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1.发明授权Use of low-molecular-weight highly sulfated polysaccharide derivatives for modulating angiogenesis 有权使用低分子量高度硫酸化的多糖衍生物调节血管发生公开(公告)号：US07833990B2
公开(公告)日：2010-11-16
申请号：US11629544
申请日：2005-06-06
申请人： Sabine Matou , Sylvia Colliec-Jouault , Dominique Helley , Jacqueline Ratiskol , Corinne Sinquin , Claire Boisset , Jean Guezennec , Anne-Marie Fischer
发明人： Sabine Matou , Sylvia Colliec-Jouault , Dominique Helley , Jacqueline Ratiskol , Corinne Sinquin , Claire Boisset , Jean Guezennec , Anne-Marie Fischer
IPC分类号： A61K31/737 , C07H1/00
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to the use of certain low-molecular weight highly sulphated polysaccharide derivatives obtained from a bacterial polysaccharide for preparing a pharmaceutical composition suitable for modulating angiogenesis, particularly for use in accelerating vascular endothelial repair with a low haemorrhage risk in the event of thrombotic injuries.
摘要翻译： 本发明涉及从细菌多糖获得的某些低分子量高度硫酸化多糖衍生物用于制备适于调节血管发生的药物组合物的用途，特别是用于加速血栓形成性损伤时出血低风险的血管内皮修复 。
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2.发明申请Use of Low-Molecular-Weight Highly Sulfated Polysaccharide Derivatives for Modulating Angiogenesis 有权使用低分子量高度硫酸化多糖衍生物调节血管生成公开(公告)号：US20070259833A1
公开(公告)日：2007-11-08
申请号：US11629544
申请日：2005-06-06
申请人： Sabine Matou , Sylvia Colliec-Jouault , Dominique Helley , Jacqueline Ratiskol , Corinne Sinquin , Claire Boisset , Jean Guezennec , Anne-Marie Fischer
发明人： Sabine Matou , Sylvia Colliec-Jouault , Dominique Helley , Jacqueline Ratiskol , Corinne Sinquin , Claire Boisset , Jean Guezennec , Anne-Marie Fischer
IPC分类号： A61K31/737 , A61P9/10 , C07H1/00
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to the use of certain low-molecular weight highly sulphated polysaccharide derivatives obtained from a bacterial polysaccharide for preparing a pharmaceutical composition suitable for modulating angiogenesis, particularly for use in accelerating vascular endothelial repair with a low haemorrhage risk in the event of thrombotic injuries.
摘要翻译： 本发明涉及从细菌多糖获得的某些低分子量高度硫酸化多糖衍生物用于制备适于调节血管发生的药物组合物的用途，特别是用于加速血栓形成性损伤时出血低风险的血管内皮修复 。
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3.发明申请Sulfated Depolymerized Derivatives of Expolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing the Same, and Uses Thereof in Tissue Regeneration 有权来自嗜温海洋细菌的多糖（Eps）的硫酸化解聚合衍生物，其制备方法及其在组织再生中的用途公开(公告)号：US20110245199A1
公开(公告)日：2011-10-06
申请号：US12986820
申请日：2011-01-07
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图示出了根据本发明的多糖衍生物GY 785 DRS如何可以以10μg（m）g / ml的浓度刺激网状或重建的结缔组织中的成纤维细胞增殖。
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4.发明申请Sulfated Depolymerized Derivatives of Exopolysaccharides (Eps) from Mesophilic Marine Bacteria, Method for Preparing Same, and Uses Thereof in Tissue Regeneration 审中-公开来自嗜温海洋细菌的多糖（Eps）的硫酸化解聚合衍生物，其制备方法及其在组织再生中的用途公开(公告)号：US20080131472A1
公开(公告)日：2008-06-05
申请号：US11629579
申请日：2005-06-06
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gerard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gerard Raguenes , Anthony Courtois , Jean Guezennec
IPC分类号： A61K31/737 , A01N1/00 , A61K9/00 , A61Q19/00 , C12P19/04
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg(m)g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图显示了根据本发明的多糖衍生物GY 785 DRS如何可以以10ug（m）g / ml的浓度刺激网状或重建结缔组织中的成纤维细胞增殖。
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5.发明授权Sulfated depolymerized derivatives of expolysaccharides (EPS) from mesophilic marine bacteria, method for preparing the same, and uses thereof in tissue regeneration 有权嗜温海洋细菌的多糖（EPS）的硫酸化解聚衍生物及其制备方法及其在组织再生中的应用公开(公告)号：US08598142B2
公开(公告)日：2013-12-03
申请号：US12986820
申请日：2011-01-07
申请人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
发明人： Karim Senni , Farida Gueniche , Myriam Yousfi , Florence Fioretti , Gaston-Jacques Godeau , Sylvia Colliec-Jouault , Jacqueline Ratiskol , Corinne Sinquin , Gérard Raguenes , Anthony Courtois , Jean Guezennec
IPC分类号： A61K31/715 , A61P17/02
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 μg (m) g/ml.
