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公开(公告)号：US07803538B2
公开(公告)日：2010-09-28
申请号：US10869977
申请日：2004-06-17
申请人： Sandrine Mace , Sylvain Ricard , Emmanuelle Cousin , Laurent Pradier , Jésus Benavides , Jean-François Deleuze
发明人： Sandrine Mace , Sylvain Ricard , Emmanuelle Cousin , Laurent Pradier , Jésus Benavides , Jean-François Deleuze
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a method for diagnosing an individual for early onset Alzheimer's disease by measuring the presence or absence of the minor allele of the rs908832 polymorphism of the ABCA2 gene. The presence of the minor allele of the rs908832 polymorphism of the ABCA2 gene indicates that the individual may be suffering from Alzheimer's disease or exhibits an increased risk of developing Alzheimer's disease.
摘要翻译： 本发明涉及通过测定ABCA2基因的rs908832多态性的次要等位基因的存在或不存在来诊断个体的早发性阿尔茨海默病的方法。 ABCA2基因的rs908832多态性的次要等位基因的存在表明该个体可能患有阿尔茨海默氏病或表现出发展为阿尔茨海默氏病的风险增加。
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公开(公告)号：US20050003417A1
公开(公告)日：2005-01-06
申请号：US10869977
申请日：2004-06-17
申请人： Sandrine Mace , Sylvain Ricard , Emmanuelle Cousin , Laurent Pradier , Jesus Benavides , Jean-Francois Deleuze
发明人： Sandrine Mace , Sylvain Ricard , Emmanuelle Cousin , Laurent Pradier , Jesus Benavides , Jean-Francois Deleuze
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Methods for the diagnosis or for the prognosis of Alzheimer's disease in an individual. Said method comprises at least one step of detection of the presence or absence of the minor allele of the rs908832 polymorphism of the ABCA2 gene. The presence of the minor allele of the rs908832 polymorphism of the ABCA2 gene indicates that the individual may be suffering from Alzheimer's disease or else exhibits an increased risk of developing Alzheimer's disease.
摘要翻译： 用于个体诊断或预测阿尔茨海默病的方法。 所述方法包括检测ABCA2基因的rs908832多态性的次要等位基因的存在或不存在的至少一个步骤。 ABCA2基因的rs908832多态性的次要等位基因的存在表明个体可能患有阿尔茨海默病，或者表现出发展为阿尔茨海默病的风险增加。
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3.发明授权公开(公告)号：US09364519B2
公开(公告)日：2016-06-14
申请号：US13602913
申请日：2012-09-04
申请人： Sibylle Hess , Christian Hoelscher , Andrees Boehme , Agnes Menut , Laurent Pradier , Veronique Taupin
发明人： Sibylle Hess , Christian Hoelscher , Andrees Boehme , Agnes Menut , Laurent Pradier , Veronique Taupin
CPC分类号： A61K38/2278 , A61K38/26
摘要： The present application relates to a pharmaceutical composition for use in the prevention or/and treatment of a neurodegenerative disease, the composition comprising desPro36Exendin-4(1-39)-Lys6-NH2 or/and a pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier, adjuvant, or/and auxiliary substance. In addition, the present application relates to the use of the pharmaceutical composition for the treatment and prevention of a neurodegenerative disease.
摘要翻译： 本申请涉及用于预防或/和治疗神经变性疾病的药物组合物，该组合物包含desPro36Exendin-4（1-39）-Lys6-NH2或其药学上可接受的盐，以及任选的药学上可接受的盐 可接受的载体，佐剂或/和辅助物质。 此外，本申请涉及药物组合物用于治疗和预防神经变性疾病的用途。
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4.发明授权Humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide 有权对原始原纤维形式的β-淀粉样蛋白肽特异的人源化抗体公开(公告)号：US08614299B2
公开(公告)日：2013-12-24
申请号：US13319710
申请日：2010-05-11
申请人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Marc Duchesne , Vincent Mikol , Souad Naimi , Laurent Pradier , Yi Shi
发明人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Marc Duchesne , Vincent Mikol , Souad Naimi , Laurent Pradier , Yi Shi
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , C07H21/04 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/92 , C12N15/63 , C12N2015/8518
摘要： The present application relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, and to the use of said antibodies in the field of Alzheimer's disease.
摘要翻译： 本申请涉及对原始原纤维形式的β-淀粉样蛋白肽特异性的人源化抗体以及所述抗体在阿尔茨海默氏病领域中的应用。
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5.发明申请Transgenic animals exhibiting major disorders related to Alzheimer's disease 有权表现出与阿尔茨海默病相关的主要疾病的转基因动物公开(公告)号：US20050076400A1
公开(公告)日：2005-04-07
申请号：US10957311
申请日：2004-10-01
申请人： Caty Casas Louzao , Patrick Benoit , Laurent Pradier , Gunter Tremp , Jean-Michel Itier , Veronique Blanchard-Bregeon
发明人： Caty Casas Louzao , Patrick Benoit , Laurent Pradier , Gunter Tremp , Jean-Michel Itier , Veronique Blanchard-Bregeon
IPC分类号： A01K67/027 , C12N15/85
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/0312
摘要： The present invention relates to nonhuman transgenic animals exhibiting major disorders related to Alzheimer's disease. The animals can be used for demonstrating compounds intended for the treatment of Alzheimer's disease.
