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公开(公告)号：US20200347432A1
公开(公告)日：2020-11-05
申请号：US16863603
申请日：2020-04-30
发明人： Kristin Baker , Kelly Flentie , Aleksandar Vacic , Eric Stern , Ali Ersen , Benjamin R. Spears , Matthew Briscoe
摘要： Continuous monitoring of blood cultures using pH- (or CO2—) based detection platforms is the current clinical gold standard. Despite the ubiquity of these systems in state-of-the-art clinical microbiology laboratories, they offer slow times-to-result (TTR) because microorganism detection typically requires >109 colony forming units (CFU) to be present whereas only 1-1000 CFU are typically present in septic patient blood samples. These TTRs are further lengthened for samples collected from spoke sites in consolidated hub-and-spoke laboratory models, an increasingly common model for integrated hospital networks and reference laboratories, because sample transport time, typically >4 hours, is lost. Here we introduce new methods that allow microorganisms to be detected at
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公开(公告)号：US20180088141A1
公开(公告)日：2018-03-29
申请号：US15829710
申请日：2017-12-01
发明人： Aleksandar Vacic , Nathan Purmort , Eric Stern , Anna Passernig , Paul Otten , Randy Tragni , Rohan Hayes , Andriy Tsupryk , Bruce Richardson
CPC分类号： G01N35/02 , B01J20/041 , C12M33/10 , C12M41/36 , C12M41/48 , C12M47/02 , C12Q1/18 , G01N21/01 , G01N35/00 , G01N35/0099 , G01N35/028 , G01N35/1065 , G01N2021/0112 , G01N2035/00118 , G01N2035/00237 , G01N2035/00346 , G01N2035/00356 , G01N2035/00465 , G01N2035/00485 , G01N2035/00524 , G01N2035/00841 , G01N2035/0425
摘要： In some aspects, automated rapid antimicrobial susceptibility testing systems for performing a multi-assay testing sequence can include an automated incubation assembly having a nest assembly adapted to house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, the incubation assembly facilitating incubation of one or more test panels in order to undergo the multi-assay testing sequence; a robotic handling assembly configured to accept one or more incoming test panels and move them to and from the incubation assembly for incubation between each assay of the multi-assay testing sequence; an automated liquid handling assembly configured to exchange one or more fluids in the plurality of wells of the test panels; and an optical assembly for interrogation and readout of each assay of the multi-assay testing sequence being performed in the plurality of wells.
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公开(公告)号：US20160047816A1
公开(公告)日：2016-02-18
申请号：US14809116
申请日：2015-07-24
IPC分类号： G01N33/58
CPC分类号： G01N33/587 , B82Y15/00
摘要： Among other things, the present invention provides assay methods for detecting or quantifying one or more analytes in a sample, which involve the use of dissociable nanoparticles that comprise one or more signaling agents (e.g., the nanoparticles conceal or partially conceal the signaling agents).
摘要翻译： 除其他之外，本发明提供了用于检测或定量样品中的一种或多种分析物的测定方法，其涉及使用包含一种或多种信号传导剂（例如纳米颗粒隐藏或部分隐藏信号传导剂）的可离解纳米颗粒。
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公开(公告)号：US20240069049A1
公开(公告)日：2024-02-29
申请号：US18488369
申请日：2023-10-17
发明人： Aleksandar Vacic , Nathan Purmort , Eric Stern , Anna Passernig , Paul Otten , Randy Tragni , Ronan Hayes , Andriy Tsupryk , Bruce Richardson
CPC分类号： G01N35/02 , B01J20/041 , C12Q1/18 , G01N21/01 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/028 , G01N35/1065 , C12M47/02
摘要： In some aspects, automated rapid antimicrobial susceptibility testing systems for performing a multi-assay testing sequence can include an automated incubation assembly having a nest assembly adapted to house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, the incubation assembly facilitating incubation of one or more test panels in order to undergo the multi-assay testing sequence; a robotic handling assembly configured to accept one or more incoming test panels and move them to and from the incubation assembly for incubation between each assay of the multi-assay testing sequence; an automated liquid handling assembly configured to exchange one or more fluids in the plurality of wells of the test panels; and an optical assembly for interrogation and readout of each assay of the multi-assay testing sequence being performed in the plurality of wells.
