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    Four-roller type sizing mill apparatus for producing round steel rods
    1.
    发明授权
    Four-roller type sizing mill apparatus for producing round steel rods 失效
    用于生产圆钢棒的四辊式上浆机设备

    公开(公告)号：US5363682A

    公开(公告)日：1994-11-15

    申请号：US982982

    申请日：1992-11-30

    申请人： Ryo Takeda ,  Eisuke Yamanaka ,  Hidenori Kondo ,  Kiyoji Ino ,  Hiroshi Hagihara ,  Takaya Suzuki ,  Sadao Yoshizawa ,  Atsumu Nakamura

    发明人： Ryo Takeda ,  Eisuke Yamanaka ,  Hidenori Kondo ,  Kiyoji Ino ,  Hiroshi Hagihara ,  Takaya Suzuki ,  Sadao Yoshizawa ,  Atsumu Nakamura

    IPC分类号： B21B1/18 ,  B21B13/12 ,  B21B31/18 ,  B21B31/26 ,  B21B35/10 ,  B21B35/04

    CPC分类号： B21B13/12 ,  B21B1/18 ,  B21B2203/182 ,  B21B31/18 ,  B21B31/26 ,  B21B35/10

    摘要： A four-roller type sizing mill apparatus for forming round steel rods, comprises two four-roller mills each having two pair of facing rollers. One pair of facing rollers is arranged in rolling direction perpendicular to the rolling direction of the other pair of rollers. The two four-roller mills are arranged in line, with the rolling direction of one of the two four-roller mills being shifted by 45.degree. from the rolling direction of the other four-roller mill. The two pair of rollers of a first four-roller mill positioned closer to the rolling material inlet are separated from each other by a distance which is greater than zero and not greater than five times the projected contact length of one of the pair of rollers positioned closer to the rolling material inlet. The distance is measured between a first standard straight line which passes through the centers of one of the pair of rollers and lies on a plane parallel to the side surfaces of the same pair of rollers and a second standard straight line obtained by projecting the axes of the other pair of rollers onto the above-mentioned plane.

    摘要翻译： 用于形成圆钢棒的四辊式定型磨机装置包括两个四辊磨机，每个具有两对面对辊。 一对面对辊沿垂直于另一对辊的轧制方向的轧制方向布置。 两个四辊磨机排列成一列，两个四辊磨机之一的轧制方向从另一个四辊磨机的轧制方向偏移45°。 位于更靠近轧制材料入口的第一个四辊磨机的两对辊彼此分开一段距离，该距离大于零和不大于定位的一对辊之一的投影接触长度的五倍 更靠近滚动材料入口。 在通过一对辊中的一个辊的中心并位于平行于同一对辊的侧表面的平面上的第一标准直线之间测量距离，以及通过将 另一对辊到上述平面上。

    Microorganism and method for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using the novel microorganism
    2.
    发明授权
    Microorganism and method for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using the novel microorganism 有权
    微生物和使用新型微生物制备十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃中间体的方法

    公开(公告)号：US08084237B2

    公开(公告)日：2011-12-27

    申请号：US12280067

    申请日：2006-12-21

    申请人： Kazuaki Igarashi ,  Shuichi Takizawa ,  Norihiko Higaki ,  Hiroshi Hagihara

    发明人： Kazuaki Igarashi ,  Shuichi Takizawa ,  Norihiko Higaki ,  Hiroshi Hagihara

    IPC分类号： C12P17/04 ,  C12N1/16 ,  C12N1/14

    CPC分类号： C12N1/14 ,  C12P17/04

    摘要： This invention relates to a novel microorganism that efficiently produces a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. As a result of concentrated studies, a plurality of novel microorganisms having properties of interest that are not classified as conventional microorganisms were isolated and identified. The novel microorganism of the present invention belongs to Ascomycetes and has the ability of producing a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. Such microorganism of Ascomycetes represents a new finding and it can be effective for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan and an intermediate thereof.