摘要翻译： 本发明涉及显示与阿尔茨海默氏病有关的主要病症的非人类转基因动物。 动物可用于展示用于治疗阿尔茨海默病的化合物。
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公开(公告)号：US20060287230A1
公开(公告)日：2006-12-21
申请号：US11390195
申请日：2006-03-28
申请人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Francoise Rosier-Montus , Olga Corti
发明人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Francoise Rosier-Montus , Olga Corti
IPC分类号： A61K38/17 , A61K39/395 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.
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公开(公告)号：US07132396B2
公开(公告)日：2006-11-07
申请号：US09785548
申请日：2001-02-20
申请人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
发明人： Hana Koutnikova , Alexis Brice , Alain Fournier , Laurent Pradier , Catherine Prades , Isabelle Arnould-Reguigne , Marie-Françoise Rosier-Montus , Olga Corti
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention relates to novel compounds and their uses, in particular their pharmaceutical or diagnostic uses or their use as pharmacological targets. More particularly, the present invention relates to a novel protein, referred to as PAP1, as well as to novel peptides and compounds which are capable of modulating, at least partially, the activity of parkin.
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8.发明授权Antibodies specific of the β-amyloid peptides and their uses as diagnostic agents or drugs 失效β-淀粉状蛋白肽特异性抗体及其用途作为诊断剂或药物公开(公告)号：US08343493B2
公开(公告)日：2013-01-01
申请号：US12740217
申请日：2008-10-24
申请人： Eugeen VanMechelen , Pierre Grognet , Nicolas Sergeant , Marie Gompel , Andre Delacourte , Luc Buee , Laurent Pradier , Veronique Blanchard-Bregeon
发明人： Eugeen VanMechelen , Pierre Grognet , Nicolas Sergeant , Marie Gompel , Andre Delacourte , Luc Buee , Laurent Pradier , Veronique Blanchard-Bregeon
IPC分类号： A61K39/395 , C12P21/08 , C07K16/18 , C12N5/20 , C12N5/12 , G01N33/533 , G01N33/534 , G01N33/535
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/4711 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A monoclonal antibody which specifically binds to the N-terminal region of Aβ8-x peptide, x being included from 11 to 42, and recognizes neither Aβ1-40 nor Aβ1-42 and which presents a high affinity with respect to Aβ8-x peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide Aβ8-x.
摘要翻译： 特异性结合A＆Bgr。8-x肽的N-末端区域的单克隆抗体，x包含在11至42中，并且既不识别A＆bgr; 1-40也不识别为1-42，并且与 至A-Bgr; 8-x肽，例如通过单克隆抗体和肽A和Bgr之间的免疫复合物形成确定8-x。
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9.发明申请ANTIBODIES SPECIFIC OF THE BETA-AMYLOID PEPTIDES AND THEIR USES AS DIAGNOSTIC AGENTS OR DRUGS 失效抗坏血酸蛋白酶的抗体及其作为诊断试剂或药物的用途公开(公告)号：US20110059092A1
公开(公告)日：2011-03-10
申请号：US12740217
申请日：2008-10-24
申请人： Eugeen Vanmechelen , Pierre Grognet , Nicolas Sergeant , Marie Gompel , Andre Delacourte , Luc Buee , Laurent Pradier , Veronique Blanchard-bregeon
发明人： Eugeen Vanmechelen , Pierre Grognet , Nicolas Sergeant , Marie Gompel , Andre Delacourte , Luc Buee , Laurent Pradier , Veronique Blanchard-bregeon
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53 , C12N9/96 , C12N5/16 , G01N33/566 , C07K7/00 , C07K16/18 , A61P25/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/4711 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to a monoclonal antibody which specifically binds to the N-terminal region of Aβ8-x peptide, x being comprised from 11 to 42, and recognises neither Aβ1-40 nor Aβ1-42 and which presents a high affinity with respect to Aβ8-x peptide, such as determined by an immunological complex formation between the monoclonal antibody and the peptide Aβ8-x.
摘要翻译： 本发明涉及特异性结合A-Bgr-8-x肽的N-末端区域的单克隆抗体，x由11至42组成，并且不识别A和Bgr 1-40和A＆bgr 1-42，其中 相对于A＆Bgr; 8-x肽的高亲和力，例如通过单克隆抗体和肽A和Bgr之间的免疫复合物形成8-x来确定。
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10.发明授权Method for determining the ability of a compound to modify the interaction between parkin and the p38 protein 有权确定化合物修饰parkin和p38蛋白之间相互作用的能力的方法公开(公告)号：US07070940B2
公开(公告)日：2006-07-04
申请号：US10622817
申请日：2003-07-18
申请人： Olga Corti , Cornelia Hampe , Alexis Brice , Laurent Pradier , Thomas Rooney , Alain Fournier
发明人： Olga Corti , Cornelia Hampe , Alexis Brice , Laurent Pradier , Thomas Rooney , Alain Fournier
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47
摘要： The present invention relates to a method for determining the ability of a compound to modify the interaction between parkin and the p38 protein, and in particular to a method for screening for or detecting compounds intended for the prevention and/or treatment of neurodegenerative pathological conditions. The present inventions also relates to compounds identified in the above screening method.
摘要翻译： 本发明涉及一种测定化合物修饰parkin和p38蛋白之间相互作用的能力的方法，特别涉及用于筛选或检测旨在预防和/或治疗神经变性病理状况的化合物的方法 。 本发明还涉及上述筛选方法鉴定的化合物。
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