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    RECOMBINANT AVIAN INFECTIOUS CORYZA VACCINE AND PROCESS FOR PREPARING SAME
    1.
    发明申请
    RECOMBINANT AVIAN INFECTIOUS CORYZA VACCINE AND PROCESS FOR PREPARING SAME 审中-公开
    重组AVIAN感染性CORYZA VACCINE及其制备方法

    公开(公告)号：US20130183330A1

    公开(公告)日：2013-07-18

    申请号：US13616255

    申请日：2012-09-14

    申请人： Ryuichi SAKAMOTO ,  Susumu Baba ,  Masashi Sakaguchi ,  Hiroshi Mizokami

    发明人： Ryuichi SAKAMOTO ,  Susumu Baba ,  Masashi Sakaguchi ,  Hiroshi Mizokami

    IPC分类号： A61K39/02

    CPC分类号： A61K39/02 ,  A61K39/102 ,  C07K14/465

    摘要： A recombinant avian infectious coryza vaccine and a process for preparing the same are provided. A process for preparing a recombinant avian infectious coryza vaccine which comprises step of constructing E. coli that may produce as an inclusion body a fusion peptide consisting of peptides derived from outer-membrane protein of Avibacterium paragarinarum serotype A and serotype C, step of culturing said E. coli and colleting and purifying inclusion body from culture, and step of preparing a preparation comprising said purified inclusion body, and an avian infectious coryza vaccine comprising as an active ingredient the fusion peptide. A linker sequence may be inserted between the respective peptides comprising the fusion peptide. For the peptide derived from the serotypes A and C, an amino acid sequence region of Region 2 or its vicinity responsible for protection from infection may be used.

    摘要翻译： 提供了重组禽传染性鼻炎疫苗及其制备方法。 一种制备重组禽传染性鼻炎疫苗的方法，其包括构建可以产生作为包涵体的大肠杆菌的步骤，所述融合肽由衍生自副杆菌素A型血清型A和血清型C的外膜蛋白的肽组成，培养所述 大肠杆菌和来自培养物的收集和纯化包涵体，以及制备包含所述纯化的包涵体的制剂的步骤和包含作为活性成分的融合肽的禽传染性疫苗疫苗的步骤。 可以在包含融合肽的各个肽之间插入接头序列。 对于源自血清型A和C的肽，可以使用负责防止感染的区域2或其附近的氨基酸序列区域。

    Recombinant avian infectious coryza vaccine and process for preparing same
    2.
    发明授权
    Recombinant avian infectious coryza vaccine and process for preparing same 有权
    重组禽传染性鼻炎疫苗及其制备方法

    公开(公告)号：US08647634B2

    公开(公告)日：2014-02-11

    申请号：US13142178

    申请日：2009-12-24

    申请人： Ryuichi Sakamoto ,  Susumu Baba ,  Masashi Sakaguchi ,  Hiroshi Mizokami

    发明人： Ryuichi Sakamoto ,  Susumu Baba ,  Masashi Sakaguchi ,  Hiroshi Mizokami

    IPC分类号： A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61K39/38 ,  A01N63/00

    CPC分类号： A61K39/02 ,  A61K39/102 ,  C07K14/465

    摘要： A recombinant avian infectious coryza vaccine and a process for preparing the same are provided. A process for preparing a recombinant avian infectious coryza vaccine which comprises step of constructing E. coli that may produce as an inclusion body a fusion peptide consisting of peptides derived from outer-membrane protein of Avibacterium paragarinarum serotype A and serotype C, step of culturing said E. coli and collecting and purifying inclusion body from culture, and step of preparing a preparation comprising said purified inclusion body, and an avian infectious coryza vaccine comprising as an active ingredient the fusion peptide. A linker sequence may be inserted between the respective peptides comprising the fusion peptide. For the peptide derived from the serotypes A and C, an amino acid sequence region of Region 2 or its vicinity responsible for protection from infection may be used.

