-
公开(公告)号：US06867305B2
公开(公告)日：2005-03-15
申请号：US09796959
申请日：2001-03-01
IPC分类号： A61K31/337 , A61K31/475 , A61K45/06 , C07D277/30 , C07D417/06 , C07D263/32
CPC分类号： C07D417/06 , A61K31/337 , A61K31/475 , A61K45/06 , A61K2300/00
摘要： The present invention provides convergent processes for preparing epothilones, desoxyepothilones, and analogues thereof. The present invention further provides novel compositions and methods for the treatment of cancer and additionally provides methods for the treatment of cancer which has developed a multi-drug phenotype.
摘要翻译： 本发明提供用于制备埃坡霉素，脱氧头孢烯酮及其类似物的收敛方法。 本发明还提供了用于治疗癌症的新型组合物和方法，并且另外提供了治疗已发展成多种药物表型的癌症的方法。
-
公开(公告)号：US07115651B2
公开(公告)日：2006-10-03
申请号：US09938754
申请日：2001-08-24
申请人： Samuel J. Danishefsky , Robert M. Garbaccio , Daniel K. Baeschlin , Shawn J. Stachel , David Solit , Neal Rosen
发明人： Samuel J. Danishefsky , Robert M. Garbaccio , Daniel K. Baeschlin , Shawn J. Stachel , David Solit , Neal Rosen
IPC分类号： A61P7/00 , A61K31/385 , A61K31/335 , C07D339/00 , C07D313/00
CPC分类号： C07D491/04 , C07D225/06 , C07D313/00 , C07D493/04
摘要： The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) wherein R0–R4, Z, X, A—B, D—E, G—J, and K—L are as defined herein, the synthesis thereof and the use of these compounds as therapeutic agents.
摘要翻译： 本发明涉及其中R 0〜R 4，Z，X，AB，DE，GJ和KL的结构（及其药学上可接受的衍生物）的化合物是 如本文所定义，其合成和这些化合物作为治疗剂的用途。
-
公开(公告)号：US08957056B2
公开(公告)日：2015-02-17
申请号：US11597678
申请日：2005-05-25
申请人： Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson , Malcolm A. S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
发明人： Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson , Malcolm A. S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
IPC分类号： A61K31/395 , A61K31/335 , C07D313/00 , C07D225/02 , A61K31/365 , A61K31/435
CPC分类号： A61K31/395 , A61K31/365 , A61K31/435
摘要： In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, -R, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis.
-
4.发明授权Compounds, compositions and methods for reducing toxicity and treating or preventing diseases 有权用于减少毒性和治疗或预防疾病的化合物，组合物和方法公开(公告)号：US08859615B2
公开(公告)日：2014-10-14
申请号：US13061508
申请日：2009-08-27
申请人： Samuel J. Danishefsky , Ting-Chao Chou , Xiaoguang Lei , Heedong Yun , Fay Ng , John Hartung , Dalibor Sames
发明人： Samuel J. Danishefsky , Ting-Chao Chou , Xiaoguang Lei , Heedong Yun , Fay Ng , John Hartung , Dalibor Sames
IPC分类号： A61K31/191 , A61K31/357 , C07C31/22 , C07D317/12 , C07C33/048 , A61K31/047 , A61K31/075 , A61K31/165 , A61K31/196 , A61K31/337 , A61K31/343 , A61K31/4192 , A61K31/427 , A61K31/661 , A61K31/675 , A61K31/7048 , A61K45/06 , C07C33/05 , C07C33/14 , C07C33/30 , C07C43/315 , C07C49/24 , C07D249/04 , C07D317/16 , C07D317/18 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/26 , C07D317/28 , C07D317/30
CPC分类号： C07C33/048 , A61K31/047 , A61K31/075 , A61K31/165 , A61K31/196 , A61K31/337 , A61K31/343 , A61K31/357 , A61K31/4192 , A61K31/427 , A61K31/661 , A61K31/675 , A61K31/7048 , A61K45/06 , C07B2200/07 , C07C33/05 , C07C33/14 , C07C33/30 , C07C43/315 , C07C49/24 , C07C2601/02 , C07C2601/14 , C07D249/04 , C07D317/16 , C07D317/18 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/26 , C07D317/28 , C07D317/30 , A61K2300/00
摘要： The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).
