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    Certain nicotinamido-n-benzoic acid derivatives
    3.
    发明授权
    Certain nicotinamido-n-benzoic acid derivatives 失效
    某些烟酰氨基 - 正苯甲酸衍生物

    公开(公告)号：US4181658A

    公开(公告)日：1980-01-01

    申请号：US878602

    申请日：1978-02-16

    申请人： Volker Hitzel ,  Rudi Weyer ,  Karl Geisen ,  Werner Pfaff

    发明人： Volker Hitzel ,  Rudi Weyer ,  Karl Geisen ,  Werner Pfaff

    IPC分类号： C07D213/81 ,  C07D213/80 ,  C07D213/82 ,  C07D213/56 ,  A61K31/44

    CPC分类号： C07D213/80 ,  C07D213/82 ,  Y10S514/866

    摘要： Benzoic acid derivatives of the formula ##STR1## wherein T is hydrogen or halogen, W is a carboxyl group, an ester or salt thereof; X is ##STR2## wherein R.sub.1 is alkyl having from 2 to 8 carbon atoms, aralkyl or phenyl, cycloalkyl, cycloalkylalkyl or alkylcycloalkyl; R.sub.2 is hydrogen or halogen, R.sub.3 is alkyl having from 5 to 8 carbon atoms, aralkyl or phenyl, or cycloalkyl having from 5 to 8 carbon atoms; R.sub.4 is hydrogen or alkyl; Y is a single chemical bond or a hydrocarbon chain having from 1 to 3 carbon atoms; and Z is hydrogen, halogen, alkyl, alkoxy, alkoxyalkoxy or alkenyloxy, have a blood sugar lowering effect and can be used for the treatment of Diabetes mellitus.

    摘要翻译： 其中T为氢或卤素，W为羧基，其酯或其盐的式IMAMA的苯甲酸衍生物; X是其中R1是具有2至8个碳原子的烷基，芳烷基或苯基，环烷基，环烷基烷基或烷基环烷基; R2是氢或卤素，R3是具有5-8个碳原子的烷基，芳烷基或苯基，或具有5-8个碳原子的环烷基; R4是氢或烷基; Y是单个化学键或具有1至3个碳原子的烃链; Z为氢，卤素，烷基，烷氧基，烷氧基烷氧基或烯氧基，具有降血糖作用，可用于治疗糖尿病。

    CHEMICAL PROCESS FOR THE PRODUCTION OF HALOALKENONE ETHERS
    7.
    发明申请
    CHEMICAL PROCESS FOR THE PRODUCTION OF HALOALKENONE ETHERS 有权
    化学工艺生产哈洛酮类化合物

    公开(公告)号：US20120095265A1

    公开(公告)日：2012-04-19

    申请号：US13254795

    申请日：2010-03-02

    申请人： David Anthony Jackson ,  Florian Schleth ,  Devender Singh Negi ,  Werner Pfaff

    发明人： David Anthony Jackson ,  Florian Schleth ,  Devender Singh Negi ,  Werner Pfaff

    IPC分类号： C07C45/00

    CPC分类号： C07C45/65 ,  C07C45/41 ,  C07C45/455 ,  C07C49/255 ,  C07C49/175

    摘要： The present invention relates to a continuous process for producing a haloalkenone ether of the Formula (I) wherein R1 is C1-C6 haloalkyl, R2 is a C1-C6 alkyl or phenyl, the process comprising:—(i) reacting, in a first continuous stirred tank reactor comprising a solvent, a halide of Formula (II) wherein R1 is as previously defined and R3 is halogen, with a vinyl ether of Formula (III) wherein R2 is as previously defined, to form an intermediate compound of Formula (IV), wherein the concentration of the vinyl ether of Formula (III) in the reaction mass is 15% or less w/w; and (ii) transferring the reaction mass from the first continuous stirred tank reactor into a subsequent continuous stirred tank reactor, wherein the conditions within the subsequent reactor permit the elimination of hydrogen halide (HR3) from the intermediate compound of Formula (IV) to provide the haloalkenone ether of Formula (I).

    摘要翻译： 本发明涉及制备式（I）的卤代烯酮醚的连续方法，其中R 1是C 1 -C 6卤代烷基，R 2是C 1 -C 6烷基或苯基，该方法包括：（ⅰ） 连续搅拌釜反应器，其包含溶剂，式（II）的卤化物，其中R 1如前所定义且R 3是卤素，与式（III）的乙烯基醚（其中R 2如前所定义）形成中间体式 IV），其中反应物质中式（III）的乙烯基醚的浓度为w / w为15％以下; 和（ii）将反应物质从第一连续搅拌釜反应器转移到随后的连续搅拌釜反应器中，其中随后反应器中的条件允许从式（IV）的中间体化合物除去卤化氢（HR 3），以提供 式（I）的卤代烯酮醚。

    Chemical process for the production of haloalkenone ethers
    9.
    发明授权
    Chemical process for the production of haloalkenone ethers 有权
    用于生产卤代烯酮醚的化学方法

    公开(公告)号：US08552222B2

    公开(公告)日：2013-10-08

    申请号：US13254795

    申请日：2010-03-02

    申请人： David Anthony Jackson ,  Florian Schleth ,  Devender Singh Negi ,  Werner Pfaff

    发明人： David Anthony Jackson ,  Florian Schleth ,  Devender Singh Negi ,  Werner Pfaff

    IPC分类号： C07C45/63 ,  C07C45/64

    CPC分类号： C07C45/65 ,  C07C45/41 ,  C07C45/455 ,  C07C49/255 ,  C07C49/175

    摘要： The present invention relates to a continuous process for producing a haloalkenone ether of the Formula (I) wherein R1 is C1-C6 haloalkyl, R2 is a C1-C6 alkyl or phenyl, the process comprising:—(i) reacting, in a first continuous stirred tank reactor comprising a solvent, a halide of Formula (II) wherein R1 is as previously defined and R3 is halogen, with a vinyl ether of Formula (III) wherein R2 is as previously defined, to form an intermediate compound of Formula (IV), wherein the concentration of the vinyl ether of Formula (III) in the reaction mass is 15% or less w/w; and (ii) transferring the reaction mass from the first continuous stirred tank reactor into a subsequent continuous stirred tank reactor, wherein the conditions within the subsequent reactor permit the elimination of hydrogen halide (HR3) from the intermediate compound of Formula (IV) to provide the haloalkenone ether of Formula (I).

    摘要翻译： 本发明涉及制备式（I）的卤代烯酮醚的连续方法，其中R 1是C 1 -C 6卤代烷基，R 2是C 1 -C 6烷基或苯基，该方法包括：（ⅰ） 连续搅拌釜反应器，其包含溶剂，式（II）的卤化物，其中R 1如前所定义且R 3是卤素，与式（III）的乙烯基醚（其中R 2如前所定义）形成中间体式 IV），其中反应物质中式（III）的乙烯基醚的浓度为w / w为15％以下; 和（ii）将反应物质从第一连续搅拌釜反应器转移到随后的连续搅拌釜反应器中，其中随后反应器中的条件允许从式（IV）的中间体化合物除去卤化氢（HR 3），以提供 式（I）的卤代烯酮醚。