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1.发明授权公开(公告)号：US07972800B2
公开(公告)日：2011-07-05
申请号：US12428877
申请日：2009-04-23
Applicant: Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
Inventor： Yasuaki Ito , Ryo Fujii , Makoto Kobayashi , Shuji Hinuma , Tadatoshi Hashimoto , Yasuhiro Tanaka
IPC: G01N33/53 , C07K14/435
CPC classification number: G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/68 , G01N2333/726 , G01N2500/00
Abstract: By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.
Abstract translation: 通过使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和可电离金属元素或其盐 可以有效地筛选上述受体蛋白质或其拮抗剂的激动剂或其盐。
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2.发明申请公开(公告)号：US20070202550A1
公开(公告)日：2007-08-30
申请号：US11701719
申请日：2007-02-02
Applicant: Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
Inventor： Takuya Watanabe , Kuniko Kikuchi , Yasuko Terao , Yasushi Shintani , Shuji Hinuma , Shoji Fukusumi , Ryo Fujii , Masaki Hosoya , Chieko Kitada
CPC classification number: C07K14/705 , C07K14/723 , C07K16/28 , G01N33/566 , G01N33/74 , G01N2333/726
Abstract: The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.
Abstract translation: 本发明中的多肽具有促进和抑制催乳素分泌的作用，因此可用作预防和治疗与催乳素分泌有关的催乳激素分泌兴奋剂的各种疾病的药物，例如 作为低血糖症，精神发育不良，绝经期症状，甲状腺机能减退等。多肽可用作预防和治疗各种疾病的催乳素分泌抑制剂，其与催乳素分泌相关，例如垂体瘤，间脑瘤 肿瘤，月经紊乱，自身免疫性疾病，催乳素瘤，不育症，阳ence，闭经，泌乳，肢端肥大症，Chiari-Frommel综合征，阿尔贡兹 - 德尔卡斯蒂略综合征，福布斯 - 奥尔布赖特综合征，淋巴瘤，Sheehan综合征，精子发生障碍等。
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公开(公告)号：US06492324B1
公开(公告)日：2002-12-10
申请号：US09255518
申请日：1999-02-22
Applicant: Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
Inventor： Shuji Hinuma , Kazuhiko Tatemoto , Masaki Hosoya , Yugo Habata , Ryo Fujii , Chieko Kitada
IPC: C07K400
CPC classification number: C07K14/705 , A61K38/00 , A61K48/00 , C07K14/4702
Abstract: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency syndrome) or the like.
Abstract translation: 本发明涉及一种涉及调节中枢神经系统功能，循环功能，免疫功能，胃肠功能，代谢功能，生殖功能等的新型多肽，可用作治疗或预防各种疾病的药物 ，例如 艾滋病毒感染或艾滋病（获得性免疫缺陷综合征）等。
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公开(公告)号：US06228984B1
公开(公告)日：2001-05-08
申请号：US08776971
申请日：1997-02-07
Applicant: Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
Inventor： Shuji Hinuma , Yugo Habata , Yuji Kawamata , Masaki Hosoya , Ryo Fujii , Shoji Fukusumi , Chieko Kitada
IPC: C07K1447
CPC classification number: C07H21/04 , A61K38/00 , C07K14/575 , C07K14/705 , C07K14/72 , C07K16/28
Abstract: The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.
Abstract translation: 本发明涉及用于人垂体和小鼠胰腺衍生的G蛋白偶联受体蛋白质的配体多肽。 编码配体多肽的配体多肽或DNA可用于（1）开发药物如垂体功能调节剂，中枢神经系统功能调节剂和胰腺功能调节剂，以及（2）重组受体蛋白的发育和筛选 的药物候选化合物。 特别地，通过利用根据本发明的重组G蛋白偶联受体蛋白表达的受体结合测定系统，可以筛选对人类和其他温血动物特异性的G蛋白偶联受体的激动剂和拮抗剂， 获得的激动剂或拮抗剂可用作各种疾病的治疗和预防剂。
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5.发明授权公开(公告)号：US09695507B2
公开(公告)日：2017-07-04
申请号：US14128371
申请日：2012-05-31
Applicant: Ryo Fujii , Masaru Nakamura , Yoshio Imahori , Masaharu Hoshi
Inventor： Ryo Fujii , Masaru Nakamura , Yoshio Imahori , Masaharu Hoshi
Abstract: Provided are an automatic lithium target regenerating apparatus and an automatic lithium target regenerating method, which are equipped with a measurement function of a lithium film thickness of a lithium target, and may automatically regenerate the consumed lithium target by moving a vapor deposition source to the lithium target. An automatic lithium target regenerating apparatus (106) is allowed to automatically regenerate lithium of a lithium target. The automatic lithium target regenerating apparatus (106) includes a lithium vapor deposition unit (1) for vapor-depositing the lithium on the lithium target. The lithium vapor deposition unit (1) is allowed to vapor-deposit the lithium on the lithium target by moving to the lithium target side.
