公开(公告)号：US4367336A

公开(公告)日：1983-01-04

申请号：US237056

申请日：1981-02-23

申请人： Ryuzo Nishiyama ,  Kanichi Fujikawa ,  Isao Yokomichi ,  Takahiro Haga ,  Toru Koyanagi

发明人： Ryuzo Nishiyama ,  Kanichi Fujikawa ,  Isao Yokomichi ,  Takahiro Haga ,  Toru Koyanagi

IPC分类号： A01N57/16 ,  C07D213/79 ,  C07D213/84 ,  C07F9/58 ,  C07D213/55

CPC分类号： C07D213/79 ,  A01N57/16 ,  C07D213/84 ,  C07F9/582

摘要： A 2-substituted-5-trifluoromethylpyridine compound represented by Formula (I): ##STR1## wherein X is a hydrogen atom or a halogen atom, and Y is a cyano group or a carboxy group, provided that Y is a cyano group, then X is a halogen atom, or a salt thereof, and a process for the production of the same. This compound is useful as an intermediate for the production of various fine chemicals.

摘要翻译： 由式（I）表示的2-取代-5-三氟甲基吡啶化合物：其中X是氢原子或卤素原子，Y是氰基或羧基，其中Y是氰基 组，则X为卤原子或其盐，及其制备方法。 该化合物可用作生产各种精细化学品的中间体。

公开(公告)号：US5256674A

公开(公告)日：1993-10-26

申请号：US631992

申请日：1990-12-21

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Masato Omatsu ,  Hiroshi Sasaki ,  Masayuki Morita ,  Kiyomitsu Yoshida

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Masato Omatsu ,  Hiroshi Sasaki ,  Masayuki Morita ,  Kiyomitsu Yoshida

IPC分类号： A01N43/50 ,  A01N55/10 ,  A01P7/04 ,  C07D401/06 ,  C07D401/14 ,  C07D417/06 ,  C07D417/14 ,  C07F7/08 ,  C07F7/10 ,  C07F7/12 ,  A01N43/40

CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D417/06

摘要： An imidazolidine derivative having the formula (I) or its salt: ##STR1## wherein X is an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, ##STR2## (in which each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 is independently a hydrogen atom or an alkyl group, R.sup.5 is an alkyl group which may be substituted with a halogen atom, a cycloalkyl group which may be substituted or a phenyl group which may be substituted, W is an oxygen atom or a sulfur atom, and each of k, l, m and n is independently 0 or 1, provided that (a) case where all of k, l and m are 0 at the same time and (b) case where m and n are 0 at the same time and R.sup.5 is an alkyl group which may be substituted with a halogen atom, are excluded), or ##STR3## group (in which each of R.sup.6 and R.sup.7 is independently a hydrogen atom or an alkyl group, each of R.sup.8 and R.sup.9 is independently an alkyl gorup, R.sup.10 is an alkyl group which may be substituted, an aryl group which may be substituted, a pyridyl group which may be substituted, an alkenyl group which may be substituted with a halogen atom or an alkynyl group which may be substituted with a halogen atom); Y is a 6-chloro-3-pyridyl group or a 2-chloro-5-thiazolyl group; Z is a hydrogen atom, an alkyl group or an acyl group; and j is an integer of from 0 to 2.

公开(公告)号：US4727077A

公开(公告)日：1988-02-23

申请号：US823521

申请日：1986-01-29

申请人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama

发明人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama

IPC分类号： C07C273/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61K31/44 ,  A61K31/505 ,  A61K47/10 ,  A61K47/40 ,  A61K47/44 ,  C07D239/34 ,  C07D251/22 ,  A61K31/53

CPC分类号： A61K9/02 ,  A61K31/44 ,  A61K31/505 ,  A61K47/10 ,  A61K47/40 ,  A61K47/44 ,  A61K9/0019 ,  A61K9/2013 ,  A61K9/4858 ,  C07D239/34 ,  Y10S514/946

摘要： A benzoyl urea compound having the formula: ##STR1## wherein A is a bromine atom or a chlorine atom.