    摘要翻译： 本发明涉及一种利用香紫苏醇作为底物有效生产十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃中间体的新型微生物。 作为浓缩研究的结果，分离并鉴定出许多具有未分类为常规微生物的感兴趣的新型微生物。 本发明的新型微生物属于子囊菌纲，具有使用香紫苏醇作为底物生产十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃中间体的能力。 子囊菌的这种微生物代表新的发现，对于生产十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃及其中间体是有效的。

    Mutant alpha-amylases
    3.
    发明申请
    Mutant alpha-amylases 审中-公开
    突变型α-淀粉酶

    公开(公告)号：US20050181493A1

    公开(公告)日：2005-08-18

    申请号：US10988529

    申请日：2004-11-16

    申请人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    发明人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    IPC分类号： C11D3/386 ,  C12N1/21 ,  C12N9/28 ,  C12N15/56 ,  C11D7/42

    CPC分类号： C12N9/2417 ,  C11D3/386

    摘要： The invention relates to a mutant α-amylase obtained by making replacement or deletion of at least one of amino acid residues such as the 167th Gln, 169th Tyr and 178th Ala in the amino acid sequence set forth in SEQ ID NO:1 in an α-amylase having said amino acid sequence, or an α-amylase having a homology of at least 70% to said amino acid sequence, a gene encoding the mutant α-amylase, a vector, transformed cells, a process for producing a mutant α-amylase, comprising culturing the transformed cells, and a detergent composition comprising the mutant α-amylase. The mutant α-amylase of the invention has excellent properties of high resistance to chelating agents, high specific activity in an alkaline region and excellent stability to heat, and is hence useful for detergents for automatic dish washer, laundry detergents and the like.

    摘要翻译： 本发明涉及通过使SEQ ID NO：1所示的氨基酸序列中的至少一个氨基酸残基例如第167位Gln，第169位和第178位氨基酸置换成α位点而获得的突变型α-淀粉酶 具有所述氨基酸序列的淀粉酶或与所述氨基酸序列具有至少70％同源性的α-淀粉酶，编码突变型α-淀粉酶的基因，载体，转化细胞，用于产生突变型α-淀粉酶的方法， 包括培养转化细胞的淀粉酶和包含突变型α-淀粉酶的洗涤剂组合物。 本发明的突变型α-淀粉酶具有优异的抗螯合剂抗性，在碱性区域中具有高比活性和优异的耐热稳定性，因此可用于自动洗碗机，衣物洗涤剂等的洗涤剂。

    Recombinant Microorganism and a Method for Producing Poly-Gamma-Glutamic Acid
    4.
    发明申请
    Recombinant Microorganism and a Method for Producing Poly-Gamma-Glutamic Acid 审中-公开
    重组微生物和产生多糖 - 谷氨酸的方法

    公开(公告)号：US20100248308A1

    公开(公告)日：2010-09-30

    申请号：US12678798

    申请日：2008-09-19

    申请人： Kazuhisa Sawada ,  Hiroshi Hagihara

    发明人： Kazuhisa Sawada ,  Hiroshi Hagihara

    IPC分类号： C12P21/02 ,  C12N1/21 ,  C12N15/75

    CPC分类号： C12N15/74 ,  C12N9/93 ,  C12P21/02

    摘要： A recombinant microorganism having poly-γ-glutamic acid-producing ability, prepared by introducing a Bacillus subtilis pgsB gene or a gene functionally equivalent thereto, and a Bacillus subtilis pgsC gene or a gene functionally equivalent thereto, among a group of genes relating to synthesis of poly-γ-glutamic acid, into a host microorganism, in which no Bacillus subtilis pgsA gene or a gene functionally equivalent thereto is being introduced into the host microorganism; and a method of producing poly-γ-glutamic acid employing the recombinant microorganism.

