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公开(公告)号：US10207269B2
公开(公告)日：2019-02-19
申请号：US15022879
申请日：2014-09-18
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SLIPCHIP CORPORATION
Inventor： Rustem F. Ismagilov , Feng Shen , Liang Li , David Selck , Joe Baker , Espir Kahatt , Chris Da Costa
Abstract: The present invention relates to fluidic systems for controlling one or more fluids and/or one or more reagents. These systems can be used in combination with one or more devices for assaying, processing, and/or storing samples. In particular, the systems and related methods can allow for dispensing fluid in a controlled manner and/or introducing pause(s) when implementing assays or processes.
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公开(公告)号：US09822356B2
公开(公告)日：2017-11-21
申请号：US13868028
申请日：2013-04-22
Applicant: SLIPCHIP CORPORATION , CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. Ismagilov , Feng Shen , Liang Li , Yu-Hsiang Hsu , Stefano Begolo , Mikhail Karymov , David Selck , Stephanie McCalla , Philip James Homewood
CPC classification number: C12N15/1003 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L3/52 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/0678 , B01L2300/045 , B01L2300/0681 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0406 , B01L2400/0487 , B01L2400/0644 , B01L2400/065 , G01N33/525
Abstract: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.
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公开(公告)号：US09803237B2
公开(公告)日：2017-10-31
申请号：US13869856
申请日：2013-04-24
Applicant: California Institute of Technology , SlipChip Corporation
Inventor： Rustem F. Ismagilov , Feng Shen
CPC classification number: C12Q1/686 , B01L3/502738 , B01L7/52 , B01L2200/0668 , B01L2200/0673 , B01L2300/0681 , B01L2300/069 , B01L2300/0864 , B01L2300/0867 , B01L2300/161 , B01L2400/0409 , B01L2400/0487 , B01L2400/065
Abstract: The present invention relates to fluidic devices for compartmentalizing samples. In particular, the devices and related systems and methods allow for compartmentalization by using one or more first chambers connect by a first channel (e.g., where the cross-sectional dimension of the first channel is less than the cross-sectional dimension of at least one first chamber).
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4.发明申请MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES 审中-公开用于定量和检测核酸和其他分析物的多功能装置，试剂盒和相关方法公开(公告)号：US20150225803A1
公开(公告)日：2015-08-13
申请号：US14177194
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
IPC: C12Q1/70
CPC classification number: C12Q1/703 , C12Q1/6851 , C12Q1/707 , C12Q2600/158 , C12Q2561/113
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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公开(公告)号：US11542545B2
公开(公告)日：2023-01-03
申请号：US15524449
申请日：2015-11-05
Inventor： Rustem F. Ismagilov , Eugenia Khorosheva , Travis S. Schlappi , Matthew S. Curtis , Nathan G. Schoepp , Hedia Maamar , Feng Shen , Erik B. Jue
IPC: C12Q1/6851 , C12Q1/689 , C12Q1/6809 , C12Q1/18 , C12Q1/686 , B01L3/00 , B01L7/00
Abstract: Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.
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Patent Agency Ranking
6.发明申请ANALYSIS DEVICES, KITS, AND RELATED METHODS FOR DIGITAL QUANTIFICATION OF NUCLEIC ACIDS AND OTHER ANALYTES 审中-公开用于数字量化核酸和其他分析物的分析装置，试剂盒和相关方法公开(公告)号：US20160362734A1
公开(公告)日：2016-12-15
申请号：US15247795
申请日：2016-08-25
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Bing Sun , Wenbin Du
CPC classification number: C12Q1/6851 , B01F13/0094 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2300/0864 , B01L2300/0896 , C12Q2531/119 , C12Q2537/149 , C12Q2563/159 , C12Q2565/629
Abstract: Provided are devices and methods for effecting processing of samples, including essentially isothermal amplification of nucleic acids, at multiple reaction locations in a single device. In some embodiments, the disclosed devices and methods provide for effecting parallel sample processing in several hundred locations on a single device.
Abstract translation: 提供了用于在单个装置中的多个反应位置处理样品的装置和方法，包括基本上等温的核酸扩增。 在一些实施例中，所公开的设备和方法提供了在单个设备上在几百个位置中实现并行样本处理。
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7.发明申请MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES 审中-公开用于定量和检测核酸和其他分析物的多功能装置，试剂盒和相关方法公开(公告)号：US20170051365A9
公开(公告)日：2017-02-23
申请号：US14177194
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
IPC: C12Q1/70
CPC classification number: C12Q1/703 , C12Q1/6851 , C12Q1/707 , C12Q2600/158 , C12Q2561/113
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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8.发明授权Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes 有权用于定量和检测核酸和其他分析物的多体积仪器，试剂盒和相关方法公开(公告)号：US09493826B2
公开(公告)日：2016-11-15
申请号：US14177190
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
CPC classification number: C12Q1/6851 , B01F5/0085 , B01F13/0094 , B01F15/0218 , B01L3/5025 , B01L3/502738 , B01L3/50851 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2300/045 , B01L2300/049 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q2531/119 , C12Q2537/149 , C12Q2563/159 , C12Q2565/629
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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9.发明申请MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES 有权用于定量和检测核酸和其他分析物的多功能装置，试剂盒和相关方法公开(公告)号：US20140336064A1
公开(公告)日：2014-11-13
申请号：US14177190
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
IPC: C12Q1/68
CPC classification number: C12Q1/6851 , B01F5/0085 , B01F13/0094 , B01F15/0218 , B01L3/5025 , B01L3/502738 , B01L3/50851 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2300/045 , B01L2300/049 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q2531/119 , C12Q2537/149 , C12Q2563/159 , C12Q2565/629
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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10.发明申请公开(公告)号：US20130309679A1
公开(公告)日：2013-11-21
申请号：US13868028
申请日：2013-04-22
Applicant: SlipChip, LLC , California Institute of Technology
Inventor： Rustem F. Ismagilov , Feng Shen , Liang Li , Yu-Hsiang Hsu , Stefano Begolo , Mikhail Karymov , David Selck , Stephanie McCalla , Philip James Homewood
IPC: C12N15/10
CPC classification number: C12N15/1003 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L3/52 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/0678 , B01L2300/045 , B01L2300/0681 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0406 , B01L2400/0487 , B01L2400/0644 , B01L2400/065 , G01N33/525
Abstract: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.
Abstract translation: 本发明涉及用于制备，加工，储存，保存和/或分析样品的流体装置。 特别地，装置和相关系统和方法允许通过使用一个或多个捕获区域和/或自动化分析来制备和/或分析样品（例如生物样本样品）。
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