摘要翻译： 具有下式的苯甲酰脲化合物：其中A是溴原子或氯原子。

公开(公告)号：US4327089A

公开(公告)日：1982-04-27

申请号：US215777

申请日：1980-12-12

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Osamu Imai

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Osamu Imai

IPC分类号： A01N57/16 ,  A01N57/08 ,  A01N57/24 ,  C07D213/78 ,  C07F9/58

CPC分类号： C07D213/78 ,  A01N57/08 ,  C07F9/582

摘要： A novel O-(N-alkoxy-pyridinecarboximidoyl)-phosphate represented by the following formula: ##STR1## wherein X is a halogen atom, a lower alkyl group, a lower acyloxy group, a trifluoromethyl group or a nitro group; Y is an oxygen atom or a sulfur atom; R is a lower alkyl group; n is an integer of 0 to 3; and Z.sub.1 and Z.sub.2 are each a lower alkoxy group, a lower alkylthio group, a phenyl group which may be substituted by a lower alkyl group, a phenoxy group, a haloalkoxy group or a lower alkylamino group, useful as an active ingredient of insecticides or acaricides.

摘要翻译： 由下式表示的新型O-（N-烷氧基 - 吡啶甲酰亚胺基） - 磷酸酯：其中X为卤素原子，低级烷基，低级酰氧基，三氟甲基或硝基; Y是氧原子或硫原子; R是低级烷基; n为0〜3的整数， 并且Z 1和Z 2各自为低级烷氧基，低级烷硫基，可被低级烷基取代的苯基，苯氧基，卤代烷氧基或低级烷基氨基，可用作杀虫剂的活性成分或 杀螨剂

公开(公告)号：US4849425A

公开(公告)日：1989-07-18

申请号：US824088

申请日：1986-01-30

申请人： Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Tadakazu Suyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

发明人： Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Tadakazu Suyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

IPC分类号： C07C273/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61K31/44 ,  A61K31/505 ,  A61K47/10 ,  A61K47/40 ,  A61K47/44 ,  C07D239/34

CPC分类号： A61K9/02 ,  A61K31/44 ,  A61K31/505 ,  A61K47/10 ,  A61K47/40 ,  A61K47/44 ,  A61K9/0019 ,  A61K9/2013 ,  A61K9/4858 ,  C07D239/34 ,  Y10S514/946

摘要： A pharmaceutical composition comprises a benzoyl urea compound having the formula: ##STR1## wherein X is a nitro group, Y is a chlorine atom, Z.sub.2 is a hydrogen atom, Z.sub.1 is a halogen atom, and A is a nitrogen atom, and at least one member selected from the group consisting of a cyclodextrin, a polyethylene glycol and a refined oil.

公开(公告)号：US4783451A

公开(公告)日：1988-11-08

申请号：US878266

申请日：1986-06-25

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Hiroshi Okada ,  Kiyomitsu Yoshida ,  Osamu Imai

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Hiroshi Okada ,  Kiyomitsu Yoshida ,  Osamu Imai

IPC分类号： A01N57/32 ,  C07F9/553 ,  C07F9/572 ,  C07F9/59 ,  C07F9/6503 ,  C07F9/653 ,  C07F9/6533 ,  C07F9/6539 ,  C07F9/6544 ,  C07F9/6558 ,  C07F9/40

CPC分类号： C07F9/5721 ,  A01N57/32 ,  C07F9/5532 ,  C07F9/591 ,  C07F9/65032 ,  C07F9/653 ,  C07F9/6533 ,  C07F9/6539 ,  C07F9/6544 ,  C07F9/65586

摘要： An organophosphorus compound having the formula: ##STR1## wherein X is ##STR2## Z is an oxygen atom or a sulfur atom, and each of R.sub.1 and R.sub.2 is an alkyl group which may be substituted by halogen, alkoxy or alkylthio. The compound is useful as an insecticide, miticide, nematicide or soil pesticide.