摘要翻译： 本发明涉及由深水热环境的嗜温海洋细菌排泄的海洋天然胞外多糖（EPSs）的某些低分子量硫酸化多糖衍生物，其中所述衍生物可以通过包括以下步骤的方法获得： 所述天然EPSs随后是硫酸化所得的解聚衍生物的步骤。 本发明还涉及所述低分子量硫酸化多糖衍生物作为伤口愈合剂的用途，特别是用于制备适于治疗或预防结缔组织，特别是皮肤和牙龈组织疾病的药物组合物。 该图显示了根据本发明的多糖衍生物GY 785 DRS如何可以以10ug（m）g / ml的浓度刺激网状或重建结缔组织中的成纤维细胞增殖。
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6.发明申请CHONDROGENIC DIFFERENTIATION MEDIA AND METHODS FOR INDUCING CHONDROGENIC DIFFERENTIATION OF CELLS 审中-公开造血分化培养基和诱导细胞成纤维细胞增生的方法公开(公告)号：US20130336937A1
公开(公告)日：2013-12-19
申请号：US14001523
申请日：2012-03-16
申请人： Emilie Rederstorff , Corinne Sinquin , Jacqueline Ratiskol , Sylvia Colliec-Jouault , Jérome Guicheux , Pierre Weiss , Christophe Merceron
发明人： Emilie Rederstorff , Corinne Sinquin , Jacqueline Ratiskol , Sylvia Colliec-Jouault , Jérome Guicheux , Pierre Weiss , Christophe Merceron
IPC分类号： C12N5/077
CPC分类号： C12N5/0655 , A61K35/32 , C12N2500/25 , C12N2500/38 , C12N2500/72 , C12N2501/15 , C12N2501/39 , C12N2501/90 , C12N2506/1384
摘要： The invention provides chondrogenic differentiation media comprising chondrogenic growth factors and low-molecular-weight sulfated polysaccharide derivatives of marine native exopolysaccharides (EPS) excreted by mesophilic marine bacteria from deep-sea hydrothermal environments. The invention relates to methods for inducing chondrogenic differentiation in pluripotent or multipotent cells, to cartilage tissues obtained by such methods, and to the use of such cartilage tissues for therapeutic purposes.
摘要翻译： 本发明提供软骨形成分化培养基，其包括软骨形成生长因子和由深海热液环境中嗜温海洋细菌排泄的海洋天然外多糖（EPS）的低分子量硫酸化多糖衍生物。 本发明涉及用于诱导多能性或多能细胞中的软骨形成分化的方法，通过这些方法获得的软骨组织以及用于治疗目的的这种软骨组织的用途。
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7.发明申请公开(公告)号：US20130032650A1
公开(公告)日：2013-02-07
申请号：US13509029
申请日：2010-11-29
申请人： Claire Boisset , Tinaig Le Costaouec , Joelle Cozien , Corinne Sinquin , Jacqueline Ratiskol , William Helbert , Gaelle Correc , Veronique Larreta Garde
发明人： Claire Boisset , Tinaig Le Costaouec , Joelle Cozien , Corinne Sinquin , Jacqueline Ratiskol , William Helbert , Gaelle Correc , Veronique Larreta Garde
IPC分类号： B02C19/00
CPC分类号： C08B37/003 , C08B15/00 , C08B30/12 , C08B35/00 , C08B37/0021 , C08B37/0024 , C08B37/0039 , C08B37/0042 , C08B37/0045 , C08B37/0054 , C08B37/006 , C08B37/0069 , C08B37/0084 , C08B37/0096 , C08H8/00
摘要： A method for controlled reduction of the weight average molar mass of a polysaccharide down to a lower and determined weight average molar mass, which method includes a step for mechanical milling of the polysaccharide by a ball mill, until the polysaccharide having the desired weight average molar mass is obtained.
摘要翻译： 将多糖的重量平均摩尔质量控制降低到较低且测定的重均摩尔质量的方法，该方法包括通过球磨机机械研磨多糖的步骤，直到具有所需重均摩尔数的多糖 获得质量。
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