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    Genetic alterations related to familial alzheimer's disease
    3.
    发明授权
    Genetic alterations related to familial alzheimer's disease 失效
    遗传改变与家族性阿尔茨海默病有关

    公开(公告)号：US06248555B1

    公开(公告)日：2001-06-19

    申请号：US08706344

    申请日：1996-08-30

    申请人： Rudolph Tanzi ,  Wilma Wasco

    发明人： Rudolph Tanzi ,  Wilma Wasco

    IPC分类号： C12N1512

    CPC分类号： C07K14/4711 ,  A01K2217/05

    摘要： Isolated nucleic acid molecules are provided encoding human PS1 gene products. Mutant PS1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of the activity of the PS1 polypeptide and mutants thereof. Also provided are diagnostic methods for detecting Alzheimer's disease and therapeutic methods for treating the same.

    摘要翻译： 提供分离的核酸分子编码人类PS1基因产物。 还提供了突变体PS1多肽，载体，宿主细胞以及用于制备它的重组方法也是如此。 本发明进一步涉及鉴定PS1多肽及其突变体的活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测阿尔茨海默氏病的诊断方法和用于治疗它们的治疗方法。

    DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE (AD)
    5.
    发明申请
    DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE (AD) 审中-公开
    诊断和治疗阿尔茨海默病（AD）

    公开(公告)号：US20110200564A1

    公开(公告)日：2011-08-18

    申请号：US12915470

    申请日：2010-10-29

    申请人： Rudolph Tanzi ,  Lars Bertram ,  Christoph Lange ,  Can Zhang

    发明人： Rudolph Tanzi ,  Lars Bertram ,  Christoph Lange ,  Can Zhang

    IPC分类号： A61K35/30 ,  C12Q1/68 ,  A61K38/02 ,  A61K31/7088 ,  A61K48/00 ,  A61P25/28

    CPC分类号： A61K38/1709 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： Disclosed herein are novel methods, assays and systems for detecting an increased risk for Alzheimer's disease (AD) in a subject by identifying at least one nuclei acid polymorphism described herein in a biological sample from the subject. Levels of the genes associated with the nucleic acid polymorphism described herein are also determined for detection of higher risk for AD. Disclosed herein further provides methods for treating AD by administering to a subject in need thereof with ATXN1.

    摘要翻译： 本文公开了用于通过鉴定来自受试者的生物样品中本文所述的至少一种核酸多态性来检测受试者中阿尔茨海默氏病（AD）的增加的风险的新方法，测定和系统。 与本文所述的核酸多态性相关的基因的水平也被确定用于检测AD的较高风险。 本文公开的方法还提供了通过用ATXN1向有需要的受试者施用治疗AD的方法。

    Methods for reducing amyloid beta levels
    7.
    发明申请
    Methods for reducing amyloid beta levels 审中-公开
    降低淀粉样蛋白β水平的方法

    公开(公告)号：US20060172964A1

    公开(公告)日：2006-08-03

    申请号：US11344973

    申请日：2006-02-01

    申请人： Rudolph Tanzi ,  Zhongcong Xie

    发明人： Rudolph Tanzi ,  Zhongcong Xie

    IPC分类号： A61K48/00

    CPC分类号： C12N15/113 ,  C12N2310/14

    摘要： The present invention relates to the treatment and prophylactic prevention of Alzheimer's disease. More specifically, the present invention relates to methods and compositions for reducing production of β amyloid by reducing or preventing the binding of amyloid precursor protein (APP) to an X11 adaptor protein. Also provided are methods for identifying molecules that modulate APP-X11 binding.

    摘要翻译： 本发明涉及阿尔茨海默病的治疗和预防性预防。 更具体地说，本发明涉及通过减少或预防淀粉样蛋白前体蛋白（APP）与X11衔接蛋白的结合来降低β淀粉样蛋白产生的方法和组合物。 还提供了用于鉴定调节APP-X11结合的分子的方法。

    PREVENTION AND TREATMENT OF POST-OPERATIVE COGNITIVE DYSFUNCTION (POCD)
    10.
    发明申请
    PREVENTION AND TREATMENT OF POST-OPERATIVE COGNITIVE DYSFUNCTION (POCD) 审中-公开
    预防和治疗术后认知功能障碍（POCD）

    公开(公告)号：US20120316247A1

    公开(公告)日：2012-12-13

    申请号：US13502969

    申请日：2010-10-20

    申请人： Zhongcong Xie ,  Rudolph Tanzi

    发明人： Zhongcong Xie ,  Rudolph Tanzi

    IPC分类号： A61K31/05 ,  A61P25/28 ,  A61P25/00 ,  A61K31/08 ,  A61P23/00

    CPC分类号： A61K33/22 ,  A61K31/03 ,  A61K31/045

    摘要： Disclosed herein is a method for administering compositions. Also disclosed are kits comprising a compound of formula (I) to (V), or an enantiomer, an analog, a derivative, an isomer, prodrug, or a pharmaceutically acceptable salt thereof, for use in temporal proximity to anesthesia. The methods, compositions and kits provided herein can be used for reducing anesthesia-induced neurotoxicity and post-operative cognitive dysfunction (POCD) in a subject.

    摘要翻译： 本文公开了一种用于施用组合物的方法。 还公开了包含式（I）至（V）化合物或其对映异构体，类似物，衍生物，异构体，前药或其药学上可接受的盐的试剂盒，用于临时接近麻醉。 本文提供的方法，组合物和试剂盒可用于减少受试者中麻醉诱发的神经毒性和术后认知功能障碍（POCD）。