摘要翻译： 具有下式的有机磷化合物：其中X是氧原子或硫原子，R 1和R 2各自是烷基 其可以被卤素，烷氧基或烷硫基取代。 该化合物可用作杀虫剂，杀螨剂，杀线虫剂或土壤农药。

公开(公告)号：US5102884A

公开(公告)日：1992-04-07

申请号：US554449

申请日：1990-07-19

申请人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

发明人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

IPC分类号： A61K31/505 ,  C07C237/42 ,  C07C275/46 ,  C07C311/31 ,  C07D239/34 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

CPC分类号： C07D239/34 ,  C07C237/42 ,  C07C311/31

摘要： A substituted benzoylurea compound of the formula (I): ##STR1## wherein R.sup.1 is a hydrogen atom, a halogen atom or a nitro group, each of R.sup.2 and R.sup.3 is a hydrogen atom, an alkyl group, --COR.sup.6 (wherein R.sup.6 is an alkyl group or an alkoxy group) or --SO.sub.2 R.sup.6 (wherein R.sup.6 is as defined above), or R.sup.2 and R.sup.3 may form together with the adjacent nitrogen atom a heterocyclic ring, R.sup.4 is a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkylthio group or a nitro group, and R.sup.5 is a halogen atom, a nitro group or a substituted or unsubstituted alkyl group, or its salt.

公开(公告)号：US4987135A

公开(公告)日：1991-01-22

申请号：US324559

申请日：1989-03-16

申请人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

发明人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Hiroshi Okada

IPC分类号： C07D295/12 ,  A61K31/50 ,  A61K31/505 ,  A61P35/00 ,  C07C257/08 ,  C07C275/54 ,  C07C313/34 ,  C07C323/44 ,  C07C327/58 ,  C07C329/04 ,  C07C381/04 ,  C07C381/08 ,  C07D213/64 ,  C07D213/81 ,  C07D237/14 ,  C07D239/34 ,  C07D295/155 ,  C07D401/12 ,  C07F9/24 ,  C07F9/6512

CPC分类号： C07D213/64 ,  C07C257/08 ,  C07C327/58 ,  C07D237/14 ,  C07D239/34 ,  C07D295/155 ,  C07D401/12 ,  C07F9/65127 ,  C07C2101/08 ,  C07C2101/14

摘要： A substituted benzene derivative represented by a formula: ##STR1## where A represents: ##STR2## wherein X is a hydrogen atom, a halogen atom or a nitro group, R.sup.1 is --X.sup.1 Z.sup.1 (X.sup.1 is an oxygen atom or a sulfur atom and Z.sup.1 is a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group), --COZ.sup.1 group (Z.sup.1 is as defined above), ##STR3## group (Z.sup.1 is as defined above, Z.sup.2 is --CO.sub.2 Z.sup.3 wherein Z.sup.3 is the same as Z.sup.1, or --SO.sub.2 Z.sup.3 wherein Z.sup.3 is as defined above and n is 0 or 1), ##STR4## (Z.sup.1 and Z.sup.3 are as defined above) or ##STR5## (X.sup.2, X.sup.3 and X.sup.4 are, respectively, an oxygen atom or a sulfur atom and Z.sup.4 and Z.sup.5 are the same as Z.sup.1), and R.sup.3 is a nitro group or ##STR6## (R.sup.4 and R.sup.5 are, respectively, an alkyl group, or they may form a heterocyclic group together with the adjacent nitrogen atom), or ##STR7## wherein X and R.sup.3 are as defined above and R.sup.2 is --X.sup.1 Z.sup.1 (X.sup.1 and Z.sup.1 are as defined above); Y is a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted or unsubstituted alkylthio group, a nitro group or ##STR8## (R.sup.6 and R.sup.7 are, respectively, a substituted or unsubstituted alkyl group); R is ##STR9## (R.sup.8 is the same as Y and q is an integer of 1 to 4), ##STR10## (R.sup.8 is as defined above, and r is an integer of 1 to 3) or ##STR11## (R.sup.8 and r are defined above); and m is an integer, of 1 to 4, or its salt.

