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公开(公告)号：US20200338554A1
公开(公告)日：2020-10-29
申请号：US16830016
申请日：2020-03-25
发明人： Yasuhisa MINAGAWA , Masaru TANAKA , Haruka EMURA , Kazuki SUTO
IPC分类号： B01L3/00
摘要： The present invention provides a medical analysis device and a cell analysis method, which can capture specific cells such as many types of cancer cells including cancer cells not expressing EpCAM and stem cells. Provided is a medical analysis device including a well portion, the well portion having a hydrophilic silane compound layer formed at least partly on the inner surface thereof.
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公开(公告)号：US20170320056A1
公开(公告)日：2017-11-09
申请号：US15495412
申请日：2017-04-24
摘要： Provided are a medical analysis device and a cell analysis method which can capture many cancer cells, including cancer cells not expressing EpCAM. A medical analysis device including a flow channel zone that includes a chamber zone, the inner surface of the flow channel zone being at least partially provided with a layer of a hydrophilic polymer having a thickness of 2 to 200 nm.
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公开(公告)号：US20170037212A1
公开(公告)日：2017-02-09
申请号：US15107039
申请日：2014-12-08
发明人： Yasuhisa MINAGAWA
CPC分类号： C08J7/18 , A61M5/3129 , A61M5/31513 , A61M2005/3131 , B60C1/0016 , B60C1/0025 , B60C11/00 , B60C11/1346 , C08J2315/02 , C08J2319/00 , C08J2323/28 , C08L15/02
摘要： The present invention provides a method for surface-modifying a rubber vulcanizate or a thermoplastic elastomer, which can cost-effectively provide a variety of functions, such as remarkable sliding properties or biocompatibility, according to the application. The present invention relates to a method for surface-modifying a rubber vulcanizate or a thermoplastic elastomer as a modification target, the method including: step 1 of forming polymerization initiation points A on a surface of the modification target; step 2 of radically polymerizing a non-functional monomer starting from the polymerization initiation points A to grow non-functional polymer chains; step 3 of washing the modification target on which the non-functional polymer chains are grown; step 4 of forming polymerization initiation points B on a surface of the non-functional polymer chains; and step 5 of radically polymerizing a fluorine-containing functional monomer starting from the polymerization initiation points B to grow fluorine-containing functional polymer chains.
摘要翻译： 本发明提供一种橡胶硫化橡胶或热塑性弹性体的表面改性方法，其可根据应用成本有效地提供各种功能，如显着的滑动性能或生物相容性。 本发明涉及一种用于表面改性橡胶硫化橡胶或热塑性弹性体作为改性靶的方法，该方法包括：在改性靶表面上形成聚合引发点A的步骤1; 从聚合引发点A开始自由基聚合非官能单体的步骤2以生长非功能性聚合物链; 洗涤非功能性聚合物链生长的改性对象的步骤3; 在非功能性聚合物链的表面上形成聚合引发点B的步骤4; 以及从聚合引发点B开始自由基聚合含氟官能单体的步骤5，以生长含氟官能聚合物链。
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公开(公告)号：US20160184487A1
公开(公告)日：2016-06-30
申请号：US14954019
申请日：2015-11-30
发明人： Yasuhisa MINAGAWA
IPC分类号： A61L31/04 , A61L31/02 , C08K5/5425 , A61L31/14 , C08F292/00
CPC分类号： A61L31/048 , A61L29/02 , A61L29/085 , A61L29/145 , A61L31/022 , A61L31/10 , A61L31/14 , A61L31/145 , A61L2400/10 , A61L2420/02 , A61L2420/06 , A61L2420/08 , C08F292/00 , C08K5/5425 , C08L33/00
摘要： Provided are surface-modified metals such as metal medical devices e.g., guide wires, syringe needles, and metal tubes in medical devices or equipment, and methods for modifying a metal surface, wherein a lubricant layer is firmly bonded to the surface to impart lubricity to the surface and, further, improve the durability of the lubricant layer on the surface, thereby suppressing deterioration of the sliding properties. Included is a surface-modified metal having a surface at least partially treated by polymerization of a monomer in the presence of a thermal polymerization initiator.
摘要翻译： 提供表面改性金属例如金属医疗装置，例如医疗装置或设备中的导丝，注射针和金属管，以及用于改变金属表面的方法，其中润滑剂层牢固地结合到表面以赋予润滑性 并且进一步提高表面上的润滑剂层的耐久性，从而抑制滑动性能的劣化。 包括表面改性的金属，其表面在热聚合引发剂的存在下通过单体的聚合至少部分地进行处理。
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公开(公告)号：US20160058919A1
公开(公告)日：2016-03-03
申请号：US14828697
申请日：2015-08-18
CPC分类号： A61L31/10 , A61L31/022 , A61L2400/10 , C08L83/04
摘要： The present invention provides metal medical devices which are provided with sliding properties (lubricity), low protein adsorption properties and low cell adsorption properties and further in which these properties are prevented from deteriorating. The present invention relates to a metal medical device having a surface at least partially treated with a copolymer C of a polymerizable silane compound A and a polymerizable compound B that contains a functional group.
