公开(公告)号：US20200158703A1

公开(公告)日：2020-05-21

申请号：US16612949

申请日：2017-09-14

Applicant: SHIMADZU CORPORATION

Inventor： Wataru FUKUI

IPC: G01N30/72

Abstract: An ionization probe connection jig used to connect an outlet-side flow path of a column 113 and an inlet-side flow path of an ionization probe 211 in a liquid chromatograph, the ionization probe connection jig includes: a first element fixture 10 fixed to a first element 113 that is one of the column 113 and the ionization probe 211; a second element fixture 20 fixed to a second element 211 that is the other; and a movement regulating tool 30 that permits the first element fixture 10 to advance in an axial direction of the first element 113 while regulating the first element 113 or the first element fixture 10 and the second element 211 or the second element fixture 20 such that flow paths of the first element 113 and the second element 211 are matched with each other, and regulates the second element fixture 20 such that the second element fixture 20 does not retreat beyond a predetermined position in a axial direction of the second element 211.

公开(公告)号：US20180374694A1

公开(公告)日：2018-12-27

申请号：US16062891

申请日：2015-12-17

Applicant: SHIMADZU CORPORATION

Inventor： Wataru FUKUI

IPC: H01J49/16 ,  H01J49/26 ,  H01J49/14 ,  H01J49/24 ,  H01J49/04 ,  H01J49/06

Abstract: Provided is an ion analyzer characterized by: an ionization chamber (10) to be maintained at atmospheric pressure; an analysis chamber (11) for analyzing an ion generated in the ionization chamber (10); a vacuum pump (15, 16) for evacuating the inside of the analysis chamber (11); a capillary (102) for allowing the ionization chamber (10) and the analysis chamber (11) to communicate with each other; a conductance changer (103, 104) for changing the conductance of the capillary (102); and a controller (20) for operating the conductance changer (103, 104) in such a manner as to decrease the conductance of the capillary (102) when the degree of vacuum in the analysis chamber (11) is lower than a predetermined degree of vacuum.

公开(公告)号：US20210190737A1

公开(公告)日：2021-06-24

申请号：US16622078

申请日：2017-09-14

Applicant: SHIMADZU CORPORATION

Inventor： Wataru FUKUI

IPC: G01N30/72

Abstract: A liquid chromatograph that ionizes a sample eluted from a column 113 using an ionization probe 211 connected to the column 113 and analyzes the sample using an ion analyzer 200, the liquid chromatograph includes: a column oven 114 in which the column 113 is accommodated; and a guide mechanism 1, 1141a that is provided inside the column oven 114, permits the column 113 to move in a predetermined direction following movement of the ionization probe 211, and regulates movement in other directions.

公开(公告)号：US20150380226A1

公开(公告)日：2015-12-31

申请号：US14640137

申请日：2015-03-06

Applicant: SHIMADZU CORPORATION

Inventor： Wataru FUKUI ,  Kazuo MUKAIBATAKE

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0445 ,  H01J49/0404 ,  H01J49/10

Abstract: An ionization chamber 100 is provided between a liquid chromatograph unit 60 and a mass spectrometer 50, and is formed of: an atomization means 15; and an ion introducing pipe 19 of which the entrance portion is created within the ionization chamber 100 in the horizontal direction that is perpendicular to the Z direction and of which the exit portion is created within the mass spectrometer unit 50. A liquid sample that has been fed from the liquid chromatograph unit 60 is sprayed in the Z direction by the atomization means 15 while being ionized within the ionization chamber 100, wherein the entrance portion has an opening in such a form that corresponds to the spread in the XY plane of the liquid sample sprayed in the Z direction. The sprayed liquid sample is then fed into the mass spectrometer unit 50 while being desolvated, which effectively contributes to analysis.

Abstract translation: 电离室100设置在液相色谱单元60和质谱仪50之间，由雾化装置15形成; 离子导入管19，其在离子化室100内沿垂直于Z方向的水平方向形成入口部分，并且在质谱仪单元50内形成出口部分。液体样品已经被 从液相色谱单元60供给的液体色谱单元60在雾化装置15的同时在Z方向喷射，同时被离子化在离子化室100内，其中入口部具有与液面XY平面上的扩散相对应的开口 样品在Z方向喷雾。 然后喷射的液体样品被进料到质谱仪单元50中，同时进行脱溶剂，这有效地有助于分析。

公开(公告)号：US20210208113A1

公开(公告)日：2021-07-08

申请号：US16754154

申请日：2017-10-27

Applicant: SHIMADZU CORPORATION

Inventor： Wataru FUKUI

IPC: G01N30/06 ,  B01J20/281

Abstract: An ESI sprayer tube 10 includes: a first tube 11 having an inlet end; a second tube 12 having the inner diameter larger than the outer diameter of the first tube 11, the second tube 12 being located outside the first tube 11; and a tube fixation portion 14 formed to fill a space between the first tube 11 and the second tube 12, in a side close to the inlet end.

