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    Methods and compositions to treat cardiovascular disease using 1419, 58765 and 2210
    2.
    发明申请
    Methods and compositions to treat cardiovascular disease using 1419, 58765 and 2210 审中-公开
    使用1419,58765和2210治疗心血管疾病的方法和组合物

    公开(公告)号：US20050142604A1

    公开(公告)日：2005-06-30

    申请号：US11064551

    申请日：2005-02-24

    申请人： Thomas Logan ,  Miyoung Chun

    发明人： Thomas Logan ,  Miyoung Chun

    IPC分类号： G01N33/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P3/06 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/68 ,  G01N33/53 ,  G01N33/567

    CPC分类号： G01N33/6887 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2500/04 ,  G01N2800/32

    摘要： The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1419, 58765 or 2210 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.

    摘要翻译： 本发明涉及用于诊断和治疗心血管疾病的方法，包括但不限于动脉粥样硬化，再灌注损伤，高血压，再狭窄，动脉炎症，血栓形成和内皮细胞疾病。 具体地，本发明鉴定了心血管疾病状态中1419,58765或2210基因的差异表达，相对于它们在正常或非心血管疾病状态中的表达和/或响应于与心血管疾病相关的操作。 本发明描述了各种心血管疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能调节心血管疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为心血管疾病治疗的方法。

    Sample tube and vial processing system, and method for processing the sample
    3.
    发明申请
    Sample tube and vial processing system, and method for processing the sample 有权
    样品管和小瓶处理系统以及处理样品的方法

    公开(公告)号：US20070224089A1

    公开(公告)日：2007-09-27

    申请号：US11388312

    申请日：2006-03-23

    申请人： Thomas Logan

    发明人： Thomas Logan

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50825 ,  B01L3/565 ,  B01L2200/026 ,  B01L2300/047 ,  G01N1/40 ,  G01N2001/4033

    摘要： An apparatus for processing an analyte includes a first receptacle having a first aperture, the first aperture having a first configuration; and a second receptacle having a second aperture, the second aperture having a second configuration. The first configuration and the second configuration are complementary, such that the first and second apertures engage each other at a sealing surface, whereby analyte solution within the first receptacle passes into the second receptacle substantially without leaking at the engaged first and second apertures. A method for processing an analyte comprises engaging the first and second receptacles at the sealing surface; putting a first batch of analyte solution into the first receptacle, processing the analyte solution; transferring the processed analyte solution into the second receptacle, and disengaging the second receptacle from the first receptacle.

    摘要翻译： 用于处理分析物的装置包括具有第一孔的第一容器，所述第一孔具有第一构型; 以及具有第二孔的第二容器，所述第二孔具有第二构型。 第一构造和第二构造是互补的，使得第一孔和第二孔在密封表面处彼此接合，由此第一容器内的分析物溶液基本上不会在接合的第一孔和第二孔处泄漏进入第二容器。 用于处理分析物的方法包括在密封表面处接合第一和第二容器; 将第一批分析物溶液放入第一个容器中，处理分析物溶液; 将经处理的分析物溶液转移到第二容器中，并将第二容器与第一容器分离。

    Novel stimulative triple disposition lettered didactic cue T-shirt/sweat shirt style garment teaching tool
    4.
    发明申请
    Novel stimulative triple disposition lettered didactic cue T-shirt/sweat shirt style garment teaching tool 审中-公开
    新颖的刺激性三重配置字母教诲T恤/汗衫衬衫风格的服装教学工具

    公开(公告)号：US20060040241A1

    公开(公告)日：2006-02-23

    申请号：US10914760

    申请日：2004-08-10

    申请人： Thomas Logan

    发明人： Thomas Logan

    IPC分类号： G09B19/00

    CPC分类号： G09B17/00

    摘要： A teaching tool consisting of T-shirt style garments lettered with salient high value didactic content presented in three coordinating mutually enhancing special dispositions (mirror image, inverted, and standard grammar) for low cost, low technology, universally available, formal and informal, school and home, group and individual use. It enhances knowledge acquisition by creating and potentiating novelty, curiosity, surprise and amusement qualities. This tool is suited well for vocabulary, definitions, tables, formulas and number manipulations and is suited to biographic sketches, historical gems and general curricular data for all ages.

