公开(公告)号：US20040151641A1

公开(公告)日：2004-08-05

申请号：US10764217

申请日：2004-01-23

Applicant: SYMYX TECHNOLOGIES, INC.

Inventor： Lynn Van Erden ,  William H. Chandler JR.

IPC: B01J019/00

CPC classification number: B01L3/5025 ,  B01J3/04 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/0031 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00477 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00704 ,  B01J2219/0072 ,  B01J2219/00736 ,  G01N35/028

Abstract: An apparatus and method for synthesis and screening of materials are disclosed. According to one aspect of the present invention, a parallel batch reactor for effecting chemical reactions includes a pressure chamber, and a plurality of reaction wells. Each of the reaction wells is in isolatable fluid communication with the pressure chamber such that during a first pressurizing stage of operation, each of the reaction wells can be simultaneously pressurized through common fluid communication with the pressure chamber, and such that during a second reaction stage of operation, each of the reaction wells can be fluidically isolated from at least one other of said plurality of reaction wells.

Abstract translation: 公开了一种合成和筛选材料的装置和方法。 根据本发明的一个方面，用于实现化学反应的并行间歇反应器包括压力室和多个反应孔。 每个反应井与压力室可分离流体连通，使得在第一加压阶段期间，每个反应井可以通过与压力室的常见流体连通同时加压，并且使得在第二反应阶段 每个反应孔可以与所述多个反应孔中的至少另一个的流体分离。

公开(公告)号：US20020106813A1

公开(公告)日：2002-08-08

申请号：US10060075

申请日：2002-01-28

Applicant: Symyx Technologies, Inc.

Inventor： Matthew F. Smith ,  John F. Varni ,  G. Cameron Dales ,  Trevor G. Frank ,  Rakesh Jain ,  Lynn Van Erden

IPC: B01J019/00

CPC classification number: B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00313 ,  B01J2219/00335 ,  B01J2219/00337 ,  B01J2219/00373 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00601 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00722 ,  C40B40/14 ,  C40B60/14 ,  Y10T436/2575 ,  Y10T436/25875

Abstract: A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including condensed gases, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.

Abstract translation: 一种并联反应器系统，包括用于保持反应混合物的反应器中的反应器和容器，以及用于将流体反应材料引入容器的插管。 机器人系统可操作以将插管插入反应器中的插管通道中，用于将反应材料（包括冷凝气体）输送到相应的容器，并且在输送后从插管通道中抽出插管。 还公开了相关方法。

公开(公告)号：US20040110636A1

公开(公告)日：2004-06-10

申请号：US10641906

申请日：2003-08-15

Applicant: Symyx Technologies, Inc.

Inventor： Claus Lugmair ,  Alfred Hagemeyer ,  Lynn Van Erden ,  Anthony F. Volpe JR. ,  David M. Lowe ,  Yumin Liu

IPC: B01J023/02

CPC classification number: B07B1/00 ,  B01J19/0046 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/009 ,  B01J2219/00313 ,  B01J2219/00319 ,  B01J2219/00351 ,  B01J2219/00481 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/007 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00756 ,  B01L3/5025 ,  B22F2998/00 ,  C40B30/08 ,  C40B40/18 ,  G01N31/10 ,  B22F9/04

Abstract: Methods and apparatus for combinatorial (i.e., high-throughput) materials research, such as catalysis research, that involves parallel apparatus for simultaneously effecting mechanical treatments such as grinding, mixing, pressing, crushing, sieving, and/or fractionating of such materials are disclosed. The methods and apparatus are useful for mechanically treating catalysis materials and other solid materials, including without limitation, electronic materials such as phosphors, colorants such as pigments, and pharmaceuticals such as crystalline drugs or drug candidates. The simultaneous protocols and parallel apparatus offer substantial improvements in overall throughput for preparing arrays of materials, such as catalysis materials.

Abstract translation: 公开了用于组合（即，高通量）材料研究的方法和装置，例如催化研究，涉及用于同时进行诸如研磨，混合，压制，粉碎，筛分和/或分级的机械处理的并行装置。 。 所述方法和装置可用于机械处理催化材料和其它固体材料，包括但不限于电子材料如磷光体，着色剂如颜料，以及药物如结晶药物或药物候选物。 同时协议和并行设备在制备材料阵列（例如催化材料）方面提供总体通量的显着改进。

公开(公告)号：US20030190260A1

公开(公告)日：2003-10-09

申请号：US10116862

申请日：2002-04-05

Applicant: Symyx Technologies, Inc.

Inventor： Tony N. Wheeler ,  Lynn Van Erden ,  William H. Chandler JR. ,  Richard Tiede ,  Robert J. Saxton ,  Anil Guram

IPC: G01N035/00 ,  G01N035/04

CPC classification number: B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00333 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00601 ,  B01J2219/00686 ,  B01J2219/00722 ,  B01L7/00 ,  B01L9/06 ,  C40B40/14 ,  C40B50/08 ,  C40B60/14 ,  G01N2035/00376 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A combinatorial chemistry reactor system for the parallel processing of reaction mixtures. The system comprises a frame, a head mounted in fixed position on the frame, and a reactor block having a plurality of wells therein for containing reaction mixtures. The reactor block is movable with respect to the head between a first position in which the reactor block and head are assembled for conducting reactions in the wells and a second position in which the reactor block is removed from the head for providing access to the vessels. Gaps in the reactor block between the wells serve to thermally isolate the wells from one another. Other features relating to pressure relief, reactor block temperature control, and sensor mounting are also disclosed.