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42 条记录 (耗时 0.023 秒)

    Hydrolyzable delivery system using crosslinked polymeric resins as vehicles
    2.
    发明授权
    Hydrolyzable delivery system using crosslinked polymeric resins as vehicles 失效
    使用交联聚合物树脂作为载体的可水解递送系统

    公开(公告)号：US6096834A

    公开(公告)日：2000-08-01

    申请号：US50043

    申请日：1998-03-30

    申请人： Samuel J. Tremont

    发明人： Samuel J. Tremont

    IPC分类号： A61K47/48 ,  C08F8/00 ,  C08C9/12 ,  A61F13/00 ,  A61K31/74 ,  A61K39/395 ,  C08C19/24

    CPC分类号： A61K47/48176 ,  C08F8/30 ,  C08F8/32

    摘要： This invention provides a method of preparing a polymeric delivery system for active ingredients. The delivery system is formed either by attaching the active ingredient to a linker through a hydrolyzable covalent bond, then forming a covalent bond between the linker and a portion of the subunits of a crosslinked polymer, or by attaching a linker to a portion of the subunits of a crosslinked polymer, then attaching the active ingredient to the polymer-linker combination through a hydrolyzable covalent bond. The invention also provides a delivery system comprising an active ingredient covalently bonded through a hydrolyzable covalent bond to a linker, which is in turn covalently bonded to a portion of subunits of a crosslinked polymer.

    摘要翻译： 本发明提供了制备用于活性成分的聚合物递送系统的方法。 递送系统通过将活性成分连接到可通过可水解共价键的接头形成，然后在接头与交联聚合物的一部分亚单位之间形成共价键，或通过将接头连接到亚单位的一部分 的交联聚合物，然后通过可水解共价键将活性成分连接到聚合物 - 连接体组合。 本发明还提供了一种递送系统，其包含通过可水解共价键共价键合到接头的活性成分，其接着共价键合到交联聚合物的一部分亚单位。

    Controlled functional density poly (secondary amines) and method for preparation thereof
    3.
    发明授权
    Controlled functional density poly (secondary amines) and method for preparation thereof 失效
    受控功能密度聚（仲胺）及其制备方法

    公开(公告)号：US5457147A

    公开(公告)日：1995-10-10

    申请号：US383046

    申请日：1995-02-03

    申请人： Martin P. McGrath ,  Samuel J. Tremont

    发明人： Martin P. McGrath ,  Samuel J. Tremont

    IPC分类号： C08C19/34 ,  C08F8/04 ,  C08F8/32 ,  C08K3/02

    CPC分类号： C08F8/04 ,  C08C19/34 ,  C08F8/32

    摘要： A process for preparing a controlled functional density poly(secondary amine) comprising: (a) contacting a polymer containing olefinic unsaturation with carbon monoxide in hydrogen under hydroformylation conditions in the presence of a hydroformylation catalyst to produce a controlled functional density polyaldehyde containing reactive carbon-carbon double bonds, and (b) contacting the polyaldehyde with hydrogen and a primary amine under reductive amination conditions in the presence of a ruthenium-containing imine hydrogenation catalyst or (b.sup.1) contacting the polyaldehyde with a sterically hindered aliphatic or cycloaliphatic primary amine or an aromatic primary amine under reductive amination conditions in the presence of an alkali metal borohydride to produce poly(secondary amine) having a substantially equivalent ratio of secondary amine groups to reactive carbon-carbon double bonds as the ratio of aldehyde groups to reactive carbon-carbon double bonds in the polyaldehyde.

    摘要翻译： 一种制备受控功能密度聚（仲胺）的方法，包括：（a）在加氢甲酰化条件下，在加氢甲酰化催化剂存在下，使含有烯属不饱和的聚合物与一氧化碳在氢气中接触，以产生受控的功能密度聚醛， 碳双键，和（b）在还原胺化条件下，在含钌亚胺氢化催化剂存在下使聚醛与伯胺接触，或（b1）使多醛与空间位阻的脂族或脂环族伯胺或 芳族伯胺在还原胺化条件下在碱金属硼氢化物存在下反应生成具有基本上当量的仲胺基与反应性碳 - 碳双键的比例的聚（仲胺）作为醛基与反应性碳 - 碳双重比例 多醛中的键。

    Dehydrocoupling of toluene
    6.
    发明授权
    Dehydrocoupling of toluene 失效
    甲苯脱氢耦合