摘要翻译： 本发明提供式（I）化合物，包含有效量的式（I）化合物，任选地与化学治疗药物如微管蛋白结合药物组合的组合物，及其用于降低细胞毒性剂毒性的方法， 治疗或预防癌症或神经性疾病，诱导化学保护性II期酶，DNA或蛋白质合成，增强免疫系统，治疗炎症，改善和增强总体健康或福祉，以及制备式（I）化合物的方法， 。
-
公开(公告)号：US08513429B2
公开(公告)日：2013-08-20
申请号：US13367612
申请日：2012-02-07
申请人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
发明人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
IPC分类号： C07D493/04 , C07D417/06
CPC分类号： C07D413/06 , C07D313/00 , C07D417/02 , C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
-
公开(公告)号：US20130095173A1
公开(公告)日：2013-04-18
申请号：US13703563
申请日：2011-06-10
申请人： Samuel J. Danishefsky , Govind Ragupathi , Philip O. Livingston , Jianglong Zhu , Karthik Iyer , Guangbin Yang
发明人： Samuel J. Danishefsky , Govind Ragupathi , Philip O. Livingston , Jianglong Zhu , Karthik Iyer , Guangbin Yang
CPC分类号： C07K17/02 , A61K39/0011 , A61K2039/60 , A61K2039/6081 , C07K1/1075
摘要： Glycopeptide conjugates comprising GM2 and/or Gb5 carbohydrate determinants, and methods of making and using such conjugates are disclosed. The immunogenicity of select glycopeptide conjugates is demonstrated.
摘要翻译： 公开了包含GM2和/或Gb5碳水化合物决定簇的糖肽缀合物，以及制备和使用这些缀合物的方法。 证明了选择性糖肽缀合物的免疫原性。
-
公开(公告)号：US08202911B2
公开(公告)日：2012-06-19
申请号：US13053161
申请日：2011-03-21
IPC分类号： A61K31/12 , C07C49/587
CPC分类号： C07D313/00 , A61K31/365 , A61K31/395 , A61K31/435 , C07D225/02 , C07D405/06 , C07D495/04 , A61K2300/00
摘要： In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 一方面，本发明提供包含治疗有效量的通式（I）化合物的药物组合物，其中R 1 -R 6，R a -R c，Q，Y 1，Y 2和n如本文所定义，其中组合物为 配制成以约0.1mg / kg至约50mg / kg体重的剂量施用于受试者。 另一方面，本发明提供一种用于治疗受试者的乳腺肿瘤转移的方法，其包括向有需要的受试者施用治疗有效量的上述直接描述的本发明组合物和药学上可接受的载体，佐剂或媒介物。
-
8.发明申请SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO, ANALOGUES AND USES THEREOF 有权EPOTHILONES的合成，其中间体，其模拟物及其用途公开(公告)号：US20110263663A1
公开(公告)日：2011-10-27
申请号：US13040211
申请日：2011-03-03
申请人： Samuel J. Danishefsky , Peter Bertinato , Dai-shi Su , Dongfang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J. Sorensen , Aaron Balog , Kenneth A. Savin
发明人： Samuel J. Danishefsky , Peter Bertinato , Dai-shi Su , Dongfang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J. Sorensen , Aaron Balog , Kenneth A. Savin
IPC分类号： A61K31/427 , A61P35/00
CPC分类号： A61K31/704 , A61K31/335 , A61K31/337 , A61K31/425 , A61K31/475 , A61K31/70 , A61K45/06 , C07C69/007 , C07D277/24 , C07D313/00 , C07D417/06 , C07D417/14 , C07D493/04 , C07F7/1804 , A61K2300/00
摘要： The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
摘要翻译： 本发明提供用于制备埃坡霉素A和B，脱氧头孢菌素A和B及其类似物的收敛方法。 还提供了与埃坡霉素A和B相关的类似物以及可用于制备它的中间体。 本发明还提供了基于埃坡霉素类似物的新型组合物和治疗癌症和癌症的方法，其已经开发出多药耐药表型。
-
公开(公告)号：USRE41990E1
公开(公告)日：2010-12-07
申请号：US11649750
申请日：2007-01-04
申请人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , Dongfang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J. Sorensen , Aaron Balog , Kenneth A. Savin
发明人： Samuel J. Danishefsky , Peter Bertinato , Dai-Shi Su , Dongfang Meng , Ting-Chao Chou , Ted Kamenecka , Erik J. Sorensen , Aaron Balog , Kenneth A. Savin
IPC分类号： A61K31/365 , A61K31/427 , C07D277/22 , C07D313/00
CPC分类号： A61K31/704 , A61K31/335 , A61K31/337 , A61K31/425 , A61K31/475 , A61K31/70 , A61K45/06 , C07C69/007 , C07D277/24 , C07D313/00 , C07D417/06 , C07D417/14 , C07D493/04 , C07F7/1804 , A61K2300/00
摘要： The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.
-
公开(公告)号：US07759374B2
公开(公告)日：2010-07-20
申请号：US11546715
申请日：2006-10-12
申请人： Samuel J. Danishefsky , Alexey Rivkin , Fumikiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
发明人： Samuel J. Danishefsky , Alexey Rivkin , Fumikiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
IPC分类号： A61K31/427 , A61K31/422 , A61K31/42 , C07D277/20 , C07D263/30 , C07D261/06
CPC分类号： C07D413/06 , C07D313/00 , C07D417/02 , C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
-
-
-
-
-
-
-
-
-
搜索结果
109 条记录 (耗时 0.066 秒)
