公开(公告)号：US20240331995A1

公开(公告)日：2024-10-03

申请号：US18400531

申请日：2023-12-29

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Shin FUJITA ,  Junichi TANIGUCHI ,  Shinjiro FUJITA ,  Shiro MIZUTANI

IPC: H01J49/42 ,  H01J49/02

CPC classification number: H01J49/4215 ,  H01J49/022

Abstract: A quadrupole mass filter (50) has a main-rod section (500) including rod electrodes arranged around a central axis C and a first pre-rod section (501) including pre-rod electrodes. Along with an RF voltage having a frequency corresponding to the m/z of an ion, DC voltage is applied to the pre-rod electrodes. The DC voltage and the amplitude of the RF voltage are determined so that a-value and q-value substantially satisfy the conditions that a≠0, (π−βx·π)N={(½)+m}π and βy·π·N={(½)+n}π, where m, n and N are natural numbers, with the X-axis direction connecting the centers of two rod electrodes facing each other across the central axis in a plane perpendicular to the central axis, the Y-axis direction connecting the centers of the other two rod electrodes in the plane, and βx and βy representing β values (0

公开(公告)号：US20220130652A1

公开(公告)日：2022-04-28

申请号：US17271836

申请日：2018-08-31

Applicant: SHIMADZU CORPORATION

Inventor： Tasuku MURATA ,  Shinjiro FUJITA

IPC: H01J49/00 ,  H01J49/16

Abstract: Disclosed is an analysis method for ionizing a sample arranged in an ionizing unit of an analysis device in a state where the sample is in contact with a solvent to perform analyzation. The method includes a first mass analysis step of obtaining first measurement data by causing the solvent not in contact with the sample to adhere to a probe, and then performing mass analysis to the solvent adhering to the probe, a second mass analysis step, performed subsequently to the first mass analysis step, of obtaining second measurement data by causing the sample in the solvent to adhere to the probe or causing the sample adhering to the probe to be brought into contact with the solvent, and then performing mass analysis to the solvent and the sample adhering to the probe, and a measurement data generation step of generating measurement data, associated with the sample, based on the first measurement data and the second measurement data.

公开(公告)号：US20230352290A1

公开(公告)日：2023-11-02

申请号：US18182486

申请日：2023-03-13

Applicant: SHIMADZU CORPORATION

Inventor： Shinjiro FUJITA

IPC: H01J49/02

CPC classification number: H01J49/025

Abstract: In a mass spectrometer, a detector generates a current-pulse signal corresponding to an incident ion, with a gain corresponding to a detector voltage which is given by a voltage-generating section. A branching section divides, into branches, a voltage-pulse signal which is based on the current-pulse signal taken from the detector's anode. A pulse-counting section detects the signal one branch by a pulse-count method. An analog detection section detects the signal in another branch by an analogue detection method. A conversion-information storage section holds conversion information showing a relationship between an unsaturated predetermined pulse-count value and the corresponding analog detection value under the detector voltage given to the detector during a measurement. A converted-count-value calculation section calculates a converted count value when the pulse-count value or the analog detection value obtained by a measurement exceeds a predetermined value, using the analog detection value obtained by the measurement and the conversion information.

公开(公告)号：US20160329203A1

公开(公告)日：2016-11-10

申请号：US15110306

申请日：2014-02-10

Applicant: SHIMADZU CORPORATION

Inventor： Shinjiro FUJITA

IPC: H01J49/16 ,  H01J49/24 ,  G01N30/72 ,  G01N30/86 ,  H01J49/00 ,  H01J49/42

CPC classification number: H01J49/165 ,  G01N30/7266 ,  G01N30/8631 ,  G01N30/8651 ,  H01J49/0031 ,  H01J49/107 ,  H01J49/168 ,  H01J49/24 ,  H01J49/4215

Abstract: A mass spectrometer including an ionization source including an ESI probe (201), an ESI power source (24), a corona needle (202) and an APCI power source (24); an ionization condition storage section (41) for storing a plurality of ionization conditions related to the liquid sample, set by an analysis operator, with the ionization conditions differing from each other in the value of the ESI voltage or/and the value of the APCI voltage; a mass spectrometry executer (43) for conducting a mass spectrometry for an ion generated from the liquid sample using each of the plurality of ionization conditions; and a mass spectrometry result selector (44) for selecting, for each of the one or plurality of components, a mass spectrometry result in which the ion is detected with a suitable level of intensity for an analysis, from the mass spectrometry results respectively obtained for the plurality of ionization conditions.