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公开(公告)号：US11268126B2
公开(公告)日：2022-03-08
申请号：US16367081
申请日：2019-03-27
IPC分类号： C12Q1/18 , B01L3/02 , B01L3/00 , G01N33/569 , G01N35/00
摘要： An improved system, method and interface for automated rapid antimicrobial susceptibility testing (AST) is disclosed which includes, in one aspect, a carrier population station comprising a workstation having a graphic user interface (GUI). The GUI accepts information from a lab technologist, including information related to a scope of testing to be performed on a microorganism containing sample. The GUI controls intelligent assignment of microorganism containing samples to test panels in a manner that maximize utilization of the test carrier by grouping together samples of similar tests scopes and advantageously testing those samples using one multiplexed test panel. Customizing workflow in accordance with test scope to facilitate parallel processing of multiple samples advantageously reduces laboratory waste, decreases test latencies, increases AST system throughput and efficiency, and thus lowers the costs to the AST lab.
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公开(公告)号：US20200080128A1
公开(公告)日：2020-03-12
申请号：US16685737
申请日：2019-11-15
发明人： Eric Stern , Aleksandar Vacic , Benjamin Spears , Alec Flyer , Kelly Flentie
摘要： The present invention relates, in part, to methods and kits for rapidly determining antimicrobial susceptibility of microorganisms.
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公开(公告)号：US20190276871A1
公开(公告)日：2019-09-12
申请号：US15887794
申请日：2018-02-02
摘要： The present invention provides, among other things, a master cartridge for effective storage and transportation of antimicrobials, the master cartridge comprising multiple reservoir units for placing a plurality of antimicrobials at high concentration from which multiple patient cartridges could be generated for testing a plurality of biological samples, and methods for using the same.
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公开(公告)号：US20190106670A1
公开(公告)日：2019-04-11
申请号：US16152816
申请日：2018-10-05
摘要： The present disclosure is related to in vitro diagnostic devices, systems, and methods, particularly microbiological diagnostic devices. The systems and methods described herein can relate to automating incubation of samples including heating, agitation, automated loading and unloading, and considerations for limiting evaporation.
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公开(公告)号：US20170211121A1
公开(公告)日：2017-07-27
申请号：US15464240
申请日：2017-03-20
发明人： Eric Stern , Aleksandar Vacic , Benjamin Spears , Kelly Flentie , Alec Flyer
CPC分类号： C12Q1/18 , C12Q1/025 , G01N2333/195 , G01N2458/00 , G01N2500/10
摘要： The present invention relates, in part, to methods and kits for rapidly determining antimicrobial susceptibility of microorganisms.
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公开(公告)号：US11828766B2
公开(公告)日：2023-11-28
申请号：US16226164
申请日：2018-12-19
发明人： Aleksandar Vacic , Nathan Purmort , Eric Stern , Anna Passernig , Paul Otten , Randy Tragni , Ronan Hayes , Andriy Tsupryk , Bruce Richardson
IPC分类号： G01N35/02 , G01N35/00 , G01N35/10 , B01J20/04 , C12Q1/18 , G01N21/01 , C12M1/00 , C12M1/26 , C12M1/36 , C12M1/34 , G01N35/04 , G01N15/02
CPC分类号： G01N15/02 , B01J20/041 , C12Q1/18 , G01N21/01 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/028 , G01N35/1065 , C12M33/10 , C12M41/36 , C12M41/48 , C12M47/02 , G01N2021/0112 , G01N2035/00039 , G01N2035/00118 , G01N2035/00148 , G01N2035/00237 , G01N2035/00346 , G01N2035/00356 , G01N2035/00465 , G01N2035/00485 , G01N2035/00524 , G01N2035/00841 , G01N2035/0425
摘要： In some aspects, automated rapid antimicrobial susceptibility testing systems for performing a multi-assay testing sequence can include an automated incubation assembly having a nest assembly adapted to house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, the incubation assembly facilitating incubation of one or more test panels in order to undergo the multi-assay testing sequence; a robotic handling assembly configured to accept one or more incoming test panels and move them to and from the incubation assembly for incubation between each assay of the multi-assay testing sequence; an automated liquid handling assembly configured to exchange one or more fluids in the plurality of wells of the test panels; and an optical assembly for interrogation and readout of each assay of the multi-assay testing sequence being performed in the plurality of wells.
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