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    Method and System for Aortic Valve Calcification Evaluation
    4.
    发明申请
    Method and System for Aortic Valve Calcification Evaluation 有权
    主动脉瓣钙化评估方法与系统

    公开(公告)号：US20130155064A1

    公开(公告)日：2013-06-20

    申请号：US13713603

    申请日：2012-12-13

    申请人： Sasa Grbic ,  Razvan Ioan Ionasec ,  Fernando Vega-Higuera ,  Dominik Bernhardt ,  Dorin Comaniciu

    发明人： Sasa Grbic ,  Razvan Ioan Ionasec ,  Fernando Vega-Higuera ,  Dominik Bernhardt ,  Dorin Comaniciu

    IPC分类号： A61B5/055 ,  G06T17/00

    CPC分类号： A61B5/055 ,  G06T7/11 ,  G06T7/149 ,  G06T7/162 ,  G06T17/00 ,  G06T2207/20081 ,  G06T2207/20156 ,  G06T2207/30048 ,  G06T2207/30101

    摘要： A method and system for automatic aortic valve calcification evaluation is disclosed. A patient-specific aortic valve model in a 3D medical image volume, such as a 3D computed tomography (CT) volume. Calcifications in a region of the 3D medical image volume defined based on the aortic valve model. A 2D calcification plot is generated that shows locations of the segmented calcifications relative to aortic valve leaflets of the patient-specific aortic valve model. The 2D calcification plot can be used for assessing the suitability of a patient for a Transcatheter Aortic Valve Replacement (TAVI) procedure, as well as risk assessment, positioning of an aortic valve implant, and selection of a type of aortic valve implant.

    摘要翻译： 公开了一种自动主动脉瓣钙化评价方法和系统。 3D医学图像体积中的患者特异性主动脉瓣模型，例如3D计算机断层摄影（CT）体积。 基于主动脉瓣模型定义的3D医学图像体积的区域中的钙化。 生成2D钙化曲线，其显示相对于患者特异性主动脉瓣模型的主动脉瓣叶的分段钙化的位置。 2D钙化图可用于评估患者对于经导管主动脉瓣置换（TAVI）程序的适用性，以及风险评估，主动脉瓣植入物的定位和主动脉瓣植入物的选择。

    Method and System for Non-Invasive Functional Assessment of Coronary Artery Stenosis
    5.
    发明申请
    Method and System for Non-Invasive Functional Assessment of Coronary Artery Stenosis 审中-公开
    冠状动脉狭窄无创功能评估方法与系统

    公开(公告)号：US20140058715A1

    公开(公告)日：2014-02-27

    申请号：US14070810

    申请日：2013-11-04

    申请人： Puneet Sharma ,  Lucian Mihai Itu ,  Ali Kamen ,  Bogdan Georgescu ,  Xudong Zheng ,  Huseyin Tek ,  Dorin Comaniciu ,  Dominik Bernhardt ,  Fernando Vega-Higuera ,  Michael Scheuering

    发明人： Puneet Sharma ,  Lucian Mihai Itu ,  Ali Kamen ,  Bogdan Georgescu ,  Xudong Zheng ,  Huseyin Tek ,  Dorin Comaniciu ,  Dominik Bernhardt ,  Fernando Vega-Higuera ,  Michael Scheuering

    IPC分类号： G06F19/00

    CPC分类号： G16B5/00 ,  A61B5/02007 ,  A61B5/1128 ,  A61B6/032 ,  A61B6/503 ,  A61B6/5217 ,  A61B2576/023 ,  G16H50/50

    摘要： A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure.

    摘要翻译： 公开了冠状动脉狭窄非侵入性评估的方法和系统。 从休息状态下获得的患者的医学图像数据中提取冠状动脉的患者特异性解剖学测量。 基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。 基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。 使用冠状动脉循环模型和患者特异性充血边界条件模拟冠状动脉至少一个狭窄区域的血流量和压力。 基于模拟的充血血流量和压力计算至少一个狭窄区域的分数流量储备（FFR）。

    Method and System for Non-Invasive Functional Assessment of Coronary Artery Stenosis
    6.
    发明申请
    Method and System for Non-Invasive Functional Assessment of Coronary Artery Stenosis 审中-公开
    冠状动脉狭窄无创功能评估方法与系统

    公开(公告)号：US20130246034A1

    公开(公告)日：2013-09-19

    申请号：US13794113

    申请日：2013-03-11

    申请人： Puneet Sharma ,  Lucian Mihai Itu ,  Ali Kamen ,  Bogdan Georgescu ,  Xudong Zheng ,  Huseyin Tek ,  Dorin Comaniciu ,  Dominik Bernhardt ,  Fernando Vega-Higuera ,  Michael Scheuering

    发明人： Puneet Sharma ,  Lucian Mihai Itu ,  Ali Kamen ,  Bogdan Georgescu ,  Xudong Zheng ,  Huseyin Tek ,  Dorin Comaniciu ,  Dominik Bernhardt ,  Fernando Vega-Higuera ,  Michael Scheuering

    IPC分类号： G06F19/12

    CPC分类号： G16B5/00 ,  A61B5/02007 ,  A61B5/1128 ,  A61B6/032 ,  A61B6/503 ,  A61B6/5217 ,  A61B2576/023 ,  G16H50/50

    摘要： A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure.