    摘要翻译： 由低成本，低技术，普及，正规和非正式的学校组成的三个协调相互增强的特殊处理（镜像，倒置和标准语法）的T恤风格的服装组成的教学工具 和家庭，团体和个人使用。 它通过创造和增强新奇，好奇心，惊喜和娱乐品质来增强知识获取。 该工具适用于词汇，定义，表格，公式和数字操作，适用于所有年龄段的传记草图，历史宝石和一般课程数据。

    DOSIMETRY APPARATUS , SYSTEMS, AND METHODS
    5.
    发明申请
    DOSIMETRY APPARATUS , SYSTEMS, AND METHODS 有权
    DOSIMETRY设备，系统和方法

    公开(公告)号：US20110024640A1

    公开(公告)日：2011-02-03

    申请号：US12936357

    申请日：2009-04-06

    申请人： Jukka Kahilainen ,  Thomas Logan

    发明人： Jukka Kahilainen ,  Thomas Logan

    IPC分类号： G01T1/02 ,  G01T1/24

    CPC分类号： G01T1/026 ,  G01T1/02 ,  G01T1/14 ,  G01T1/185 ,  G01T1/24 ,  G01T1/244 ,  G01T3/00 ,  G01T3/08 ,  G01T7/00 ,  H01J47/002 ,  H01J47/005 ,  H01J47/02 ,  H05K5/0278

    摘要： A direct ion storage (DIS) radiation detector or dosimeter has a design that is easy and low cost to manufacture using semiconductor processing techniques. The detectors include internal communications interfaces so they are easy to read. Different interfaces, including wired, e.g. USB ports, and wireless interfaces, may be used, so that the dosimeters may be read over the internet. The detectors can thus be deployed or used in a variety of detection systems and screening methods, including periodic or single time screening of people, objects, or containers at a location by means of affixed dosimeters; screening of objects, containers or people at a series of locations by means of affixed dosimeters, and surveillance of an area by monitoring moving dosimeters affixed to people or vehicles.

    摘要翻译： 直接离子存储（DIS）辐射检测器或剂量计具有使用半导体处理技术制造成本容易且成本低的设计。 检测器包括内部通信接口，因此易于阅读。 不同的接口，包括有线，例如 可以使用USB端口和无线接口，使得可以通过互联网读取剂量计。 因此，检测器可以被部署或用于各种检测系统和筛选方法中，包括通过固定的剂量计定期或单次对人，物体或容器进行筛选; 通过固定剂量计对一系列地点的物体，集装箱或人员进行筛查，并通过监测贴在人员或车辆上的移动剂量计监视区域。

    Syringe
    6.
    发明申请
    Syringe 审中-公开
    注射器

    公开(公告)号：US20070148326A1

    公开(公告)日：2007-06-28

    申请号：US11320941

    申请日：2005-12-28

    申请人： Mitchell Hastings ,  Thomas Logan

    发明人： Mitchell Hastings ,  Thomas Logan

    IPC分类号： A61L27/32 ,  A61M5/315 ,  A61M25/00 ,  A61M5/32 ,  B05D3/00

    CPC分类号： A61M5/31513 ,  A61M5/3129

    摘要： The present invention relates to a syringe including a barrel and a plunger. The barrel, the plunger, or both the barrel and the plunger can be made from or coated with a material that provides advantageous function and/or durability of these components. In certain embodiments, the barrel, the plunger, or both the barrel and the plunger can include or can be coated with a silicon material, such as silicon carbide or silicon oxide, or with a siloxane, such as a polymeric siloxane. In certain embodiments, the plunger can include or can be coated with a steel more durable than stainless steel. The invention also includes systems and methods employing such a syringe.

    摘要翻译： 本发明涉及一种包括镜筒和柱塞的注射器。 桶，柱塞或筒和柱塞可以由提供这些部件的有利功能和/或耐久性的材料制成或涂覆。 在某些实施例中，筒体，柱塞或筒体和柱塞两者可以包括或可以用诸如碳化硅或氧化硅的硅材料或与硅氧烷（例如聚合硅氧烷）一起涂覆。 在某些实施例中，柱塞可以包括或可以涂覆比不锈钢更耐用的钢。 本发明还包括采用这种注射器的系统和方法。

    Dosimetry apparatus, systems, and methods
    7.
    发明授权
    Dosimetry apparatus, systems, and methods 有权
    测量仪器，系统和方法

    公开(公告)号：US09134430B2

    公开(公告)日：2015-09-15

    申请号：US12936357

    申请日：2009-04-06

    申请人： Jukka Kahilainen ,  Thomas Logan

    发明人： Jukka Kahilainen ,  Thomas Logan

    IPC分类号： G01T1/24 ,  G01T1/02 ,  G01T1/14 ,  H01J47/00 ,  H01J47/02 ,  G01T3/08 ,  G01T3/00 ,  H05K5/02 ,  G01T1/185 ,  G01T7/00