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Patent Agency Ranking
6.发明授权公开(公告)号：US07927821B2
公开(公告)日：2011-04-19
申请号：US11578325
申请日：2005-04-11
Applicant: Ryo Fujii , Shoichi Okubo , Kazunori Nishi , Shuji Hinuma , Masaaki Mori
Inventor： Ryo Fujii , Shoichi Okubo , Kazunori Nishi , Shuji Hinuma , Masaaki Mori
IPC: G01N33/53 , G01N33/567 , G01N33/566 , C07K1/00 , C07K14/00 , C07K17/00
CPC classification number: G01N33/76 , A61K31/403 , A61K31/4155 , A61K31/4523 , A61K38/1796 , C07K14/705 , G01N2333/726
Abstract: The present invention provides a method of screening an agonist or antagonist to a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and the ligand or a salt thereof; etc. The present invention is useful for screening agents for the prevention/treatment of, e.g., leukopenia, leukemia, lymphoma, malignant tumor, ulcerative colitis, rheumatoid arthritis, inflammatory bowel disorders, tonsil disorders, collagen disease, inflammatory disease, leukocytosis, heart failure, inherited muscle disorders, muscular dystrophy, neuromuscular degenerative disease, myocardial infarction, obesity, mellitus diabetes, hyperlipemia, arteriosclerosis, metabolic syndrome, thrombocytopenia, thrombocytosis, cancer, pulmonary edema, multiple organ failure, etc.
Abstract translation: 本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含 使用受体蛋白或其盐和配体或其盐; 本发明可用于预防/治疗例如白细胞减少症，白血病，淋巴瘤，恶性肿瘤，溃疡性结肠炎，类风湿性关节炎，炎性肠病，扁桃体病，胶原病，炎性疾病，白细胞增多症，心脏病 失败，遗传性肌肉疾病，肌营养不良症，神经肌肉退行性疾病，心肌梗死，肥胖症，糖尿病，高脂血症，动脉硬化，代谢综合征，血小板减少症，血小板增多症，癌症，肺水肿，多器官衰竭等。
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公开(公告)号：US07833722B2
公开(公告)日：2010-11-16
申请号：US11587631
申请日：2005-04-26
Applicant: Ryo Fujii , Masataka Harada , Shuji Hinuma
Inventor： Ryo Fujii , Masataka Harada , Shuji Hinuma
IPC: G01N33/53
CPC classification number: C07K14/705 , A61K31/7088 , A61K38/00 , G01N33/6896 , G01N33/74 , G01N2333/726 , G01N2500/04
Abstract: The present invention provides a method of screening an agonist/antagonist of a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or its salt and a ligand or its salt; and so on. The screening method of the present invention is useful for screening an agent for the prevention/treatment of nervous system diseases or neuropathic pains.
Abstract translation: 本发明提供筛选G蛋白偶联受体蛋白激动剂/拮抗剂的方法，其包含与SEQ ID NO：1所示的氨基酸序列相同或基本上相同的氨基酸序列，或其盐，其包含 使用受体蛋白或其盐和配体或其盐; 等等。 本发明的筛选方法可用于筛选用于预防/治疗神经系统疾病或神经性疼痛的药剂。
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8.发明授权Method of screening compounds which alter the binding properties of GPR39, and homologs thereof, to bile acid 有权筛选将GPR39的结合特性及其同系物改变为胆汁酸的化合物的方法公开(公告)号：US07781175B2
公开(公告)日：2010-08-24
申请号：US11587285
申请日：2005-04-22
Applicant: Ryo Fujii , Kazunori Nishi , Yasuhiro Tanaka , Masaaki Mori
Inventor： Ryo Fujii , Kazunori Nishi , Yasuhiro Tanaka , Masaaki Mori
IPC: G01N33/53 , G01N33/567
CPC classification number: G01N33/566 , G01N2333/726 , G01N2500/00 , Y10S435/975
Abstract: The present invention relates to screening of an agonist/antagonist, etc. Specifically, the present invention provides a method of screening an agonist or antagonist of a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, which comprises using the receptor protein or a salt thereof and a cholesterol metabolism-related substance, and so on.
Abstract translation: 本发明涉及激动剂/拮抗剂等的筛选。具体而言，本发明提供筛选G蛋白偶联受体蛋白的激动剂或拮抗剂的方法，其包含与氨基酸相同或基本上相同的氨基酸序列 由SEQ ID NO：1表示的序列或其盐，其包括使用受体蛋白质或其盐和胆固醇代谢相关物质等。
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公开(公告)号：US20090233854A1
公开(公告)日：2009-09-17
申请号：US12097622
申请日：2006-12-19
Applicant: Ryo Fujii
Inventor： Ryo Fujii
CPC classification number: A61K38/1709
Abstract: The present invention provides a preventive/therapeutic agent for mood disorders or drug dependence, and so on. A pharmaceutical composition of the present invention comprising a substance promoting the function of an apelin receptor APJ or the like is useful as the preventive/therapeutic agent for mood disorders, drug dependence, etc.
Abstract translation: 本发明提供了用于情绪障碍或药物依赖性的预防/治疗剂等。 包含促进apelin受体APJ等的功能的本发明的药物组合物可用作情绪障碍，药物依赖性等的预防/治疗剂。
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公开(公告)号：US07517661B2
公开(公告)日：2009-04-14
申请号：US10554234
申请日：2004-04-22
Applicant: Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
Inventor： Makoto Kobayashi , Yugo Habata , Ryo Fujii , Shuji Hinuma
IPC: G01N33/567 , C07K14/705
CPC classification number: G01N33/74 , A61K38/177 , G01N2333/726 , G01N2500/04
Abstract: The use of a G-protein coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof and a ligand peptide comprising the amino acid sequence represented by any of SEQ ID NO: 3 to 7, or a salt thereof, enables efficient screening of an agonist or antagonist for the above receptor protein or a salt thereof.
Abstract translation: 使用包含与SEQ ID NO：1所示的氨基酸序列相同或基本相同的氨基酸序列的G蛋白偶联受体蛋白或其盐和配体肽，所述配体肽包含由SEQ ID NO： SEQ ID NO：3至7或其盐能够有效筛选上述受体蛋白质的激动剂或拮抗剂或其盐。
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