公开(公告)号：US20210146395A1

公开(公告)日：2021-05-20

申请号：US16641019

申请日：2017-09-14

Applicant: Shimadzu Corporation

Inventor： Wataru FUKUI

IPC: B05B15/65 ,  B05B5/16

Abstract: In an ESI sprayer including a pipe connecting jig used to connect an inlet-side pipe and an ESI capillary, a through-hole having an inner diameter corresponding to an outer diameter of the inlet-side pipe at one end and an inner diameter corresponding to an outer diameter of the ESI capillary at another end is formed in an axial direction of a conductive cylindrical body in which at least both ends are plastically deformable, and a gap forming protrusion protruding inward from a circumferential wall of the through-hole is provided in the cylindrical body.

公开(公告)号：US20190108991A1

公开(公告)日：2019-04-11

申请号：US16090932

申请日：2016-06-02

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Wataru FUKUI

IPC: H01J49/04 ,  H01J49/16 ,  H01J49/42 ,  G01N30/72

Abstract: In the mass spectrometer system, a tip portion of a cylindrical portion (891) of a capillary (89) is coated with a coating material (892), the tip portion being an injection part for injecting a sample solution to an ionization section. Therefore, it is possible to suppress, by the coating material (892), the deformation of the capillary (89) when the sample solution is injected. In addition, it is possible to suppress the corrosion and the deformation of the capillary (89) by the coating material (892). As a result, the stability of the analysis operation in mass spectrometer system (1) can be improved.

公开(公告)号：US20230197427A1

公开(公告)日：2023-06-22

申请号：US17918375

申请日：2020-04-17

Applicant: SHIMADZU CORPORATION

Inventor： Yuta MIYAZAKI ,  Shiro MIZUTANI ,  Wataru FUKUI

IPC: H01J49/02 ,  H01J49/16

CPC classification number: H01J49/022 ,  H01J49/167

Abstract: An ion analyzer 2 including: a power feeding circuit 26 in which a power supply connection part 261, a first electrode connection part 262, a first resistance element 263, a second electrode connection part 264, a second resistance element 265, and a grounding part are provided in series; a power supply P connected to the power supply connection part 261 and configured to output both a DC positive voltage and a DC negative voltage; a first voltage supply electrode 23 connected to the first electrode connection part 262; and a second voltage supply electrode 24 connected to the second electrode connection part 264. In particular, it can be suitably used as a device for applying a voltage to a push electrode 23 and a convergence electrode 24 disposed in an ionization chamber 20 of a mass spectrometer including an ESI source 21.

公开(公告)号：US20200234940A1

公开(公告)日：2020-07-23

申请号：US16625138

申请日：2017-09-14

Applicant: SHIMADZU CORPORATION

Inventor： Wataru FUKUI

IPC: H01J49/16 ,  G01N30/72 ,  H01J49/04

Abstract: An ESI sprayer 211 configured to be used by being attached to a first hole 51 made in a housing 50 of an ionizer and a second hole 52 made at an end of the first hole 51, and the second hole 52 having an inner diameter smaller than that of the first hole 51, the second hole 52 having an end communicating with an ionization chamber 210, the ESI sprayer 211 includes: a first pipe 11 having an outer diameter smaller than an inner diameter of the first hole 51; a second pipe 12 having an outer diameter smaller than an inner diameter of the second hole 52; a pipe connecting jig 14 made of a conductive material and connecting end faces of the first pipe 11 and the second pipe 12 separated from each other; and a pipe protecting member 16 configured to be an extendable tubular body made of a conductive material and having an outer diameter smaller than the inner diameter of the first hole 51 and larger than the inner diameter of the second hole 52, the pipe protecting member 16 having one end fixed to the pipe connecting jig and being disposed so as to cover at least the end of the second pipe 52.

公开(公告)号：US20200161120A1

公开(公告)日：2020-05-21

申请号：US16626618

申请日：2017-07-18

Applicant: SHIMADZU CORPORATION

Inventor： Wataru FUKUI

IPC: H01J49/42 ,  H01J49/06 ,  H01J49/04

Abstract: The mass spectrometer includes an ionization unit, an ion transport unit, and a mass separation unit that separates transported ions according to a mass-to-charge ratio. The ion transport unit includes a transport electrode member, a voltage generator that applies a voltage to the transport electrode member, and a voltage controller that changes a voltage applied to the transport electrode member while ionization is performed. The voltage controller switches between a first voltage state in which charged particles generated in the ionization unit can enter the mass separation unit, and a second voltage state in which the charged particles cannot enter the mass separation unit, and switches a voltage state of the transport electrode member between the first voltage state and the second voltage state.