    公开(公告)号：US4278825A

    公开(公告)日：1981-07-14

    申请号：US101928

    申请日：1979-12-10

    申请人： Samuel J. Tremont ,  Alex N. Williamson

    发明人： Samuel J. Tremont ,  Alex N. Williamson

    IPC分类号： C07C2/84 ,  C07C2/72

    CPC分类号： C07C2/84 ,  C07C2523/14 ,  C07C2523/18

    摘要： Toluene dehydrocoupled products are produced by heating toluene in the vapor phase with an inorganic metal/oxygen composition which functions as an oxygen carrier and has the empirical formula:M.sub.a.sup.1 M.sub.b.sup.2 M.sub.c.sup.3 O.sub.xwhere M.sup.1 is bismuth, M.sup.2 is at least one element selected from indium, silver, Group 2a of the Periodic Table of the Elements, and mixtures thereof, and M.sup.3 is at least one element selected from zinc, germanium, thorium, the lanthanides or rare earths, Groups 1a, 3b, 4b, and 8 of the Periodic Table of the Elements, and mixtures thereof, and wherein a is 1, b is 0.01 to 10, c is 0.01 to 10, and x is a number taken to satisfy the average valences of M.sup.1, M.sup.2, and M.sup.3 in the oxidation states in which they exist in the composition. Alternatively, the same inorganic metal/oxygen composition can be employed as a catalyst or as a combination catalyst/oxygen carrier for the dehydrocoupling reaction when oxygen or an oxygen-containing gas is heated with the toluene.

    摘要翻译： 甲苯脱氢耦合产物是通过用作为氧载体的无机金属/氧组合物在气相中加热甲苯来制备的，具有以下经验式：Ma1Mb2Mc3Ox其中M1是铋，M2是选自铟，银，组中的至少一种元素 元素周期表的2a及其混合物，M3是选自锌，锗，钍，镧系元素或稀土元素中的至少一种元素，元素周期表的第1a，3b，4b和8族 ，及其混合物，其中a为1，b为0.01至10，c为0.01至10，x为满足其存在于其中的氧化态的M1，M2和M3的平均化合价数 组成。 或者，当氧气或含氧气体与甲苯一起加热时，可以使用相同的无机金属/氧组合物作为催化剂或用作脱氢耦合反应的组合催化剂/氧载体。

    Stilbene formation by means of toluene dehydrocoupling using a cobalt-lanthanide catalyst
    7.
    发明授权
    Stilbene formation by means of toluene dehydrocoupling using a cobalt-lanthanide catalyst 失效
    通过使用钴 - 镧系元素催化剂的甲苯脱氢耦合的二苯乙烯形成

    公开(公告)号：US4255602A

    公开(公告)日：1981-03-10

    申请号：US101922

    申请日：1979-12-10

    申请人： Samuel J. Tremont ,  Alex N. Williamson

    发明人： Samuel J. Tremont ,  Alex N. Williamson

    IPC分类号： C07C2/84 ,  C07C2/72

    CPC分类号： C07C2/84 ,  C07C2523/10 ,  C07C2523/75 ,  C07C2523/83

    摘要： Toluene dehydrocoupled products are produced by heating toluene in the vapor phase with an inorganic metal/oxygen composition which functions as an oxygen carrier and has the empirical formula:M.sub.a.sup.1 M.sub.b.sup.2 O.sub.xwhere M.sup.1 is cobalt and M.sup.2 is lanthanum, and wherein a is 1, b is 1 to 10, and x is a number taken to satisfy the average valences of M.sup.1 and M.sup.2 in the oxidation states in which they exist in the composition. Alternatively, the same inorganic metal/oxygen composition can be employed as a catalyst or as a combination catalyst/oxygen carrier for the dehydrocoupling reaction when oxygen or an oxygen-containing gas is heated with the toluene.

    摘要翻译： 甲苯脱氢联合产物是通过用作为氧载体的无机金属/氧组合物在气相中加热甲苯来制备的，具有经验式：Ma1Mb2Ox，其中M1是钴，M2是镧，其中a是1，b是1 至10，并且x是在其存在于组合物中的氧化态中满足M1和M2的平均化价数。 或者，当氧气或含氧气体与甲苯一起加热时，可以使用相同的无机金属/氧组合物作为催化剂或用作脱氢耦合反应的组合催化剂/氧载体。