Abstract translation: 一种质谱仪，其包括电离源，包括ESI探针（201），ESI电源（24），电晕针（202）和APCI电源（24）; 电离条件存储部分，用于存储由分析算子设定的与液体样品相关的多个电离条件，其中电离条件在ESI电压的值或/和APCI的值之间彼此不同 电压; 用于使用所述多个电离条件中的每一个对从所述液体样品产生的离子进行质谱分析的质谱执行器（43） 以及质谱分析结果选择器（44），用于对于所述一个或多个组分中的每一个，从分别获得的质谱分析结果中选择用于分析的合适的强度水平来检测离子的质谱分析结果 多个电离条件。

公开(公告)号：US20160118235A1

公开(公告)日：2016-04-28

申请号：US14889605

申请日：2013-05-08

Applicant: SHIMADZU CORPORATION

Inventor： Shinjiro FUJITA

IPC: H01J49/02 ,  H01J49/42

CPC classification number: H01J49/022 ,  H01J49/0031 ,  H01J49/4215

Abstract: In a pause time assigned for switching voltage applied to a quadrupole mass filter or other ion transport optical system so as to switch the mass-to-charge ratio of a target ion in an SIM measurement, the polarity of direct-current voltage applied to a pre-quadrupole mass filter is temporarily reversed. The voltage polarity reversal time is changed according to length of the pause time so that the ion intensity can sufficiently rise by the time the next dwell time begins. When the polarity of the voltage applied to the pre-quadrupole mass filter is reversed, the electric charges which lie on an insulating film of contaminants or other substances attached to the surface of the pre-quadrupole mass filter or on an insulating support structure are dispersed, whereby the charge-up is eliminated. Since ions are prevented from passing through, charge-up of a main quadrupole mass filter in the subsequent stage is also reduced.

Abstract translation: 在分配给四极质量滤波器或其他离子传输光学系统的切换电压的暂停时间中，以便在SIM测量中切换目标离子的质荷比，施加到一个 预四极杆质量过滤器暂时反转。 电压极性反转时间根据暂停时间的长度而改变，使得离子强度可以在下一个停留时间开始时充分上升。 当施加到前四极杆质量过滤器的电压的极性反转时，分散在附着于前四极质量过滤器表面或绝缘支撑结构上的污染物或其他物质的绝缘膜上的电荷分散 ，从而消除了充电。 由于防止离子通过，所以后续阶段的主四极体质量过滤器的充电也降低。

公开(公告)号：US20240142415A1

公开(公告)日：2024-05-02

申请号：US18382398

申请日：2023-10-20

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Shinjiro FUJITA ,  Junichi TANIGUCHI

IPC: G01N30/72 ,  H01J49/42

CPC classification number: G01N30/7233 ,  H01J49/4215 ,  G01N2030/027

Abstract: For a low-cost, high-accuracy tuning of the voltages applied to electrodes in a mass spectrometer, a chromatograph mass spectrometer (1) includes: a medium supplier (11) which supplies a medium as a mobile phase or carrier gas; a passage (15) which introduces, into the mass spectrometer, the medium supplied from the medium supplier; an ionizer (211) which ionizes the medium together with a substance coming from a member forming the passage into the medium; a measurement executer (25, 26, 43) which performs a mass separation and a measurement of a specific ion, using multiple measurement conditions which differ from each other in the value of voltage applied to at least one electrode included in one or more electrodes in the mass spectrometer; and a voltage value determiner (44) which determines the value of voltage applied to each electrode so that the intensity of the ion satisfies a predetermined criterion.

公开(公告)号：US20210210333A1

公开(公告)日：2021-07-08

申请号：US17059683

申请日：2018-06-01

Applicant: SHIMADZU CORPORATION

Inventor： Manabu UEDA ,  Shinjiro FUJITA

IPC: H01J49/42

Abstract: A quadrupole mass filter includes: four electrodes arranged to surround a central axis and constituting a quadrupole; attachment portions to which a plurality of electrical conductors are attached, at least one of the electrical conductors being arranged at a position that lies in a direction toward an area between each of the adjacent electrodes among the four electrodes, as viewed from the central axis; and a holder having a hollow portion and holding the four electrodes and the plurality of electrical conductors, wherein the electrical conductors are attached to the respective attachment portions and held by the holder with elasticity of a material constituting the electrical conductors.

公开(公告)号：US20140117227A1

公开(公告)日：2014-05-01

申请号：US13662531

申请日：2012-10-28

Applicant: SHIMADZU CORPORATION

Inventor： Shinjiro FUJITA

IPC: H01J49/26 ,  H01J49/04

CPC classification number: H01J49/26 ,  H01J49/004

Abstract: The length of a delay time d from a suspension period starting point t1 until the application of a pulse voltage is begun is changed according to the length of the suspension period during which no data is collected at the time of m/z switching. It is thus ensured that the amount of product ions can be reliably restored at a suspension period termination point t2. In addition, the peak value of the pulse voltage is also changed according to the ionic strength immediately before entering the suspension period. The ion removal rate is thus increased when the amount of remaining ions is high, and the amount of remaining ions is reliably brought to zero within the same pulse width. As a result, crosstalk can be completely removed.

Abstract translation: 根据在m / z切换时没有收集数据的暂停期间的长度，改变从停止期起点t1开始施加脉冲电压的延迟时间d的长度。 因此，确保在悬浮期间终止点t2可以可靠地恢复产物离子的量。 此外，脉冲电压的峰值也根据在进入暂停时间之前的离子强度而改变。 因此，当剩余离子量高时，离子去除率增加，剩余离子量在相同脉冲宽度内可靠地达到零。 结果，可以完全消除串扰。