    摘要翻译： 通过引入枯草芽孢杆菌pgsB基因或与其功能等同的基因和枯草芽孢杆菌pgsC基因或与其功能等同的基因制备的具有聚-γ-谷氨酸生产能力的重组微生物 的聚-γ-谷氨酸转化成宿主微生物，其中没有将枯草芽孢杆菌pgsA基因或与其功能等同的基因导入宿主微生物; 以及使用该重组微生物生产聚-γ-谷氨酸的方法。

    Microorganism and method for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using the novel microorganism
    7.
    发明授权
    Microorganism and method for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using the novel microorganism 有权
    微生物和使用新型微生物制备十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃中间体的方法

    公开(公告)号：US08293518B2

    公开(公告)日：2012-10-23

    申请号：US13300172

    申请日：2011-11-18

    申请人： Kazuaki Igarashi ,  Shuichi Takizawa ,  Norihiko Higaki ,  Hiroshi Hagihara

    发明人： Kazuaki Igarashi ,  Shuichi Takizawa ,  Norihiko Higaki ,  Hiroshi Hagihara

    IPC分类号： C12N1/16 ,  C12N1/14 ,  C12P17/04

    CPC分类号： C12N1/14 ,  C12P17/04

    摘要： This invention relates to a novel microorganism that efficiently produces a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. As a result of concentrated studies, a plurality of novel microorganisms having properties of interest that are not classified as conventional microorganisms were isolated and identified. The novel microorganism of the present invention belongs to Ascomycetes and has the ability of producing a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. Such microorganism of Ascomycetes represents a new finding and it can be effective for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan and an intermediate thereof.

    摘要翻译： 本发明涉及一种利用香紫苏醇作为底物有效生产十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃中间体的新型微生物。 作为浓缩研究的结果，分离并鉴定出许多具有未分类为常规微生物的感兴趣的新型微生物。 本发明的新型微生物属于子囊菌纲，具有使用香紫苏醇作为底物生产十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃中间体的能力。 子囊菌的这种微生物代表新的发现，对于生产十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃及其中间体是有效的。

    Mutant α-amylases
    8.
    发明授权
    Mutant α-amylases 失效
    突变型α-淀粉酶

    公开(公告)号：US07078212B1

    公开(公告)日：2006-07-18

    申请号：US09590375

    申请日：2000-06-09

    申请人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    发明人： Keiji Endo ,  Kazuaki Igarashi ,  Yasuhiro Hayashi ,  Hiroshi Hagihara ,  Katsuya Ozaki

    IPC分类号： C12N9/26 ,  C12N9/28 ,  C07H21/04

    CPC分类号： C12N9/2417 ,  C11D3/386

    摘要： The invention relates to a mutant α-amylase obtained by making replacement or deletion of at least one of amino acid residues such as the 167th Gln, 169th Tyr and 178th Ala in the amino acid sequence set forth in SEQ ID NO:1 in an α-amylase having said amino acid sequence, or an α-amylase having a homology of at least 70% to said amino acid sequence, a gene encoding the mutant α-amylase, a vector, transformed cells, a process for producing a mutant α-amylase, comprising culturing the transformed cells, and a detergent composition comprising the mutant α-amylase.The mutant α-amylase of the invention has excellent properties of high resistance to chelating agents, high specific activity in an alkaline region and excellent stability to heat, and is hence useful for detergents for automatic dish washer, laundry detergents and the like.

    摘要翻译： 本发明涉及通过使SEQ ID NO：1所示的氨基酸序列中的至少一个氨基酸残基例如第167位Gln，第169位和第178位氨基酸置换成α位点而获得的突变型α-淀粉酶 具有所述氨基酸序列的淀粉酶或与所述氨基酸序列具有至少70％同源性的α-淀粉酶，编码突变型α-淀粉酶的基因，载体，转化细胞，用于产生突变型α-淀粉酶的方法， 包括培养转化细胞的淀粉酶和包含突变型α-淀粉酶的洗涤剂组合物。 本发明的突变型α-淀粉酶具有优异的抗螯合剂抗性，在碱性区域中具有高比活性和优异的耐热稳定性，因此可用于自动洗碗机，衣物洗涤剂等的洗涤剂。