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    Process for the manufacture of aromatic sulphonic acid esters of aromatic amino-hydroxy compounds
    1.
    发明授权
    Process for the manufacture of aromatic sulphonic acid esters of aromatic amino-hydroxy compounds 失效
    芳香族氨基 - 羟基化合物的芳香族磺​​酸酯的制造方法

    公开(公告)号：US4158670A

    公开(公告)日：1979-06-19

    申请号：US879852

    申请日：1978-02-22

    申请人： Rolf Muller ,  Joachim Ribka ,  Horst Tappe

    发明人： Rolf Muller ,  Joachim Ribka ,  Horst Tappe

    IPC分类号： C07B61/00 ,  B01J31/00 ,  B01J31/02 ,  C07C20060101 ,  C07C67/00 ,  C07C301/00 ,  C07C303/28 ,  C07C309/63 ,  C07C309/72 ,  C07C143/68

    CPC分类号： C07C303/28

    摘要： A process for the manufacture of esters of aromatic sulphonic acids and aromatic aminohydroxy compounds, of the formula Ih.sub.2 n--a--o--so.sub.2 --b (i)comprising reacting an aromatic aminohydroxy compound of the formula IIh.sub.2 n--a--oh (ii)having a pK.sub.a value of from 8.5 to 10.1, with a sulphochloride of the formula IIIcl--SO.sub.2 --B (III)whereinA is phenylene, substituted phenylene, naphthylene or substituted naphthylene,B is phenyl, substituted phenyl, naphthyl or substituted naphthyl, and both A and B are free from --COOH and --SO.sub.3 H substituents;The reaction taking place in a reaction medium consisting essentially of water and a water-immiscible organic solvent for the sulphochloride,At a temperature of from 0.degree. to 95.degree. C., at a pH which is determined from and associated with the pK.sub.a value of said aromatic aminohydroxy compound of formula II by the equationpK.sub.a -pH=0.5 to -1.5, and in the presence of a phase transfer catalyst.

    摘要翻译： 制备式I H 2 N-AO-SO 2 -B（I）的芳族磺酸和芳族氨基羟基化合物的酯的方法，包括使具有式II的芳族氨基羟基化合物H 2 N-A-OH（II） 其中A为亚苯基，取代亚苯基，亚萘基或取代亚萘基，B为苯基，取代的苯基，萘基或取代的萘基，并且两者均为 A和B不含-COOH和-SO 3 H取代基; 在pH为0〜95℃的温度下，在由碱性水溶液组成的反应介质中进行反应和在硫酸盐的水不溶性有机溶剂中反应，其pH值由pKa值 所述式II的芳族氨基羟基化合物通过PKa-pH = 0.5至-1。

    COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES
    5.
    发明申请
    COMPOSITIONS FOR STABILIZING DNA, RNA AND PROTEINS IN BLOOD AND OTHER BIOLOGICAL SAMPLES DURING SHIPPING AND STORAGE AT AMBIENT TEMPERATURES 有权
    用于稳定血液中DNA，RNA和蛋白质的组合物和其他生物样品在环境温度下的运输和储存

    公开(公告)号：US20120052572A1

    公开(公告)日：2012-03-01

    申请号：US13191346

    申请日：2011-07-26

    申请人： Scott E. Whitney ,  Steven Wilkinson ,  Rolf Muller

    发明人： Scott E. Whitney ,  Steven Wilkinson ,  Rolf Muller

    IPC分类号： C07H21/00 ,  C09K15/30 ,  C09K15/32 ,  C12N5/078

    CPC分类号： A01N1/021 ,  C12Q1/6806 ,  C12Q2527/125

    摘要： Compositions and methods are disclosed for substantially liquid, gel, suspension, slurry, semisolid and/or colloid storage of biological samples following admixture with the herein disclosed storage composition, permitting substantial recovery of biological activity following storage without refrigeration. In certain embodiments, unfractionated blood or tissue samples may be stored without refrigeration for weeks, months or years in a form that permits recovery of intact DNA, RNA or protein components following the storage period.

