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1.发明申请SYSTEMS AND METHODS FOR ISOLATING AND CHARACTERIZING TARGET MATERIALS OF A SUSPENSION 审中-公开用于分离和表征暂停的目标材料的系统和方法公开(公告)号：US20130034841A1
公开(公告)日：2013-02-07
申请号：US13565104
申请日：2012-08-02
CPC分类号： C12M47/04
摘要： Systems and methods for isolating and characterizing various target materials of a suspension are disclosed. A suspension suspected of containing the target materials is added to a tube. A float with a specific gravity corresponding to that of the target material is inserted into the tube. The tube, float, and suspension are centrifuged together causing the various materials suspended in the suspension to separate into different layers along the axial length of the tube according to their specific gravities. The float and/or tube are configured to drive the various target materials to a region of space between the float and inner wall of the tube.
摘要翻译： 公开了用于分离和表征悬浮液的各种靶材料的系统和方法。 将疑似含有目标物质的悬浮液加入管中。 将具有对应于目标材料的比重的浮子插入管中。 将管，浮子和悬浮液离心在一起，使得悬浮在悬浮液中的各种材料根据其比重沿管的轴向长度分离成不同的层。 浮子和/或管构造成将各种目标材料驱动到管的浮子和内壁之间的空间区域。
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公开(公告)号：US20120225766A1
公开(公告)日：2012-09-06
申请号：US13409453
申请日：2012-03-01
申请人： Ronald C. Seubert , Paul C. Goodwin , Martha Stone
发明人： Ronald C. Seubert , Paul C. Goodwin , Martha Stone
IPC分类号： B01D43/00
CPC分类号： B01L3/50215 , B01D21/262 , B01D21/307 , B01D2221/10 , B01L2300/044
摘要： This disclosure is directed to tube and float systems that can be used to detect target materials in a variety of different suspensions. The tube is filled with a suspension suspected of containing a target material. When the tube, a float, and suspension are centrifuged, and the various materials suspended in the suspension are separated into different material layers along the axial length of the tube according to associated specific gravities. The float includes an insert and a float exterior that can be combined so that the float is to be positions at approximately the same level as the layer containing the target material. The float is to be positioned in, and expand the axial length of, the target material layer so that nearly the entire quantity of target material is to be positioned between the float outer surface and the inner surface of the tube.
摘要翻译： 本公开涉及可用于检测各种不同悬浮液中的靶材料的管和浮子系统。 管中充满疑似含有目标物质的悬浮液。 当管，浮子和悬浮液离心时，悬浮在悬浮液中的各种材料根据相关的比重沿管的轴向长度分离成不同的材料层。 浮子包括可以组合的插入件和浮子外部，使得浮子将位于与包含目标材料的层大致相同的水平。 浮子将被放置在目标材料层的轴向长度上并扩大，使得几乎所有的目标材料的数量都位于浮子外表面和管内表面之间。
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公开(公告)号：US4918374A
公开(公告)日：1990-04-17
申请号：US254269
申请日：1988-10-05
CPC分类号： G01R1/07342
摘要： A method and apparatus for inspecting integrated circuit probe cards in which the probe points of the probe card are scanned across a checkplate having a conductivity transition border. The impedances between the probe points and the checkplate as they cross the conductivity transition border are measured to determine when the probe points cross the border. The positions of the probe card when each of the probe points crosses the border are measured to determine the positions of the probe points relative to each other. In one embodiment, the checkplate is formed by a square conductive plate having three quadrants of insulated material and a single quadrant of conductive material mounted on its upper surface. These conductive strips connected to the conductive plate are positioned between the quadrants of insulative material to form the conductivity transition border. In other embodiments, multiple parallel strips or a single dot of conductive material are surrounded by insulative material.
