公开(公告)号：US20240142415A1

公开(公告)日：2024-05-02

申请号：US18382398

申请日：2023-10-20

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Shinjiro FUJITA ,  Junichi TANIGUCHI

IPC: G01N30/72 ,  H01J49/42

CPC classification number: G01N30/7233 ,  H01J49/4215 ,  G01N2030/027

Abstract: For a low-cost, high-accuracy tuning of the voltages applied to electrodes in a mass spectrometer, a chromatograph mass spectrometer (1) includes: a medium supplier (11) which supplies a medium as a mobile phase or carrier gas; a passage (15) which introduces, into the mass spectrometer, the medium supplied from the medium supplier; an ionizer (211) which ionizes the medium together with a substance coming from a member forming the passage into the medium; a measurement executer (25, 26, 43) which performs a mass separation and a measurement of a specific ion, using multiple measurement conditions which differ from each other in the value of voltage applied to at least one electrode included in one or more electrodes in the mass spectrometer; and a voltage value determiner (44) which determines the value of voltage applied to each electrode so that the intensity of the ion satisfies a predetermined criterion.

公开(公告)号：US20210210333A1

公开(公告)日：2021-07-08

申请号：US17059683

申请日：2018-06-01

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Shinjiro FUJITA

IPC: H01J49/42

Abstract: A quadrupole mass filter includes: four electrodes arranged to surround a central axis and constituting a quadrupole; attachment portions to which a plurality of electrical conductors are attached, at least one of the electrical conductors being arranged at a position that lies in a direction toward an area between each of the adjacent electrodes among the four electrodes, as viewed from the central axis; and a holder having a hollow portion and holding the four electrodes and the plurality of electrical conductors, wherein the electrical conductors are attached to the respective attachment portions and held by the holder with elasticity of a material constituting the electrical conductors.

公开(公告)号：US20160343562A1

公开(公告)日：2016-11-24

申请号：US14718842

申请日：2015-05-21

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/4215 ,  G01N30/7266 ,  H01J49/004 ,  H01J49/005 ,  H01J49/24

Abstract: A dwell time calculation table (51a) showing a correspondence relation between a CID gas pressure inside a collision cell (31) and a dwell time for data collection is stored in a processing condition parameter memory (51) of a controller (50). In the table (51a), as the CID gas pressure becomes higher, the dwell time becomes longer. When an instruction to execute an MRM measurement mode is given, the controller (50) determines the dwell time in accordance with the currently set CID gas pressure, and controls a data collector (41) to accumulate detection signals from an ion detector (34) during the determined dwell time and obtain the accumulated value. If the CID gas pressure inside the collision cell (31) is high, a decrease in ion speed becomes remarkable, and the rising of the ion intensity becomes slow. However, if the dwell time becomes long, influences of the slow rising on the accumulated value are relatively reduced, and the accuracy of the accumulated value is enhanced. Accordingly, the quantitative accuracy can be enhanced.

公开(公告)号：US20210391164A1

公开(公告)日：2021-12-16

申请号：US17291824

申请日：2018-11-29

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Tomohito NAKANO ,  Yuki TANAKA

IPC: H01J49/04 ,  H01J49/16 ,  H01J49/06 ,  H01J49/24

Abstract: A single type quadrupole mass spectrometer equipped with an ion source by the ESI method, which is a small device including a vacuum pump having a relatively small evacuation speed. The internal diameter of a desolvation tube for introducing ions from an ionization chamber into a first intermediate vacuum chamber is set to 0.4 mm φ, which is large for a small mass spectrometer. The evacuation speed of a rotary pump is determined so that the product of the cross-sectional opening area of the desolvation tube and the pressure in the first intermediate vacuum chamber falls within a range of 15 to 40 mm2·Pa. This can ensure high detection sensitivity and reduce clogging of the desolvation tube due to droplets. Since the pressure in the first intermediate vacuum chamber does not need to be increased more than necessary, a small rotary pump having a small evacuation speed can be used.

公开(公告)号：US20210151313A1

公开(公告)日：2021-05-20

申请号：US17022899

申请日：2020-09-16

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Takashi UMEMOTO

IPC: H01J49/42 ,  H01J49/24 ,  G01N30/72

Abstract: A vacuum chamber 11 for forming a vacuum space has two side walls opposite to each other across an ion beam axis extending within the vacuum space. One of those side walls is openable and closeable. An ion optical element 21 is placed on a base 33, which is located on the bottom surface of the vacuum chamber. A fixation band 213 fixes the ion optical element on the base by holding the element between the base and the fixation band so as to press the element onto the base. A band-catching portion 10d, located on an inside face of a side wall of the vacuum chamber on the opposite side from the openable-and-closeable side wall, catches one end of the fixation band. A band-fixing portion 214, located on the base on the side where the openable-and-closeable side wall is present, fixes the other end of the fixation band to the base.