    摘要翻译： 提供了重组禽传染性鼻炎疫苗及其制备方法。 一种制备重组禽传染性鼻炎疫苗的方法，其包括构建可以产生作为包涵体的大肠杆菌的步骤，所述融合肽由衍生自副杆菌素A型血清型A和血清型C的外膜蛋白的肽组成，培养所述 大肠杆菌，从培养物收集和纯化包涵体，以及制备包含所述纯化的包涵体的制剂的步骤和包含作为活性成分的融合肽的禽传染性疫苗疫苗。 可以在包含融合肽的各个肽之间插入接头序列。 对于源自血清型A和C的肽，可以使用负责防止感染的区域2或其附近的氨基酸序列区域。

    RECOMBINANT AVIAN INFECTIOUS CORYZA VACCINE AND PROCESS FOR PREPARING SAME
    3.
    发明申请
    RECOMBINANT AVIAN INFECTIOUS CORYZA VACCINE AND PROCESS FOR PREPARING SAME 有权
    重组AVIAN感染性CORYZA VACCINE及其制备方法

    公开(公告)号：US20120003257A1

    公开(公告)日：2012-01-05

    申请号：US13142178

    申请日：2009-12-24

    申请人： Ryuichi Sakamoto ,  Susumu Baba ,  Masashi Sakaguchi ,  Hiroshi Mizokami

    发明人： Ryuichi Sakamoto ,  Susumu Baba ,  Masashi Sakaguchi ,  Hiroshi Mizokami

    IPC分类号： A61K39/02 ,  C12P21/02 ,  C12P21/00 ,  A61P37/04 ,  A61P31/04

    CPC分类号： A61K39/02 ,  A61K39/102 ,  C07K14/465

    摘要： A recombinant avian infectious coryza vaccine and a process for preparing the same are provided. A process for preparing a recombinant avian infectious coryza vaccine which comprises step of constructing E. coli that may produce as an inclusion body a fusion peptide consisting of peptides derived from outer-membrane protein of Avibacterium paragarinarum serotype A and serotype C, step of culturing said E. coli and colleting and purifying inclusion body from culture, and step of preparing a preparation comprising said purified inclusion body, and an avian infectious coryza vaccine comprising as an active ingredient the fusion peptide. A linker sequence may be inserted between the respective peptides comprising the fusion peptide. For the peptide derived from the serotypes A and C, an amino acid sequence region of Region 2 or its vicinity responsible for protection from infection may be used.

    摘要翻译： 提供了重组禽传染性鼻炎疫苗及其制备方法。 一种制备重组禽传染性鼻炎疫苗的方法，其包括构建可以产生作为包涵体的大肠杆菌的步骤，所述融合肽由衍生自副杆菌素A型血清型A和血清型C的外膜蛋白的肽组成，培养所述 大肠杆菌和来自培养物的收集和纯化包涵体，以及制备包含所述纯化的包涵体的制剂的步骤和包含作为活性成分的融合肽的禽传染性疫苗疫苗的步骤。 可以在包含融合肽的各个肽之间插入接头序列。 对于源自血清型A和C的肽，可以使用负责防止感染的区域2或其附近的氨基酸序列区域。

    CONICAL ROLLER CAGE
    6.
    发明申请
    CONICAL ROLLER CAGE 失效
    圆锥滚子笼

    公开(公告)号：US20120321237A1

    公开(公告)日：2012-12-20

    申请号：US13578928

    申请日：2011-02-22

    申请人： Isao Usuki ,  Hiroshi Ueno ,  Hirosato Nakanishi ,  Masashi Sakaguchi ,  Kazuki Hamada ,  Hironori Hiraoka

    发明人： Isao Usuki ,  Hiroshi Ueno ,  Hirosato Nakanishi ,  Masashi Sakaguchi ,  Kazuki Hamada ,  Hironori Hiraoka