摘要翻译： 用于检查集成电路探针卡的方法和装置，其中探针卡的探针点跨越具有电导率过渡边界的检查板扫描。 测量探针点和检查板在穿过电导率过渡边界时的阻抗，以确定探针点何时越过边界。 测量每个探针点穿过边界时探针卡的位置，以确定探针点相对于彼此的位置。 在一个实施例中，该检查板由具有三个绝缘材料象限和安装在其上表面上的单个象限的导电材料的正方形导电板形成。 连接到导电板的这些导电条定位在绝缘材料的象限之间以形成电导率过渡边界。 在其他实施例中，多个平行条或单点导电材料被绝缘材料包围。
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公开(公告)号：US08445264B2
公开(公告)日：2013-05-21
申请号：US13372815
申请日：2012-02-14
IPC分类号： C12M1/34
CPC分类号： B01D21/262 , B01D21/0012 , B01D21/307 , B01D2221/10 , G01N33/491
摘要： Tube and float systems and methods for isolating, enumerating, and harvesting target materials of a suspension are described. In one aspect, a tube and float system includes a filter embedded in a tube cap. The filter enables the passage of fluids but prevents the passage of the target materials. The tube and float system can be used to isolate and enumerate the target materials by centrifuging the tube and float system with the suspension to trap the target materials between the float and inner wall of the tube. Fluids above and below the float are poured off and a second fluid can be introduced to the tube to re-suspend the trapped target material. The second fluid can be poured through the filter in the cap to trap the target material against the filter. The target material can be enumerated and analyzed.
摘要翻译： 描述了用于分离，枚举和收获悬浮液的目标材料的管和浮子系统和方法。 在一个方面，管和浮子系统包括嵌入在管帽中的过滤器。 过滤器使得流体通过，但是阻止了目标材料的通过。 管和浮子系统可用于通过离心管和浮子系统与悬浮液来分离和枚举目标材料，以将目标材料捕获在管的浮子和内壁之间。 将浮子上方和下方的流体倒出，并将第二流体引入到管中以重新悬浮被捕获的目标材料。 可以将第二流体通过盖中的过滤器倒入以将目标材料捕获到过滤器上。 目标材料可以列举和分析。
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公开(公告)号：US20110037492A1
公开(公告)日：2011-02-17
申请号：US12600153
申请日：2008-05-15
CPC分类号： G01R1/0491
摘要： An apparatus for electrically testing a semiconductor device is herein disclosed. The apparatus includes carriers for a semiconductor device and a probe card (52) that are adapted for complementary registration with one another. The coupled carriers may be stacked or used in another high-density arrangement during electrical test or burn-in to improve test cell utilization.
摘要翻译： 本文公开了一种用于电测试半导体器件的装置。 该装置包括用于半导体器件的载体和适合互相配准的探针卡（52）。 耦合的载体可以在电测试或老化期间以另一高密度布置堆叠或使用，以提高测试电池的利用率。
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公开(公告)号：US5060371A
公开(公告)日：1991-10-29
申请号：US487434
申请日：1990-03-01
IPC分类号： G01R1/073
CPC分类号： G01R1/07342 , Y10T29/49155 , Y10T29/49162
摘要： A method and apparatus for inspecting integrated circuit probe cards in which the probe points of the probe card are scanned across a checkplate having a conductivity transition border. The impedances between the probe points and the checkplate as they cross the conductivity transition border are measured to determine when the probe points cross the border. The positions of the probe card when each of the probe points crosses the border are measured to determine the positions of the probe points relative to each other. In one embodiment, the checkplate is formed by a square conductive plate having three quadrants of insulated material and a single quadrant of conductive material mounted on its upper surface. These conductive strips connected to the conductive plate are positioned between the quadrants of insulative material to form the conductivity transition border. In other embodiments, multiple parallel strips or a single dot of conductive material are surrounded by insulative material.