公开(公告)号：US20200381236A1

公开(公告)日：2020-12-03

申请号：US16771542

申请日：2018-02-07

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Kota NAGASAO

IPC: H01J49/06 ,  H01J49/42 ,  H01J49/24

Abstract: Four rod electrodes (50a to 50d) for separating ions according to a mass-to-charge ratio are held by a rod holder (51). The rod holder (51) is placed on a metal holder sustaining stand (52) provided on a bottom surface of a vacuum housing (1), and is fixed while being pressed by a fixation band (53) fixed to the holder sustaining stand (52) with screws (56). A heat release layer (55) made from heat dissipation silicone or the like is inserted between the fixation band (53) and the rod holder (51) and between the fixation band (53) and the holder sustaining stand (52). Therefore, heat generated in the rod holder (51) due to dielectric loss is not only directly transmitted to the holder sustaining stand (52), but also efficiently transmitted to the holder sustaining stand (52) through the fixation band (53).

公开(公告)号：US20190108991A1

公开(公告)日：2019-04-11

申请号：US16090932

申请日：2016-06-02

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Wataru FUKUI

IPC: H01J49/04 ,  H01J49/16 ,  H01J49/42 ,  G01N30/72

Abstract: In the mass spectrometer system, a tip portion of a cylindrical portion (891) of a capillary (89) is coated with a coating material (892), the tip portion being an injection part for injecting a sample solution to an ionization section. Therefore, it is possible to suppress, by the coating material (892), the deformation of the capillary (89) when the sample solution is injected. In addition, it is possible to suppress the corrosion and the deformation of the capillary (89) by the coating material (892). As a result, the stability of the analysis operation in mass spectrometer system (1) can be improved.

公开(公告)号：US20160189949A1

公开(公告)日：2016-06-30

申请号：US14909764

申请日：2013-08-08

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/4215 ,  H01J49/005 ,  H01J49/06 ,  H01J49/24

Abstract: The present triple quadrupole mass spectrometer determines the relationship between a parameter, such as the mass-to-charge ratio of a precursor ion or that of a product ion, and the optimal collision-gas pressure giving the highest signal intensity in an MRM measurement, derives an approximate equation expressing that relationship, and stores the information representing the equation in an optimum collision-gas pressure calculation information storage section. When a measurement is to be performed, an analysis operator enters the mass-to-charge ratio of a precursor ion or product ion of a target compound. Based on the approximate equation read from the storage section, an optimum collision-gas pressure calculator determines the optimum collision-gas pressure for the specified precursor ion or product ion, and sets this pressure as a measurement condition for the apparatus.

Abstract translation: 本发明的三重四极杆质谱仪确定了前体离子或产物离子的质荷比等参数与在MRM测量中给出最高信号强度的最佳碰撞气体压力之间的关系， 导出表示该关系的近似式，并将表示该方程的信息存储在最佳碰撞气体压力计算信息存储部中。 当进行测量时，分析算子输入目标化合物的前体离子或产物离子的质荷比。 基于从存储部分读取的近似方程，最佳碰撞气体压力计算器确定用于指定的前体离子或产物离子的最佳碰撞气体压力，并将该压力设定为该装置的测量条件。

公开(公告)号：US20240331995A1

公开(公告)日：2024-10-03

申请号：US18400531

申请日：2023-12-29

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Shin FUJITA ,  Junichi TANIGUCHI ,  Shinjiro FUJITA ,  Shiro MIZUTANI

IPC: H01J49/42 ,  H01J49/02

CPC classification number: H01J49/4215 ,  H01J49/022

Abstract: A quadrupole mass filter (50) has a main-rod section (500) including rod electrodes arranged around a central axis C and a first pre-rod section (501) including pre-rod electrodes. Along with an RF voltage having a frequency corresponding to the m/z of an ion, DC voltage is applied to the pre-rod electrodes. The DC voltage and the amplitude of the RF voltage are determined so that a-value and q-value substantially satisfy the conditions that a≠0, (π−βx·π)N={(½)+m}π and βy·π·N={(½)+n}π, where m, n and N are natural numbers, with the X-axis direction connecting the centers of two rod electrodes facing each other across the central axis in a plane perpendicular to the central axis, the Y-axis direction connecting the centers of the other two rod electrodes in the plane, and βx and βy representing β values (0

公开(公告)号：US20240087873A1

公开(公告)日：2024-03-14

申请号：US18559161

申请日：2021-05-31

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Hiroki MIYASHIRO ,  Junichi TANIGUCHI

IPC: H01J49/42

CPC classification number: H01J49/4215

Abstract: A quadrupole mass spectrometer includes a quadrupole mass filter including: a main rod portion including four main rod electrodes; a pre-rod portion including four pre-rod electrodes, where, at an end opposite to the main rod portion, the four pre-rod electrodes are disposed to be aligned on an inscribed circle having the same radius centered on the ion optical axis, and, at the other end facing the main rod portion, two pre-rod electrodes facing each other across the ion optical axis and the other two pre-rod electrodes are disposed to be aligned on an inscribed circle having different radii centered on the ion optical axis; a main voltage applying unit to apply, to each main rod electrodes, a voltage created by superimposing a DC voltage and an RF voltage; and a pre-voltage applying unit to apply an RF voltage having a same frequency as the RF voltage to each pre-rod electrodes.