2，R 3和R 4定义在 规格。 这些化合物可以在药物制剂中施用以调节大麻素受体活性，以预防和治疗各种疾病和病症，包括疼痛，炎症和瘙痒。
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