    摘要翻译： 公开了在与本文公开的储存组合物混合之后基本上液体，凝胶，悬浮液，浆体，半固体和/或胶体储存生物样品的组合物和方法，允许在没有冷藏的情况下储存后基本恢复生物活性。 在某些实施方案中，未分级血液或组织样品可以以几个月，几个月或几年的形式储存，而不会在保存期后允许回收完整的DNA，RNA或蛋白质组分。

    Genes encoding the synthetic pathway for the production of disorazole
    8.
    发明申请
    Genes encoding the synthetic pathway for the production of disorazole 审中-公开
    编码合成途径的基因用于生产二氟唑

    公开(公告)号：US20060199252A1

    公开(公告)日：2006-09-07

    申请号：US11330623

    申请日：2006-01-12

    申请人： Herbert Irschik ,  Maren Kopp ,  Rolf Muller

    发明人： Herbert Irschik ,  Maren Kopp ,  Rolf Muller

    IPC分类号： C12P19/62 ,  C12P7/64 ,  C07H21/04 ,  C12N9/10 ,  C12N1/21

    CPC分类号： C12P17/188 ,  C12N15/52

    摘要： The present invention relates to nucleic acid sequences and proteins derivable therefrom that have been identified in Sorangium cellulosum, which proteins are catalytically active or participate in the biosynthetic pathway of disorazoles. The invention provides novel sequences which are necessary components of the disorazole biosynthetic pathway in addition to genes dszA-D.

    摘要翻译： 本发明涉及在其中鉴定的核酸序列和可从其中衍生的蛋白质，其在蛋白质是催化活性的或参与disorazole的生物合成途径。 本发明提供除了基因dszA-D之外，二脱氮生物合成途径的必需组分的新序列。

    Polymer networks
    9.
    发明申请
    Polymer networks 有权
    聚合物网络

    公开(公告)号：US20060148960A1

    公开(公告)日：2006-07-06

    申请号：US10553293

    申请日：2004-04-15

    申请人： Rolf Muller ,  Federico Innerebner

    发明人： Rolf Muller ,  Federico Innerebner

    IPC分类号： C08L91/08

    CPC分类号： C08L23/06 ,  C08L23/02 ,  C08L23/04 ,  C08L23/08 ,  C08L23/10 ,  C08L29/04 ,  C08L91/06 ,  C08L91/08 ,  C08L101/00 ,  C08L2205/02 ,  C08L2666/06 ,  C08L2666/04

    摘要： Polymer mixtures containing a first long-chain polymer and a second short-chain polymer. The structural parameters of the two polymers are coordinated in such a way that a polymeric material is obtained which is easier to process while being provided with improved mechanical properties and in part also improved thermal properties compared with the first polymer at suitable conditions for producing the polymer mixture as a result of networks being formed and heterocrystallization taking place.

    摘要翻译： 含有第一长链聚合物和第二短链聚合物的聚合物混合物。 两种聚合物的结构参数以这样的方式进行协调，使得获得的聚合物材料在提供改善的机械性能的同时更容易加工，并且在适合的制备聚合物的条件下与第一聚合物相比具有改善的热性能 混合物由于形成网络而发生异质结果。

    Brushless direct current motor
    10.
    再颁专利
    Brushless direct current motor 失效
    无刷直流电机

    公开(公告)号：USRE36860E

    公开(公告)日：2000-09-12

    申请号：US710734

    申请日：1996-09-20

    申请人： Rolf Muller

    发明人： Rolf Muller

    IPC分类号： H02P6/14

    CPC分类号： H02P6/14

    摘要： The stator winding of a brushless D.C. motor receives two current pulses per 360.degree.-el. of rotor rotation, each current pulse being furnished via a respective current path. Each current path contains at least one power transistor switch having conductive and non-conductive states. These states are determined by respective driver transistor switches; when the driver transistor switch is in a high-output-impedance state the respective power transistor switch is rendered conductive, but when in the low-output-impedance state it renders the power transistor switch non-conductive. In various ways disclosed herein measures are taken to prevent the power transistor switches of both current paths from being simultaneously conductive. This may be accomplished using inherent or discrete base-emitter capacitances so connected that a power transistor switch is switched off abruptly but switches-on only after the elapse of a predetermined delay. Alternatively, the Hall voltage produced by the motor's rotor-position-sensing Hall cell may be applied to comparators such that the power transistor switches are not even commanded to conduct except during respective periods each shorter than 180.degree.-el.

    摘要翻译： 无刷直流电动机的定子绕组每360°接收两个电流脉冲。 的转子旋转，每个电流脉冲经由相应的电流路径提供。 每个电流路径包含至少一个具有导电和非导通状态的功率晶体管开关。 这些状态由相应的驱动晶体管开关决定; 当驱动晶体管开关处于高输出阻抗状态时，各个功率晶体管开关导通，但是当处于低输出阻抗状态时，使得功率晶体管开关不导通。 以本文公开的各种方式，采取措施来防止两个电流路径的功率晶体管开关同时导通。 这可以使用如此连接的固有或离散的基极 - 发射极电容来使功率晶体管开关突然断开，但是仅在经过预定延迟之后接通。 或者，电动机的转子位置感测霍尔单元产生的霍尔电压可以被施加到比较器，使得功率晶体管开关甚至不命令进行，除了在每个短于180度的各个周期内。