    CPC分类号： G01T1/026 ,  G01T1/02 ,  G01T1/14 ,  G01T1/185 ,  G01T1/24 ,  G01T1/244 ,  G01T3/00 ,  G01T3/08 ,  G01T7/00 ,  H01J47/002 ,  H01J47/005 ,  H01J47/02 ,  H05K5/0278

    摘要： A direct ion storage (DIS) radiation detector or dosimeter has a design that is easy and low cost to manufacture using semiconductor processing techniques. The detectors include internal communications interfaces so they are easy to read. Different interfaces, including wired, e.g. USB ports, and wireless interfaces, may be used, so that the dosimeters may be read over the internet. The detectors can thus be deployed or used in a variety of detection systems and screening methods, including periodic or single time screening of people, objects, or containers at a location by means of affixed dosimeters; screening of objects, containers or people at a series of locations by means of affixed dosimeters, and surveillance of an area by monitoring moving dosimeters affixed to people or vehicles.

    摘要翻译： 直接离子存储（DIS）辐射检测器或剂量计具有使用半导体处理技术制造成本容易且成本低的设计。 检测器包括内部通信接口，因此易于阅读。 不同的接口，包括有线，例如 可以使用USB端口和无线接口，使得可以通过互联网读取剂量计。 因此，检测器可以被部署或用于各种检测系统和筛选方法中，包括通过固定的剂量计定期或单次对人，物体或容器进行筛选; 通过固定剂量计对一系列地点的物体，集装箱或人员进行筛查，并通过监测贴在人员或车辆上的移动剂量计监视区域。

    Seal having low friction non-stick surface layer
    8.
    发明申请
    Seal having low friction non-stick surface layer 有权
    密封件具有低摩擦不粘表面层

    公开(公告)号：US20070125234A1

    公开(公告)日：2007-06-07

    申请号：US11291168

    申请日：2005-12-01

    申请人： Thomas Logan

    发明人： Thomas Logan

    IPC分类号： B01D53/02

    CPC分类号： G01N30/18 ,  Y10S277/91 ,  Y10S277/945

    摘要： An inlet assembly for introducing a sample into a carrier gas stream for gas chromatography is disclosed including a housing having a bore that receives a liner. A sealing member having a core with a surface layer is positioned within the bore in sealing engagement with the bore and the liner. The surface layer of the sealing member has a lower adhesion to the housing than the core. The surface layer facilitates removal of the sealing member and the liner from the bore. A method of replacing an existing liner in an inlet assembly for chromatography is also disclosed. The method includes providing a liner with a sealing member having a core with a surface layer having a lower adhesion to the housing than the core, removing the existing liner from the bore and inserting a new liner with a new sealing member into the bore.

    摘要翻译： 公开了一种用于将样品引入用于气相色谱的载气流中的入口组件，其包括具有容纳衬垫的孔的壳体。 具有表面层的芯的密封构件定位在孔内与孔和衬垫密封接合。 密封构件的表面层比芯部具有比壳体低的附着力。 表面层有助于将密封构件和衬套从孔中移除。 还公开了用于色谱法的入口组件中替换现有衬垫的方法。 该方法包括提供具有密封构件的衬垫，所述密封构件具有芯，其表面层具有比芯部更低的与壳体的附着力，从孔中移除现有衬套并且将具有新密封构件的新衬套插入孔中。

    ACTR-1, a novel human acyltransferase and uses thereof
    9.
    发明申请
    ACTR-1, a novel human acyltransferase and uses thereof 有权
    ACTR-1，一种新的人类酰基转移酶及其用途

    公开(公告)号：US20060121518A1

    公开(公告)日：2006-06-08

    申请号：US11325013

    申请日：2006-01-04

    申请人： Rosana Kapeller-Libermann ,  Thomas Logan

    发明人： Rosana Kapeller-Libermann ,  Thomas Logan

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

    CPC分类号： C12N9/1029 ,  A61K38/00 ,  C12Y203/01015

    摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为ACTR-1核酸分子。 本发明还提供了反义核酸分子，含有ACTR-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了ACTR-1基因的非人类转基因动物。 本发明还进一步提供了分离的ACTR-1蛋白，融合蛋白，抗原肽和抗ACTR-1抗体。 还提供了利用本发明组合物的诊断方法。