摘要翻译： 用于检查集成电路探针卡的方法和装置，其中探针卡的探针点跨越具有电导率过渡边界的检查板扫描。 测量探针点和检查板在穿过电导率过渡边界时的阻抗，以确定探针点何时越过边界。 测量每个探针点穿过边界时探针卡的位置，以确定探针点相对于彼此的位置。 在一个实施例中，该检查板由具有三个绝缘材料象限和安装在其上表面上的单个象限的导电材料的正方形导电板形成。 连接到导电板的这些导电条定位在绝缘材料的象限之间以形成电导率过渡边界。 在其他实施例中，多个平行条或单点导电材料被绝缘材料包围。
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公开(公告)号：US20120258531A1
公开(公告)日：2012-10-11
申请号：US13372815
申请日：2012-02-14
CPC分类号： B01D21/262 , B01D21/0012 , B01D21/307 , B01D2221/10 , G01N33/491
摘要： Tube and float systems and methods for isolating, enumerating, and harvesting target materials of a suspension are described. In one aspect, a tube and float system includes a filter embedded in a tube cap. The filter enables the passage of fluids but prevents the passage of the target materials. The tube and float system can be used to isolate and enumerate the target materials by centrifuging the tube and float system with the suspension to trap the target materials between the float and inner wall of the tube. Fluids above and below the float are poured off and a second fluid can be introduced to the tube to re-suspend the trapped target material. The second fluid can be poured through the filter in the cap to trap the target material against the filter. The target material can be enumerated and analyzed.
摘要翻译： 描述了用于分离，枚举和收获悬浮液的目标材料的管和浮子系统和方法。 在一个方面，管和浮子系统包括嵌入在管帽中的过滤器。 过滤器使得流体通过，但是阻止了目标材料的通过。 管和浮子系统可用于通过离心管和浮子系统与悬浮液来分离和枚举目标材料，以将目标材料捕获在管的浮子和内壁之间。 将浮子上方和下方的流体倒出，并将第二流体引入到管中以重新悬浮被捕获的目标材料。 可以将第二流体通过盖中的过滤器倒入以将目标材料捕获到过滤器上。 目标材料可以列举和分析。
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公开(公告)号：US20120129252A1
公开(公告)日：2012-05-24
申请号：US13296082
申请日：2011-11-14
申请人： Ronald C. Seubert
发明人： Ronald C. Seubert
CPC分类号： B01D65/08 , B01D63/087 , B01D69/02 , B01D71/52 , B01D2325/021 , B01D2325/04 , B01D2325/24
摘要： Methods and systems disclosed in the present application include membrane-like filters and methods and systems that employ these membrane-like filters to isolate circulating tumor cells and other abnormal cells from biological fluids, such as blood. The disclosed methods and systems use membrane-like filters that include a pattern or array of small, tapered apertures fabricated within a relatively thin but mechanically robust polymeric material that resists accumulation of biological-solution components and clogging during filtration of biological solutions.
摘要翻译： 本申请中公开的方法和系统包括膜状过滤器和采用这些膜状过滤器从生物流体如血液中分离循环肿瘤细胞和其他异常细胞的方法和系统。 所公开的方法和系统使用膜状过滤器，其包括在相对薄但机械坚固的聚合物材料内制造的小的锥形孔的图案或阵列，其抵抗生物溶液成分的积聚和生物溶液过滤期间的堵塞。
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公开(公告)号：US5508629A
公开(公告)日：1996-04-16
申请号：US689294
申请日：1991-04-22
CPC分类号： G01R1/07342 , Y10T29/49155 , Y10T29/49162
摘要： A method and apparatus for inspecting integrated circuit probe cards in which the probe points of the probe card are scanned across a checkplate having a conductivity transition border. The impedances between the probe points and the checkplate as they cross the conductivity transition border are measured to determine when the probe points cross the border. The positions of the probe card when each of the probe points crosses the border are measured to determine the positions of the probe points relative to each other. In one embodiment, the checkplate is formed by a square conductive plate having three quadrants of insulated material and a single quadrant of conductive material mounted on its upper surface. These conductive strips connected to the conductive plate are positioned between the quadrants of insulative material to form the conductivity transition border. In other embodiments, multiple parallel strips or a single dot of conductive material are surrounded by insulative material.
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