摘要翻译： 本发明提供了具有滑动性（润滑性），低蛋白质吸附性能和低细胞吸附性能的金属医疗装置，并且进一步防止了这些性质的劣化。 本发明涉及具有至少部分用可聚合硅烷化合物A的共聚物C和含有官能团的可聚合化合物B处理的表面的金属医疗器械。
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公开(公告)号：US20130310772A1
公开(公告)日：2013-11-21
申请号：US13775451
申请日：2013-02-25
发明人： Yasuhisa MINAGAWA
IPC分类号： B05D5/08
CPC分类号： B05D5/083 , A61L29/04 , A61L29/14 , A61L2400/18 , C08C19/28 , C08F279/02 , C08J7/18 , C08J2321/00 , Y10T428/24355 , Y10T428/31826 , C08F220/06 , C08F214/08
摘要： The present invention aims to provide a surface modification method for a rubber vulcanizate or a thermoplastic elastomer, which can impart excellent sliding properties and durability against repeated sliding motion and can allow the surface to maintain the sealing properties, without using expensive self-lubricating plastics. The present invention relates to a surface modification method for modifying a rubber vulcanizate or a thermoplastic elastomer as an object to be modified, the method including: Step 1 of allowing a photopolymerization initiator to be adsorbed on a surface of the object to be modified; and Step 2 of radical polymerizing monomers, starting from the adsorbed photopolymerization initiator, by irradiation with UV light at a wavelength of 300 nm to 400 nm to grow polymer chains on the surface of the object to be modified.
摘要翻译： 本发明的目的在于提供一种橡胶硫化橡胶或热塑性弹性体的表面改性方法，其可以赋予优异的滑动性能和耐反复滑动的耐久性，并且可以在不使用昂贵的自润滑塑料的情况下使表面保持密封性能。 本发明涉及一种改性橡胶硫化橡胶或作为改性对象的热塑性弹性体的表面改性方法，该方法包括：使光聚合引发剂吸附在被改性体的表面上的步骤1; 和从吸附的光聚合引发剂开始的自由基聚合单体的步骤2，通过用波长为300nm至400nm的UV光照射，以在待改性物体的表面上生长聚合物链。
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公开(公告)号：US20240343934A1
公开(公告)日：2024-10-17
申请号：US18608596
申请日：2024-03-18
发明人： Yasuhisa MINAGAWA , Chiaki DOKAI
IPC分类号： C09D133/14 , C07K17/08 , G01N1/40
CPC分类号： C09D133/14 , C07K17/08 , G01N1/405
摘要： Provided is a polymer-coated glass substrate having a surface with controlled irregularity and a low elastic modulus. The polymer-coated glass substrate includes a glass substrate and two or more hydrophilic polymer layers on a surface of the glass substrate.
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公开(公告)号：US20210372895A1
公开(公告)日：2021-12-02
申请号：US17244001
申请日：2021-04-29
发明人： Yasuhisa MINAGAWA
IPC分类号： G01N1/40 , C08F120/28 , C09D133/14
摘要： Provided are hydrophilic substrates provided with a hydrophilic polymer layer having controlled surface uniformity and irregularities, and methods for preparing the hydrophilic substrates. Included are hydrophilic substrates including a substrate having a surface containing at least one group represented by —N(R1)2 or —N(R2)3+ wherein each R1 or R2 is the same or different and represents a hydrogen atom or a substituted or unsubstituted hydrocarbon group optionally containing a hetero atom; and a hydrophilic polymer layer provided on the surface of the substrate.
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公开(公告)号：US20180327560A1
公开(公告)日：2018-11-15
申请号：US15954296
申请日：2018-04-16
发明人： Yasuhisa MINAGAWA , Keiji TANAKA , Hisao MATSUNO , Toyoaki HIRATA
CPC分类号： C08J7/02 , B01J20/261 , B01J20/3071 , B01J20/3078 , B01J20/321 , B01J20/327 , C08J3/005 , C08J2325/06 , C08J2333/12 , C08J2375/04 , C08J2433/14
摘要： Provided is a method of producing a polymer-impregnated base resin which is excellent in providing low adsorption of proteins and blood cells such as platelets. The method of producing a polymer-impregnated base resin includes impregnating a base resin with a polymer solution that includes a solvent able to swell the base resin.
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公开(公告)号：US20180266565A1
公开(公告)日：2018-09-20
申请号：US15866010
申请日：2018-01-09
发明人： Yasuhisa MINAGAWA
IPC分类号： F16J15/3284 , A61M5/315 , C08F293/00
CPC分类号： F16J15/3284 , A61M5/31513 , B29C39/00 , B32B25/00 , C08F293/005 , F16J1/003 , F16J15/3204
摘要： The present invention provides a gasket excellent in properties such as sliding properties and resistance to liquid leakage. The present invention relates to a gasket including a gasket base material whose surface is at least partially provided with immobilized polymer chains, the gasket having a sliding surface provided with multiple annular projections, the annular projections including a first projection nearest to the top surface of the gasket, the first projection having a surface roughness Ra of 1.0 or less.
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