    摘要翻译： 公开了冠状动脉狭窄非侵入性评估的方法和系统。 从休息状态下获得的患者的医学图像数据中提取冠状动脉的患者特异性解剖学测量。 基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。 基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。 使用冠状动脉循环模型和患者特异性充血边界条件模拟冠状动脉至少一个狭窄区域的血流量和压力。 基于模拟的充血血流量和压力计算至少一个狭窄区域的分数流量储备（FFR）。

    METHOD FOR VISUALIZING AN ATRIUM OF THE HEART IN A PATIENT
    9.
    发明申请
    METHOD FOR VISUALIZING AN ATRIUM OF THE HEART IN A PATIENT 有权
    用于在患者中观察心脏的心脏的方法

    公开(公告)号：US20120026169A1

    公开(公告)日：2012-02-02

    申请号：US13187575

    申请日：2011-07-21

    申请人： Dominik Bernhardt ,  Fernando Vega-Higuera

    发明人： Dominik Bernhardt ,  Fernando Vega-Higuera

    IPC分类号： G06T17/00 ,  G06T15/50

    CPC分类号： A61B6/481 ,  A61B6/5217

    摘要： A method is disclosed for visualizing at least one section of the wall of an atrium of the heart in a patient after an ablation for treating atrial fibrillation, in which, based on a volume data record of the heart in the patient obtained after the ablation, at least the treated atrium of the heart in the patient is segmented, wherein those voxels are established that can be considered part of the inner surface, the outer surface, and the volume situated between the inner and outer surfaces of the wall of the treated atrium. Further, in at least one embodiment of the method, there is volume rendering or ray casting such that only the voxel values of those voxels that lie on the inner surface, in the volume, or on the outer surface of the wall of the treated atrium are used for visualizing at least the section of the wall of the treated atrium of the heart. At least one embodiment of the invention moreover relates to a computational program that executes the method, a computational unit that carries out the computational program, and/or a data medium with the computational program.

    摘要翻译： 公开了一种用于在用于治疗心房颤动的消融之后在患者体内使心脏的心房壁的至少一个部分可视化的方法，其中，基于消融后获得的患者心脏的体积数据记录， 至少将患者心脏处理的心房分割，其中建立的体素可以被认为是内表面，外表面和位于治疗心房壁的内表面和外表面之间的体积的一部分 。 此外，在该方法的至少一个实施例中，存在体积渲染或射线铸造，使得仅仅处于处理的心房的壁的内表面，体积或外表面上的那些体素的体素值 用于至少可视化心脏处理的心房的壁的部分。 此外，本发明的至少一个实施例涉及执行该方法的计算程序，执行计算程序的计算单元和/或具有计算程序的数据介质。

    Device and computed tomography scanner for determining and visualizing the perfusion of the myocardial muscle
    10.
    发明授权
    Device and computed tomography scanner for determining and visualizing the perfusion of the myocardial muscle 有权
    用于确定和可视化心肌灌注的装置和计算机断层扫描仪

    公开(公告)号：US08831320B2

    公开(公告)日：2014-09-09

    申请号：US13293172

    申请日：2011-11-10

    申请人： Dominik Bernhardt ,  Michael Scheuering ,  Fernando Vega-Higuera

    发明人： Dominik Bernhardt ,  Michael Scheuering ,  Fernando Vega-Higuera

    IPC分类号： G06K9/00 ,  A61B6/03 ,  G06T7/00 ,  A61B6/00

    CPC分类号： G06F19/12 ,  A61B6/03 ,  A61B6/032 ,  A61B6/481 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  G06F17/18 ,  G06F19/00 ,  G06T7/0012 ,  G06T2207/10076 ,  G06T2207/10081 ,  G06T2207/30048 ,  G06T2207/30104 ,  G16H50/50

    摘要： A device is disclosed for determining and visualizing the perfusion of the myocardial muscle with the aid of static CCTA images. In at least one embodiment, the device includes a segmentation unit for segmenting the coronary blood vessels and the left myocardial muscle from a CCTA image of the heart; a first simulation unit for simulating the blood flow through the coronary blood vessels; and a second simulation unit by which the local perfusion of the myocardial muscle is determined on the basis of the ascertained blood flow into different regions of the myocardial muscle. The perfusion of the different regions of the myocardial muscle is visualized in a schematized image on a visualization unit. By virtue of the proposed device it is possible to dispense with further imaging examinations after the performance of a CCTA scan, thereby relieving the pressure both on the part of the physician and on the part of the patient.

    摘要翻译： 公开了一种借助于静态CCTA图像来确定和可视化心肌肌灌注的装置。 在至少一个实施例中，该装置包括用于从心脏的CCTA图像分割冠状动脉血管和左心肌的分割单元; 用于模拟通过冠状血管的血流的第一模拟单元; 以及第二模拟单元，通过该第二模拟单元，基于确定的进入心肌的不同区域的血液流量来确定心肌的局部灌注。 在可视化单元上的示意图像中可视化心肌的不同区域的灌注。 凭借所提出的装置，可以在执行CCTA扫描之后免除进一步的成像检查，从而减轻了医师和患者部分的压力。