公开(公告)号：US4985449A

公开(公告)日：1991-01-15

申请号：US365607

申请日：1989-06-13

申请人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Yasuhiro Fujii ,  Kiyomitsu Yoshida ,  Osamu Imai

发明人： Takahiro Haga ,  Tadaaki Toki ,  Toru Koyanagi ,  Yasuhiro Fujii ,  Kiyomitsu Yoshida ,  Osamu Imai

IPC分类号： A01N43/40 ,  A01N47/34 ,  A01N47/36 ,  A01P7/04 ,  C07C275/54 ,  C07D213/64 ,  C07D213/643 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D333/38

CPC分类号： C07D213/643 ,  A01N47/34 ,  A01N47/36 ,  C07C275/54 ,  C07D213/70 ,  C07D213/74 ,  C07D213/75 ,  C07D333/38

摘要： A benzoylurea compound having the formula: ##STR1## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a methyl group, provided that X.sub.1 and X.sub.2 are not simultanously hydrogen atoms, Y is independently a hydrogen atom, a halogen atom, an alkyl group which may be substituted by halogen, a --CO.sub.2 R.sub.1 group wherein R.sub.1 is a hydrogen atom, a cation or an alkyl group, or a --OR.sub.1 group wherein R.sub.1 is as defined above, A.sub.1 is .dbd.N-- or ##STR2## wherein Y is as defined above, W is an oxygen atom, a sulfur atom or ##STR3## wherein R.sub.1 is as defined above, k is an integer of from 1 to 3, l is 0 or 1, and Ar is ##STR4## wherein Z is independently a hydrogen atom, a halogen atom, an alkyl group which may be substituted by halogen, an alkoxy group which may be substituted by halogen, a nitro group, a cyano group or a --S(O).sub.n R.sub.2 group wherein R.sub.2 is an alkyl group which may be substituted by halogen and n is 0, 1 or 2, A.sub.2 is --S--, ##STR5## wherein Z is as defined above, or ##STR6## wherein Z is as defined above, and m is an integer of from 1 to 3, or a salt thereof.

公开(公告)号：US4983605A

公开(公告)日：1991-01-08

申请号：US110284

申请日：1987-10-20

申请人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

发明人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

IPC分类号： A61K9/14 ,  A61K9/19 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505 ,  A61K47/14 ,  A61K47/26

CPC分类号： A61K31/505 ,  A61K31/44 ,  A61K31/50 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K47/14 ,  A61K47/26 ,  Y10S514/961 ,  Y10S514/964

摘要： A pharmaceutical composition comprising a benzoyl urea compound (A) selected from the group consisting of a benzoyl urea compound (I) having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, and a benzoyl urea compound (II) having the formula: ##STR2## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.1 is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, as an active ingredient; a nonionic surfactant as a dispersant; and at least one member selected from the group consisting of a saccharide, a saccharide alcohol, silicic anhydride and a nonionic surfactant, as a disintegrator.

摘要翻译： 提供一种药物组合物，其包含选自具有下式的苯甲酰脲化合物（I）的苯甲酰脲化合物（A）：其中X为卤素原子，硝基或三氟甲基，其提供 当Y为硝基时，X为卤原子或硝基，Y为氢原子，卤原子，硝基或三氟甲基，Z1为卤原子或三氟甲基，Z2为氢 原子或卤素原子，A为= CH-基或氮原子，和具有下式的苯甲酰脲化合物（II）：其中X1和X2各自为氢原子，卤素 原子或硝基，条件是当Y为硝基时，X 1为氢原子，Y为氢原子，卤素原子，硝基或三氟甲基，Z为氢原子，卤素原子或 三氟甲基作为活性成分; 作为分散剂的非离子表面活性剂; 和选自糖，糖醇，硅酸酐和非离子表面活性剂的至少一种作为崩解剂。