    IPC分类号： F16C33/46

    CPC分类号： F16C33/6614 ,  F16C19/364 ,  F16C33/4635 ,  F16C33/4676 ,  F16C2240/46 ,  F16C2300/02

    摘要： A conical roller cage that implements a conical roller bearing that is able to suppress torque and that is able to smoothly supply lubricant to a raceway surface includes: a small-diameter annular portion, a large-diameter annular portion having a bore diameter larger than a bore diameter of the small-diameter annular portion, pillar portions that couple the small-diameter annular portion to the large-diameter annular portion and that are located at intervals from each other in a circumferential direction, roller partition wall portions each radially extending from a radial end face of a corresponding one of the pillar portions, and canopy portions each protruding from a radial end portion of a corresponding one the roller partition wall portions, at an opposite side to a side of the pillar portion, toward both sides in the circumferential direction.

    摘要翻译： 实现能够抑制扭矩并且能够平稳地将润滑剂供给到滚道表面的圆锥滚子轴承的圆锥滚子保持架包括：小直径环形部分，具有大于 所述小直径环状部的孔径，将所述小径环状部与所述大径环状部连接并且在周向上彼此间隔配置的柱部，从所述小直径环状部沿径向延伸的辊隔壁壁部 相对应的一个支柱部的径向端面和从相对应的一个的分隔壁部的与该柱部的一侧相反侧的径向端部朝向圆周方向的两侧突出的顶盖部 方向。

    Process for preparing variant of Erysipelothrix rhusiopathiae surface protective antigen in E. coli
    7.
    发明授权
    Process for preparing variant of Erysipelothrix rhusiopathiae surface protective antigen in E. coli 有权
    在大肠杆菌中制备欧洲白喉病毒性表皮保护性抗原变异体的方法

    公开(公告)号：US08277820B2

    公开(公告)日：2012-10-02

    申请号：US10590896

    申请日：2005-02-08

    申请人： Toshihiro Ushijima ,  Masashi Sakaguchi ,  Eiji Tokunaga

    发明人： Toshihiro Ushijima ,  Masashi Sakaguchi ,  Eiji Tokunaga

    IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  C12P21/06 ,  C12N15/09

    CPC分类号： C07K14/195 ,  A61K38/00 ,  A61K39/00

    摘要： A variant of Erysipelothrix rhusiopathiae surface protective antigen SpaA protein or of a shortened form of SpaA (ΔSpaA) in which a portion of SpaA protein is deleted for protection from Erysipelothrix rhusiopathiae infection and a process for preparing the same are provided. Introduction of amino acid substitution at a specific site in the amino acid sequence of SpaA or ΔSpaA protein provides a variant of SpaA or ΔSpaA protein which is immunogenic and is expressed in E. coli as inclusion bodies. The variant of SpaA or ΔSpaA protein of the present invention may easily be recovered and purified since it is expressed in E. coli as inclusion bodies.

    摘要翻译： 提供了Erysillolothrix rhasiopathiae表面保护性抗原SpaA蛋白或SpaA（＆Dgr。SpaA）的缩写形式的一种变体，其中一部分SpaA蛋白被缺失以防止欧莱氏杆菌性鼻病毒感染及其制备方法。 在SpaA或＆Dgr; SpaA蛋白的氨基酸序列中的特定位点引入氨基酸取代提供了SPAA或＆Dgr; SpaA蛋白的变体，其是免疫原性的并且在大肠杆菌中以包涵体表达。 本发明的SpaA或＆Dgr; SpaA蛋白质的变体可以容易地回收和纯化，因为其在大肠杆菌中作为包涵体表达。

    Curable composition
    8.
    发明授权
    Curable composition 失效
    可固化组合物

    公开(公告)号：US06320010B1

    公开(公告)日：2001-11-20

    申请号：US09462904

    申请日：2000-03-27

    申请人： Masashi Sakaguchi ,  Yoshimichi Yamanaka ,  Hidenari Tsunemi

    发明人： Masashi Sakaguchi ,  Yoshimichi Yamanaka ,  Hidenari Tsunemi

    IPC分类号： C08G7720

    CPC分类号： C08L23/02 ,  C08K5/5419 ,  C08L23/22 ,  C08L83/04 ,  C08L2666/02 ,  C08L83/00

    摘要： By incorporating (A) a saturated hydrocarbon polymer having more than one alkenyl group capable of being hydrosilylated in each molecule and having a molecular weight of 2,000 to 50,000, (B) a component comprising a compound containing more than two silicon atom-bound hydrogen atoms, on average, in each molecule, (C) a compound having, within the molecule, one alkenyl group capable of being hydrosilylated, (D) a compound having, within the molecule, at least two alkenyl groups capable of being hydrosilylated and having a molecular weight less than 2,000, and (E) a hydrosilylation catalyst, a composition having good mechanical characteristics, a high gel fraction and a small heating loss can be obtained. As a result, the invention can provide a composition to secure the uniformity within a wide range of selection not depending on its viscosity, because it is markedly relaxed the restriction on SiH-containing compounds that are curing agents possibly becoming a cause of said insufficient curing.

    摘要翻译： 通过并入（A）具有多于一个能够在每个分子中进行氢化硅烷化的链烯基并且分子量为2,000至50,000的饱和烃聚合物，（B）包含含有多于两个硅原子键合的氢原子的化合物 平均来说，在每个分子中，（C）在分子内具有一个能够被氢化硅烷基化的烯基的化合物，（D）在分子内具有至少两个能够被氢化硅烷化并且具有 分子量小于2,000，和（E）氢化硅烷化催化剂，可以获得具有良好机械特性，高凝胶分数和小的加热损失的组合物。 结果，本发明可以提供一种组合物，以确保在宽范围的选择范围内的均匀性，而不依赖于其粘度，因为显着地松弛了对含有SiH的化合物的限制，这些化合物是可能成为固化不足的原因的固化剂 。

    Wire Electric Discharge Machining Apparatus
    9.
    发明申请
    Wire Electric Discharge Machining Apparatus 审中-公开
    电线放电加工设备

    公开(公告)号：US20090236318A1

    公开(公告)日：2009-09-24

    申请号：US12083198

    申请日：2007-03-22

    申请人： Masashi Sakaguchi

    发明人： Masashi Sakaguchi

    IPC分类号： B23H7/02

    CPC分类号： B23H7/105 ,  B23H7/101 ,  B23H7/102 ,  B23H7/107

    摘要： A wire electric discharge machining apparatus can select a split guide formed from a pair of guide pieces, or an unsplittable dice guide, as an upper wire guide. An upper wire guide assembly includes a housing configured to selectively store the split guide or an adapter that the dice guide fitted into, and an actuator configured to move at least one of the pair of guide pieces. When the split guide is selected, a guide pipe configured to form a fluid jet can be moved downward through the upper wire guide assembly. When the dice guide is selected, an AWT jet nozzle configured to form a fluid jet can be attached to the adapter. Further, a jacket can be attached to the housing, the jacket having a fluid inlet configured to introduce fluid to be supplied to the AWT jet nozzle.

    摘要翻译： 电线放电加工装置可以选择由一对导片形成的分割引导件，或者是不可切割的引导引导件，作为上导线器。 上部线引导组件包括壳体，该壳体构造成选择性地存储分割导向件或插入导体引导件的适配器，以及构造成移动该对导向件中的至少一个的致动器。 当选择分流引导件时，构造成形成流体射流的引导管可以向下移动穿过上导丝器组件。 当选择骰子引导件时，配置成形成流体射流的AWT喷嘴可以附接到适配器。 此外，护套可以附接到壳体，护套具有被配置为引入待供应到AWT喷嘴的流体的流体入口。